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POU domain, class 4, transcription factor 3 (Brain-specific homeobox/POU domain protein 3.1) (Brain-3.1) (zfBrn-3.1)

 PO4F3_DANRE             Reviewed;         331 AA.
Q90435; Q52NV5;
01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
24-NOV-2009, sequence version 2.
31-JAN-2018, entry version 130.
RecName: Full=POU domain, class 4, transcription factor 3;
AltName: Full=Brain-specific homeobox/POU domain protein 3.1;
Short=Brain-3.1;
Short=zfBrn-3.1;
Name=pou4f3; Synonyms=brn-3.1, brn-3c, brn3.1, brn3c;
Danio rerio (Zebrafish) (Brachydanio rerio).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
Cyprinidae; Danio.
NCBI_TaxID=7955;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
PubMed=15930106; DOI=10.1242/dev.01861;
Xiao T., Roeser T., Staub W., Baier H.;
"A GFP-based genetic screen reveals mutations that disrupt the
architecture of the zebrafish retinotectal projection.";
Development 132:2955-2967(2005).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 196-311, TISSUE SPECIFICITY, AND
DEVELOPMENTAL STAGE.
PubMed=8605028; DOI=10.1006/bbrc.1996.0274;
Sampath K., Stuart G.W.;
"Developmental expression of class III and IV POU domain genes in the
zebrafish.";
Biochem. Biophys. Res. Commun. 219:565-571(1996).
[3]
TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
PubMed=15042710; DOI=10.1002/dvdy.10475;
DeCarvalho A.C., Cappendijk S.L., Fadool J.M.;
"Developmental expression of the POU domain transcription factor Brn-
3b (Pou4f2) in the lateral line and visual system of zebrafish.";
Dev. Dyn. 229:869-876(2004).
-!- FUNCTION: Acts as a transcriptional activator. Acts by binding to
sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in
the regulatory regions of its target genes. May play a role in
specifying terminally differentiated neuronal phenotypes.
{ECO:0000250|UniProtKB:Q63955}.
-!- SUBUNIT: Interaction with ISL1. {ECO:0000250|UniProtKB:Q63955}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q15319}.
Cytoplasm {ECO:0000250|UniProtKB:Q15319}. Note=Preferentially
localized in the nucleus. {ECO:0000250|UniProtKB:Q15319}.
-!- TISSUE SPECIFICITY: Expressed in the nervous system. Expressed in
the otic vesicle during embryogenesis. Expressed in the adult
retina in a subset of retinal ganglion cells (RGCs), and at a
lower level in the adult tectum. Not expressed in the adult
olfactory bulb. {ECO:0000269|PubMed:15042710,
ECO:0000269|PubMed:15930106, ECO:0000269|PubMed:8605028}.
-!- DEVELOPMENTAL STAGE: Weakly expressed during embryogenesis, with
stronger expression in the adult eye.
{ECO:0000269|PubMed:15042710, ECO:0000269|PubMed:8605028}.
-!- SIMILARITY: Belongs to the POU transcription factor family. Class-
4 subfamily. {ECO:0000305}.
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EMBL; AY995217; AAX86839.1; -; mRNA.
EMBL; U43658; AAB00435.1; -; Genomic_DNA.
RefSeq; NP_571353.1; NM_131278.1.
UniGene; Dr.93311; -.
ProteinModelPortal; Q90435; -.
SMR; Q90435; -.
STRING; 7955.ENSDARP00000107974; -.
PaxDb; Q90435; -.
Ensembl; ENSDART00000149175; ENSDARP00000124728; ENSDARG00000006206.
GeneID; 30534; -.
KEGG; dre:30534; -.
CTD; 5459; -.
ZFIN; ZDB-GENE-990415-24; pou4f3.
eggNOG; KOG1168; Eukaryota.
eggNOG; ENOG410XPNX; LUCA.
GeneTree; ENSGT00760000118935; -.
HOGENOM; HOG000116305; -.
HOVERGEN; HBG053120; -.
InParanoid; Q90435; -.
KO; K09366; -.
OMA; DVTYHTM; -.
OrthoDB; EOG091G0WBK; -.
PhylomeDB; Q90435; -.
PRO; PR:Q90435; -.
Proteomes; UP000000437; Chromosome 9.
Bgee; ENSDARG00000006206; -.
GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO; GO:0005634; C:nucleus; ISS:UniProtKB.
GO; GO:0003700; F:DNA binding transcription factor activity; IEA:InterPro.
GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
GO; GO:0007420; P:brain development; IEP:ZFIN.
GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
GO; GO:0048839; P:inner ear development; IEA:InterPro.
GO; GO:0007605; P:sensory perception of sound; IEA:InterPro.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
CDD; cd00086; homeodomain; 1.
CDD; cd00093; HTH_XRE; 1.
InterPro; IPR001387; Cro/C1-type_HTH.
InterPro; IPR009057; Homeobox-like_sf.
InterPro; IPR017970; Homeobox_CS.
InterPro; IPR001356; Homeobox_dom.
InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
InterPro; IPR013847; POU.
InterPro; IPR032961; POU4F3.
InterPro; IPR000327; POU_dom.
PANTHER; PTHR11636:SF43; PTHR11636:SF43; 1.
Pfam; PF00046; Homeobox; 1.
Pfam; PF00157; Pou; 1.
PRINTS; PR00028; POUDOMAIN.
SMART; SM00389; HOX; 1.
SMART; SM00352; POU; 1.
SUPFAM; SSF46689; SSF46689; 1.
SUPFAM; SSF47413; SSF47413; 1.
PROSITE; PS00027; HOMEOBOX_1; 1.
PROSITE; PS50071; HOMEOBOX_2; 1.
PROSITE; PS00035; POU_1; 1.
PROSITE; PS00465; POU_2; 1.
PROSITE; PS51179; POU_3; 1.
2: Evidence at transcript level;
Activator; Complete proteome; Cytoplasm; Differentiation; DNA-binding;
Homeobox; Nucleus; Reference proteome; Transcription;
Transcription regulation.
CHAIN 1 331 POU domain, class 4, transcription factor
3.
/FTId=PRO_0000100745.
DOMAIN 172 249 POU-specific. {ECO:0000255|PROSITE-
ProRule:PRU00530}.
DNA_BIND 267 326 Homeobox. {ECO:0000255|PROSITE-
ProRule:PRU00108}.
COMPBIAS 76 124 Ser-rich.
COMPBIAS 99 164 His-rich.
CONFLICT 299 299 A -> R (in Ref. 2; AAB00435).
{ECO:0000305}.
SEQUENCE 331 AA; 36550 MW; 26E3487CCCC7533A CRC64;
MMTMNGKQHF SMHPALHPSS EGMRRVCLPA PQLQGNIFSG FDESLLARAE ALAAADIVSH
GKSHPFKTDV TYHTMSSVPC TSSSSTVPIS HPSSNLPSHH HHHLSHQTLE GDLLDHISSS
LSVSGMGAPP DPSVMTTQAH QHHLQMGHLH QAMAMGHPHT LSVHNGMACV NDVESDPREL
EAFAERFKQR RIKLGVTQAD VGSALANLKI PGVGSLSQST ICRFESLTLS HNNMIALKPV
LQAWLEEAEA AYREKNGKPD LFNGNERKRK RTSIAAPEKR SLEAYFAIQP RPSSEKIAAI
AEKLDLKKNV VRVWFCNQRQ KQKRMKYSAV H


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