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POU domain, class 4, transcription factor 3

 PO4F3_RAT               Reviewed;         338 AA.
D3ZTL1;
02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
20-APR-2010, sequence version 1.
10-OCT-2018, entry version 78.
RecName: Full=POU domain, class 4, transcription factor 3;
Name=Pou4f3 {ECO:0000312|RGD:1310459};
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Brown Norway;
PubMed=15057822; DOI=10.1038/nature02426;
Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T.,
Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A.,
Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M.,
Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K.,
Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S.,
Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J.,
Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y.,
Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A.,
Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J.,
D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R.,
Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A.,
Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E.,
Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E.,
Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D.,
Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M.,
Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O.,
Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O.,
Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H.,
Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S.,
Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J.,
Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E.,
Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F.,
Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K.,
Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S.,
Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M.,
Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M.,
Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A.,
Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S.,
Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G.,
Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H.,
Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R.,
Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M.,
Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H.,
Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S.,
Collins F.S.;
"Genome sequence of the Brown Norway rat yields insights into
mammalian evolution.";
Nature 428:493-521(2004).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[3]
DEVELOPMENTAL STAGE, AND TISSUE SPECIFICITY.
PubMed=8637595; DOI=10.1038/381603a0;
Erkman L., McEvilly R.J., Luo L., Ryan A.K., Hooshmand F.,
O'Connell S.M., Keithley E.M., Rapaport D.H., Ryan A.F.,
Rosenfeld M.G.;
"Role of transcription factors Brn-3.1 and Brn-3.2 in auditory and
visual system development.";
Nature 381:603-606(1996).
-!- FUNCTION: Acts as a transcriptional activator. Acts by binding to
sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in
the regulatory regions of its target genes. Involved in the
auditory system development, required for terminal differentiation
of hair cells in the inner ear. {ECO:0000250|UniProtKB:Q63955}.
-!- SUBUNIT: Interacts with ISL1. {ECO:0000250|UniProtKB:Q63955}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q15319}.
Cytoplasm {ECO:0000250|UniProtKB:Q15319}. Note=Preferentially
localized in the nucleus. {ECO:0000250|UniProtKB:Q15319}.
-!- TISSUE SPECIFICITY: Expressed in the chochlea of the inner ear.
{ECO:0000269|PubMed:8637595}.
-!- DEVELOPMENTAL STAGE: At E14, strongly expressed in cochlear and
vestibular hair cells of the inner ear, in the cochlea at E18 and
coninues to the adulthood. {ECO:0000269|PubMed:8637595}.
-!- SIMILARITY: Belongs to the POU transcription factor family.
{ECO:0000255|RuleBase:RU361194, ECO:0000255|SAAS:SAAS00595129}.
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EMBL; AABR07031849; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CH473974; EDL76485.1; -; Genomic_DNA.
RefSeq; NP_001102359.1; NM_001108889.1.
UniGene; Rn.218181; -.
SMR; D3ZTL1; -.
STRING; 10116.ENSRNOP00000025465; -.
PaxDb; D3ZTL1; -.
Ensembl; ENSRNOT00000025465; ENSRNOP00000025465; ENSRNOG00000018842.
GeneID; 364855; -.
KEGG; rno:364855; -.
UCSC; RGD:1310459; rat.
CTD; 5459; -.
RGD; 1310459; Pou4f3.
eggNOG; KOG1168; Eukaryota.
eggNOG; ENOG410XPNX; LUCA.
GeneTree; ENSGT00760000118935; -.
InParanoid; D3ZTL1; -.
KO; K09366; -.
OMA; DVTYHTM; -.
OrthoDB; EOG091G0WBK; -.
PhylomeDB; D3ZTL1; -.
TreeFam; TF316413; -.
PRO; PR:D3ZTL1; -.
Proteomes; UP000002494; Chromosome 18.
Bgee; ENSRNOG00000018842; Expressed in 1 organ(s), highest expression level in brain.
GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO; GO:0005634; C:nucleus; ISS:UniProtKB.
GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:Ensembl.
GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
GO; GO:0048675; P:axon extension; IEA:Ensembl.
GO; GO:0042491; P:inner ear auditory receptor cell differentiation; IEA:Ensembl.
GO; GO:0042472; P:inner ear morphogenesis; IEA:Ensembl.
GO; GO:0050885; P:neuromuscular process controlling balance; IEA:Ensembl.
GO; GO:0051402; P:neuron apoptotic process; IEA:Ensembl.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:0031290; P:retinal ganglion cell axon guidance; IEA:Ensembl.
GO; GO:0007605; P:sensory perception of sound; IEA:Ensembl.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
GO; GO:0021562; P:vestibulocochlear nerve development; IEA:Ensembl.
CDD; cd00086; homeodomain; 1.
CDD; cd00093; HTH_XRE; 1.
InterPro; IPR001387; Cro/C1-type_HTH.
InterPro; IPR009057; Homeobox-like_sf.
InterPro; IPR017970; Homeobox_CS.
InterPro; IPR001356; Homeobox_dom.
InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
InterPro; IPR013847; POU.
InterPro; IPR032961; POU4F3.
InterPro; IPR000327; POU_dom.
PANTHER; PTHR11636:SF43; PTHR11636:SF43; 1.
Pfam; PF00046; Homeobox; 1.
Pfam; PF00157; Pou; 1.
PRINTS; PR00028; POUDOMAIN.
SMART; SM00389; HOX; 1.
SMART; SM00352; POU; 1.
SUPFAM; SSF46689; SSF46689; 1.
SUPFAM; SSF47413; SSF47413; 1.
PROSITE; PS00027; HOMEOBOX_1; 1.
PROSITE; PS50071; HOMEOBOX_2; 1.
PROSITE; PS00035; POU_1; 1.
PROSITE; PS00465; POU_2; 1.
PROSITE; PS51179; POU_3; 1.
2: Evidence at transcript level;
Activator; Complete proteome; Cytoplasm; Differentiation; DNA-binding;
Homeobox; Nucleus; Reference proteome; Transcription;
Transcription regulation.
CHAIN 1 338 POU domain, class 4, transcription factor
3.
/FTId=PRO_0000438270.
DOMAIN 179 256 POU-specific. {ECO:0000255|PROSITE-
ProRule:PRU00530}.
DNA_BIND 274 333 Homeobox. {ECO:0000255|PROSITE-
ProRule:PRU00108}.
MOTIF 56 65 POU-IV box.
{ECO:0000250|UniProtKB:Q15319}.
SEQUENCE 338 AA; 37043 MW; 35059F2307DF4C4B CRC64;
MMAMNAKQPF GMHPVLQEPK FSSLHSGSEA MRRVCLPAPQ LQGNIFGSFD ESLLARAEAL
AAVDIVSHGK NHPFKPDATY HTMSSVPCTS TSPTVPISHP AALTSHPHHP VHQGLEGDLL
EHISPTLSVS GLGAPEHSVM PAQIHPHHLG AMGHLHQAMG MSHPHAVAPH SAMPACLSDV
ESDPRELEAF AERFKQRRIK LGVTQADVGA ALANLKIPGV GSLSQSTICR FESLTLSHNN
MIALKPVLQA WLEEAEAAYR EKNSKPELFN GSERKRKRTS IAAPEKRSLE AYFAIQPRPS
SEKIAAIAEK LDLKKNVVRV WFCNQRQKQK RMKYSAVH


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