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PKHD1, fibrocystin/polyductin

 I3MKY2_ICTTR            Unreviewed;      4063 AA.
I3MKY2;
11-JUL-2012, integrated into UniProtKB/TrEMBL.
22-NOV-2017, sequence version 2.
28-MAR-2018, entry version 44.
SubName: Full=PKHD1, fibrocystin/polyductin {ECO:0000313|Ensembl:ENSSTOP00000012012};
Name=PKHD1 {ECO:0000313|Ensembl:ENSSTOP00000012012};
Ictidomys tridecemlineatus (Thirteen-lined ground squirrel)
(Spermophilus tridecemlineatus).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha;
Sciuridae; Xerinae; Marmotini; Ictidomys.
NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000012012, ECO:0000313|Proteomes:UP000005215};
[1] {ECO:0000313|Ensembl:ENSSTOP00000012012}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
The Broad Institute Genome Assembly & Analysis Group;
Computational R&D Group;
and Sequencing Platform;
Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
"The Draft Genome of Spermophilus tridecemlineatus.";
Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|Ensembl:ENSSTOP00000012012}
IDENTIFICATION.
Ensembl;
Submitted (MAY-2012) to UniProtKB.
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EMBL; AGTP01010651; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AGTP01010652; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AGTP01010653; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AGTP01010654; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AGTP01010655; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AGTP01010656; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AGTP01010657; -; NOT_ANNOTATED_CDS; Genomic_DNA.
STRING; 43179.ENSSTOP00000012012; -.
Ensembl; ENSSTOT00000013406; ENSSTOP00000012012; ENSSTOG00000013374.
eggNOG; ENOG410IEIF; Eukaryota.
eggNOG; ENOG410XQ01; LUCA.
GeneTree; ENSGT00780000121902; -.
InParanoid; I3MKY2; -.
OrthoDB; EOG091G00JT; -.
TreeFam; TF329582; -.
Proteomes; UP000005215; Unassembled WGS sequence.
GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
GO; GO:0005813; C:centrosome; IEA:Ensembl.
GO; GO:0036064; C:ciliary basal body; IEA:Ensembl.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0072686; C:mitotic spindle; IEA:Ensembl.
GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
GO; GO:0006874; P:cellular calcium ion homeostasis; IEA:Ensembl.
GO; GO:0060271; P:cilium assembly; IEA:Ensembl.
GO; GO:0001822; P:kidney development; IEA:Ensembl.
GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
GO; GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; IEA:Ensembl.
GO; GO:0051898; P:negative regulation of protein kinase B signaling; IEA:Ensembl.
GO; GO:0008284; P:positive regulation of cell proliferation; IEA:Ensembl.
GO; GO:0010824; P:regulation of centrosome duplication; IEA:Ensembl.
GO; GO:0070372; P:regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
GO; GO:0032006; P:regulation of TOR signaling; IEA:Ensembl.
Gene3D; 2.160.20.10; -; 2.
Gene3D; 2.60.40.10; -; 5.
InterPro; IPR019316; G8_domain.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR014756; Ig_E-set.
InterPro; IPR002909; IPT_dom.
InterPro; IPR037524; PA14/GLEYA.
InterPro; IPR006626; PbH1.
InterPro; IPR012334; Pectin_lyas_fold.
InterPro; IPR011050; Pectin_lyase_fold/virulence.
InterPro; IPR028839; PKHD1.
PANTHER; PTHR45107; PTHR45107; 1.
Pfam; PF10162; G8; 2.
Pfam; PF01833; TIG; 8.
SMART; SM01225; G8; 2.
SMART; SM00429; IPT; 6.
SMART; SM00710; PbH1; 10.
SUPFAM; SSF51126; SSF51126; 2.
SUPFAM; SSF81296; SSF81296; 6.
PROSITE; PS51484; G8; 2.
PROSITE; PS51820; PA14; 1.
4: Predicted;
Complete proteome {ECO:0000313|Proteomes:UP000005215};
Membrane {ECO:0000256|SAM:Phobius};
Reference proteome {ECO:0000313|Proteomes:UP000005215};
Signal {ECO:0000256|SAM:SignalP};
Transmembrane {ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAM:Phobius}.
SIGNAL 1 18 {ECO:0000256|SAM:SignalP}.
CHAIN 19 4063 {ECO:0000256|SAM:SignalP}.
/FTId=PRO_5012158227.
TRANSMEM 3854 3877 Helical. {ECO:0000256|SAM:Phobius}.
DOMAIN 324 484 PA14. {ECO:0000259|PROSITE:PS51820}.
DOMAIN 1931 2052 G8. {ECO:0000259|PROSITE:PS51484}.
DOMAIN 2746 2872 G8. {ECO:0000259|PROSITE:PS51484}.
SEQUENCE 4063 AA; 446458 MW; A339391DF41663A9 CRC64;
IMAGWLLSVM SIEVLLLAEP CLNLRIEPEE GSLAGGTWIT VIFDGLEPGV LYPTNGSQLE
IHLVNMAVPA LRSIPCDVSP VFLNFPVVTC RTRSLPSKAH EGLYSLEVRS GGQVVGSPSS
RPQDSCTFKF SKAQTPIVYQ VNPPSGVPGK LIQVYGWIIT GKLETFDFDA EYIDSPLILE
AQGDRWVTPC SLINRQTGNH YPSQEDRGLG TLQCRVEGDY IGSQNVSFSV FNKGKSMVHK
SAWLISAKQE LFLYQTHSEI LSVFPETGSH GGRTDITITG DFFDNSAQVT IAGIPCDIRH
VSPRKIECTT QAPGKGARLT APQAGNRGLL FEVGDASDGL ELTEATPGYR WQIVPNASSP
FGFWSMEGQP FRARLSGFFV APETNNYTFW IQADSQASLH FSQTEEPKTK VEVASIRVGT
ADWFDSWEQN ENEEPWQQKT AKLELLGGAK FYLEAEHYGT APSRGMRIGV QIHNTWLNPD
VVTTYLREKH QIRVQAQKLP EIQMLNVSGR GNLFLMWGNV SSQPIPANAT AHQIQTTIEE
LLAVKCTLEP LSANTLLRLG FEQGLEGSSS DGDITSGTEP FCGRFSLHQP RQLVLTPTVT
EMSYRLDKYP HLCIAYKGYM NKILKMTVSF TIGFQTIKKK NSTCDWSLPE TSPESWEFTC
TDLWDTCMHR FGDLQLPLSN VPVSIHQIVL LPLPQETGQL YVDEIIITDT NITVSPVDSG
TARPGGNLVE SISVVGSPPV YSVAFWLAGC GLELPLITAC SVPTEETEGS GPVHVTAQRL
QRTSPPVGGH FRIQLPNTEI PDVPVHISAR HLQKLLQDNA DNFTSRYLNV SDFIVKEDLN
SCYEHVWTLS WSTQIGDLPN FIRVSDQSLT GMNPAVTTRV VFDGGVFLGP VFGDMLATAN
QHTQVVVRVN DIPAHCPGSC SFQYLQESTP SVHSVWYSLD GDINPLVYIT GTGFSDDSQS
LQVTVNKMSC KVIFSNQTNV VCQSDLLPVG VHPISVLVRP SGLAVNASGE GLFLYVRPRL
DAVEPSRAAE IGGLWATIRG SSLEGVSLVL FGSKSCDIII TTSNSQRIQC KVPPRGKDEY
SVNVTVIRGN HSAVLPRAFT YVSSLNPMIV SLSRNQSNIA GGETLFIGMT RLLNYTDLDV
EIHIQDTLAQ VHAQTAQGLE VVLPPLPAGL HRISVSINGV IIRSQGVDLH IQYLTEVFSM
EPCCGSLFGG TILSISGRGF GRDPALVWVL VGNQPCDMVN LTEVSIWCET PRAPLLPDAE
ALTISAPVEV WAGNATFIHG PSASLVGKGL TFRYKVAATP VVTALWGEVT NSSLKLYVEG
SDLSNSVILL GSLKCEVETQ SLWGNLSLSG CSFPLHTLEA GVYPVQARQK DMGFANMSAV
PQQFVVTPRI MTILPMHGSV CGGTVLTIRG LALNSRRRSV QIDLSGPFTC MILHLEDRIV
LCQINQMGDP LPGASFTLNV TVVVNGLPSE CEGNCTLFMQ EDESPVVDAL TIGISGSLTT
LLIRGQRLDS RTDEPRVFID DQLPCNITFF NASQVLSQIS GLTPGLHYLS AVQTSNGYAC
LGNISRNFSI MPQVFNYFPK NFSTHGGSLL AIVGTTLRGQ NTTLIFVGQQ ACLTVNISSE
FIQCIVPAGN DSVALEIEVD GIGYHIGVVG YSDVFTPELL SVSQSDGILT FAVARISGAA
NVDIFIGRTP CVGVSGNYTV LQCTTPFLPA GKYYVRGYDR IRGWASSALV FLLKATITAV
TENFGCLGGR LVHVFGAGFS PGNISAAVCG APCQVLANAT VSAFSCLVLS LDESLAFLCG
LKPKEDSCEV ISHTYVQCDL TVSMGTERLP ELWPYLYVCE ESSQCLFEPD HWKKSDFPSF
SGFFISPKVE RDEVLIYNSS CNITMETEAE MECETPNQPI TAKITEIRKS WGQNTQGNSS
FQFCRRWSKA YSWFPEKVPQ DGDNVTVENG QLFLLDTNTS TLNLLHLKGG KLIFMDPGPI
ELRAHSILIS DGGELRIGSK GKPFQGKAEI KLYGSSHSMP FFPFGVKFLA VRNGTLSLHG
SLPEVVVTHL RAAAHAQDRV LSLEDTVDWH TGDEVVIVSG TGVEGARPAE ETVIVEAVHH
ADLHLRLPLR YSHNFTEIWV AGEHRILKVT VALLSRRITI QGNLTSERKT FLASCQEANM
AEGNLQHCLY SKSEKILGSR DLGARVIVWS SPEEPSQVQL EGVEFRDLGQ AFQKYMSSLT
LVGTMRDSYV QGCTIRSSFS RGLSIHRTLG LKVDSNVFYK ISGHALLVGT YMGMSYISWK
AIPGRKNDWS EQGNMIRNNV IISVSGAEGL SSPEMLTPSG IYIRSPTNVI EGNRVCAAGY
GYFFHLVTSQ TSQAPLLSFT RNIAHSCTRY GLFIYPKFQP PWDNDSGPIV LQNFMVWGSA
GGAQIFRSSN LHLKNFQVYS CRDFGIDILE SDANTSVTDS LLLGHFNQKG SLCMSAGIKT
PKRWELLVSN TTFVNFDLIN CVAIRTCSGC SQGQGGFTVK TNQLKFTDSS NLVAFPFPHA
AILEDLDGSL SGKNRSHILA SMETLSASCL VSASFSQIVR GSVCGEDVLF HRMSIGLVNS
PDVSYDLTLK DSRNKTTTVN YVHDTLSNHY GWMALLLDQE TYSLQFENPW INRSLQYEAT
FDNFAPGNYL LLVHTDLPPL PDILIRCGSQ MGQSLRSLPS PGRDQGCDWF FNRKSRQLTY
LVAGEGQVQV ILLVKESVPP TISASTSAPE SILKWSVPET WKDVEEGWGG HNHTIPGPGD
DILILPNRTV LVDIDLPFLR GLYVMGTLEF PVDRSNILSV ACLVVVGGEL KVGTLENPLQ
RAQKLLIHLR ASEGIFCDRY SGIRIDPGTI GVYGKVQLHS AYPKKSWTHL GANIASGNER
IIVEDAVDWQ PYDKLVLSST SYEPHEAEVL TVKEVKGHHV RIHERLKYQH TGSVHVMEDG
QHIHLAAEVG LLTRNIRIQS DTLCKGRLLV GSFRKSSREE FSGFLQLLNV EIQNFGSPSH
SSIEFTNVSA GSWIISSTVH QSCGGGIHAS ASHGIILNDN IVFGTAGHGI DLEGQAYSLT
NNLAVLMTQS VWSAIWVAGI KVNRATDIYL HGNVVAGSER LGFHLQGHRC SSQVLWSGNV
AHSNLHGLHV FKESGPDNCT CITGFLAFKN FDYGAMIQVE NSVEMENITL VDNAIGLLAA
VYVSSVPQRS IRNVQIVLRN SVIIATSSSF DCIQDRMKPY SANVTSTDRA PPNPRGGRVG
ILWPGFTSEP NQWPLEPWHK VRNGYSVSGI MKLEGVTFSG FVKSCSSDDL DICILPNVES
PGIMHPIIAE RTRMLRMKDE NKFYFPPLHH RRDLERVTCP ESDCESPRKY LFKDMDGRAL
GLPPPISVFP KTEAEWTGSF YNTGTYREEQ KCTYRALIQG FMCKQTDQVL LIIENVDITW
GIQNVYPVVS VTSGFVDVFS SVNANTLCST PRPVSTFYTI LPTRQITKVC FVDQTPQVLR
FHLLGNKSTS KFLLAVFYHE LQRPHVFLGE YFIPPTLVQS VSSLLDEPIG ANYFNIMDNL
LYVVLQGEEP IEIHTGLSIY LAFTVTISVL EKGWETVMLE KLTNFLQIDQ NQIRFTHEMP
GNEGTLKTIV DSRAKRKRNC PTVTCASHYR RVGQRRTLME MSSDTILPPA TMETISKVII
IEIGDLPRVR SSELIPSLSS SKLQKLARQV ITAQQTGVLQ NVLNMTFGAL VVTQGVIGYG
NTSSFKTESW IYTRPYVLSV LVQPSGGEVG KELPVQPQLA FLDEQNRRVE SLGLPSEPWI
ISVSLEGTSD SVLKGCTQAE TQDGYVSFSN LAVLISGSNW HFIFNVTSPP GANFTARSRP
FDVLPVTGKE RSTILMATSL CSVVSWLALI CLVCCWLKKS KNRKTKPEEV PKSQTDDQKN
HIHVSSKRPR SQEGKEIEDA LAEEDMRMKV MLGRLNQLPN HALDGVSRRK VSSHTVPEEG
PATAAPSIPR GTCAPGSPSQ QLYLQESGNW KAAQEQLLRY QLAGQDRLLL LCPDLRQESH
RWQGQSQLIK RSSSLGLSQE KKASCGATEK FCLHSAQPET VQE


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