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PKHD1, fibrocystin/polyductin

 F6TQL1_HORSE            Unreviewed;      4076 AA.
F6TQL1;
27-JUL-2011, integrated into UniProtKB/TrEMBL.
27-JUL-2011, sequence version 1.
12-SEP-2018, entry version 48.
SubName: Full=PKHD1, fibrocystin/polyductin {ECO:0000313|Ensembl:ENSECAP00000020775};
Name=PKHD1 {ECO:0000313|VGNC:VGNC:21491};
Equus caballus (Horse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000020775, ECO:0000313|Proteomes:UP000002281};
[1] {ECO:0000313|Ensembl:ENSECAP00000020775, ECO:0000313|Proteomes:UP000002281}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000020775,
ECO:0000313|Proteomes:UP000002281};
PubMed=19892987; DOI=10.1126/science.1178158;
Broad Institute Genome Sequencing Platform;
Broad Institute Whole Genome Assembly Team;
Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H.,
Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N.,
Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L.,
Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J.,
Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J.,
Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R.,
Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F.,
Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L.,
Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M.,
White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
"Genome sequence, comparative analysis, and population genetics of the
domestic horse.";
Science 326:865-867(2009).
[2] {ECO:0000313|Ensembl:ENSECAP00000020775}
IDENTIFICATION.
STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000020775};
Ensembl;
Submitted (JUL-2011) to UniProtKB.
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STRING; 9796.ENSECAP00000020775; -.
PaxDb; F6TQL1; -.
Ensembl; ENSECAT00000024985; ENSECAP00000020775; ENSECAG00000022699.
VGNC; VGNC:21491; PKHD1.
eggNOG; ENOG410IEIF; Eukaryota.
eggNOG; ENOG410XQ01; LUCA.
GeneTree; ENSGT00780000121902; -.
InParanoid; F6TQL1; -.
OMA; WVAGIKV; -.
OrthoDB; EOG091G00JT; -.
TreeFam; TF329582; -.
Proteomes; UP000002281; Chromosome 20.
Bgee; ENSECAG00000022699; Expressed in 2 organ(s), highest expression level in adult mammalian kidney.
ExpressionAtlas; F6TQL1; baseline.
GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
GO; GO:0005813; C:centrosome; IEA:Ensembl.
GO; GO:0036064; C:ciliary basal body; IEA:Ensembl.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0072686; C:mitotic spindle; IEA:Ensembl.
GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
GO; GO:0006874; P:cellular calcium ion homeostasis; IEA:Ensembl.
GO; GO:0060271; P:cilium assembly; IEA:Ensembl.
GO; GO:0001822; P:kidney development; IEA:Ensembl.
GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
GO; GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; IEA:Ensembl.
GO; GO:0051898; P:negative regulation of protein kinase B signaling; IEA:Ensembl.
GO; GO:0008284; P:positive regulation of cell proliferation; IEA:Ensembl.
GO; GO:0010824; P:regulation of centrosome duplication; IEA:Ensembl.
GO; GO:0070372; P:regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
GO; GO:0032006; P:regulation of TOR signaling; IEA:Ensembl.
Gene3D; 2.160.20.10; -; 1.
Gene3D; 2.60.40.10; -; 6.
InterPro; IPR019316; G8_domain.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR014756; Ig_E-set.
InterPro; IPR002909; IPT_dom.
InterPro; IPR037524; PA14/GLEYA.
InterPro; IPR011658; PA14_dom.
InterPro; IPR006626; PbH1.
InterPro; IPR012334; Pectin_lyas_fold.
InterPro; IPR011050; Pectin_lyase_fold/virulence.
InterPro; IPR028839; PKHD1.
PANTHER; PTHR45107; PTHR45107; 1.
Pfam; PF10162; G8; 2.
Pfam; PF07691; PA14; 1.
Pfam; PF01833; TIG; 8.
SMART; SM01225; G8; 2.
SMART; SM00429; IPT; 6.
SMART; SM00710; PbH1; 8.
SUPFAM; SSF51126; SSF51126; 3.
SUPFAM; SSF81296; SSF81296; 6.
PROSITE; PS51484; G8; 2.
PROSITE; PS51820; PA14; 1.
4: Predicted;
Complete proteome {ECO:0000313|Proteomes:UP000002281};
Membrane {ECO:0000256|SAM:Phobius};
Reference proteome {ECO:0000313|Proteomes:UP000002281};
Signal {ECO:0000256|SAM:SignalP};
Transmembrane {ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAM:Phobius}.
SIGNAL 1 17 {ECO:0000256|SAM:SignalP}.
CHAIN 18 4076 {ECO:0000256|SAM:SignalP}.
/FTId=PRO_5005676985.
TRANSMEM 3855 3878 Helical. {ECO:0000256|SAM:Phobius}.
DOMAIN 322 482 PA14. {ECO:0000259|PROSITE:PS51820}.
DOMAIN 1929 2050 G8. {ECO:0000259|PROSITE:PS51484}.
DOMAIN 2744 2870 G8. {ECO:0000259|PROSITE:PS51484}.
SEQUENCE 4076 AA; 445377 MW; 5EFE53E3EE5ACF41 CRC64;
MTTWLISLIS IETLLLAVPY LSFHIEPEEG SLAGGTWITV IFDGRLGLLY PANGSQLEIH
LMSAAVPALP SIPCDVVPVF LDLPVVMCRT RSLPSEAHEG LYYLEAHSQG QVASSSTPGP
QDSPTFKFSR AQTPFVYQVN PPSGVPGELI QVYGWIITRR SETFDFDAEY IDSPLILEAQ
GDRWVTPCSL VNRQTGSRYP VQEHHGLGTL QCRVEGHYIG SQNVSFSVFN KGKSMVHKNA
WLISANQDLF LYQTYSEILS VVPETGSLGG RTDITITGAF FDNPAQVTIA GIPCDIRHVS
PRKIACTTRA PGKGTRLTAP QAGNRGLLFE VGDAAEGLDL TEATPGYRWQ IVPNASSPFG
FWSKEGQPFR ARLSGFFVAP ETNNYTFWIQ ADSQATLYFS QSEDPRTKVK VASIRVGTAD
WFDSWEQKGN EGTWQQKTPK LELFGGARYY LEAEHHGRAP SRGMRIGVQI HNTWLNPDVV
STYLQEKHQI RIRAQRLPEI QMLTVSGRGN FLLTWDNVSS QPIPANATAH QIQTALEELL
AVKCKLEPLS ANILFRLGFE EGPEGSSSDG DLTSGTEPFC GRFSLYQPRH LVLTPPAAQK
GYRLDQYTHL CMAYKGHMNT ILKVTVSFTV DFQNVAKNIT CDWRLEGTSP NSWQFTCTDL
WNTCVHRSTD LQPPLASSPA LVHLIDLLPL SQEPGVFYMD EIVIADTNLT VSQADSGTAR
PGGNLVELLS VVGSPPVYNV TCWLAGCGPE LPLISASSVP TEGAEERSGL VHVTTQRLQR
TSLPLGGHFR IQLSNTVIPD VPVHISASHL HKLLRNNADD FTARYLNVSD FSVMEDLKSC
YERVWTLSWS AQVGDLPNFI RVSDENLTGV NPVATTRVVY DGGVFLGPIF GDMLVTANRC
PQVVVRVNDI PAHCSGSCSF RYLEASTPRV HSVCYSPDGD TDLLVYITGT SFSGDYKALQ
VTVNKTSCKV IFSNQTNVVC QADLLPVGVH QISMLVRPSG RAINASGGGL FLNVEPRLDA
VEPSRAAEIG GLWATIRGSS LEDVSLVLFG SQSCVINVTT SNSRRIQCKV PPRGKDGHVV
NVTVIREDHS TVLPMAFTYD SSLNPVITSL SRNRSSIAGG ETLFIGMALL VNDTDLDVQV
HIQETLAPVH EQMAQGLEVV LPLLPAGLHR ISVSINGVNI SSQGVDLHIH CITEVFSIEP
CCGSLLGGTI LSISGIGFSR DPALVWVLVG NQSCDIVNST ERNIWCETSP ASLLPDADDL
SVPAPVEVWA GSTSISRAPS PSLVGKGFIF MYEVAATPVV TAVRGEITDS SLRLDVEGSN
LSNSVILLGG LACGLETQSF RSNVSLSGCS FPLHSLEAGI YPLQVRQKQM GFANMSAVPQ
QFVVTPRITA IFPAHGSACG GTVLTVQGLA LSSRRGSVQV DLSGPFTCVI LSLGDQTVLC
QIHLVGDPLP GASFTLNVTV LVNELPSECQ GDCTLFLREE TTPVVDALTT NISGSLTTVL
IRGQRLGTTA DEPVVSVDDH LLCNVTFFNA SHVTCWISGL TPGPHYLSVF HRRNGYACSG
NVSRHFDILP QVFRYFPKNF SIHGGGLLTV EGTALRGQNA TLVYVGWQAC LTVNVSSDLI
QCIVPSGNGS VALNIEVDRL SHQMGVISYS NTFTPELLSL SQTDDVLTFA VAQISGAMNV
DILIGMSPCM NVSGNRTVLQ CVVPSLPAGE YQVRGYDRTR GWASSALVFT SRVSVTAVTQ
NFGCLGGRLV HVSGAGFPPE NISAAVCGAP CQVLANATVS AFSCLVLPLD VSLAFLCGLK
HEEEGCDASS RTYVQCDLTV TVGTESLLSS WPYFYICEES PSCLFAPGHW TESASPWFSG
LFISPKVERD EVLIYNSSCN ITMETEAKME CETPNQPITA KITEIRESRA QNTQGNFSFQ
FCRRWSRAHS WFPERVPQDG DNVTVEKGQL LLLDTNTSIL NLLHVKGGKL IFMDPGPIEL
RAHSILVSHG GELRIGSKDK PFQGKAEIKL YGSSHSTPFF PYGVKFLAVR NGTLSLHGLL
PEVMVTHLRA AAYARDTVLA LEDAVDWHPG DEVVIISGIG VAGAKPMEEI VIVETVHNAD
LHLRSPLRYS HNFTENWVAG EHHILKVMVV LLSRNITIRG NLTNERMKLL ASCQEASASE
GNLQNCLYSK SEKMLGSRDL GARLIVQSLP GEPSRVQLKG VLFRELGQAF RKHLSSLTLV
GAMRDSYLQG CTVWGSFSRG LSMSRTLGLK VTSNVFYNIL GHALLVGTYM EVRYILWEAM
PTRKNDESEQ GSIIRNNVII RVSGAEGLSS PEVLTPSGIY IRNPTNVVEG NRVCAAGYGY
FFHLVTSRTS QAPLLSFTGN VAHSCTRYGL FVYPKFQPPW DDGTGPTLIQ NFMVWGGAGG
AQIFRSSNLL LKNFQIYSCR DFGIDILESD ANTSVTDSLL LGHFAHKGSL CMSAGIKTPK
RQELVVSNTT FVNFDLTECV AIRTCSGCSR GQGGFTVKTN QLKFTNSPNL VAFPFAHAAI
LEDLDGSLSG KNRSHILASM ETLSASCWVN TSFSQVVSGS VCGEDVLFHR MSIGLANAPD
VSSDLTMTDS RNKTTTVNYV RDTLSNRYGW MALLLDQEMY SLRFETPWIS RSLQYSATFD
NFAPGNYLLL VHADVWPYPD ILMWCGSHVG RSLPSLPSPG RDQGCDWFFD SQLRQLTYLV
SGEGQVRVIL QVKEGVPPTI SASTSVPESA LKWSHPEAWT GVEEGWGGHN HTTPGPGDDV
LILPNRTVLV DTDLPFLKGL YVMGTLEFPV DRSNILSVAC MVIAGGELKV GTLENPLEKE
QKLLILLRAS EGVFCDRFDG IHIDPGTIGV YGKVQLHSAY PKKSWTHLGA DIASGNERII
VEDAVDWRPH DKIVLSSSSY EPHETEVLTV KEVKGHHVRL HERLKHRHIG NVHVMEDGRY
IRLAAEVGLL TRNIQIQSDT SCKGRLRVGS FRKSSREEFS GVLQLSNVEI QNFGSPLYSS
IELTNVSAGS WIISSTLHQS CSGGIHAVAS HGIILNDNIV FGTAGHGIDL EGQAYSLSNN
LVVLMTQSAW STVWVAGIKV NRAKDINLRG NVVAGSERLG FHIRGHSCSS PEALWSDNVA
HSSLHGLHFY QESGLDNCTG ISGFLAFKNF DYGAMLHVEN SVEMENITLV DNAVGLLAVV
YVSSVPQSSI GNVQIVLRNS VIVATSSSFD CIQDRIKPCS ANSTSTDRAP SNPKGGRIGI
LWPAFTSEPN QWPQEPWHKV RNGHSVSGIM KLQDVTFSSF VKSCYSDDLD VCILPNAENV
GIMHPITAER TRMLKIKDKN KFYFPPLQTR KDLGILVCPE LDCESPRKYL FKDLDGRALG
LPPPVSVFPK IEAEWTGSFF NTGTFREEQK CVYRPLIQGY ICKQTDQVIL ILDNADATWA
MRKLYPVVSV TSGFVDTFSS VNANTPCSTS GSVSTFYSIL PTREITKVCF VDQTPQVLRF
FLLGNKSTSK LLLAVFYHEL QSPQVFLGGS FIPPTLVQST SSLLDEPIGS NYFSIMDNLL
YVVLQGEEPV EILSDASLHL VLTVMFSILE KGWEVMFFER LTEFLQIGQD QIRFTHEMPG
NEATLKAIAD SRTKRKRNCP TVTCANHYRA GRRRPLMIEM SSHRVPPPTT TEPISKVMVI
EIGDLPTVKS TGPIPSLSSN KLQNLAHQII TAQQTGLLEN VLNMTIGGLM VTQSKGVIGY
GNTSSFKTGN LIYIRPYALS VLVQPSDGEV GKELPVQPQL VFLDKQNRRV ESLGTPSEPW
AVSISLEGTS DSVLKGCTQA EAQDGYVRFS NLAVLISGSN WHFIFTVISP PGVNFTARSR
PFAILPVTRS ESSTIILAAS LCSVVSWLAL CCLVCCWFKK SKSRKIKSEE ISESQTNDQK
NPTHVPSKRQ GSQVETGKED AVMGEDMRKK VMLGKLNQLP HQSLNGVSRR KVSRRTVGEE
HGSQEGAAVP APNLTSLTSH GHTCAPGSPA RQVCVQETGN WKKAQEQLLR YQLAGQDQLL
LLCPDLRQER QRMQGQSQLG KEGGRLGLSQ EKKTSCGATE SFCLHSVRPE TIQEQL


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