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PKHD1, fibrocystin/polyductin

 M3YC98_MUSPF            Unreviewed;      4056 AA.
M3YC98;
01-MAY-2013, integrated into UniProtKB/TrEMBL.
01-MAY-2013, sequence version 1.
28-MAR-2018, entry version 36.
SubName: Full=PKHD1, fibrocystin/polyductin {ECO:0000313|Ensembl:ENSMPUP00000008955};
Name=PKHD1 {ECO:0000313|Ensembl:ENSMPUP00000008955};
Mustela putorius furo (European domestic ferret) (Mustela furo).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Mustelidae;
Mustelinae; Mustela.
NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000008955, ECO:0000313|Proteomes:UP000000715};
[1] {ECO:0000313|Ensembl:ENSMPUP00000008955}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ID#1420 {ECO:0000313|Ensembl:ENSMPUP00000008955};
Di Palma F., Alfoldi J., Johnson J., Jaffe D., Berlin A., Gnerre S.,
Grabherr M., Hall G., Lara M., MacCallum I., Mauceli E.,
Przyblyski D., Ribeiro F., Russell P., Sharpe T., Turner-Maier J.,
Walker B.J., Young S., Birren B., Lindblad-Toh K.;
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|Ensembl:ENSMPUP00000008955}
IDENTIFICATION.
Ensembl;
Submitted (MAR-2013) to UniProtKB.
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EMBL; AEYP01077761; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AEYP01077762; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AEYP01077763; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AEYP01077764; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AEYP01077765; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AEYP01077766; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AEYP01077767; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AEYP01077768; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AEYP01077769; -; NOT_ANNOTATED_CDS; Genomic_DNA.
RefSeq; XP_012900961.1; XM_013045507.1.
STRING; 9669.ENSMPUP00000008955; -.
Ensembl; ENSMPUT00000009102; ENSMPUP00000008955; ENSMPUG00000009027.
GeneID; 101673150; -.
CTD; 5314; -.
eggNOG; ENOG410IEIF; Eukaryota.
eggNOG; ENOG410XQ01; LUCA.
GeneTree; ENSGT00780000121902; -.
InParanoid; M3YC98; -.
OMA; WVAGIKV; -.
OrthoDB; EOG091G00JT; -.
Proteomes; UP000000715; Unassembled WGS sequence.
GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
GO; GO:0005813; C:centrosome; IEA:Ensembl.
GO; GO:0036064; C:ciliary basal body; IEA:Ensembl.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0072686; C:mitotic spindle; IEA:Ensembl.
GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
GO; GO:0006874; P:cellular calcium ion homeostasis; IEA:Ensembl.
GO; GO:0060271; P:cilium assembly; IEA:Ensembl.
GO; GO:0001822; P:kidney development; IEA:Ensembl.
GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
GO; GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; IEA:Ensembl.
GO; GO:0051898; P:negative regulation of protein kinase B signaling; IEA:Ensembl.
GO; GO:0008284; P:positive regulation of cell proliferation; IEA:Ensembl.
GO; GO:0010824; P:regulation of centrosome duplication; IEA:Ensembl.
GO; GO:0070372; P:regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
GO; GO:0032006; P:regulation of TOR signaling; IEA:Ensembl.
Gene3D; 2.160.20.10; -; 2.
Gene3D; 2.60.40.10; -; 5.
InterPro; IPR019316; G8_domain.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR014756; Ig_E-set.
InterPro; IPR002909; IPT_dom.
InterPro; IPR037524; PA14/GLEYA.
InterPro; IPR006626; PbH1.
InterPro; IPR012334; Pectin_lyas_fold.
InterPro; IPR011050; Pectin_lyase_fold/virulence.
InterPro; IPR028839; PKHD1.
PANTHER; PTHR45107; PTHR45107; 1.
Pfam; PF10162; G8; 2.
Pfam; PF01833; TIG; 8.
SMART; SM01225; G8; 2.
SMART; SM00429; IPT; 5.
SMART; SM00710; PbH1; 7.
SUPFAM; SSF51126; SSF51126; 2.
SUPFAM; SSF81296; SSF81296; 6.
PROSITE; PS51484; G8; 2.
PROSITE; PS51820; PA14; 1.
4: Predicted;
Complete proteome {ECO:0000313|Proteomes:UP000000715};
Membrane {ECO:0000256|SAM:Phobius};
Reference proteome {ECO:0000313|Proteomes:UP000000715};
Signal {ECO:0000256|SAM:SignalP};
Transmembrane {ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAM:Phobius}.
SIGNAL 1 17 {ECO:0000256|SAM:SignalP}.
CHAIN 18 4056 {ECO:0000256|SAM:SignalP}.
/FTId=PRO_5004044620.
TRANSMEM 3853 3876 Helical. {ECO:0000256|SAM:Phobius}.
DOMAIN 323 483 PA14. {ECO:0000259|PROSITE:PS51820}.
DOMAIN 1931 2052 G8. {ECO:0000259|PROSITE:PS51484}.
DOMAIN 2743 2869 G8. {ECO:0000259|PROSITE:PS51484}.
SEQUENCE 4056 AA; 444386 MW; 044C8408DAE771BA CRC64;
MTVWLISLMS MEILLLAVPS RSFHIEPEEG SLAGGTWITV IFDGLESEFL YPANGAQLEI
HLVNVAEPSL PSIPCDVSPV FLDLPVVMCR TRSLLSEAHE GLYYLEVHSG GQVVGSPSPG
PRDNCTFKFS RAQTPIVYQV TPPSGAPGKL IHVYGWIITG RSETFDFEAE YIESPLIMEA
QGDKWVTACS LVNRQTGSRY PLQEDHGLGT LQCRVEGNYI GSQNVSFSVF NKGKSIVHKN
AWMISAKLEL FLYQTHSEIL SVFPDTGSLG GRTDITITGD FFDNPVQVTI AGIPCDIRDV
SPRKIECTTR APGKSARLTA PQAGNRGLLF EVGEAVEGLD LTSGMPGYQW QIVPNASSPP
GFWSKEGLPF RARLSGFFVA PETNNYTFWI QADNQASLYF SHSEDPKTKV KVASIKVGIA
DWFDAWEQNG HDGTWQRKTP KLELVGGTSY FLEAEHGGRA PSRGMRIGVQ IHNTWLNPDV
VSTYLREKQQ IRIHAQRLPE IQMLTVSGRG SFVLTWDNVT SQPIPGNVTA HQIQRAIEEL
LAVKCKLEPL SASSLLWLGF EQGPEGSSFE GDLTSGTEPF CGRFSLHQPR HLVLIPLASQ
EGYQLDQYTH LCLAYKGHKN NILKVTVFFT TDSQNFIKKN ITCDWSLVGT SPDSWRFTCT
DLWETCVQGS VDLQPALANS SVLVYQIDLF PLSQETRGFY VDEIIIADTN ITVSQADSET
ARPGGNLVES LCVEGSPPVY NVSFWLVGCG RELPLITASS VPTEGGQEES GVVQVTTQRI
QKTSPPLGGY FRIQLPTTEI PDIPVHVSAS DLRKLLQNNA DNFTSRYLNV NDFAVTEDLR
SCYEHVWTLS WSTQVGDLPN FIRVSDAHLT GVDPAAAMRV VYDGGVFLGP IFGDMLVTAN
QHTQVVVRVN DIPAHCSGSC SFQYLEESTP QVHLVWYSLD GDIHLLVYIF GTSFSGDPQA
VQVTVNKTIC RVLFSNETNV VCQTDLLPVG MHRLSVVVRP SGCAINASGE ALFLNVEPRL
VAVEPSRAAE IGGLWATIQG SGLEDVSLVL FGSRSCAIDI TRSNSQRIQC KVPPRGKDGP
IVNLTVITGD HSAVLPMAFT YDSSLNPVII SLSRNRSNIA GGETLSIRMA LLGNYSDLDV
EVHIQDTLVP AHVQMPHSLE VVLPPLPPGL HRISVSINGV SIRSRRVDLH IQYVTDVFSI
EPCCGSLLGG TILTVSGVGF SRDPDLVWVL VGNRTCDIVN STDTVIWCET PPSALLPKAD
VPTVPAPVEV WAGNASLVRG PLPSLVGKGF TFMYEVARTP VVTAVQGEMT NNSLRLSVEG
NNLPNSVILL GFLNCDLEMQ SLWNNMSLSG CSFPLHSLEA GTYPLQVRQK QMGFANMSAV
PQQFVMTPRI MAILPTRGSA CGGTVLTVRG LALNSRKRSV QVHLSGPFSC VILSLGDQTV
LCQISQVDAP LPNASFTLNI TVLVNGLPSE CQGLCTLSLR EETTPIVDSL TTNISGSLTM
VLIRGQKLDI TTDEPMVFVD NHLPCVVTFF NASHVACRIS DLTPGLHYVS IFHTRIGYAC
FGNVSRHFHI LPEVSHYFPK NFSIHGGSLL SMEGIALRGE NSTLVFIGQQ ACLTVSISSK
FIQCIVPAGN GSGGLVIEVD GLSYRMGVIG YSNAFTPQLL SISQTDDILT MVVAQVSGAK
NVDIFIGMSP CVGVSGNYTV LQCVVPPLPA GEYPVRGYDR MRGWASSVLV FTSTVTISAV
TENFGCLGGS LVHVFGGGFS PGNISAAVCG APCQVLANAT VSAFSCLVPP LDVSLAFLCG
LKHAEESCEA SSSSYVQCDL TFAVGTETLP QSWPYLYICE ESPQCLFAPD HWTESAFPWF
SGLFLSPKVE RDEVLIYNSS CNIAMETEAK MECETPNQPI TAKITEIRKS RGQNTQGSFS
FHFCRRWSRA HSWFPERVPQ DGDNVTVENG HSLLLDTNTS ILSLLHVKGG KLIFMDAGPI
ELRAHSILIS DGGELWIGSE DKPFQGKAEI KLYGSSHSTP FFPYGVKFLA VRNGTLSLHG
LLPEVTITHL RAAASAQDTV LALEDAVDWC PGDEVVIISG IGFEGAKPTE EIVIVEAVHK
TDLHLRSPLR YSHNFTENWV AGERHILKVT VVLLSRRVTI QGNLTAERKK HLASCQEASA
SEGNLQDCFY SKSEKILGSR DLGARVIVQS FAEEPSRVQL KGVQFRALGQ AFRKHLSSLT
LVGAMRDSYI QGCTVWSSFS RGLSMSRTLG LKVDSNVFYN ILGHALLVGT DMDIKYMSWE
ATPEKTTEQG NLIRNNVIIS VSGTEGLSSP ETLTPSGIYI RNPTNIIEGN RVYVAGLGYF
FHLVTSQTSQ APLLSFTQNI AHSCTRSGLF IYPQFRPPWD NGRGPTLFQN FTVWGSAGGA
QIFRSSNLHL KNFQVYSCRD FGIDILESDA NTSITDSLLL GHFAHKGSLC MSAGIKTPKR
WELIISNTTF VNFDLTDCVA IRTCAGCSRG QGGFTVKTNQ LKFINSPNLV AFPFTHAAIL
EDLDGSLSGK NRSHILASME TLPASCLVNE SFSQIVHGSV CGEDVLFHRM SIGLANVPDV
SYDLTMTDSR NKTTTVNYVH DTLSNLYGWM ALLLDQETYS LQFDTPWINS SLQYSATFGS
FIPGNYLLLV HTVLWPYPDI HVRCGNQVGR SLPSLPSPGR DQGCDWFFNT QLRQLTYLVS
GEGHIQVTLQ VKEGVPPTIS ASTSASESAF KWSLPEAWTG IEEGWGGHNH TIPGPGDDVL
ILPNRTVLVD TNLPVLRGLY VMGTLEFPVD RSNVLSVACM VIAGGELKVG TLENPLEKEQ
KLLILLRASE GVSCDRFNGI LIDPGTIGIY GKVQLHGACP KKSWTRLAAD IASGNERIIV
QDTVDWRPHD KIVLSSSSYE PHEAEVLTVK EAQAHHVKIH EQLKHRHVGS VHVMEDGRSI
RLAAEVGLLT RNIQIQPDIS CRVRLLVGSF RKSSSEEFSG VLQLSNVEIQ NFGSPLYSAV
ELLNASAGTW IISSTLHQSC GGGIRVAASH GIILKDNLVF GAVGHGIDLQ GQNFTLSNNL
VVLITQSAWS TMWVAGIKVN QAKDISLDGN VVAGSERLGF HIRGHRCSSP EALWSDNVAH
SSLHGLHLYK ENGFDHCTGI SGFLAFKNFD YGAMLHVENS VEMENITLVD NTIGLLAVVY
VSSAPQGHTE NVQVTLRNSV IVATSSSFDC IQDRVKPRSA NLTSTDRAPS NPRGGRVGIL
WPVFTSKPNR WPQEPWHRVR NGHSISGMMK LQDVTFSSFV KSCYSDDLDV CILPSVENTG
IMHPIIAERT KMLKIKDKNK FYFPPLQARK GLEMLVCPES DCENPRKYLF KDLDGRALGL
PPPVSVFPKM EAEWTGSFFN TGTFREEQKC TYRALIQGYI CKQTDQVILI LDNVDATWAM
RKLYPVVSIT RDFVDTFSGV NFNTPCSASG SVSTFYSILP TREITKVCFV EQPPQVLRFF
LLGNKSASKL LLAIFYHEFQ SPRVFIGESF IPPILVQSTS SLLDESLGSN YFSILDNLLY
VVLQGPEPIE IRSGVSIHLA LTVTFSVLEK GWEIIILERL TDFLQVHQDQ IRFIYEMSGN
EATLKAIADN KAKRKRNCPT VSCASHYRVG QRKPLMMEMS SYSVPPTTVE TVSKVIVIEI
GDLPTIKSTG LISYLSSNKL QNLAHQIITA QQTGVLENVL NMTVGALLVT QSKGVTGYGN
TSSSKTENLI YIRPYALSVL VQPSDGEVGK ELTVQPRLVF LDKQNRRIES LGPPSEPWTI
SVSLEGTSDS VLKGCTRAES QDGYVSFSNL AVLISGSNWH FLFTVTSPPG VNFTARSRSF
TVLPVRRSEK STIILAASLC SVASWLALCC LVCCWLKKSK SRKIKSEDIS EFQTNSQKNH
IHISSKHPRS QETKKEDAMM GEEIKMKVIV DRLNQLPHQS LNGVSRRKVG RRAAQKEGGR
REEVVAPAPS ITGVTSQGHT CDPGSPAQQV YLQETGTWKE AQEQLVRYQM AGQDQRLLLC
PDLRQEREQM QGQTPLSQER GHLGLSQEKK ASCGAT


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