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PKHD1, fibrocystin/polyductin

 F7GKG2_MONDO            Unreviewed;      4081 AA.
F7GKG2;
27-JUL-2011, integrated into UniProtKB/TrEMBL.
09-JAN-2013, sequence version 2.
12-SEP-2018, entry version 45.
SubName: Full=PKHD1, fibrocystin/polyductin {ECO:0000313|Ensembl:ENSMODP00000023481};
Name=PKHD1 {ECO:0000313|Ensembl:ENSMODP00000023481};
Monodelphis domestica (Gray short-tailed opossum).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000023481, ECO:0000313|Proteomes:UP000002280};
[1] {ECO:0000313|Ensembl:ENSMODP00000023481, ECO:0000313|Proteomes:UP000002280}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=17495919; DOI=10.1038/nature05805;
Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L.,
Duke S., Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J.,
Kamal M., Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A.,
Benos P.V., Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L.,
Deakin J.E., Fazzari M.J., Glass J.L., Grabherr M., Greally J.M.,
Gu W., Hore T.A., Huttley G.A., Kleber M., Jirtle R.L., Koina E.,
Lee J.T., Mahony S., Marra M.A., Miller R.D., Nicholls R.D., Oda M.,
Papenfuss A.T., Parra Z.E., Pollock D.D., Ray D.A., Schein J.E.,
Speed T.P., Thompson K., VandeBerg J.L., Wade C.M., Walker J.A.,
Waters P.D., Webber C., Weidman J.R., Xie X., Zody M.C., Baldwin J.,
Abdouelleil A., Abdulkadir J., Abebe A., Abera B., Abreu J.,
Acer S.C., Aftuck L., Alexander A., An P., Anderson E., Anderson S.,
Arachi H., Azer M., Bachantsang P., Barry A., Bayul T., Berlin A.,
Bessette D., Bloom T., Bloom T., Boguslavskiy L., Bonnet C.,
Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P.,
Costello M., D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C.,
Dhargay N., Dooley K., Dooley E., Doricent M., Dorje P., Dorjee K.,
Dupes A., Elong R., Falk J., Farina A., Faro S., Ferguson D.,
Fisher S., Foley C.D., Franke A., Friedrich D., Gadbois L., Gearin G.,
Gearin C.R., Giannoukos G., Goode T., Graham J., Grandbois E.,
Grewal S., Gyaltsen K., Hafez N., Hagos B., Hall J., Henson C.,
Hollinger A., Honan T., Huard M.D., Hughes L., Hurhula B., Husby M.E.,
Kamat A., Kanga B., Kashin S., Khazanovich D., Kisner P., Lance K.,
Lara M., Lee W., Lennon N., Letendre F., LeVine R., Lipovsky A.,
Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., Lubonja R.,
Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A.,
Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N.,
Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., Osman S.,
Markiewicz E., Oyono O.L., Patti C., Phunkhang P., Pierre F.,
Priest M., Raghuraman S., Rege F., Reyes R., Rise C., Rogov P.,
Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., Shih D.,
Sparrow T., Spaulding J., Stalker J., Stange-Thomann N.,
Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T.,
Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T.,
Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A.,
Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C.,
Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
Samollow P.B., Lander E.S., Lindblad-Toh K.;
"Genome of the marsupial Monodelphis domestica reveals innovation in
non-coding sequences.";
Nature 447:167-177(2007).
[2] {ECO:0000313|Ensembl:ENSMODP00000023481}
IDENTIFICATION.
Ensembl;
Submitted (JUL-2011) to UniProtKB.
-----------------------------------------------------------------------
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STRING; 13616.ENSMODP00000023481; -.
Ensembl; ENSMODT00000023897; ENSMODP00000023481; ENSMODG00000018828.
eggNOG; ENOG410IEIF; Eukaryota.
eggNOG; ENOG410XQ01; LUCA.
GeneTree; ENSGT00780000121902; -.
InParanoid; F7GKG2; -.
OMA; WVAGIKV; -.
OrthoDB; EOG091G00JT; -.
TreeFam; TF329582; -.
Proteomes; UP000002280; Chromosome 2.
Bgee; ENSMODG00000018828; Expressed in 3 organ(s), highest expression level in adult mammalian kidney.
GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
GO; GO:0005813; C:centrosome; IEA:Ensembl.
GO; GO:0036064; C:ciliary basal body; IEA:Ensembl.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0072686; C:mitotic spindle; IEA:Ensembl.
GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
GO; GO:0006874; P:cellular calcium ion homeostasis; IEA:Ensembl.
GO; GO:0060271; P:cilium assembly; IEA:Ensembl.
GO; GO:0001822; P:kidney development; IEA:Ensembl.
GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
GO; GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; IEA:Ensembl.
GO; GO:0051898; P:negative regulation of protein kinase B signaling; IEA:Ensembl.
GO; GO:0008284; P:positive regulation of cell proliferation; IEA:Ensembl.
GO; GO:0010824; P:regulation of centrosome duplication; IEA:Ensembl.
GO; GO:0070372; P:regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
GO; GO:0032006; P:regulation of TOR signaling; IEA:Ensembl.
Gene3D; 2.160.20.10; -; 1.
Gene3D; 2.60.40.10; -; 5.
InterPro; IPR019316; G8_domain.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR014756; Ig_E-set.
InterPro; IPR002909; IPT_dom.
InterPro; IPR007742; NosD_dom.
InterPro; IPR037524; PA14/GLEYA.
InterPro; IPR006626; PbH1.
InterPro; IPR012334; Pectin_lyas_fold.
InterPro; IPR011050; Pectin_lyase_fold/virulence.
InterPro; IPR028839; PKHD1.
PANTHER; PTHR45107; PTHR45107; 1.
Pfam; PF10162; G8; 2.
Pfam; PF05048; NosD; 1.
Pfam; PF01833; TIG; 5.
SMART; SM01225; G8; 2.
SMART; SM00429; IPT; 5.
SMART; SM00710; PbH1; 8.
SUPFAM; SSF51126; SSF51126; 4.
SUPFAM; SSF81296; SSF81296; 6.
PROSITE; PS51484; G8; 2.
PROSITE; PS51820; PA14; 1.
4: Predicted;
Complete proteome {ECO:0000313|Proteomes:UP000002280};
Membrane {ECO:0000256|SAM:Phobius};
Reference proteome {ECO:0000313|Proteomes:UP000002280};
Signal {ECO:0000256|SAM:SignalP};
Transmembrane {ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAM:Phobius}.
SIGNAL 1 26 {ECO:0000256|SAM:SignalP}.
CHAIN 27 4081 {ECO:0000256|SAM:SignalP}.
/FTId=PRO_5003354155.
TRANSMEM 3863 3886 Helical. {ECO:0000256|SAM:Phobius}.
DOMAIN 330 490 PA14. {ECO:0000259|PROSITE:PS51820}.
DOMAIN 1939 2059 G8. {ECO:0000259|PROSITE:PS51484}.
DOMAIN 2753 2879 G8. {ECO:0000259|PROSITE:PS51484}.
SEQUENCE 4081 AA; 450461 MW; 54B680679F1D285B CRC64;
MSHLVCKMIA CLYSLMTIEM ILLAASCRNW HIVPDEGSVA GGTWITIVFD GLEQSFLYPT
SGSQLEISLV NVDLPWLPHV PCDVSPVYED VALLRCQTRS LQWETQEGLY YLEVRSGGQL
FSSMSKGSWD NCTFKFSKAQ TPIVYQVNPP SGVPGNLIQV HGWIITGRTE TFDNDVEYID
SPLTLQAQGG EWITPCSLVD REKGNRYPVE EDHGIGVLQC RVEGHYIGSQ NVSFSVFNKG
KSTVHKDAWL ISAKQELFLY QTYSEIWSVF PVSGSLGGGT DITITGDFFD YSAQVTIAGI
PCRIKYISPR KIECTTRPLK QDTKLTSPHP GNRGLLFEVG DAQEDLDPTN TTPGYRWQIV
PNASSPFGFW SEEGQHFRAR LSGFFVSPET NNYTFWIQAD SPASLYFSQS ADPENKMKVA
FIQAGATDWF NSWERNGHLE AWQQKSQKLE LLGGAKYYLE ANHYGVTPSH GMSIGVQIHN
TWLNPDVVNS YHREKLQIRA RAQRIPEIQI LNVTGTGTFC LTWDGVSSQP VTTNATAAEI
QAAIEELLTV KCKLEPLSAQ ILLWFGFEKG LEDSGPDGDL TSGTEPFCGR FSIHQPQFLV
RTSEAMQMRY QLDQYTHLCF AYKGHMNDTM TLSVSFTNKF HKPVKKKIVC EWNPEQLTPE
SWKFVCNELW ETCVRHSGGL YTRLANSPVL VHRIDMSPLE HEKSHFYIDE IIVADRNLTV
SQVHSRIARP GGKLIESLSV TGAPSTYNIT LWMAGCGCEL PLIQPCYLPP EEANESSRRV
SVTVQRLQRM SPALEGHFRI QLPNTVISGI PVHISAHDLL ELLQNSGDDF ASQFLNVSDF
KVQKDLSSCY EHVWTLMWMS QIGDLPNIIR VSAENLTGII PTVSTRVVYD GGIFLGPIFG
DMLVTPNTYP QVTMRVNDIP AHCSGSCSFQ YLQESTPLVQ AVWYSYDDDI NLLVCIMGSG
FPGDSGALKI KVNQQICEIT FSNQTYVTCK MGFLPIGKYQ VVMLVRHLGF ALNVTGGEGI
HFNIEPKLKI MEPSVAPEIG GLWTTIQGTN LEHVSLVLFG SQPCPVNITT RKIERIQCKV
PPWGNSSRIL VNVTIITRNV SVSYPEAFKY SPSLNPVILS LSRIRSNTAG DQTLFIGTTS
LANYTDLNVE VHIQDTLATI LKQVPQGLEV ALPSLPAGWH NISVTMNGVN IIAEGVDLQI
QYITEVFKIE PCCGSLLGGT TLTISGIGFS KDPSLVTVSV GNQTCNIVNS TEETIWCETS
AAPHLPGTES QAVMVPIEVL VGNIRAHHGP SFGLGKDFTF IYHTALTPFV TAMQGQIRGD
MLEFQVEGNN LSESVVLLGH MKCDLELQFF SFNRTQYFCS LPLANMEAGI YPIQVFRKDI
GFANISAVPH SFTVAPQITD IFPTHGSVCG GTWLTVIGLA FKSRMKLVQI DLSDHHTCAI
WKWNDQMILC QVSFVGHLPK ASLAMNVTIT ANGISSECQG NCTFYLQEES TPIVETLTTS
VSGTLTTMLI GGQKLATATD ELVVLVDDHL SCDITFYNAT WVECQLSDLG PGLHHFSLLN
GRSGFACLGT LAPHFSIVPQ VLGYHPQNFS INGGGLLTIE GTTLRGKNTT SVLIGHQPCF
TVNISSVLIQ CIVPPGNGTV DLEIEVDGNL IDVGIISYSE VFTPALLFIL QIDGLIVTFM
VARTSGAKNM QIFIGASPCV GILGNYTVLQ CSVAQLPTGE YQVKGFDRFR GWASSTLVFT
SNVTITSIHR NFGCLSGSLL HVHGSGFSPG NMSAEVCGVP CQVLDNATVT NFSCLVLPLD
ASLAFLCNLR PLEESCKATK TTYIQCELTV TVGTINLLRS WSYIYMCEEN PWCSLVLDHQ
VDSSLGLFSG LFISPKVERD EVLIYNSSCN ITMETEAEME CEAPNQPITA KITEIRKNWG
QNTQDYFQLQ VCRRWSRAHS WIPQGWPQDG DNVTVESGQT LLLDITTSVL SMLHIKGGKL
IFTGPGPIEL HAHCILVSHG GELQIGSLDE PYHGKALIYL HGSSSTTFYP YGAKFLAVRN
GTLSLHGLRP EVSITHLRTA AQANDTMLAL EDHVDWHPGE EVIISGVTLE GSQRQEEIAI
IESTHGANLH LQSPLRYSHG ILEHNIGGHH IALRVTVALL SRNIAIQGHL TNEGMAHLQL
CTEAKIPEDD FQQCLYLRSE KNLGSMNLGA VVIVQSLPGE PSQVQLQGVQ FQYMGQAFQK
HLCALNVIGP IRDSYIRSCS VWDSFSRGLS LSRTSNLIVE NNVFYNILGH GLLVGTHMEM
KHFPWKAVPR RKTDWSRQGN IVRSNVVIGV FGTEGLSNIE VLSPAGIYIQ DPISVVERNM
VCAAGYGYFF HLGTSETSKA PLRSFTQNVA HSCTRYGLLV YPRFEPPQVN DTGPTLFQNF
TAWGSQGGVQ IFRSSNLQLK NFQIYSCKDF GIDILESDAN SSIVESLLLS HYSSKKGSSC
MSAGIKTPKR QELLVSKTTF VNFDQKNCIS LRTCSSCYRG QGGFTVKTEQ LKFLNSPNRI
AFPFPHAAIL EDLDGSVSGN KGRYLLASVE NLASSCQVNQ SFGQTVKGSV CGPDVIFHRM
SIGLAEAPDV AYDLTVTDSK NQTMTINFVN DTLSNLYGWM ALLLDQDTYL LRFEASWIKS
SLQYSATFDN FTSGNYLLVV HKDLQPYADI LVICGTRIGQ SLLSSPSATR DQACDWFFNS
HLGELTYLVS GEGQVHLTLL VKERIIPATP VPSDVPKSIL KWSHPGTWQG VEEGWGGYNH
TTPAPGDDVV ILPNKTILVD TDLPFLKGLY VLGTLEFPVN RSNVLNVACI IVAGGELKVG
TFPEPLHKGQ KLLIQLRASE GDYCDRLDGI NIAPGTFGVY GKVQLHSAYP RKAWTHLGAD
IASGNERILV KDEVDWRPQD KIVLSSSSYE PHEAEILTIK EVMGQNVRLY EHLNHRHLGS
SHSMEDGRHI SLAAEVGLLT RNIKIQPDAP CGGRMVVGSF QKPNGEEFSG TLQLSNVEIQ
NFGSLLYPSI EFNNVSLGSW MISSSVHQSC GGGIRVSSSK SIFLHDNILF DTTGHGIDLE
GQNHSLIKNL IVLTKQPQRA MDWVTGIKVN QVNDANLIGN AVAGSERIGF HIKGHDCSMA
ENPWVGNVVH SSLHGLHVYK GDGLYNCTKI SGFLSYKNFD YGAMFHVENN LEINNMTLVD
NVVGLLPLVY ASFPEQCSLE KKQIVLRNSI IVATSSSFDC IEDRIKPLSA DFTSRDRPPS
NPRGGRVGIL WPGFTAEPNQ WPQDAWHKVK NYPSVSGIMR LEGVTFSDFV KSCYSNDLDV
CILPNPDSPG IIPPIMAERT KMLKVKDQNK FYFSLPWLRK ETGKIVCPEL DCESPMKYLF
KDLDGSVLDL PPPISVFPKS KSEWVGSCFN TGIFREDRKC TYRPSMQSFV CKQMDYILLI
LDNITIAPGK KIPSSVVSVT SGFVETFSSI VAHSSCSASL SIPAFYSLLP TNSLTKICFV
NGVPQAMRFY LIGSERSSKV LAVFYPELQS PRVFFRGQFI PPTSVLSDSW QENGATGTNH
FSFMDNLLYI LLQGDEPVEV QSAISIYVAF TVTLSSALED WEPAIDQRLA HFLQIGQDHI
RIVHILPGGE RILKAFADGV AKRKHHCPSG TPCTNCHRLG QHRNFMRKMK MWVPPSTFSE
TISKVVVIEI GDLSGIGNAK VASSLSTDGL QCLVHRIITS QQTGELQEAL NMPVEALLIS
QSAGVFTSGN SSSLDTGSVV YIQPFTLSVQ VQPSSGEVGI ELPVQPHLVF LDKQGRVVES
LGPPSEPWIV TVSLEGASET VLKGHTHAEA HQGRVSFSNL AVSSSGSNWY FLFTVTSPPG
AKFNVRSEPF AVLPVNKGEK STILMALVLC SAASWMALCF LVFCWLKKSK KTKTKETSGP
QVADRKKNPQ VKHNSHPTRN QERLEETKKG TTVIQEDMRQ KAIQGKPNQS SYQQSLNGLT
RRMIRTGHRE GGRGEVPTEV IAHLPSQGHD DLSSGTPAQQ VPIQEVRDWK DGQAHLLGYH
PTEQDQLLVL YPSFDQEGQK LPEQRHADRK SDHLGYYWDR KAKSESFHLH SLQQAPLQGQ
L


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