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PKHD1, fibrocystin/polyductin

 H2PJC2_PONAB            Unreviewed;      4074 AA.
H2PJC2;
21-MAR-2012, integrated into UniProtKB/TrEMBL.
21-MAR-2012, sequence version 1.
28-MAR-2018, entry version 40.
SubName: Full=PKHD1, fibrocystin/polyductin {ECO:0000313|Ensembl:ENSPPYP00000018684};
Name=PKHD1 {ECO:0000313|Ensembl:ENSPPYP00000018684};
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Pongo.
NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000018684, ECO:0000313|Proteomes:UP000001595};
[1] {ECO:0000313|Ensembl:ENSPPYP00000018684, ECO:0000313|Proteomes:UP000001595}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Wilson R.K., Mardis E.;
"A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|Ensembl:ENSPPYP00000018684}
IDENTIFICATION.
Ensembl;
Submitted (FEB-2012) to UniProtKB.
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EMBL; ABGA01019456; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ABGA01019457; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ABGA01151708; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ABGA01151709; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ABGA01183336; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ABGA01183337; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ABGA01183338; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ABGA01183339; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ABGA01183340; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ABGA01183341; -; NOT_ANNOTATED_CDS; Genomic_DNA.
STRING; 9601.ENSPPYP00000018684; -.
Ensembl; ENSPPYT00000019425; ENSPPYP00000018684; ENSPPYG00000016702.
eggNOG; ENOG410IEIF; Eukaryota.
eggNOG; ENOG410XQ01; LUCA.
GeneTree; ENSGT00780000121902; -.
InParanoid; H2PJC2; -.
OMA; WVAGIKV; -.
OrthoDB; EOG091G00JT; -.
TreeFam; TF329582; -.
Proteomes; UP000001595; Chromosome 6.
GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
GO; GO:0005813; C:centrosome; IEA:Ensembl.
GO; GO:0036064; C:ciliary basal body; IEA:Ensembl.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0072686; C:mitotic spindle; IEA:Ensembl.
GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
GO; GO:0006874; P:cellular calcium ion homeostasis; IEA:Ensembl.
GO; GO:0060271; P:cilium assembly; IEA:Ensembl.
GO; GO:0001822; P:kidney development; IEA:Ensembl.
GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
GO; GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; IEA:Ensembl.
GO; GO:0051898; P:negative regulation of protein kinase B signaling; IEA:Ensembl.
GO; GO:0008284; P:positive regulation of cell proliferation; IEA:Ensembl.
GO; GO:0010824; P:regulation of centrosome duplication; IEA:Ensembl.
GO; GO:0070372; P:regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
GO; GO:0032006; P:regulation of TOR signaling; IEA:Ensembl.
Gene3D; 2.160.20.10; -; 2.
Gene3D; 2.60.40.10; -; 6.
InterPro; IPR019316; G8_domain.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR014756; Ig_E-set.
InterPro; IPR002909; IPT_dom.
InterPro; IPR037524; PA14/GLEYA.
InterPro; IPR006626; PbH1.
InterPro; IPR012334; Pectin_lyas_fold.
InterPro; IPR011050; Pectin_lyase_fold/virulence.
InterPro; IPR028839; PKHD1.
PANTHER; PTHR45107; PTHR45107; 1.
Pfam; PF10162; G8; 2.
Pfam; PF01833; TIG; 7.
SMART; SM01225; G8; 2.
SMART; SM00429; IPT; 6.
SMART; SM00710; PbH1; 10.
SUPFAM; SSF51126; SSF51126; 2.
SUPFAM; SSF81296; SSF81296; 6.
PROSITE; PS51484; G8; 2.
PROSITE; PS51820; PA14; 1.
4: Predicted;
Complete proteome {ECO:0000313|Proteomes:UP000001595};
Membrane {ECO:0000256|SAM:Phobius};
Reference proteome {ECO:0000313|Proteomes:UP000001595};
Signal {ECO:0000256|SAM:SignalP};
Transmembrane {ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAM:Phobius}.
SIGNAL 1 17 {ECO:0000256|SAM:SignalP}.
CHAIN 18 4074 {ECO:0000256|SAM:SignalP}.
/FTId=PRO_5003568984.
TRANSMEM 3859 3882 Helical. {ECO:0000256|SAM:Phobius}.
DOMAIN 322 485 PA14. {ECO:0000259|PROSITE:PS51820}.
DOMAIN 1932 2053 G8. {ECO:0000259|PROSITE:PS51484}.
DOMAIN 2747 2873 G8. {ECO:0000259|PROSITE:PS51484}.
SEQUENCE 4074 AA; 446654 MW; 47C9EFE6005DA10B CRC64;
MTAWLISLMS IEVLLLAVPH LSLHIEPEEG SLAGGTWITV IFDGLELGVL YPNNGSQLEI
HLVNVNMVVP ALRSIPCDVF PVFLDLPVVT CRTRSVLSEA HEGLYFLEAY FGGQLVSSPN
PGPRDSCTFK FSKVQTPIVH HVYPPSGVPG KRIHVYGWII TGRLETFDFD AEYIDSPVIL
EAQGDKWVTP CSLINRQTGR CYPIQEDHGL GTLQCRVEGD YIGSQNVSFS VFNKGKSMVH
KKAWLISAKQ DLFLYQTHSE ILSVFPETGS LGGRTDITIT GDFFDSSAQV TIAGIPCDIR
HVSPRKIECT TRAPGKDVRL TTPQPGNRGL LFEVGDAVEG LELTEATPGY RWQIVPNASS
PFGFWSQEGQ PFRARLSGFF VAPETNNYTF WIQADSQASL HFSWSEEPRT KVKVASISVG
TADWFDSWEQ NRDEGTWQQK TPKLELLGGA KYYLEAEHHG IAPSRGMRIG VQIHNTWLNP
DVVTTYLREK HQIRVQAQRL PEVQVLNVSG RGNFFLTWDN VSSQPIPANA TAHLIQTNIE
ELLAVKCKLE PLWANILLRL GFEQGPEVSN SDGDLTSGTE PFCGRFSLCQ PRHLVLTPPA
AQKGYRLDQY THLCLAYKGH MNKILKMTVS FTIGFQNMVK NTTCDWSLTR TSPESWQFHC
TDLWETCVRC SGDLQPPPAN SPVLVHQIDL LPLAQETGLF YVDEIIIADT NVTVSQADSG
TARPGGNLVE SVSVVGSPPV YSVTSWLAGC GTELPLITAR SVPTEGTEEG SGLVLVTTQR
RQWTSPPLGG HFRIQLPNTV ISDVPVQISA HHLHQLLQNN ANDFTSRYLN ASDFTVKEDL
YTCYEHVWTL SWSAQIGDLP NFIRVSDGNL TGVNPAAAMR VVYDGGVFLG PIFGDMLATA
NQHSQVVVRV NDVPAHCPGS CSFQYLQGST PCVHSVWYSI DGDINLMIYI TGTGFSGDSQ
FLQVTVNKTN CKVIFSNQTN VVCQTDLLPV GMHRILMLVR PSGLAISATG EDLFLNVEPR
LDMVEPSRAA DIGGLWATIR GSSLEGVSLI LFGSYSCAIN VTTSNSSRIQ CKVPPRGKDG
HIVNVTVIRG DHFAVLPRAF TYVSSLNPVI VTLSRNTSNI AGGETLVIGV ARLVNYTDMD
VEVHVQDALA PVHTQSAWGL EVALPPLPAG LHRISVSING VSIRSQGVDL HIQYLTEVFS
IEPCCGSLLG GTILSISGIG FSRDPALVWV LVGNRSCDIV NLTEVSIWCE TLPAPQIPHA
DTPTVPAAVE VWAGNRSFAH GPSPSLVGKG FTFMYEAAAT PVVTAMQGEI TNSSLSLHVG
GSNLSNSVIL LGNLNCDVET QSFQGNASLS GCSIPLHSLE AGIYPLQVCQ KQMGFANMSV
VPQQFAVMPR IMAIFPSQGS ACGGTILTVR GLLLNSRRRS VRVDLSGPFT CVILSLGDHT
ILCQVSLEGD PLPGASFSLN VTVLVNGLTS ECQGNCALFI REEASPVMDA LSTNTSGSLT
TVLIRGQRLA TTADEPMVFV DDQLPCNVTF FNASHVVCQT RDLAPGPHYL SVFYTRNGYA
CSGNVSRHFY IMPQVFHYFP KNFSMHGGSL LTIEGTGLRG QNTTSVYIDQ QACLTVSIGA
ELIRCIVPTG NGSVALEIEV DGLWRHIGVI GYNNAFTPEL ISISQSDDIL TFAVAQISGA
ANIDIFIGTS PCMGVSGNHT VLQCVVPSLP AGEYHVRGYD CIRGWASSAL VFTSRVIITA
VTENFGCLGG RLVHVFGAGF SPGNVSAAVC GAPCRVLANA TVSAFSCLVL PLDVSLAFLC
GLKDEEDSCE AARHTYVQCD LTVAVGMEQL LESWPYLYIC EESSQCLFVP DHWAESMSPS
FSGLFISPKV ERDEVLIYNS SCNITMETEA EMECETPNQP ITVKITEIRK RWGQNTQGNF
SLQFCRRWSR THSWFPERLP QDGDNVTVEN GQLLLLDTNT SILNLLHIKG GKLIFMAPGP
IELRAHAILV SDGGELRIGS EDKPFQGRAQ ITLYGSSYST PFFPYGVKFL AVRNGTLSLH
GSLPEVIVTS LRATAHAQDT VLALEDAVDW HPGDEVVIIS GTGVEGAKPM EEIVTVETVQ
DTDLYLKSPL RYSHNFTENW VAGEQHILKA TVALLSRSIT IQGNLTNERE KLLVSCQEAN
APEGNLQHCL YSMSEKILGS RDMGARVIVQ SFPEEPSQVQ LKGVQFRVLG QAFHKHLSSL
TLVGAMRESF IQGCTVRNSF SRGLSMCGTL GLKVDSNVFY NILGHALLVG TCMEMRYISW
EAIHGRKDDW SGHGNIIRNN VIIRVSGAEG LSNPEMLTPS GIYIRSPTNV IEGNRVCGAG
YGYFFHLMTN KTSQAPLLSF TQNIAHSCTR YGLFVYPKFQ PPWDNVTGTT LFQSFTVWES
AGGAQIFRSS NLRLKNFQVY SCRDFGIDIL ESDANTSVTD SLLLGHFAHK GSLCMSSGIK
TPKRWELMVS NTTFVNFDLI NCVAIRTCSD CSQGQGGFTV KTSQLKFTNS SNLVAFPFPH
AAILEDLDGS LSGKNRSHIL ASMETLSPSC LVNASFGRVV HGSACGRGVL FHRMSIGLAH
TPEVYYDLTM TDSRNKTTTV NYVCDTLSNP HGWMALLVDQ ETYSLQSENL WINRSLQYSA
TFDNFAPGNY LLLVHTDLPP YPDILLRCGS RVGLSFPFLP SPGQNQGCDW FFNSQLRQLT
YLVSGEGQVQ VILRVKEGMP PTISASTSAP ESALKWSLPE TWQGVEEGWG GYNNTIPGPG
DDVLILPNRT VLVDTDLPFF KGLYVMGTLD FPVDRSNVLS VACMVIAGGE LKVGTLENPL
EKEQKLLILL RASEGVFCDR MNGIHIDPGT IGVYGKVQLY SAYPKNSWTH LGADIASGNE
RIIVEDAVDW RPHDKIVLSS SSYEPHEAEV LTVKEVKGHH VRIYEQLKHR HIGSVHVTED
GRHIRLAAEV GLLTRNIQIQ PDVSCRGRLF VGSFRKSSGE EFSGVLQLLN VEIQNFGSPL
YSSVEFSNVS AGSWIISSTL HQSCGGGIHA AASHGVLLND NIVFGTTGHG IDLEGQAYTV
TNNLVVLMTQ PAWSTIWVAG IKVNQVKDIN LHGNVVAGSE RLGFHIRGHK CSSCELLWSD
NVAHSNLHGL HLYKESGLDN CTRISGFLAF KNFDYGAMLH VENSVEIENI TLVDNTIGLL
AVVYVFSAPQ NSIKKVQIVL RNSVIVATSS SFDCIQDKVK PHSANLTSTD RAPSNPRGGR
VGILWPVFTS EPNQWPQEPW HKVRNDRSIS GIMKFQDVTF SSFVKSCYNN DLDVCILPNA
ENSGIMHPIT AERTRMLKIK DKNKFYFPSL QPRKDLGKVV CPELDCVSPR KYLFKDLDGR
ALGLPPPVSV FPKTEAEWTA SFFNAGTFRE EQKCTYRFLM QGFICKQTDQ VVLILDSTDA
IWAIQKLYPV VSVTSGFVDV FSSVNANIPC STSGSVSTFY SILPTRQISK VCFMDQTPQV
LRFFLLGNKS TSKLLLAVFY HELQSPHVFL GESFIPPTLV QSASLLLNES IGANYFNIMD
NLLYVVLQGE EPIEIRSGVS IHLALTVMVS VLEKGWEIVI LERLTNFLQI GRNQIRFIHE
MPGHEETLKA IADNRAKRKR NCPTVTCTSH YRRVGQRRPL MMEMNSYRAS PPTTVETISK
VIVIEIGDSP TVRSTGTISS LSSNKLQNLA HQVITAQQTG VLENVLNMTI GALLVTQSKG
VIGYGNTSSF KTGNLIYIRP YALSILVQPS DGEVGNELPV QPQLVFLDGQ NRRVESLGPP
SEPWTISASL EGASDSVLKG CTQAETQDGY VSFYNLAVLI SGSNWHFIFT VTSPPGVNFT
ARSKPFAVLP VTRKEKSTII LAASLSSVAS WLALSCLVCC WLKRSKSRKT KPEEIPESQT
NNQNNHIHIS SKRRESQGPK KEDTVVGEDM RMRVMLGKVN QSPHQLMNGV SRRKVSRHIV
REEEAAVPAP GTTGITSHGH ICAPGAPAQQ MYLQETGNWK EGQEQLLRYQ LAGQDQLLLL
CPDFRQERQQ LPGQSRLSKQ SGSLGLSQEK KASCGATEAF CLHSVHPETI QEQL


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