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PI-3 kinase (Phosphoinositide 3-kinase, Dp110) (Pi3K92E, isoform A) (Pi3K92E, isoform B) (EC 2.7.1.-) (EC 2.7.1.137) (EC 2.7.1.153) (EC 2.7.1.154) (Pi3K92E, isoform C) (Putative uncharacterized protein Pi3K92E) (SD05105p)

 P91634_DROME            Unreviewed;      1088 AA.
P91634;
01-MAY-1997, integrated into UniProtKB/TrEMBL.
01-MAY-1997, sequence version 1.
22-NOV-2017, entry version 168.
SubName: Full=PI-3 kinase {ECO:0000313|EMBL:ABG88073.1};
SubName: Full=Phosphoinositide 3-kinase, Dp110 {ECO:0000313|EMBL:CAA70291.1};
SubName: Full=Pi3K92E, isoform A {ECO:0000313|EMBL:AAF55792.1};
SubName: Full=Pi3K92E, isoform B {ECO:0000313|EMBL:AAN14359.1};
EC=2.7.1.- {ECO:0000313|EMBL:AAF55792.1, ECO:0000313|EMBL:AAN14359.1, ECO:0000313|EMBL:AGB96150.1};
EC=2.7.1.137 {ECO:0000313|EMBL:AAF55792.1, ECO:0000313|EMBL:AAN14359.1, ECO:0000313|EMBL:AGB96150.1};
EC=2.7.1.153 {ECO:0000313|EMBL:AAF55792.1, ECO:0000313|EMBL:AAN14359.1, ECO:0000313|EMBL:AGB96150.1};
EC=2.7.1.154 {ECO:0000313|EMBL:AAF55792.1, ECO:0000313|EMBL:AAN14359.1, ECO:0000313|EMBL:AGB96150.1};
SubName: Full=Pi3K92E, isoform C {ECO:0000313|EMBL:AGB96150.1};
SubName: Full=SD05105p {ECO:0000313|EMBL:AAO24928.1};
SubName: Full=Uncharacterized protein Pi3K92E {ECO:0000313|EMBL:CCB63076.1};
Name=Pi3K92E {ECO:0000313|EMBL:AAF55792.1,
ECO:0000313|FlyBase:FBgn0015279};
Synonyms=anon-92Ed {ECO:0000313|EMBL:AAF55792.1},
Dmel\CG4141 {ECO:0000313|EMBL:AAF55792.1},
Dmp110 {ECO:0000313|EMBL:AAF55792.1},
DP110 {ECO:0000313|EMBL:AAF55792.1},
Dp110 {ECO:0000313|EMBL:AAF55792.1},
dP110 {ECO:0000313|EMBL:AAF55792.1},
dp110 {ECO:0000313|EMBL:AAF55792.1},
dp110alpha {ECO:0000313|EMBL:AAF55792.1},
dP13K {ECO:0000313|EMBL:AAF55792.1},
dPI3K {ECO:0000313|EMBL:AAF55792.1},
dPI3K[92E] {ECO:0000313|EMBL:AAF55792.1},
Dpp110 {ECO:0000313|EMBL:AAF55792.1},
p110 {ECO:0000313|EMBL:AAF55792.1},
p120 {ECO:0000313|EMBL:AAF55792.1},
PI(3)K {ECO:0000313|EMBL:AAF55792.1},
PI-3 kinase {ECO:0000313|EMBL:AAF55792.1},
PI-3-K {ECO:0000313|EMBL:AAF55792.1},
PI3'K {ECO:0000313|EMBL:AAF55792.1},
PI3K {ECO:0000313|EMBL:AAF55792.1},
PI3k {ECO:0000313|EMBL:AAF55792.1},
Pi3K {ECO:0000313|EMBL:AAF55792.1},
Pi3k {ECO:0000313|EMBL:AAF55792.1},
pi3k {ECO:0000313|EMBL:AAF55792.1},
PI3K-92D {ECO:0000313|EMBL:AAF55792.1},
PI3K-92E {ECO:0000313|EMBL:AAF55792.1},
PI3K-Dp110 {ECO:0000313|EMBL:AAF55792.1},
PI3K-dp110 {ECO:0000313|EMBL:AAF55792.1},
PI3K-I {ECO:0000313|EMBL:AAF55792.1},
Pi3K92D {ECO:0000313|EMBL:AAF55792.1},
PI3K92E {ECO:0000313|EMBL:AAF55792.1},
Pi3k92e {ECO:0000313|EMBL:AAF55792.1},
pi3k92e {ECO:0000313|EMBL:AAF55792.1},
Pi3K92E|p110 {ECO:0000313|EMBL:AAF55792.1},
Pi3Kp110 {ECO:0000313|EMBL:AAF55792.1},
PI[[3]]K {ECO:0000313|EMBL:AAF55792.1},
PiK92E {ECO:0000313|EMBL:AAF55792.1},
rea {ECO:0000313|EMBL:AAF55792.1},
type-1 PI3K {ECO:0000313|EMBL:AAF55792.1};
ORFNames=CG4141 {ECO:0000313|EMBL:AAF55792.1,
ECO:0000313|FlyBase:FBgn0015279},
Dmel_CG4141 {ECO:0000313|EMBL:AAF55792.1};
Drosophila melanogaster (Fruit fly).
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
Ephydroidea; Drosophilidae; Drosophila; Sophophora.
NCBI_TaxID=7227 {ECO:0000313|EMBL:CAA70291.1};
[1] {ECO:0000313|EMBL:CAA70291.1}
NUCLEOTIDE SEQUENCE.
PubMed=8978685;
Leevers S.J., Weinkove D., MacDougall L.K., Hafen E., Waterfield M.D.;
"The Drosophila phosphoinositide 3-kinase Dp110 promotes cell
growth.";
EMBO J. 15:6584-6594(1996).
[2] {ECO:0000313|EMBL:AAF55792.1, ECO:0000313|Proteomes:UP000000803}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
PubMed=10731132; DOI=10.1126/science.287.5461.2185;
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D.,
Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L.,
Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D.,
Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J.,
Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C.,
Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z.,
Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X.,
Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H.,
Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.,
Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J.,
Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O.,
Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
"The genome sequence of Drosophila melanogaster.";
Science 287:2185-2195(2000).
[3] {ECO:0000313|EMBL:AAF55792.1, ECO:0000313|Proteomes:UP000000803}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
PubMed=12537568;
Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A.,
Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A.,
George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R.,
Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J.,
Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C.,
Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.;
"Finishing a whole-genome shotgun: release 3 of the Drosophila
melanogaster euchromatic genome sequence.";
Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002).
[4] {ECO:0000313|EMBL:AAF55792.1, ECO:0000313|Proteomes:UP000000803}
GENOME REANNOTATION.
STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P.,
Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A.,
Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
Lewis S.E.;
"Annotation of the Drosophila melanogaster euchromatic genome: a
systematic review.";
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
[5] {ECO:0000313|EMBL:AAF55792.1, ECO:0000313|Proteomes:UP000000803}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
PubMed=12537573;
Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R.,
Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M.,
Ashburner M., Celniker S.E.;
"The transposable elements of the Drosophila melanogaster euchromatin:
a genomics perspective.";
Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002).
[6] {ECO:0000313|EMBL:AAF55792.1, ECO:0000313|Proteomes:UP000000803}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
PubMed=12537574;
Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A.,
Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G.,
Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M.,
Karpen G.H.;
"Heterochromatic sequences in a Drosophila whole-genome shotgun
assembly.";
Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002).
[7] {ECO:0000313|EMBL:AAO24928.1}
NUCLEOTIDE SEQUENCE.
Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J.,
Champe M., Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E.,
George R., Gonzalez M., Guarin H., Kronmiller B., Li P., Liao G.,
Miranda A., Mungall C.J., Nunoo J., Pacleb J., Paragas V., Park S.,
Patel S., Phouanenavong S., Wan K., Yu C., Lewis S.E., Rubin G.M.,
Celniker S.;
Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
[8] {ECO:0000313|EMBL:AAF55792.1, ECO:0000313|Proteomes:UP000000803}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
PubMed=16110336; DOI=10.1371/journal.pcbi.0010022;
Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D.,
Ashburner M., Anxolabehere D.;
"Combined evidence annotation of transposable elements in genome
sequences.";
PLoS Comput. Biol. 1:166-175(2005).
[9] {ECO:0000313|EMBL:ABG88073.1}
NUCLEOTIDE SEQUENCE.
STRAIN=C {ECO:0000313|EMBL:ABG88075.1}, and
W {ECO:0000313|EMBL:ABG88073.1};
PubMed=17043223; DOI=10.1073/pnas.0604592103;
Williams K.D., Busto M., Suster M.L., So A.K., Ben-Shahar Y.,
Leevers S.J., Sokolowski M.B.;
"Natural variation in Drosophila melanogaster diapause due to the
insulin-regulated PI3-kinase.";
Proc. Natl. Acad. Sci. U.S.A. 103:15911-15915(2006).
[10] {ECO:0000313|EMBL:AAF55792.1}
NUCLEOTIDE SEQUENCE.
Berkeley Drosophila Genome Project;
Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R.,
Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E.,
Yu C., Rubin G.;
"Drosophila melanogaster release 4 sequence.";
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
[11] {ECO:0000313|EMBL:AAF55792.1}
NUCLEOTIDE SEQUENCE.
Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S.,
Svirskas R., Rubin G.;
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
[12] {ECO:0000313|EMBL:AAF55792.1, ECO:0000313|Proteomes:UP000000803}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
PubMed=17569856; DOI=10.1126/science.1139815;
Smith C.D., Shu S., Mungall C.J., Karpen G.H.;
"The Release 5.1 annotation of Drosophila melanogaster
heterochromatin.";
Science 316:1586-1591(2007).
[13] {ECO:0000313|EMBL:AAF55792.1, ECO:0000313|Proteomes:UP000000803}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
PubMed=17569867; DOI=10.1126/science.1139816;
Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M.,
Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A.,
Dimitri P., Karpen G.H., Celniker S.E.;
"Sequence finishing and mapping of Drosophila melanogaster
heterochromatin.";
Science 316:1625-1628(2007).
[14] {ECO:0000313|EMBL:CCB63076.1}
NUCLEOTIDE SEQUENCE.
STRAIN=CN15III {ECO:0000313|EMBL:CCB63079.1},
CN16III {ECO:0000313|EMBL:CCB63080.1},
CN1III {ECO:0000313|EMBL:CCB63077.1},
CN23III {ECO:0000313|EMBL:CCB63082.1},
CN25III {ECO:0000313|EMBL:CCB63083.1},
CN34III {ECO:0000313|EMBL:CCB63084.1},
CN35III {ECO:0000313|EMBL:CCB63085.1},
CN36III {ECO:0000313|EMBL:CCB63086.1}, and
CN7III {ECO:0000313|EMBL:CCB63076.1};
Alvarez-Ponce D., Guirao-Rico S., Orengo D.J., Segarra C., Rozas J.,
Aguade M.;
"Molecular population genetics of the insulin/TOR signal transduction
pathway: A network-level analysis in Drosophila melanogaster.";
Mol. Biol. Evol. 29:123-132(2012).
[15] {ECO:0000313|EMBL:AAF55792.1}
NUCLEOTIDE SEQUENCE.
FlyBase;
Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
-!- SIMILARITY: Belongs to the PI3/PI4-kinase family.
{ECO:0000256|PROSITE-ProRule:PRU00879,
ECO:0000256|SAAS:SAAS00936814}.
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EMBL; AE014297; AAF55792.1; -; Genomic_DNA.
EMBL; AE014297; AAN14359.1; -; Genomic_DNA.
EMBL; BT003173; AAO24928.1; -; mRNA.
EMBL; DQ792599; ABG88073.1; -; Genomic_DNA.
EMBL; DQ792600; ABG88075.1; -; Genomic_DNA.
EMBL; AE014297; AGB96150.1; -; Genomic_DNA.
EMBL; Y09070; CAA70291.1; -; mRNA.
EMBL; FR870118; CCB63076.1; -; Genomic_DNA.
EMBL; FR870119; CCB63077.1; -; Genomic_DNA.
EMBL; FR870121; CCB63079.1; -; Genomic_DNA.
EMBL; FR870122; CCB63080.1; -; Genomic_DNA.
EMBL; FR870124; CCB63082.1; -; Genomic_DNA.
EMBL; FR870125; CCB63083.1; -; Genomic_DNA.
EMBL; FR870126; CCB63084.1; -; Genomic_DNA.
EMBL; FR870127; CCB63085.1; -; Genomic_DNA.
EMBL; FR870128; CCB63086.1; -; Genomic_DNA.
PIR; T13950; T13950.
RefSeq; NP_001262770.1; NM_001275841.1.
RefSeq; NP_650902.1; NM_142645.3.
RefSeq; NP_732536.1; NM_169910.2.
UniGene; Dm.1876; -.
DIP; DIP-21625N; -.
MINT; MINT-935585; -.
STRING; 7227.FBpp0083348; -.
EnsemblMetazoa; FBtr0083940; FBpp0083348; FBgn0015279.
EnsemblMetazoa; FBtr0083941; FBpp0083349; FBgn0015279.
EnsemblMetazoa; FBtr0334643; FBpp0306705; FBgn0015279.
GeneID; 42446; -.
KEGG; dme:Dmel_CG4141; -.
UCSC; CG4141-RA; d. melanogaster.
CTD; 42446; -.
FlyBase; FBgn0015279; Pi3K92E.
eggNOG; KOG0904; Eukaryota.
eggNOG; COG5032; LUCA.
GeneTree; ENSGT00760000119110; -.
KO; K00922; -.
OMA; SLNWASH; -.
OrthoDB; EOG091G027R; -.
BRENDA; 2.7.1.137; 1994.
Reactome; R-DME-109704; PI3K Cascade.
Reactome; R-DME-110478; Insulin signaling pathway.
Reactome; R-DME-1250342; PI3K events in ERBB4 signaling.
Reactome; R-DME-1257604; PIP3 activates AKT signaling.
Reactome; R-DME-1266695; Interleukin-7 signaling.
Reactome; R-DME-1660499; Synthesis of PIPs at the plasma membrane.
Reactome; R-DME-180292; GAB1 signalosome.
Reactome; R-DME-1963642; PI3K events in ERBB2 signaling.
Reactome; R-DME-198203; PI3K/AKT activation.
Reactome; R-DME-210993; Tie2 Signaling.
Reactome; R-DME-2730905; Role of LAT2/NTAL/LAB on calcium mobilization.
Reactome; R-DME-4420097; VEGFA-VEGFR2 Pathway.
Reactome; R-DME-5654689; PI-3K cascade:FGFR1.
Reactome; R-DME-5654695; PI-3K cascade:FGFR2.
Reactome; R-DME-5654710; PI-3K cascade:FGFR3.
Reactome; R-DME-5654720; PI-3K cascade:FGFR4.
Reactome; R-DME-6811558; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
GenomeRNAi; 42446; -.
Proteomes; UP000000803; Chromosome 3R.
Bgee; FBgn0015279; -.
GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
GO; GO:0005943; C:phosphatidylinositol 3-kinase complex, class IA; IPI:FlyBase.
GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
GO; GO:0016303; F:1-phosphatidylinositol-3-kinase activity; IDA:FlyBase.
GO; GO:0035005; F:1-phosphatidylinositol-4-phosphate 3-kinase activity; IDA:FlyBase.
GO; GO:0001727; F:lipid kinase activity; IDA:FlyBase.
GO; GO:0035004; F:phosphatidylinositol 3-kinase activity; ISS:FlyBase.
GO; GO:0046934; F:phosphatidylinositol-4,5-bisphosphate 3-kinase activity; IDA:FlyBase.
GO; GO:0017124; F:SH3 domain binding; IPI:FlyBase.
GO; GO:0002250; P:adaptive immune response; IBA:GO_Central.
GO; GO:0006914; P:autophagy; IMP:FlyBase.
GO; GO:0005975; P:carbohydrate metabolic process; IMP:FlyBase.
GO; GO:0060326; P:cell chemotaxis; IBA:GO_Central.
GO; GO:0035212; P:cell competition in a multicellular organism; IMP:FlyBase.
GO; GO:0016049; P:cell growth; TAS:FlyBase.
GO; GO:0009267; P:cellular response to starvation; IMP:FlyBase.
GO; GO:0048813; P:dendrite morphogenesis; IDA:FlyBase.
GO; GO:0055115; P:entry into diapause; IMP:FlyBase.
GO; GO:0007390; P:germ-band shortening; IMP:FlyBase.
GO; GO:0045087; P:innate immune response; IBA:GO_Central.
GO; GO:0002168; P:instar larval development; IMP:FlyBase.
GO; GO:0008286; P:insulin receptor signaling pathway; TAS:FlyBase.
GO; GO:0036335; P:intestinal stem cell homeostasis; IGI:FlyBase.
GO; GO:0002164; P:larval development; IMP:FlyBase.
GO; GO:0030536; P:larval feeding behavior; IMP:FlyBase.
GO; GO:0007436; P:larval salivary gland morphogenesis; IMP:FlyBase.
GO; GO:0006629; P:lipid metabolic process; IMP:FlyBase.
GO; GO:0007552; P:metamorphosis; IMP:FlyBase.
GO; GO:0035264; P:multicellular organism growth; IMP:FlyBase.
GO; GO:0010507; P:negative regulation of autophagy; IMP:FlyBase.
GO; GO:0042059; P:negative regulation of epidermal growth factor receptor signaling pathway; IGI:FlyBase.
GO; GO:0016322; P:neuron remodeling; IMP:FlyBase.
GO; GO:0048477; P:oogenesis; IMP:FlyBase.
GO; GO:0030707; P:ovarian follicle cell development; IMP:FlyBase.
GO; GO:0014065; P:phosphatidylinositol 3-kinase signaling; IBA:GO_Central.
GO; GO:0046854; P:phosphatidylinositol phosphorylation; IDA:FlyBase.
GO; GO:0016310; P:phosphorylation; NAS:FlyBase.
GO; GO:0030307; P:positive regulation of cell growth; TAS:FlyBase.
GO; GO:0045793; P:positive regulation of cell size; IMP:FlyBase.
GO; GO:0045927; P:positive regulation of growth; TAS:FlyBase.
GO; GO:0045572; P:positive regulation of imaginal disc growth; IMP:FlyBase.
GO; GO:0046622; P:positive regulation of organ growth; IMP:FlyBase.
GO; GO:0045727; P:positive regulation of translation; IMP:FlyBase.
GO; GO:0006468; P:protein phosphorylation; IBA:GO_Central.
GO; GO:0042127; P:regulation of cell proliferation; IMP:FlyBase.
GO; GO:0008361; P:regulation of cell size; IMP:FlyBase.
GO; GO:0050773; P:regulation of dendrite development; IMP:FlyBase.
GO; GO:0010906; P:regulation of glucose metabolic process; IMP:FlyBase.
GO; GO:0010883; P:regulation of lipid storage; IMP:FlyBase.
GO; GO:0048169; P:regulation of long-term neuronal synaptic plasticity; IDA:FlyBase.
GO; GO:0007346; P:regulation of mitotic cell cycle; IMP:FlyBase.
GO; GO:0040014; P:regulation of multicellular organism growth; IMP:FlyBase.
GO; GO:0046620; P:regulation of organ growth; NAS:FlyBase.
GO; GO:2000377; P:regulation of reactive oxygen species metabolic process; IGI:FlyBase.
GO; GO:0051823; P:regulation of synapse structural plasticity; IMP:FlyBase.
GO; GO:0006979; P:response to oxidative stress; IMP:FlyBase.
GO; GO:0060074; P:synapse maturation; IDA:FlyBase.
GO; GO:0051124; P:synaptic growth at neuromuscular junction; IMP:FlyBase.
Gene3D; 1.10.1070.11; -; 1.
Gene3D; 2.60.40.150; -; 1.
InterPro; IPR016024; ARM-type_fold.
InterPro; IPR035892; C2_domain_sf.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR000403; PI3/4_kinase_cat_dom.
InterPro; IPR036940; PI3/4_kinase_cat_sf.
InterPro; IPR018936; PI3/4_kinase_CS.
InterPro; IPR003113; PI3K_adapt-bd_dom.
InterPro; IPR002420; PI3K_C2_dom.
InterPro; IPR000341; PI3K_Ras-bd_dom.
InterPro; IPR008290; PI3K_Vps34.
InterPro; IPR015433; PI_Kinase.
InterPro; IPR001263; PInositide-3_kin_accessory_dom.
InterPro; IPR029071; Ubiquitin-like_domsf.
PANTHER; PTHR10048; PTHR10048; 2.
Pfam; PF00454; PI3_PI4_kinase; 1.
Pfam; PF00792; PI3K_C2; 1.
Pfam; PF02192; PI3K_p85B; 1.
Pfam; PF00794; PI3K_rbd; 1.
Pfam; PF00613; PI3Ka; 1.
PIRSF; PIRSF000587; PI3K_Vps34; 3.
SMART; SM00142; PI3K_C2; 1.
SMART; SM00143; PI3K_p85B; 1.
SMART; SM00144; PI3K_rbd; 1.
SMART; SM00145; PI3Ka; 1.
SMART; SM00146; PI3Kc; 1.
SUPFAM; SSF48371; SSF48371; 1.
SUPFAM; SSF49562; SSF49562; 1.
SUPFAM; SSF54236; SSF54236; 1.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS00915; PI3_4_KINASE_1; 1.
PROSITE; PS00916; PI3_4_KINASE_2; 1.
PROSITE; PS50290; PI3_4_KINASE_3; 1.
PROSITE; PS51544; PI3K_ABD; 1.
PROSITE; PS51547; PI3K_C2; 1.
PROSITE; PS51546; PI3K_RBD; 1.
PROSITE; PS51545; PIK_HELICAL; 1.
1: Evidence at protein level;
Complete proteome {ECO:0000313|Proteomes:UP000000803};
Kinase {ECO:0000256|PROSITE-ProRule:PRU00269,
ECO:0000256|SAAS:SAAS00936663, ECO:0000313|EMBL:CAA70291.1};
Proteomics identification {ECO:0000213|PeptideAtlas:P91634};
Reference proteome {ECO:0000313|Proteomes:UP000000803};
Transferase {ECO:0000256|PROSITE-ProRule:PRU00269,
ECO:0000256|SAAS:SAAS00936663, ECO:0000313|EMBL:CAA70291.1}.
DOMAIN 41 129 PI3K-ABD. {ECO:0000259|PROSITE:PS51544}.
DOMAIN 214 304 PI3K-RBD. {ECO:0000259|PROSITE:PS51546}.
DOMAIN 344 522 C2 PI3K-type.
{ECO:0000259|PROSITE:PS51547}.
DOMAIN 544 721 PIK helical.
{ECO:0000259|PROSITE:PS51545}.
DOMAIN 816 1067 PI3K/PI4K. {ECO:0000259|PROSITE:PS50290}.
SEQUENCE 1088 AA; 127006 MW; ABDEF07902AAB81C CRC64;
MNMMDNRALA YVAHQPKYET PPEEAEPPCM RFSVNLWKNE MLNWVDLICL LPNGFLLELR
VNPANTIQVI KVEMVNQAKQ MPLGYVIKEA CEYQVYGIST FNIEPYTDET KRLSEVQPYF
GILSLGERTD TTSFSSDYEL TKMVNGMIGT TFDHNRTHGS PEIDDFRLYM TQTCDNIELE
RSAYTWQQRL LYEHPLRLAN STKMPELIRE RHPTRTFLIV VKNENDQSTF TLSVNEQDTP
FSLTESTLQK MNRSQMKMND RTSDYILKVS GRDEYLLGDY PLIQFLYIQE MLSDSAVPNV
VLQSVYRLES YINHHNEQAM VTKRPLPKKR TVHLHKSISS LWDMGNYFQL TLHSISNVNF
DKTRALKVGV HVCLYHGDKK LCAQRSTDSP NGNFDTFLFN DLVMDFDIQM RNLPRMTRLC
IVIFEVTKMS RSKKSSNNKD IALKDVPYNK NPLAWVNTTI FDHKDILRTG RHTLYTWTYA
DDIQSVEVFH PLGTIEPNPR KEECALVDLT FLSSGTGTVR YPSEEVVLQY AADREQVNRL
QRQLAGPEKP IKELKELMAN YTGLDKIYEM VDQDRNAIWE RRNDILRELP EELSILLHCV
YWKERDDVAD MWYLLKQWPL ISIERSLELL DYAYPDPAVR RFAIRCLHFL KDEDLLLYLL
QLVQAIKHES YLESDLVVFL LERALRNQRI GHYFFWHLRS EMQTPSMQTR FGLLLEVYLK
GCKHHVAPLR KQLHVLEKLK QGSLIAKKGS KEKVKTMLQD FLRDQRNSAV FQNIQNPLNP
SFRCSGVTPD RCKVMDSKMR PLWVVFENAD VNASDVHIIF KNGDDLRQDM LTLQMLRVMD
QLWKRDGMDF RMNIYNCISM EKSLGMIEVV RHAETIANIQ KEKGMFSATS PFKKGSLLSW
LKEHNKPADK LNKAINEFTL SCAGYCVATY VLGVADRHSD NIMVKRNGQL FHIDFGHILG
HFKEKLGVRR ERVPFVLTHD FVYVINKGFN DRESKEFCHF QELCERAFLV LRKHGCLILS
LFSMMISTGL PELSSEKDLD YLRETLVLDY TEEKAREHFR AKFSEALANS WKTSLNWASH
NFSKNNKQ


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