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POU domain, class 3, transcription factor 2 (Brain-specific homeobox/POU domain protein 2) (Brain-2) (Brn-2) (Nervous system-specific octamer-binding transcription factor N-Oct-3) (Octamer-binding protein 7) (Oct-7) (Octamer-binding transcription factor 7) (OTF-7)

 PO3F2_MOUSE             Reviewed;         445 AA.
P31360; A2AJY1;
01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
01-JUL-1993, sequence version 1.
12-SEP-2018, entry version 165.
RecName: Full=POU domain, class 3, transcription factor 2;
AltName: Full=Brain-specific homeobox/POU domain protein 2;
Short=Brain-2;
Short=Brn-2;
AltName: Full=Nervous system-specific octamer-binding transcription factor N-Oct-3;
AltName: Full=Octamer-binding protein 7;
Short=Oct-7;
AltName: Full=Octamer-binding transcription factor 7;
Short=OTF-7;
Name=Pou3f2; Synonyms=Brn-2, Brn2, Otf7;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
TISSUE=Brain;
PubMed=1565620; DOI=10.1073/pnas.89.8.3280;
Hara Y., Rovescalli C., Kim Y., Nirenberg M.;
"Structure and evolution of four POU domain genes expressed in mouse
brain.";
Proc. Natl. Acad. Sci. U.S.A. 89:3280-3284(1992).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=C57BL/6J;
PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
Lindblad-Toh K., Eichler E.E., Ponting C.P.;
"Lineage-specific biology revealed by a finished genome assembly of
the mouse.";
PLoS Biol. 7:E1000112-E1000112(2009).
[3]
FUNCTION.
PubMed=20107439; DOI=10.1038/nature08797;
Vierbuchen T., Ostermeier A., Pang Z.P., Kokubu Y., Suedhof T.C.,
Wernig M.;
"Direct conversion of fibroblasts to functional neurons by defined
factors.";
Nature 463:1035-1041(2010).
[4]
FUNCTION.
PubMed=24243019; DOI=10.1016/j.cell.2013.09.028;
Wapinski O.L., Vierbuchen T., Qu K., Lee Q.Y., Chanda S.,
Fuentes D.R., Giresi P.G., Ng Y.H., Marro S., Neff N.F., Drechsel D.,
Martynoga B., Castro D.S., Webb A.E., Suedhof T.C., Brunet A.,
Guillemot F., Chang H.Y., Wernig M.;
"Hierarchical mechanisms for direct reprogramming of fibroblasts to
neurons.";
Cell 155:621-635(2013).
[5]
INTERACTION WITH ISL1.
PubMed=24643061; DOI=10.1371/journal.pone.0092105;
Li R., Wu F., Ruonala R., Sapkota D., Hu Z., Mu X.;
"Isl1 and Pou4f2 form a complex to regulate target genes in developing
retinal ganglion cells.";
PLoS ONE 9:E92105-E92105(2014).
[6]
FUNCTION.
PubMed=27281220; DOI=10.1038/nature18323;
Treutlein B., Lee Q.Y., Camp J.G., Mall M., Koh W., Shariati S.A.,
Sim S., Neff N.F., Skotheim J.M., Wernig M., Quake S.R.;
"Dissecting direct reprogramming from fibroblast to neuron using
single-cell RNA-seq.";
Nature 534:391-395(2016).
-!- FUNCTION: Transcription factor that plays a key role in neuronal
differentiation (PubMed:24243019). Binds preferentially to the
recognition sequence which consists of two distinct half-sites,
('GCAT') and ('TAAT'), separated by a non-conserved spacer region
of 0, 2, or 3 nucleotides (By similarity). The combination of
three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is
sufficient to reprogram fibroblasts and other somatic cells into
induced neuronal (iN) cells in vitro (PubMed:20107439,
PubMed:24243019, PubMed:27281220). Acts downstream of ASCL1,
accessing chromatin that has been opened by ASCL1, and promotes
transcription of neuronal genes (PubMed:24243019).
{ECO:0000250|UniProtKB:P56222, ECO:0000269|PubMed:20107439,
ECO:0000269|PubMed:24243019, ECO:0000269|PubMed:27281220}.
-!- SUBUNIT: Interacts with PQBP1 (By similarity). Interaction with
ISL1 (PubMed:24643061). {ECO:0000250|UniProtKB:P20265,
ECO:0000269|PubMed:24643061}.
-!- SUBCELLULAR LOCATION: Nucleus.
-!- TISSUE SPECIFICITY: Expressed specifically in the neuroectodermal
cell lineage.
-!- SIMILARITY: Belongs to the POU transcription factor family. Class-
3 subfamily. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; M88300; AAA39961.1; -; Genomic_DNA.
EMBL; AL772230; CAM22634.1; -; Genomic_DNA.
CCDS; CCDS18005.1; -.
PIR; S31224; S31224.
RefSeq; NP_032925.1; NM_008899.2.
UniGene; Mm.129387; -.
UniGene; Mm.389520; -.
UniGene; Mm.487875; -.
ProteinModelPortal; P31360; -.
SMR; P31360; -.
BioGrid; 202306; 1.
STRING; 10090.ENSMUSP00000136147; -.
iPTMnet; P31360; -.
PhosphoSitePlus; P31360; -.
MaxQB; P31360; -.
PaxDb; P31360; -.
PeptideAtlas; P31360; -.
PRIDE; P31360; -.
Ensembl; ENSMUST00000178174; ENSMUSP00000136147; ENSMUSG00000095139.
GeneID; 18992; -.
KEGG; mmu:18992; -.
UCSC; uc008sdp.2; mouse.
CTD; 5454; -.
MGI; MGI:101895; Pou3f2.
eggNOG; KOG3802; Eukaryota.
eggNOG; ENOG410XQ7X; LUCA.
GeneTree; ENSGT00760000118935; -.
HOGENOM; HOG000116303; -.
HOVERGEN; HBG053120; -.
InParanoid; P31360; -.
KO; K09365; -.
OMA; SFTVNGM; -.
OrthoDB; EOG091G0U0S; -.
PhylomeDB; P31360; -.
TreeFam; TF316413; -.
ChiTaRS; Pou3f2; mouse.
PRO; PR:P31360; -.
Proteomes; UP000000589; Chromosome 4.
Bgee; ENSMUSG00000095139; Expressed in 128 organ(s), highest expression level in thymus.
CleanEx; MM_POU3F2; -.
Genevisible; P31360; MM.
GO; GO:0005634; C:nucleus; IDA:MGI.
GO; GO:0005667; C:transcription factor complex; IDA:MGI.
GO; GO:0003677; F:DNA binding; IDA:MGI.
GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:UniProtKB.
GO; GO:0071837; F:HMG box domain binding; ISO:MGI.
GO; GO:0042802; F:identical protein binding; ISO:MGI.
GO; GO:0000978; F:RNA polymerase II proximal promoter sequence-specific DNA binding; IDA:NTNU_SB.
GO; GO:0043565; F:sequence-specific DNA binding; IDA:MGI.
GO; GO:0003713; F:transcription coactivator activity; IDA:UniProtKB.
GO; GO:0001077; F:transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding; IDA:NTNU_SB.
GO; GO:0014002; P:astrocyte development; IMP:MGI.
GO; GO:0071310; P:cellular response to organic substance; IDA:MGI.
GO; GO:0021799; P:cerebral cortex radially oriented cell migration; IGI:MGI.
GO; GO:0008544; P:epidermis development; IMP:MGI.
GO; GO:0021869; P:forebrain ventricular zone progenitor cell division; IGI:MGI.
GO; GO:0021979; P:hypothalamus cell differentiation; IMP:MGI.
GO; GO:0022011; P:myelination in peripheral nervous system; IGI:MGI.
GO; GO:0010629; P:negative regulation of gene expression; IMP:CACAO.
GO; GO:0007399; P:nervous system development; IDA:UniProtKB.
GO; GO:0021985; P:neurohypophysis development; IMP:MGI.
GO; GO:0048666; P:neuron development; IDA:UniProtKB.
GO; GO:0030182; P:neuron differentiation; IDA:UniProtKB.
GO; GO:0048663; P:neuron fate commitment; IDA:UniProtKB.
GO; GO:0048665; P:neuron fate specification; IDA:UniProtKB.
GO; GO:0008284; P:positive regulation of cell proliferation; ISO:MGI.
GO; GO:0040018; P:positive regulation of multicellular organism growth; IMP:MGI.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:NTNU_SB.
GO; GO:0050770; P:regulation of axonogenesis; IMP:MGI.
GO; GO:0045595; P:regulation of cell differentiation; IMP:MGI.
GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IDA:UniProtKB.
GO; GO:0006355; P:regulation of transcription, DNA-templated; ISO:MGI.
GO; GO:0014044; P:Schwann cell development; IGI:MGI.
CDD; cd00086; homeodomain; 1.
InterPro; IPR009057; Homeobox-like_sf.
InterPro; IPR017970; Homeobox_CS.
InterPro; IPR001356; Homeobox_dom.
InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
InterPro; IPR013847; POU.
InterPro; IPR000327; POU_dom.
InterPro; IPR016362; TF_POU_3.
Pfam; PF00046; Homeobox; 1.
Pfam; PF00157; Pou; 1.
PIRSF; PIRSF002629; Transcription_factor_POU; 1.
PRINTS; PR00028; POUDOMAIN.
SMART; SM00389; HOX; 1.
SMART; SM00352; POU; 1.
SUPFAM; SSF46689; SSF46689; 1.
SUPFAM; SSF47413; SSF47413; 1.
PROSITE; PS00027; HOMEOBOX_1; 1.
PROSITE; PS50071; HOMEOBOX_2; 1.
PROSITE; PS00035; POU_1; 1.
PROSITE; PS00465; POU_2; 1.
PROSITE; PS51179; POU_3; 1.
1: Evidence at protein level;
Activator; Complete proteome; Differentiation; DNA-binding; Homeobox;
Neurogenesis; Nucleus; Phosphoprotein; Reference proteome;
Transcription; Transcription regulation.
CHAIN 1 445 POU domain, class 3, transcription factor
2.
/FTId=PRO_0000100723.
DOMAIN 264 338 POU-specific. {ECO:0000255|PROSITE-
ProRule:PRU00530}.
DNA_BIND 356 415 Homeobox. {ECO:0000255|PROSITE-
ProRule:PRU00108}.
COMPBIAS 68 90 Poly-Gly.
COMPBIAS 125 149 Poly-Gln.
MOD_RES 343 343 Phosphoserine.
{ECO:0000250|UniProtKB:P20265}.
SEQUENCE 445 AA; 47149 MW; 1A47F10950EECE8A CRC64;
MATAASNHYS LLTSSASIVH AEPPGGMQQG AGGYREAQSL VQGDYGALQS NGHPLSHAHQ
WITALSHGGG GGGGGGGGGG GGGGGGGGDG SPWSTSPLGQ PDIKPSVVVQ QGGRGDELHG
PGALQQQHQQ QQQQQQQQQQ QQQQQQQQQQ QRPPHLVHHA ANHHPGPGAW RSAAAAAHLP
PSMGASNGGL LYSQPSFTVN GMLGAGGQPA GLHHHGLRDA HDEPHHADHH PHPHSHPHQQ
PPPPPPPQGP PGHPGAHHDP HSDEDTPTSD DLEQFAKQFK QRRIKLGFTQ ADVGLALGTL
YGNVFSQTTI CRFEALQLSF KNMCKLKPLL NKWLEEADSS SGSPTSIDKI AAQGRKRKKR
TSIEVSVKGA LESHFLKCPK PSAQEITSLA DSLQLEKEVV RVWFCNRRQK EKRMTPPGGT
LPGAEDVYGG SRDTPPHHGV QTPVQ


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