Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

POU domain, class 4, transcription factor 1 (Brain-specific homeobox/POU domain protein 3A) (Brain-3A) (Brn-3A)

 PO4F1_RAT               Reviewed;         420 AA.
P20266; Q91XM4;
01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
02-NOV-2016, sequence version 3.
05-DEC-2018, entry version 152.
RecName: Full=POU domain, class 4, transcription factor 1;
AltName: Full=Brain-specific homeobox/POU domain protein 3A;
Short=Brain-3A;
Short=Brn-3A;
Name=Pou4f1; Synonyms=Brn-3, Brn3, Brn3a;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA] OF 279-406, AND TISSUE SPECIFICITY.
PubMed=2739723; DOI=10.1038/340035a0;
He X., Treacy M.N., Simmons D.M., Ingraham H.A., Swanson L.W.,
Rosenfeld M.G.;
"Expression of a large family of POU-domain regulatory genes in
mammalian brain development.";
Nature 340:35-42(1989).
[2]
NUCLEOTIDE SEQUENCE [MRNA] OF 285-400.
PubMed=1383937; DOI=10.1093/nar/20.19.5093;
Lillycrop K.A., Budrahan V.S., Lakin N.D., Terrenghi G., Wood J.N.,
Polak J.M., Latchman D.S.;
"A novel POU family transcription factor is closely related to Brn-3
but has a distinct expression pattern in neuronal cells.";
Nucleic Acids Res. 20:5093-5096(1992).
[3]
NUCLEOTIDE SEQUENCE [MRNA] OF 329-401.
Vogelaar C.F., Smits S.M., Brakkee J.H., Gispen W.H., Smidt M.P.,
Schrama L.H., Hoekman M.F.M., Burbach J.P.H.;
"Homeobox gene repertoire in adult rat dorsal root ganglia.";
Neurosci. Res. Commun. 32:49-59(2003).
[4]
ALTERNATIVE SPLICING, AND TISSUE SPECIFICITY.
PubMed=8835784; DOI=10.1007/BF02736850;
Liu Y.Z., Dawson S.J., Latchman D.S.;
"Alternative splicing of the Brn-3a and Brn-3b transcription factor
RNAs is regulated in neuronal cells.";
J. Mol. Neurosci. 7:77-85(1996).
[5]
FUNCTION.
PubMed=10640682; DOI=10.1016/S0169-328X(99)00271-5;
Smith M.D., Ensor E.A., Stohl L., Wagner J.A., Latchman D.S.;
"Regulation of NGFI-A (Egr-1) gene expression by the POU domain
transcription factor Brn-3a.";
Brain Res. Mol. Brain Res. 74:117-125(1999).
[6]
FUNCTION.
PubMed=11053412; DOI=10.1074/jbc.M007068200;
Ensor E., Smith M.D., Latchman D.S.;
"The BRN-3A transcription factor protects sensory but not sympathetic
neurons from programmed cell death/apoptosis.";
J. Biol. Chem. 276:5204-5212(2001).
-!- FUNCTION: Multifunctional transcription factor with different
regions mediating its different effects (PubMed:10640682). Acts by
binding (via its C-terminal domain) to sequences related to the
consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions
of its target genes. Regulates the expression of specific genes
involved in differentiation and survival within a subset of
neuronal lineages (PubMed:11053412). It has been shown that
activation of some of these genes requires its N-terminal domain,
maybe through a neuronal-specific cofactor. Ativates BCL2
expression and protects neuronal cells from apoptosis (via the N-
terminal domain). Induces neuronal process outgrowth and the
coordinate expression of genes encoding synaptic proteins. Exerts
its major developmental effects in somatosensory neurons and in
brainstem nuclei involved in motor control. Stimulates the binding
affinity of the nuclear estrogene receptor ESR1 to DNA estrogen
response element (ERE), and hence modulates ESR1-induced
transcriptional activity. May positively regulate POU4F2 and
POU4F3. Regulates dorsal root ganglion sensory neuron
specification and axonal projection into the spinal cord. Plays a
role in TNFSF11-mediated terminal osteoclast differentiation.
Negatively regulates its own expression interacting directly with
a highly conserved autoregulatory domain surrounding the
transcription initiation site (By similarity).
{ECO:0000250|UniProtKB:P17208, ECO:0000269|PubMed:10640682,
ECO:0000269|PubMed:11053412}.
-!- FUNCTION: Isoform 2: Able to act as transcription factor, cannot
regulate the expression of the same subset of genes than isoform
1. Does not have anitapoptotic effect on neuronal cells.
{ECO:0000250|UniProtKB:P17208}.
-!- SUBUNIT: Interacts (via N-terminus) with RIT2; the interaction
controls POU4F1 transactivation activity on some neuronal target
genes. Isoform 1 interacts with POU4F2; this interaction inhibits
both POU4F1 DNA-binding and transcriptional activities. Isoform 1
interacts (C-terminus) with ESR1 (via DNA-binding domain); this
interaction decreases the estrogen receptor ESR1 transcriptional
activity in a DNA- and ligand 17-beta-estradiol-independent
manner. {ECO:0000250|UniProtKB:P17208}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P17208}.
Cytoplasm {ECO:0000250|UniProtKB:P17208}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1 {ECO:0000303|PubMed:8835784}; Synonyms=Brn-3A-Long
{ECO:0000303|PubMed:8835784};
IsoId=P20266-1; Sequence=Displayed;
Name=2 {ECO:0000303|PubMed:8835784}; Synonyms=Brn-3A-Short
{ECO:0000303|PubMed:8835784};
IsoId=P20266-2; Sequence=VSP_058638;
-!- TISSUE SPECIFICITY: Detected in brain, spinal cord and dorsal root
ganglion (PubMed:2739723, PubMed:8835784). Isoform 2 is detected
in brain, spinal cord, dorsal root ganglion and spleen
(PubMed:8835784). {ECO:0000269|PubMed:2739723,
ECO:0000269|PubMed:8835784}.
-!- DOMAIN: The C-terminal domain is able to act as both DNA-binding
domain and a transcriptional activator. The N-terminal domain is
also required for transactivation activity on some target genes
acting as a discrete activation domain. Neurite outgrowth and
expression of genes required for synapse formation are primarily
dependent on the C-terminal domain, however the N-terminal domain
is required for maximal induction. {ECO:0000250|UniProtKB:P17208}.
-!- SIMILARITY: Belongs to the POU transcription factor family. Class-
4 subfamily. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; AF390075; AAK70502.1; -; mRNA.
PIR; S05045; S05045.
RefSeq; XP_008769153.1; XM_008770931.2. [P20266-1]
UniGene; Rn.232568; -.
ProteinModelPortal; P20266; -.
MINT; P20266; -.
STRING; 10116.ENSRNOP00000012828; -.
PaxDb; P20266; -.
PRIDE; P20266; -.
GeneID; 114503; -.
KEGG; rno:114503; -.
UCSC; RGD:620074; rat. [P20266-1]
CTD; 5457; -.
RGD; 620074; Pou4f1.
eggNOG; KOG1168; Eukaryota.
eggNOG; ENOG410XPNX; LUCA.
HOGENOM; HOG000116305; -.
HOVERGEN; HBG053120; -.
InParanoid; P20266; -.
KO; K09366; -.
PhylomeDB; P20266; -.
PRO; PR:P20266; -.
Proteomes; UP000002494; Unplaced.
GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO; GO:0005634; C:nucleus; ISS:UniProtKB.
GO; GO:0003677; F:DNA binding; TAS:RGD.
GO; GO:0003700; F:DNA-binding transcription factor activity; TAS:RGD.
GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
GO; GO:0003697; F:single-stranded DNA binding; ISS:UniProtKB.
GO; GO:0003713; F:transcription coactivator activity; ISS:UniProtKB.
GO; GO:0003714; F:transcription corepressor activity; ISS:UniProtKB.
GO; GO:0071345; P:cellular response to cytokine stimulus; ISS:UniProtKB.
GO; GO:0071392; P:cellular response to estradiol stimulus; ISS:UniProtKB.
GO; GO:0072332; P:intrinsic apoptotic signaling pathway by p53 class mediator; ISS:UniProtKB.
GO; GO:0043066; P:negative regulation of apoptotic process; TAS:RGD.
GO; GO:0043524; P:negative regulation of neuron apoptotic process; IMP:RGD.
GO; GO:0043069; P:negative regulation of programmed cell death; ISS:UniProtKB.
GO; GO:0031175; P:neuron projection development; ISS:UniProtKB.
GO; GO:0071158; P:positive regulation of cell cycle arrest; ISS:UniProtKB.
GO; GO:0010628; P:positive regulation of gene expression; ISS:UniProtKB.
GO; GO:0045672; P:positive regulation of osteoclast differentiation; ISS:UniProtKB.
GO; GO:2000679; P:positive regulation of transcription regulatory region DNA binding; ISS:UniProtKB.
GO; GO:0051090; P:regulation of DNA-binding transcription factor activity; ISS:UniProtKB.
GO; GO:0007283; P:spermatogenesis; IEP:RGD.
GO; GO:0006366; P:transcription by RNA polymerase II; TAS:RGD.
CDD; cd00086; homeodomain; 1.
CDD; cd00093; HTH_XRE; 1.
InterPro; IPR001387; Cro/C1-type_HTH.
InterPro; IPR009057; Homeobox-like_sf.
InterPro; IPR017970; Homeobox_CS.
InterPro; IPR001356; Homeobox_dom.
InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
InterPro; IPR013847; POU.
InterPro; IPR015584; POU4-TF1.
InterPro; IPR000327; POU_dom.
PANTHER; PTHR11636:SF42; PTHR11636:SF42; 1.
Pfam; PF00046; Homeodomain; 1.
Pfam; PF00157; Pou; 1.
PRINTS; PR00028; POUDOMAIN.
SMART; SM00389; HOX; 1.
SMART; SM00352; POU; 1.
SUPFAM; SSF46689; SSF46689; 1.
SUPFAM; SSF47413; SSF47413; 1.
PROSITE; PS50071; HOMEOBOX_2; 1.
PROSITE; PS00035; POU_1; 1.
PROSITE; PS00465; POU_2; 1.
PROSITE; PS51179; POU_3; 1.
2: Evidence at transcript level;
Alternative splicing; Complete proteome; Cytoplasm;
Developmental protein; DNA-binding; Homeobox; Nucleus;
Reference proteome; Transcription; Transcription regulation.
CHAIN 1 420 POU domain, class 4, transcription factor
1.
/FTId=PRO_0000100738.
DOMAIN 261 338 POU-specific. {ECO:0000255|PROSITE-
ProRule:PRU00530}.
DNA_BIND 356 415 Homeobox. {ECO:0000255|PROSITE-
ProRule:PRU00108}.
MOTIF 57 66 POU-IV box.
COMPBIAS 100 108 His-rich. {ECO:0000255|PROSITE-
ProRule:PRU00009}.
COMPBIAS 130 185 Gly-rich. {ECO:0000255|PROSITE-
ProRule:PRU00008}.
COMPBIAS 204 257 Ala-rich. {ECO:0000255|PROSITE-
ProRule:PRU00001}.
VAR_SEQ 1 84 Missing (in isoform 2).
{ECO:0000303|PubMed:8835784}.
/FTId=VSP_058638.
CONFLICT 340 340 A -> P (in Ref. 1). {ECO:0000305}.
SEQUENCE 420 AA; 43275 MW; 64B4FAE98FE27011 CRC64;
MMSMNSKQPH FAMHPTLPEH KYPSLHSSSE AIRRACLPTP PLQSNLFASL DETLLARAEA
LAAVDIAVSQ GKSHPFKPDA TYHTMNSVPC TSTSTVPLAH HHHHHHHHQA LEPGDLLDHI
SSPSLALMAG AGGAGAAGGG GAPTRPRGAG GPGGGGGPGG GGPGVAGRRR GPGGGGGGPG
GGLLGXSAHP HPHMHGXGHL SHPAAAAAMN MPSGLPHPGL VAAAAHHGAA AAAAAAAAGQ
VAAASAAAAV VGAAGLASIC DSDTDPRELE AFAERFKQRR IKLGVTQADV GSALANLKIP
GVGSLSQSTI CRFESLTLSH NNMIALKPIL QAWLEEAEGA QREKMNKPEL FNGGEKKRKR
TSIAAPEKRS LEAYFAVQPR PSSEKIAAIA EKLDLKKNVV RVWFCNQRQK QKRMKFSATY


Related products :

Catalog number Product name Quantity
18-003-42046 POU domain. class 6. transcription factor 1 - mPOU homeobox protein; Brain-specific homeobox_POU domain protein 5; Brain-5; Brn-5 protein Polyclonal 0.05 mg Aff Pur
EIAAB31756 Brain-5,Brain-specific homeobox_POU domain protein 5,BRN5,Brn-5,Homo sapiens,Human,MPOU,mPOU homeobox protein,POU domain, class 6, transcription factor 1,POU6F1,TCFB1
18-003-43038 POU domain. class 3. transcription factor 4 - Brain-specific homeobox_POU domain protein 4; Brain-4; Brn-4 Polyclonal 0.1 mg Protein A
EIAAB31755 Brain-5,Brain-specific homeobox_POU domain protein 5,Brn5,Brn-5,POU domain, class 6, transcription factor 1,Pou6f1,Rat,Rattus norvegicus
EIAAB31747 Brain-3B,Brain-specific homeobox_POU domain protein 3B,Brn-3.2,Brn3b,Brn-3B,Mouse,Mus musculus,POU domain, class 4, transcription factor 2,Pou4f2
E1616p ELISA kit Brain-1,Brain-specific homeobox_POU domain protein 1,BRN1,Brn-1,Pig,POU domain, class 3, transcription factor 3,POU3F3,Sus scrofa 96T
E1616p ELISA Brain-1,Brain-specific homeobox_POU domain protein 1,BRN1,Brn-1,Pig,POU domain, class 3, transcription factor 3,POU3F3,Sus scrofa 96T
EIAAB31750 Brain-3C,Brain-specific homeobox_POU domain protein 3C,Brn3c,Brn-3C,Brn-3c,Mouse,Mus musculus,POU domain, class 4, transcription factor 3,Pou4f3
U1616p CLIA Brain-1,Brain-specific homeobox_POU domain protein 1,BRN1,Brn-1,Pig,POU domain, class 3, transcription factor 3,POU3F3,Sus scrofa 96T
EIAAB31749 Brain-3C,Brain-specific homeobox_POU domain protein 3C,BRN3C,Brn-3C,Homo sapiens,Human,POU domain, class 4, transcription factor 3,POU4F3
EIAAB31745 Brain-3A,Brain-specific homeobox_POU domain protein 3A,Brn3,Brn-3,Brn-3.0,Brn3a,Brn-3A,Mouse,Mus musculus,POU domain, class 4, transcription factor 1,Pou4f1
EIAAB31743 Brain-3A,Brain-specific homeobox_POU domain protein 3A,Brn3,Brn-3,Brn3a,Brn-3A,POU domain, class 4, transcription factor 1,Pou4f1,Rat,Rattus norvegicus
EIAAB31748 Brain-3B,Brain-specific homeobox_POU domain protein 3B,BRN3B,Brn-3B,Homo sapiens,Human,POU domain, class 4, transcription factor 2,POU4F2
E1616r ELISA Brain-1,Brain-specific homeobox_POU domain protein 1,Brn1,Brn-1,Brn-1,POU domain, class 3, transcription factor 3,Pou3f3,Rat,Rattus norvegicus,Rhs2 96T
E1616r ELISA kit Brain-1,Brain-specific homeobox_POU domain protein 1,Brn1,Brn-1,Brn-1,POU domain, class 3, transcription factor 3,Pou3f3,Rat,Rattus norvegicus,Rhs2 96T
U1616r CLIA Brain-1,Brain-specific homeobox_POU domain protein 1,Brn1,Brn-1,Brn-1,POU domain, class 3, transcription factor 3,Pou3f3,Rat,Rattus norvegicus,Rhs2 96T
EIAAB31744 Brain-3A,Brain-specific homeobox_POU domain protein 3A,BRN3A,Brn-3A,Homeobox_POU domain protein RDC-1,Homo sapiens,Human,Oct-T1,POU domain, class 4, transcription factor 1,POU4F1,RDC1
EIAAB31746 Brain-3A,Brain-specific homeobox_POU domain protein 3A,BRN3A,Brn-3A,BRN-3A,Chicken,Gallus gallus,POU domain, class 4, transcription factor 1,POU4F1
U1643r CLIA Brain-4,Brain-specific homeobox_POU domain protein 4,Brn4,Brn-4,Brn-4,Oct-9,Octamer-binding protein 9,Octamer-binding transcription factor 9,Otf9,OTF-9,POU domain, class 3, transcription factor 4 96T
E1643r ELISA Brain-4,Brain-specific homeobox_POU domain protein 4,Brn4,Brn-4,Brn-4,Oct-9,Octamer-binding protein 9,Octamer-binding transcription factor 9,Otf9,OTF-9,POU domain, class 3, transcription factor 96T
E1643r ELISA kit Brain-4,Brain-specific homeobox_POU domain protein 4,Brn4,Brn-4,Brn-4,Oct-9,Octamer-binding protein 9,Octamer-binding transcription factor 9,Otf9,OTF-9,POU domain, class 3, transcription fa 96T
18-003-42329 POU domain. class 4. transcription factor 3 - Brain-specific homeobox_POU domain protein 3C; Brn-3C Polyclonal 0.1 mg Protein A
18-003-42034 POU domain. class 4. transcription factor 2 - Brain-specific homeobox_POU domain protein 3B; Brn-3B Polyclonal 0.1 mg Protein A
18-003-44082 POU domain. class 4. transcription factor 2 - Brain-specific homeobox_POU domain protein 3B; Brn-3B Polyclonal 0.05 mg Aff Pur
E1616h ELISA kit Brain-1,Brain-specific homeobox_POU domain protein 1,BRN1,Brn-1,Homo sapiens,Human,Oct-8,Octamer-binding protein 8,Octamer-binding transcription factor 8,OTF8,OTF-8,POU domain, class 3, tra 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur | Gentaur





GENTAUR Ltd.
Unicorn House, Station Cl
Hertfordshire, Potters Bar EN6 1TL
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017
RIB 30004 00187 00010092253 10
BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG
IBAN FR76 3000 4001 8700 0100 9225 310
france@gentaur.com | Gentaur | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: +49 0241 40 08 90 86, +49 0241 95 78 94 78, +49 0241 40 08 90 86
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur | Gentaur