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POTE ankyrin domain family member C (ANKRD26-like family B member 2) (Prostate, ovary, testis-expressed protein on chromosome 18) (POTE-18)

 POTEC_HUMAN             Reviewed;         542 AA.
B2RU33;
22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
22-JUL-2008, sequence version 2.
25-OCT-2017, entry version 77.
RecName: Full=POTE ankyrin domain family member C;
AltName: Full=ANKRD26-like family B member 2;
AltName: Full=Prostate, ovary, testis-expressed protein on chromosome 18;
Short=POTE-18;
Name=POTEC; Synonyms=A26B2, POTE18;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16177791; DOI=10.1038/nature03983;
Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D.,
Taylor T.D., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K.,
FitzGerald M.G., Yang X., Abouelleil A., Allen N.R., Anderson S.,
Bloom T., Bugalter B., Butler J., Cook A., DeCaprio D., Engels R.,
Garber M., Gnirke A., Hafez N., Hall J.L., Norman C.H., Itoh T.,
Jaffe D.B., Kuroki Y., Lehoczky J., Lui A., Macdonald P., Mauceli E.,
Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C., Noguchi H.,
O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K.,
Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R.,
Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S.;
"DNA sequence and analysis of human chromosome 18.";
Nature 437:551-555(2005).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-375, AND VARIANTS ALA-3
AND ASP-86.
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
TISSUE SPECIFICITY.
PubMed=12475935; DOI=10.1073/pnas.262655399;
Bera T.K., Zimonjic D.B., Popescu N.C., Sathyanarayana B.K., Kumar V.,
Lee B., Pastan I.;
"POTE, a highly homologous gene family located on numerous chromosomes
and expressed in prostate, ovary, testis, placenta, and prostate
cancer.";
Proc. Natl. Acad. Sci. U.S.A. 99:16975-16980(2002).
[4]
ERRATUM.
Bera T.K., Zimonjic D.B., Popescu N.C., Sathyanarayana B.K., Kumar V.,
Lee B., Pastan I.;
Proc. Natl. Acad. Sci. U.S.A. 100:1462-1462(2003).
-!- TISSUE SPECIFICITY: Expressed in prostate and testis.
{ECO:0000269|PubMed:12475935}.
-!- SIMILARITY: Belongs to the POTE family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAI40941.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};
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EMBL; AP006261; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC140940; AAI40941.1; ALT_SEQ; mRNA.
CCDS; CCDS45835.1; -.
RefSeq; NP_001131143.1; NM_001137671.1.
UniGene; Hs.454726; -.
ProteinModelPortal; B2RU33; -.
SMR; B2RU33; -.
BioGrid; 132700; 10.
STRING; 9606.ENSP00000351856; -.
iPTMnet; B2RU33; -.
PhosphoSitePlus; B2RU33; -.
BioMuta; POTEC; -.
EPD; B2RU33; -.
MaxQB; B2RU33; -.
PaxDb; B2RU33; -.
PRIDE; B2RU33; -.
Ensembl; ENST00000358970; ENSP00000351856; ENSG00000183206.
GeneID; 388468; -.
KEGG; hsa:388468; -.
UCSC; uc010dln.4; human.
CTD; 388468; -.
EuPathDB; HostDB:ENSG00000183206.16; -.
GeneCards; POTEC; -.
H-InvDB; HIX0027435; -.
HGNC; HGNC:33894; POTEC.
HPA; HPA042822; -.
neXtProt; NX_B2RU33; -.
OpenTargets; ENSG00000183206; -.
PharmGKB; PA164724729; -.
eggNOG; ENOG410IHJ1; Eukaryota.
eggNOG; COG0666; LUCA.
GeneTree; ENSGT00560000076605; -.
HOGENOM; HOG000293138; -.
InParanoid; B2RU33; -.
KO; K17299; -.
OMA; YMASEIG; -.
PhylomeDB; B2RU33; -.
TreeFam; TF337879; -.
GenomeRNAi; 388468; -.
PRO; PR:B2RU33; -.
Proteomes; UP000005640; Chromosome 18.
Bgee; ENSG00000183206; -.
CleanEx; HS_POTEC; -.
ExpressionAtlas; B2RU33; baseline and differential.
Genevisible; B2RU33; HS.
CDD; cd00204; ANK; 2.
Gene3D; 1.25.40.20; -; 2.
InterPro; IPR002110; Ankyrin_rpt.
InterPro; IPR020683; Ankyrin_rpt-contain_dom.
InterPro; IPR036770; Ankyrin_rpt-contain_sf.
Pfam; PF12796; Ank_2; 2.
PRINTS; PR01415; ANKYRIN.
SMART; SM00248; ANK; 6.
SUPFAM; SSF48403; SSF48403; 1.
PROSITE; PS50297; ANK_REP_REGION; 1.
PROSITE; PS50088; ANK_REPEAT; 5.
2: Evidence at transcript level;
ANK repeat; Coiled coil; Complete proteome; Polymorphism;
Reference proteome; Repeat.
CHAIN 1 542 POTE ankyrin domain family member C.
/FTId=PRO_0000345419.
REPEAT 138 171 ANK 1.
REPEAT 172 201 ANK 2.
REPEAT 205 234 ANK 3.
REPEAT 238 267 ANK 4.
REPEAT 271 300 ANK 5.
REPEAT 304 333 ANK 6.
REPEAT 337 373 ANK 7.
COILED 489 538 {ECO:0000255}.
VARIANT 3 3 T -> A (in dbSNP:rs28535987).
{ECO:0000269|PubMed:15489334}.
/FTId=VAR_045825.
VARIANT 10 10 A -> T (in dbSNP:rs45488295).
/FTId=VAR_045826.
VARIANT 13 13 A -> T (in dbSNP:rs45561536).
/FTId=VAR_045827.
VARIANT 28 28 F -> C (in dbSNP:rs45626231).
/FTId=VAR_045828.
VARIANT 30 30 H -> P (in dbSNP:rs9807633).
/FTId=VAR_045829.
VARIANT 36 36 K -> R (in dbSNP:rs45570841).
/FTId=VAR_045830.
VARIANT 66 66 H -> R (in dbSNP:rs9807555).
/FTId=VAR_045831.
VARIANT 72 72 C -> Y (in dbSNP:rs45554841).
/FTId=VAR_045832.
VARIANT 86 86 H -> D (in dbSNP:rs45469098).
{ECO:0000269|PubMed:15489334}.
/FTId=VAR_045833.
VARIANT 166 166 M -> I (in dbSNP:rs12454500).
/FTId=VAR_045834.
VARIANT 221 221 C -> R (in dbSNP:rs7505568).
/FTId=VAR_045835.
CONFLICT 337 337 S -> C (in Ref. 2; AAI40941).
{ECO:0000305}.
SEQUENCE 542 AA; 61188 MW; E0268580D8A7F86E CRC64;
MVTEVCSMPA ASAVKKPFDL RSKMGKWFHH RFPCCKGSGK SNMGTSGDHD DSFMKMLRSK
MGKCCHHCFP CCRGSGTSNV GTSGDHDNSF MKTLRSKMGK WCCHCFPCCR GSGKSNVGAW
GDYDDSAFME PRYHVRREDL DKLHRAAWWG KVPRKDLIVM LRDTDMNKRD KQKRTALHLA
SANGNSEVVQ LLLDRRCQLN VLDNKKRTAL IKAVQCQEDE CVLMLLEHGA DQNIPDEYGN
TTLHYAVHNE DKLMAKALLL YGADIESKNK CGLTPLLLGV HEQKQQVVKF LIKKKANLNA
LDRYGRTALI LAVCCGSASI VNLLLEQNVD VSSQDLSGQT AREYAVSSHH HVICELLSDY
KEKQMLKISS ENSNPEQDLK LTSEEESQRL KVSENSQPEK MSQEPEINKD CDREVEEEIK
KHGSNPVGLP ENLTNGASAG NGDDGLIPQR RSRKPENQQF PDTENEEYHS DEQNDTRKQL
SEEQNTGISQ DEILTNKQKQ IEVAEKKMNS ELSLSHKKEE DLLRENSMLQ EEIAMLISGD
WN


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