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PKHD1, fibrocystin/polyductin

 W5PUY7_SHEEP            Unreviewed;      4079 AA.
W5PUY7;
16-APR-2014, integrated into UniProtKB/TrEMBL.
16-APR-2014, sequence version 1.
28-MAR-2018, entry version 28.
SubName: Full=PKHD1, fibrocystin/polyductin {ECO:0000313|Ensembl:ENSOARP00000014269};
Name=PKHD1 {ECO:0000313|Ensembl:ENSOARP00000014269};
Ovis aries (Sheep).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Caprinae; Ovis.
NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000014269, ECO:0000313|Proteomes:UP000002356};
[1] {ECO:0000313|Ensembl:ENSOARP00000014269, ECO:0000313|Proteomes:UP000002356}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000014269};
PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C.,
Wang J., Wang W., Xun X.;
"The sheep genome reference sequence: a work in progress.";
Anim. Genet. 41:449-453(2010).
[2] {ECO:0000313|Ensembl:ENSOARP00000014269}
IDENTIFICATION.
Ensembl;
Submitted (FEB-2014) to UniProtKB.
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EMBL; AMGL01058918; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AMGL01058919; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AMGL01058920; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AMGL01058921; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AMGL01058922; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AMGL01058923; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AMGL01058924; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AMGL01058925; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AMGL01058926; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AMGL01058927; -; NOT_ANNOTATED_CDS; Genomic_DNA.
Ensembl; ENSOART00000014476; ENSOARP00000014269; ENSOARG00000013288.
GeneTree; ENSGT00780000121902; -.
OMA; WVAGIKV; -.
OrthoDB; EOG091G00JT; -.
Proteomes; UP000002356; Chromosome 20.
GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
GO; GO:0005813; C:centrosome; IEA:Ensembl.
GO; GO:0036064; C:ciliary basal body; IEA:Ensembl.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0072686; C:mitotic spindle; IEA:Ensembl.
GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
GO; GO:0006874; P:cellular calcium ion homeostasis; IEA:Ensembl.
GO; GO:0060271; P:cilium assembly; IEA:Ensembl.
GO; GO:0001822; P:kidney development; IEA:Ensembl.
GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
GO; GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; IEA:Ensembl.
GO; GO:0051898; P:negative regulation of protein kinase B signaling; IEA:Ensembl.
GO; GO:0008284; P:positive regulation of cell proliferation; IEA:Ensembl.
GO; GO:0010824; P:regulation of centrosome duplication; IEA:Ensembl.
GO; GO:0070372; P:regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
GO; GO:0032006; P:regulation of TOR signaling; IEA:Ensembl.
Gene3D; 2.160.20.10; -; 2.
Gene3D; 2.60.40.10; -; 6.
InterPro; IPR019316; G8_domain.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR014756; Ig_E-set.
InterPro; IPR002909; IPT_dom.
InterPro; IPR037524; PA14/GLEYA.
InterPro; IPR011658; PA14_dom.
InterPro; IPR006626; PbH1.
InterPro; IPR012334; Pectin_lyas_fold.
InterPro; IPR011050; Pectin_lyase_fold/virulence.
InterPro; IPR028839; PKHD1.
PANTHER; PTHR45107; PTHR45107; 1.
Pfam; PF10162; G8; 2.
Pfam; PF07691; PA14; 1.
Pfam; PF01833; TIG; 7.
SMART; SM01225; G8; 2.
SMART; SM00429; IPT; 5.
SMART; SM00710; PbH1; 10.
SUPFAM; SSF51126; SSF51126; 3.
SUPFAM; SSF81296; SSF81296; 6.
PROSITE; PS51484; G8; 2.
PROSITE; PS51820; PA14; 1.
4: Predicted;
Complete proteome {ECO:0000313|Proteomes:UP000002356};
Membrane {ECO:0000256|SAM:Phobius};
Reference proteome {ECO:0000313|Proteomes:UP000002356};
Signal {ECO:0000256|SAM:SignalP};
Transmembrane {ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAM:Phobius}.
SIGNAL 1 17 {ECO:0000256|SAM:SignalP}.
CHAIN 18 4079 {ECO:0000256|SAM:SignalP}.
/FTId=PRO_5004871030.
TRANSMEM 3858 3881 Helical. {ECO:0000256|SAM:Phobius}.
DOMAIN 323 483 PA14. {ECO:0000259|PROSITE:PS51820}.
DOMAIN 1931 2052 G8. {ECO:0000259|PROSITE:PS51484}.
DOMAIN 2746 2872 G8. {ECO:0000259|PROSITE:PS51484}.
SEQUENCE 4079 AA; 445014 MW; 9D0A259BF8F55837 CRC64;
MTGSLIYLTS IKILLLAVPC LNIHIEPEEG SLAGGTWITV IFDGLELGLL HPANGSQLEI
HLVNVALPTL PSIPCDVSPV FLDVPAVMCR TRSLLPEAQE GVYSLEVQAG GQVVGSPHPG
PQDSCTFKFS RAQTPIVYQV NPASGVPGKL IHVYGWIITG RSETFDFDAE YIDSPLILEA
QGDKWITPCS LVNRQTGSRY PIQEDHGLGT LQCRVEGNYI GSQNVSFSVF NKGKSVIHKD
AWLVSAKQDL FLYQTYSEIL SVFPETGSLG GRTDITITGD FFDNPAQVTI AGIPCDIRHV
SPRRIECTTR APSKGARLSA PQAGNRGLLF EVGDASEDLD LTEATPGYSW QIAPNASSPS
GFWSKEGQPF RARLSGFFVA PETNNYTFWI QADNQASLYF SWSEDLRTKV KMASIRVGTA
DWFDSWEQNG SDKTQQQKTP KLELRGGARY YLEAEHRGTA PSSGVRIGVQ IHNTWLNPDV
VSTYLREKHQ IRAWAQRLPE IQMLTVSGTG NFFLTWDNVS SQPIPANATA HQIQTAVEEL
LAVKCKLEPL AANILLWQGF EQGLEGSTSD GHLTSGTEPF CGRFSLHQPR HLVLTPPAAQ
KVYRLDQYTH LCLAYRGHEN TTLKMTVSFT VGLQNPVKNL TCDWSLLGTS PRCWQFTCTD
LWKTCVRHSS HLQLPPANSP VLVHQIDLLP LSPEMGMFFV DEIIIADTNL TVSQADTGTA
RPGGNLLESL SVVGSPPVYN VTSWLAGCGL ELPLITASAV PTEGAEEGSG LVQVTTRRLQ
RTSPPLGGHF RIQLSNTAIP GVPVHISASH LQKLLQTSAD DFTSRYLNVS DFTVTEDLKS
CYEHVWTFSW SSQVGDLPNF IKVSNENLTG VNPAVITRVV YDGGIFLGPI FGDMLVTANR
YTQVAVRVND IPAYCSGSCA FQYLEGSTPQ VYSVWYALAN AVGLLVYITG TSFSGDYKAL
QVTVNKTSCK VIFSNQTNVV CQTSLLPVGV HQILMLVRPS GLAINASGGG LFLNVEPRLD
AVEPSRAADI GGLWATVRGS GLDNVNLVLF GSQSCVINVT TSSSQRIQCK VPSKGEDGPT
VNVTVILGGR SVVLAMAFTY VSSLNPVIVS LSRNGSGIAG GEIISIGMVL PVNHTDLDAE
VRIGDTRAWV QAQTAQGLEV VLPPLPAGLH GISVSINGVH IHAQGVDLHI QYITEVFSIQ
PRCGSLVGGT ILSISGRGFS RDRALLWVLV GSRSCDIVNS TETSVWCETP PPAPLPPPPL
PLSAPVPVEV WAGSKPFPHR PSPRLVGKGF TFMYEVAATP VVTVMRGEVA NQSLRLYVEG
QNLSDSVVLL GNLSCDLQTP SPGSNLSLAG CTFSLDTLEA GLYPLQIHQR QMGFADMSAV
PRQWVVMPQI TAVFPTRGST CGGTVLTVRG LAFRSSRGSV EVDLSGPFTC VILSFGDQTV
LCRITPVGDP LPGASFTLNV TVLVNGLPSM CQGNCTLFLC EETTPIMDDW TTNISGSLTT
VLVRGQRLGI TADEPVVFVD DRLACTVTFH NASHVACWIS DLSPGPHYLS VLHARYGYAC
SSNFSRHFHV WPQVFHYFPK NVSLHGGSLL TLEGTALKGL NSTLVYIGQQ ACLTVSLGSE
LIQCAVPAGN GSAALDIEVD GASYQMGVIG YSSAFTPELL SVSQSDDVLT FSVARISGAA
NIDIFIGMSP CVGVSGNHTL LHCVVPSLPT GEYQVRGYDR MRGWASSVLV FTSRVTITAV
TENFGRLGGR LVHVFGTGFS PGNISAAVCG APCQVLANAT VSAFSCLVLP LDVSLASLCD
LRPEEEDCET SSCSYIHCDL TITVGTESLP ESWPYFYICE ESSRCLLARD HWTESTLPSF
SGLFISPKVE RDEVLIYNSS CTITMETEAK MECETPNQPI TAKITEIRKS RGQNTQGNFI
FQFCGRWSRA HSWFPKRPPQ EGDNVTVEKG QLLLLDTNTS ILNFLHVKGG KLIFLDLGPL
ELRTHSILVS DGGELRIGSE DKPFQGKARI KLYGSSYSAR FFPYGVKFLA VRNGTLSLHG
SLPEVVVTHL RATANAHDTV LALEDAVDWH AGDEVLVISG MRAEGAKPKE EIVTVETAHS
TDLQLRSPLR YSHNSTENWV AGEHHVLKVM LVLLSRSITI QGNLTDERVQ FLASCQGASA
SEGDLQNCLY SKSEKMLGSR DLGARVIVQS FPEEPSQVQL KGVQFRDLGQ AFHEHVSSLM
LIGAMRGSYL QGCTVWQSFS RGLSMSQTSS LKVDSNVFYD ISGHALLVGT SPKIRYIPWE
VIPGGEKGWS EQGNIIRNNV IIRVSGAEGL SSPEVVTPSG IYIRHPTNVI EGNRVFAAGY
GYFFHLVTNK TSQAPLLSFT RNSAHSCTRS GLFVYPKFQP PWDNSTGSTL FQNFTVWGSA
GGAQIFRSSN LHLKNFQVYA CRDFGIDVLE SDANTSITDS LLLGHFAHRG NLCMSAGIKS
PRRWELRVSN TTFVNFDLTH CVAIRTCSGC SQGQGGFTVK TNQLKFVNSP NLVAFPSPHA
AILEDLDGSL SGKNRSHILA SMETLPASCV VKASFSQLVH GSVCEENVLF HRMSIGLANA
LNISHDLTIT DSRNKTTTVS YVHDTLSNPY GWMALLLDQE TYSLRFKNPW ASSALQYSAT
FDNFAPGNYL LLVHTDVWVY PDILIRCGSH VGRSLSSLPS PGRDQGCDWF FDSQLRQLTY
LVSGEGQVKV VLQVRKGVGP TISASTSVPK SVLKWSLPET WEGVAEGWGG HSGASPGPGE
DVLILSNRTV LVDTDLPPLR GLYVMGTLEF PVDRSNILSV ACMLIAGGEL RVGTSENPLE
KEKKLLIHLR ASEGVFCDRF NGIHIDPGTV GVFGKVQLHS AYPKKSWTRL GADIASGNER
IIVEDTVDWR PHDKIVLSSS SYEPHEAEVL TVKEVRGHHI RIHERLRHRH IGSAHFMEGG
RHIRLAAEVG LLTRNIQIQG DTPCRGRLLV GSFRKSSVEE FSGILQLFNV EIQNFGSPLH
SSIELTNVSA GSWIISSSLH QSCGGGIHAA ASQGVILNDN VVFSTAGHGI DLEGQDYSLS
KNLVVLMTQS AWSPVWVAGI KVNKAKNTHL HGNVVAGSER LGFHIQGHRC SSPESLWSDN
VAHSSLHGLH LYKGSGLVNC TGISGFLAFK NFDYGAMLQV ENSMEIENLT LVDNTVGLFT
AVYVSSAPRC YIRNLQIVLR NSVIVATSSS FDCIQDRVKP HSANLTSPDR APSNPKGGRV
GMLWPVFTSE PNRWPQEPWH KVRNGHLISG IMKLQDVTFS SFVKSCYSDD LDVCILPNAE
NTGIVPPIMA ERTSMLKIKD KNKFYFPPLQ TRKDLETLVC SESDCESPGK YLFKDLDGRA
LGLPPPVSVF PKTEAEWTGS FFNTGIFREE QKCTYRPLIN GYICKQTDQV ILILDSADTT
WAMQKLYPVV SVTSGFVDTF SSINASAPCS ISRSVSAFYS IVPTRKITKV CFVDQTPRVL
HFFLLGNKNT SKLLLAVFYH ELQSPYVFLG DRFIPPTQVH SASSLLNESI GANYFSITDN
LLYVVLQGEE PIEIQSSVSI HLALNVMFSV LEKGWEIMIL ERLTVFLQIS QDQIRFIHQM
PGNEATLKAM ADSRAKRKRN CPTVTCTSHD RVGQRRPLMV EMSSYRDLPP TTMETISKVM
VIEIGDLPTV RNAGLIPSLS SNKLQNLAHQ VIIAQQTGLL ESVLNMTIGA LLVTQSKGVI
GYGNTSSFKT GNLIYIRPYS LSVLVQPSDG EVGKELTIQP QLVFLDKQNR RVESLGPPSE
PWVISVSLEG TLDSVLRGCT HAGTQDGYVS FSNLAVLISG SNWHFIFTVI SPPAGVNFTA
RSRSFAVLPV TPSERPTIIM AASLCSGVSW LALCCLVCCW FKKSKTRKIK NEEISETQTN
DQRNHSHVSP KHQGSQVETE KEVTRMAEDL RMKVMLAKLN QLPHQSLNGV SRRKVSHRVV
REEGGSREEA TVPAPSIASV TSHRNTCTPG SPAQQECLQE SRGWKGAQEQ VLRYQLAGQD
QLLLLCPDLR RERQRLQGQS QLGKGHISLE LSQEKPGSCG ATEAFCLHSV HPEAVQEQL


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