Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

POU domain, class 4, transcription factor 1 (Brain-specific homeobox/POU domain protein 3A) (Brain-3A) (Brn-3A) (Brn-3.0)

 PO4F1_MOUSE             Reviewed;         421 AA.
P17208; E9QPT6;
01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
27-JUL-2011, sequence version 3.
22-NOV-2017, entry version 152.
RecName: Full=POU domain, class 4, transcription factor 1;
AltName: Full=Brain-specific homeobox/POU domain protein 3A;
Short=Brain-3A;
Short=Brn-3A;
AltName: Full=Brn-3.0;
Name=Pou4f1; Synonyms=Brn-3, Brn3, Brn3a;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
PubMed=8162704;
Theil T., Zechner U., Klett C., Adolph S., Moeroey T.;
"Chromosomal localization and sequences of the murine Brn-3 family of
developmental control genes.";
Cytogenet. Cell Genet. 66:267-271(1994).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=C57BL/6J;
PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
Lindblad-Toh K., Eichler E.E., Ponting C.P.;
"Lineage-specific biology revealed by a finished genome assembly of
the mouse.";
PLoS Biol. 7:E1000112-E1000112(2009).
[3]
NUCLEOTIDE SEQUENCE [MRNA] OF 286-401.
STRAIN=T6 / TW1; TISSUE=Testis;
PubMed=1970171; DOI=10.1093/nar/18.6.1634;
Goldsborough A., Ashworth A., Willison K.R.;
"Cloning and sequencing of POU-boxes expressed in mouse testis.";
Nucleic Acids Res. 18:1634-1634(1990).
[4]
ALTERNATIVE SPLICING, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
PubMed=8290353; DOI=10.1093/nar/21.25.5921;
Theil T., McLean-Hunter S., Zoernig M., Moeroey T.;
"Mouse Brn-3 family of POU transcription factors: a new aminoterminal
domain is crucial for the oncogenic activity of Brn-3a.";
Nucleic Acids Res. 21:5921-5929(1993).
[5]
INTERACTION WITH POU4F2 (ISOFORM 1).
PubMed=8537352; DOI=10.1074/jbc.270.52.30958;
Theil T., Roedel B., Spiegelhalter F., Moeroey T.;
"Short isoform of POU factor Brn-3b can form a heterodimer with Brn-3a
that is inactive for octamer motif binding.";
J. Biol. Chem. 270:30958-30964(1995).
[6]
FUNCTION, DOMAIN, AND DNA-BINDING.
PubMed=8621561; DOI=10.1074/jbc.271.15.9108;
Budhram-Mahadeo V., Morris P.J., Lakin N.D., Dawson S.J.,
Latchman D.S.;
"The different activities of the two activation domains of the Brn-3a
transcription factor are dependent on the context of the binding
site.";
J. Biol. Chem. 271:9108-9113(1996).
[7]
DEVELOPMENTAL STAGE.
PubMed=8637595; DOI=10.1038/381603a0;
Erkman L., McEvilly R.J., Luo L., Ryan A.K., Hooshmand F.,
O'Connell S.M., Keithley E.M., Rapaport D.H., Ryan A.F.,
Rosenfeld M.G.;
"Role of transcription factors Brn-3.1 and Brn-3.2 in auditory and
visual system development.";
Nature 381:603-606(1996).
[8]
FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=8876243; DOI=10.1073/pnas.93.21.11950;
Xiang M., Gan L., Zhou L., Klein W.H., Nathans J.;
"Targeted deletion of the mouse POU domain gene Brn-3a causes
selective loss of neurons in the brainstem and trigeminal ganglion,
uncoordinated limb movement, and impaired suckling.";
Proc. Natl. Acad. Sci. U.S.A. 93:11950-11955(1996).
[9]
FUNCTION, DOMAIN, AND MUTAGENESIS OF VAL-378.
PubMed=8972215; DOI=10.1128/MCB.17.1.345;
Smith M.D., Dawson S.J., Latchman D.S.;
"The Brn-3a transcription factor induces neuronal process outgrowth
and the coordinate expression of genes encoding synaptic proteins.";
Mol. Cell. Biol. 17:345-354(1997).
[10]
FUNCTION, AND INTERACTION WITH ESR1 (ISOFORM 1).
PubMed=9448000; DOI=10.1128/MCB.18.2.1029;
Budhram-Mahadeo V., Parker M., Latchman D.S.;
"POU transcription factors Brn-3a and Brn-3b interact with the
estrogen receptor and differentially regulate transcriptional activity
via an estrogen response element.";
Mol. Cell. Biol. 18:1029-1041(1998).
[11]
FUNCTION, AND MUTAGENESIS OF VAL-378.
PubMed=9694219;
Dawson S.J., Palmer R.D., Morris P.J., Latchman D.S.;
"Functional role of position 22 in the homeodomain of Brn-3
transcription factors.";
NeuroReport 9:2305-2309(1998).
[12]
FUNCTION, FUNCTION (ISOFORM 2), DOMAIN, AND MUTAGENESIS OF VAL-378.
PubMed=9722627; DOI=10.1093/nar/26.18.4100;
Smith M.D., Dawson S.J., Boxer L.M., Latchman D.S.;
"The N-terminal domain unique to the long form of the Brn-3a
transcription factor is essential to protect neuronal cells from
apoptosis and for the activation of Bbcl-2 gene expression.";
Nucleic Acids Res. 26:4100-4107(1998).
[13]
FUNCTION.
PubMed=10640682; DOI=10.1016/S0169-328X(99)00271-5;
Smith M.D., Ensor E.A., Stohl L., Wagner J.A., Latchman D.S.;
"Regulation of NGFI-A (Egr-1) gene expression by the POU domain
transcription factor Brn-3a.";
Brain Res. Mol. Brain Res. 74:117-125(1999).
[14]
FUNCTION.
PubMed=12441296; DOI=10.1242/dev.00194;
Trieu M., Ma A., Eng S.R., Fedtsova N., Turner E.E.;
"Direct autoregulation and gene dosage compensation by POU-domain
transcription factor Brn3a.";
Development 130:111-121(2003).
[15]
FUNCTION, FUNCTION (ISOFORM 2), AND INTERACTION WITH RIT2.
PubMed=12934100; DOI=10.1038/sj.onc.1206635;
Calissano M., Latchman D.S.;
"Functional interaction between the small GTP-binding protein Rin and
the N-terminal of Brn-3a transcription factor.";
Oncogene 22:5408-5414(2003).
[16]
FUNCTION, DNA-BINDING, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND
INDUCTION.
PubMed=17668438; DOI=10.1002/jcb.21257;
Schulze-Spaete U., Battaglino R., Fu J., Sharma A., Vokes M.,
Stashenko P.;
"Brn3 transcription factors control terminal osteoclastogenesis.";
J. Cell. Biochem. 102:1-12(2007).
[17]
FUNCTION, DISRUPTION PHENOTYPE, AND DEVELOPMENTAL STAGE.
PubMed=22326227; DOI=10.1016/j.ydbio.2012.01.021;
Zou M., Li S., Klein W.H., Xiang M.;
"Brn3a/Pou4f1 regulates dorsal root ganglion sensory neuron
specification and axonal projection into the spinal cord.";
Dev. Biol. 364:114-127(2012).
-!- FUNCTION: Multifunctional transcription factor with different
regions mediating its different effects (PubMed:10640682,
PubMed:8621561, PubMed:9694219, PubMed:9722627). Acts by binding
(via its C-terminal domain) to sequences related to the consensus
octamer motif 5'-ATGCAAAT-3' in the regulatory regions of its
target genes (PubMed:8621561, PubMed:17668438). Regulates the
expression of specific genes involved in differentiation and
survival within a subset of neuronal lineages. It has been shown
that activation of some of these genes requires its N-terminal
domain, maybe through a neuronal-specific cofactor
(PubMed:12934100). Ativates BCL2 expression and protects neuronal
cells from apoptosis (via the N-terminal domain) (PubMed:9722627).
Induces neuronal process outgrowth and the coordinate expression
of genes encoding synaptic proteins (PubMed:8972215). Exerts its
major developmental effects in somatosensory neurons and in
brainstem nuclei involved in motor control. Stimulates the binding
affinity of the nuclear estrogene receptor ESR1 to DNA estrogen
response element (ERE), and hence modulates ESR1-induced
transcriptional activity (PubMed:9448000). May positively regulate
POU4F2 and POU4F3 (PubMed:8876243). Regulates dorsal root ganglion
sensory neuron specification and axonal projection into the spinal
cord (PubMed:22326227). Plays a role in TNFSF11-mediated terminal
osteoclast differentiation (PubMed:17668438). Negatively regulates
its own expression interacting directly with a highly conserved
autoregulatory domain surrounding the transcription initiation
site (PubMed:12441296). {ECO:0000269|PubMed:10640682,
ECO:0000269|PubMed:12441296, ECO:0000269|PubMed:12934100,
ECO:0000269|PubMed:17668438, ECO:0000269|PubMed:22326227,
ECO:0000269|PubMed:8621561, ECO:0000269|PubMed:8876243,
ECO:0000269|PubMed:8972215, ECO:0000269|PubMed:9448000,
ECO:0000269|PubMed:9694219, ECO:0000269|PubMed:9722627}.
-!- FUNCTION: Isoform 2: Able to act as transcription factor, cannot
regulate the expression of the same subset of genes than isoform 1
(PubMed:12934100). Does not have antiapoptotic effect on neuronal
cells (PubMed:9722627). {ECO:0000269|PubMed:12934100,
ECO:0000269|PubMed:9722627}.
-!- SUBUNIT: Interacts (via N-terminus) with RIT2; the interaction
controls POU4F1 transactivation activity on some neuronal target
genes (PubMed:12934100). Isoform 1 interacts with POU4F2 isoform
2; this interaction inhibits both POU4F1 DNA-binding and
transcriptional activities (PubMed:8537352). Isoform 1 interacts
(C-terminus) with ESR1 (via DNA-binding domain); this interaction
decreases the estrogen receptor ESR1 transcriptional activity in a
DNA- and ligand 17-beta-estradiol-independent manner
(PubMed:9448000). {ECO:0000269|PubMed:12934100,
ECO:0000269|PubMed:8537352, ECO:0000269|PubMed:9448000}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17668438}.
Cytoplasm {ECO:0000269|PubMed:17668438}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1; Synonyms=Brn-3A-Long {ECO:0000303|PubMed:8290353};
IsoId=P17208-1; Sequence=Displayed;
Name=2 {ECO:0000303|PubMed:8290353}; Synonyms=Brn-3A-Short
{ECO:0000303|PubMed:8290353};
IsoId=P17208-2; Sequence=VSP_058637;
-!- TISSUE SPECIFICITY: Expressed in mature osteoclasts (at protein
level) (PubMed:17668438). Brain, peripheral sensory nervous system
and retina (PubMed:8162704). In the adult nervous system,
predominates in the medial habenula, superficial gray of the
superior colliculus, red nucleus, mesencephalic nucleus of the
trigeminal ganglion, nucleus ambiguus, inferior olivary nucleus,
and peripheral sensory ganglia (PubMed:8290353).
{ECO:0000269|PubMed:17668438, ECO:0000269|PubMed:8162704,
ECO:0000269|PubMed:8290353}.
-!- DEVELOPMENTAL STAGE: Expressed in the spinal cord from E11 to the
adult stage (PubMed:8290353). As early as E10.5 to E15.5, strongly
expressed in all dorsal root ganglion neurons (PubMed:22326227).
In retinal ganglion cells, expression starts at E15.5 and exhibits
a slow decrease with moderate levels detectable at P8
(PubMed:8637595). {ECO:0000269|PubMed:22326227,
ECO:0000269|PubMed:8290353, ECO:0000269|PubMed:8637595}.
-!- INDUCTION: Up-regulated by the osteoclast differentiation factor
TNFSF11 (PubMed:17668438). {ECO:0000269|PubMed:17668438}.
-!- DOMAIN: The C-terminal domain is able to act as both DNA-binding
domain and a transcriptional activator. The N-terminal domain is
also required for transactivation activity on some target genes
acting as a discrete activation domain (PubMed:8621561,
PubMed:9722627). Neurite outgrowth and expression of genes
required for synapse formation are primarily dependent on the C-
terminal domain, however the N-terminal domain is required for
maximal induction (PubMed:8972215). {ECO:0000269|PubMed:8621561,
ECO:0000269|PubMed:8972215, ECO:0000269|PubMed:9722627}.
-!- DISRUPTION PHENOTYPE: Mutants have defective suckling and
uncoordinated limb and trunk movements, leading to early postnatal
death. They show a loss of neurons in the trigerminal ganglia, the
medial habenula, the red nucleus and the caudal region of the
inferior olivary nucleus (PubMed:8876243). Mutant dorsal root
ganglions are defective in sensory neuron specification, and
sensory afferent axons fail to form normal trajectories in the
spinal cord (PubMed:22326227). {ECO:0000269|PubMed:22326227,
ECO:0000269|PubMed:8876243}.
-!- SIMILARITY: Belongs to the POU transcription factor family. Class-
4 subfamily. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; S69350; AAB30577.2; -; Genomic_DNA.
EMBL; AC121997; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; X51959; CAA36218.1; -; mRNA.
CCDS; CCDS27319.1; -. [P17208-1]
RefSeq; NP_035273.3; NM_011143.4. [P17208-1]
RefSeq; XP_006518768.1; XM_006518705.3. [P17208-1]
RefSeq; XP_006518769.1; XM_006518706.3. [P17208-1]
UniGene; Mm.246550; -.
ProteinModelPortal; P17208; -.
SMR; P17208; -.
BioGrid; 202310; 2.
STRING; 10090.ENSMUSP00000060798; -.
PhosphoSitePlus; P17208; -.
PaxDb; P17208; -.
PRIDE; P17208; -.
Ensembl; ENSMUST00000053016; ENSMUSP00000060798; ENSMUSG00000048349. [P17208-1]
GeneID; 18996; -.
KEGG; mmu:18996; -.
UCSC; uc007uxb.2; mouse. [P17208-1]
CTD; 5457; -.
MGI; MGI:102525; Pou4f1.
eggNOG; KOG1168; Eukaryota.
eggNOG; ENOG410XPNX; LUCA.
GeneTree; ENSGT00760000118935; -.
HOGENOM; HOG000116305; -.
HOVERGEN; HBG031829; -.
InParanoid; P17208; -.
KO; K09366; -.
OMA; KYTTLHS; -.
OrthoDB; EOG091G0WBK; -.
TreeFam; TF316413; -.
Reactome; R-MMU-6804759; Regulation of TP53 Activity through Association with Co-factors.
PRO; PR:P17208; -.
Proteomes; UP000000589; Chromosome 14.
Bgee; ENSMUSG00000048349; -.
CleanEx; MM_POU4F1; -.
Genevisible; P17208; MM.
GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO; GO:0043005; C:neuron projection; IDA:MGI.
GO; GO:0000790; C:nuclear chromatin; IDA:BHF-UCL.
GO; GO:0005634; C:nucleus; IDA:UniProtKB.
GO; GO:0003682; F:chromatin binding; IGI:ParkinsonsUK-UCL.
GO; GO:0003677; F:DNA binding; IDA:MGI.
GO; GO:0051020; F:GTPase binding; IPI:ParkinsonsUK-UCL.
GO; GO:0000980; F:RNA polymerase II distal enhancer sequence-specific DNA binding; IDA:NTNU_SB.
GO; GO:0000981; F:RNA polymerase II transcription factor activity, sequence-specific DNA binding; ISO:MGI.
GO; GO:0043565; F:sequence-specific DNA binding; IDA:UniProtKB.
GO; GO:0003697; F:single-stranded DNA binding; IDA:UniProtKB.
GO; GO:0003713; F:transcription coactivator activity; IMP:UniProtKB.
GO; GO:0003714; F:transcription corepressor activity; IMP:UniProtKB.
GO; GO:0003705; F:transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; IDA:BHF-UCL.
GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IMP:MGI.
GO; GO:0001077; F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding; IDA:UniProtKB.
GO; GO:0001205; F:transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding; IDA:NTNU_SB.
GO; GO:0021535; P:cell migration in hindbrain; IMP:MGI.
GO; GO:0071345; P:cellular response to cytokine stimulus; IDA:UniProtKB.
GO; GO:0071392; P:cellular response to estradiol stimulus; IDA:UniProtKB.
GO; GO:0021953; P:central nervous system neuron differentiation; IMP:MGI.
GO; GO:0021986; P:habenula development; IMP:MGI.
GO; GO:0060384; P:innervation; IMP:MGI.
GO; GO:0072332; P:intrinsic apoptotic signaling pathway by p53 class mediator; IMP:UniProtKB.
GO; GO:0007498; P:mesoderm development; IMP:MGI.
GO; GO:0043066; P:negative regulation of apoptotic process; IGI:ParkinsonsUK-UCL.
GO; GO:0043524; P:negative regulation of neuron apoptotic process; IMP:BHF-UCL.
GO; GO:0043069; P:negative regulation of programmed cell death; IMP:UniProtKB.
GO; GO:2001208; P:negative regulation of transcription elongation from RNA polymerase I promoter; IGI:ParkinsonsUK-UCL.
GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.
GO; GO:0007399; P:nervous system development; IDA:MGI.
GO; GO:0030182; P:neuron differentiation; IMP:MGI.
GO; GO:0048665; P:neuron fate specification; IMP:BHF-UCL.
GO; GO:0031175; P:neuron projection development; IDA:UniProtKB.
GO; GO:0048935; P:peripheral nervous system neuron development; IMP:BHF-UCL.
GO; GO:0048934; P:peripheral nervous system neuron differentiation; IMP:MGI.
GO; GO:0043065; P:positive regulation of apoptotic process; IGI:MGI.
GO; GO:0071158; P:positive regulation of cell cycle arrest; IMP:UniProtKB.
GO; GO:0010628; P:positive regulation of gene expression; IDA:UniProtKB.
GO; GO:0045672; P:positive regulation of osteoclast differentiation; IMP:UniProtKB.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
GO; GO:2000679; P:positive regulation of transcription regulatory region DNA binding; IDA:UniProtKB.
GO; GO:0051355; P:proprioception involved in equilibrioception; IMP:MGI.
GO; GO:0050767; P:regulation of neurogenesis; IMP:MGI.
GO; GO:0051090; P:regulation of sequence-specific DNA binding transcription factor activity; IDA:UniProtKB.
GO; GO:0006355; P:regulation of transcription, DNA-templated; IMP:MGI.
GO; GO:0048880; P:sensory system development; IMP:BHF-UCL.
GO; GO:0001967; P:suckling behavior; IMP:MGI.
GO; GO:0021559; P:trigeminal nerve development; IMP:BHF-UCL.
GO; GO:0003223; P:ventricular compact myocardium morphogenesis; IMP:UniProtKB.
CDD; cd00086; homeodomain; 1.
CDD; cd00093; HTH_XRE; 1.
InterPro; IPR001387; Cro/C1-type_HTH.
InterPro; IPR009057; Homeobox-like_sf.
InterPro; IPR017970; Homeobox_CS.
InterPro; IPR001356; Homeobox_dom.
InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
InterPro; IPR013847; POU.
InterPro; IPR015584; POU4-TF1.
InterPro; IPR000327; POU_dom.
PANTHER; PTHR11636:SF42; PTHR11636:SF42; 1.
Pfam; PF00046; Homeobox; 1.
Pfam; PF00157; Pou; 1.
PRINTS; PR00028; POUDOMAIN.
SMART; SM00389; HOX; 1.
SMART; SM00352; POU; 1.
SUPFAM; SSF46689; SSF46689; 1.
SUPFAM; SSF47413; SSF47413; 1.
PROSITE; PS00027; HOMEOBOX_1; 1.
PROSITE; PS50071; HOMEOBOX_2; 1.
PROSITE; PS00035; POU_1; 1.
PROSITE; PS00465; POU_2; 1.
PROSITE; PS51179; POU_3; 1.
1: Evidence at protein level;
Alternative splicing; Complete proteome; Cytoplasm;
Developmental protein; DNA-binding; Homeobox; Nucleus;
Reference proteome; Transcription; Transcription regulation.
CHAIN 1 421 POU domain, class 4, transcription factor
1.
/FTId=PRO_0000100737.
DOMAIN 262 339 POU-specific. {ECO:0000255|PROSITE-
ProRule:PRU00530}.
DNA_BIND 357 416 Homeobox. {ECO:0000255|PROSITE-
ProRule:PRU00108}.
MOTIF 57 66 POU-IV box.
COMPBIAS 100 108 Poly-His.
COMPBIAS 130 187 Gly-rich.
COMPBIAS 205 258 Ala-rich.
VAR_SEQ 1 84 Missing (in isoform 2). {ECO:0000305}.
/FTId=VSP_058637.
MUTAGEN 378 378 V->I: Abolishes transcriptional activity.
Increases transcriptional repression.
Disrupts induction of neurite outgrowth
and expression of synaptic genes. No
effect on transactivation of BCL2
expression. {ECO:0000269|PubMed:8972215,
ECO:0000269|PubMed:9694219,
ECO:0000269|PubMed:9722627}.
CONFLICT 179 179 G -> A (in Ref. 1; AAB30577).
{ECO:0000305}.
SEQUENCE 421 AA; 42767 MW; 64EC98E5C0CF79E2 CRC64;
MMSMNSKQPH FAMHPTLPEH KYPSLHSSSE AIRRACLPTP PLQSNLFASL DETLLARAEA
LAAVDIAVSQ GKSHPFKPDA TYHTMNSVPC TSTSTVPLAH HHHHHHHHQA LEPGDLLDHI
SSPSLALMAG AGGAGAAGGG GGAHDGPGGG GGPGGGGGPG GGGPGGGGGG GGPGGGGGGP
GGGLLGGSAH PHPHMHGLGH LSHPAAAAAM NMPSGLPHPG LVAAAAHHGA AAAAAAAAAG
QVAAASAAAA VVGAAGLASI CDSDTDPREL EAFAERFKQR RIKLGVTQAD VGSALANLKI
PGVGSLSQST ICRFESLTLS HNNMIALKPI LQAWLEEAEG AQREKMNKPE LFNGGEKKRK
RTSIAAPEKR SLEAYFAVQP RPSSEKIAAI AEKLDLKKNV VRVWFCNQRQ KQKRMKFSAT
Y


Related products :

Catalog number Product name Quantity
18-003-42046 POU domain. class 6. transcription factor 1 - mPOU homeobox protein; Brain-specific homeobox_POU domain protein 5; Brain-5; Brn-5 protein Polyclonal 0.05 mg Aff Pur
EIAAB31756 Brain-5,Brain-specific homeobox_POU domain protein 5,BRN5,Brn-5,Homo sapiens,Human,MPOU,mPOU homeobox protein,POU domain, class 6, transcription factor 1,POU6F1,TCFB1
18-003-43038 POU domain. class 3. transcription factor 4 - Brain-specific homeobox_POU domain protein 4; Brain-4; Brn-4 Polyclonal 0.1 mg Protein A
EIAAB31755 Brain-5,Brain-specific homeobox_POU domain protein 5,Brn5,Brn-5,POU domain, class 6, transcription factor 1,Pou6f1,Rat,Rattus norvegicus
EIAAB31747 Brain-3B,Brain-specific homeobox_POU domain protein 3B,Brn-3.2,Brn3b,Brn-3B,Mouse,Mus musculus,POU domain, class 4, transcription factor 2,Pou4f2
E1616p ELISA kit Brain-1,Brain-specific homeobox_POU domain protein 1,BRN1,Brn-1,Pig,POU domain, class 3, transcription factor 3,POU3F3,Sus scrofa 96T
E1616p ELISA Brain-1,Brain-specific homeobox_POU domain protein 1,BRN1,Brn-1,Pig,POU domain, class 3, transcription factor 3,POU3F3,Sus scrofa 96T
EIAAB31750 Brain-3C,Brain-specific homeobox_POU domain protein 3C,Brn3c,Brn-3C,Brn-3c,Mouse,Mus musculus,POU domain, class 4, transcription factor 3,Pou4f3
U1616p CLIA Brain-1,Brain-specific homeobox_POU domain protein 1,BRN1,Brn-1,Pig,POU domain, class 3, transcription factor 3,POU3F3,Sus scrofa 96T
EIAAB31749 Brain-3C,Brain-specific homeobox_POU domain protein 3C,BRN3C,Brn-3C,Homo sapiens,Human,POU domain, class 4, transcription factor 3,POU4F3
EIAAB31745 Brain-3A,Brain-specific homeobox_POU domain protein 3A,Brn3,Brn-3,Brn-3.0,Brn3a,Brn-3A,Mouse,Mus musculus,POU domain, class 4, transcription factor 1,Pou4f1
EIAAB31743 Brain-3A,Brain-specific homeobox_POU domain protein 3A,Brn3,Brn-3,Brn3a,Brn-3A,POU domain, class 4, transcription factor 1,Pou4f1,Rat,Rattus norvegicus
EIAAB31748 Brain-3B,Brain-specific homeobox_POU domain protein 3B,BRN3B,Brn-3B,Homo sapiens,Human,POU domain, class 4, transcription factor 2,POU4F2
E1616r ELISA Brain-1,Brain-specific homeobox_POU domain protein 1,Brn1,Brn-1,Brn-1,POU domain, class 3, transcription factor 3,Pou3f3,Rat,Rattus norvegicus,Rhs2 96T
E1616r ELISA kit Brain-1,Brain-specific homeobox_POU domain protein 1,Brn1,Brn-1,Brn-1,POU domain, class 3, transcription factor 3,Pou3f3,Rat,Rattus norvegicus,Rhs2 96T
U1616r CLIA Brain-1,Brain-specific homeobox_POU domain protein 1,Brn1,Brn-1,Brn-1,POU domain, class 3, transcription factor 3,Pou3f3,Rat,Rattus norvegicus,Rhs2 96T
EIAAB31744 Brain-3A,Brain-specific homeobox_POU domain protein 3A,BRN3A,Brn-3A,Homeobox_POU domain protein RDC-1,Homo sapiens,Human,Oct-T1,POU domain, class 4, transcription factor 1,POU4F1,RDC1
EIAAB31746 Brain-3A,Brain-specific homeobox_POU domain protein 3A,BRN3A,Brn-3A,BRN-3A,Chicken,Gallus gallus,POU domain, class 4, transcription factor 1,POU4F1
U1643r CLIA Brain-4,Brain-specific homeobox_POU domain protein 4,Brn4,Brn-4,Brn-4,Oct-9,Octamer-binding protein 9,Octamer-binding transcription factor 9,Otf9,OTF-9,POU domain, class 3, transcription factor 4 96T
E1643r ELISA Brain-4,Brain-specific homeobox_POU domain protein 4,Brn4,Brn-4,Brn-4,Oct-9,Octamer-binding protein 9,Octamer-binding transcription factor 9,Otf9,OTF-9,POU domain, class 3, transcription factor 96T
E1643r ELISA kit Brain-4,Brain-specific homeobox_POU domain protein 4,Brn4,Brn-4,Brn-4,Oct-9,Octamer-binding protein 9,Octamer-binding transcription factor 9,Otf9,OTF-9,POU domain, class 3, transcription fa 96T
18-003-42329 POU domain. class 4. transcription factor 3 - Brain-specific homeobox_POU domain protein 3C; Brn-3C Polyclonal 0.1 mg Protein A
18-003-42034 POU domain. class 4. transcription factor 2 - Brain-specific homeobox_POU domain protein 3B; Brn-3B Polyclonal 0.1 mg Protein A
18-003-44082 POU domain. class 4. transcription factor 2 - Brain-specific homeobox_POU domain protein 3B; Brn-3B Polyclonal 0.05 mg Aff Pur
E1616h ELISA kit Brain-1,Brain-specific homeobox_POU domain protein 1,BRN1,Brn-1,Homo sapiens,Human,Oct-8,Octamer-binding protein 8,Octamer-binding transcription factor 8,OTF8,OTF-8,POU domain, class 3, tra 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur