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PRA1 family protein 3 (ADP-ribosylation factor-like protein 6-interacting protein 5) (ARL-6-interacting protein 5) (Aip-5)

 PRAF3_PONAB             Reviewed;         188 AA.
Q5R4X8;
31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
21-DEC-2004, sequence version 1.
25-APR-2018, entry version 65.
RecName: Full=PRA1 family protein 3;
AltName: Full=ADP-ribosylation factor-like protein 6-interacting protein 5;
Short=ARL-6-interacting protein 5;
Short=Aip-5;
Name=ARL6IP5; Synonyms=PRAF3;
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Pongo.
NCBI_TaxID=9601;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain cortex;
The German cDNA consortium;
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Regulates intracellular concentrations of taurine and
glutamate. Negatively modulates SLC1A1/EAAC1 glutamate transport
activity by decreasing its affinity for glutamate in a PKC
activity-dependent manner. May be involved in membrane traffic.
{ECO:0000250|UniProtKB:Q8R5J9, ECO:0000250|UniProtKB:Q9ES40}.
-!- SUBUNIT: Homodimer. Heterodimer with ARL6IP1. Forms multimers.
Interacts with prenylated RAB1A, RAB3A and SLC1A1/EAAC1. Does not
interact with VAMP1, VAMP2 or VAMP3. Interacts with ARL6.
Interacts with SLC1A1/EAAC1. {ECO:0000250|UniProtKB:Q8R5J9,
ECO:0000250|UniProtKB:Q9ES40}.
-!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
{ECO:0000250|UniProtKB:Q9ES40}; Multi-pass membrane protein
{ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q9ES40};
Multi-pass membrane protein {ECO:0000255}. Cytoplasm
{ECO:0000250|UniProtKB:Q9ES40}. Cytoplasm, cytoskeleton
{ECO:0000250|UniProtKB:Q9ES40}. Note=Also exists as a soluble form
in the cytoplasm. Associated with microtubules.
{ECO:0000250|UniProtKB:Q9ES40}.
-!- SIMILARITY: Belongs to the PRA1 family. {ECO:0000305}.
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EMBL; CR861111; CAH93188.1; -; mRNA.
RefSeq; NP_001127640.1; NM_001134168.1.
ProteinModelPortal; Q5R4X8; -.
STRING; 9601.ENSPPYP00000015350; -.
Ensembl; ENSPPYT00000015963; ENSPPYP00000015350; ENSPPYG00000013728.
GeneID; 100174720; -.
KEGG; pon:100174720; -.
CTD; 10550; -.
eggNOG; KOG4050; Eukaryota.
eggNOG; ENOG4111MUC; LUCA.
GeneTree; ENSGT00390000008631; -.
HOVERGEN; HBG053661; -.
InParanoid; Q5R4X8; -.
KO; K20393; -.
OMA; AHNKDIL; -.
OrthoDB; EOG091G0QS5; -.
TreeFam; TF105479; -.
Proteomes; UP000001595; Chromosome 3.
GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0008631; P:intrinsic apoptotic signaling pathway in response to oxidative stress; IEA:Ensembl.
GO; GO:0015813; P:L-glutamate transmembrane transport; IEA:Ensembl.
GO; GO:0002037; P:negative regulation of L-glutamate import across plasma membrane; ISS:UniProtKB.
GO; GO:0010917; P:negative regulation of mitochondrial membrane potential; IEA:Ensembl.
GO; GO:0043280; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:Ensembl.
GO; GO:0032874; P:positive regulation of stress-activated MAPK cascade; IEA:Ensembl.
InterPro; IPR004895; Prenylated_rab_accept_PRA1.
Pfam; PF03208; PRA1; 1.
2: Evidence at transcript level;
Acetylation; Cell membrane; Complete proteome; Cytoplasm;
Cytoskeleton; Endoplasmic reticulum; Membrane; Reference proteome;
Transmembrane; Transmembrane helix.
CHAIN 1 188 PRA1 family protein 3.
/FTId=PRO_0000256850.
TOPO_DOM 1 35 Cytoplasmic. {ECO:0000250}.
TRANSMEM 36 56 Helical. {ECO:0000255}.
TRANSMEM 57 77 Helical. {ECO:0000255}.
TOPO_DOM 78 93 Cytoplasmic. {ECO:0000250}.
TRANSMEM 94 114 Helical. {ECO:0000255}.
TRANSMEM 115 135 Helical. {ECO:0000255}.
TOPO_DOM 136 188 Cytoplasmic. {ECO:0000250}.
REGION 103 117 Required for homodimer formation and
heterodimer formation with ARL6IP1.
{ECO:0000250|UniProtKB:Q8R5J9}.
REGION 136 188 Targeting to endoplasmic reticulum
membrane. {ECO:0000250|UniProtKB:Q9ES40}.
MOD_RES 1 1 N-acetylmethionine.
{ECO:0000250|UniProtKB:O75915}.
SEQUENCE 188 AA; 21615 MW; 3AA708C6D0901B44 CRC64;
MDVNIAPLRA WDDFFPGSDR FARPDFRDIS KWNNRVVSNL LYYQTNYLVV AAMMISIVGF
LSPFNMILGG IVVVLVFTGF VWAAHNKDVL RRMKKRYPTT FVMVVMLASY FLISMFGGVM
VFVFGITFPL LLMFIHASLR LRNLKNKLEN KMEGIGLKRT PMGIVLDALE QQEEGINRLT
DYISKVKE


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