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PTEN induced putative kinase 1 (Predicted) (PTEN-induced putative kinase 1)

 D3Z9M9_RAT              Unreviewed;       257 AA.
D3Z9M9;
20-APR-2010, integrated into UniProtKB/TrEMBL.
20-APR-2010, sequence version 1.
12-SEP-2018, entry version 67.
SubName: Full=PTEN induced putative kinase 1 (Predicted) {ECO:0000313|EMBL:EDL80874.1};
SubName: Full=PTEN-induced putative kinase 1 {ECO:0000313|Ensembl:ENSRNOP00000058880};
Name=Pink1 {ECO:0000313|Ensembl:ENSRNOP00000058880,
ECO:0000313|RGD:1305769};
Synonyms=Pink1_predicted {ECO:0000313|EMBL:EDL80874.1};
ORFNames=rCG_31005 {ECO:0000313|EMBL:EDL80874.1};
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000058880, ECO:0000313|Proteomes:UP000002494};
[1] {ECO:0000313|Ensembl:ENSRNOP00000058880, ECO:0000313|Proteomes:UP000002494}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000058880,
ECO:0000313|Proteomes:UP000002494};
PubMed=15057822; DOI=10.1038/nature02426;
Rat Genome Sequencing Project Consortium;
Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T.,
Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A.,
Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M.,
Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K.,
Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S.,
Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J.,
Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y.,
Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A.,
Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J.,
D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R.,
Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A.,
Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E.,
Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E.,
Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D.,
Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M.,
Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O.,
Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O.,
Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H.,
Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S.,
Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J.,
Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E.,
Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F.,
Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K.,
Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S.,
Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M.,
Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M.,
Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A.,
Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S.,
Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G.,
Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H.,
Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R.,
Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M.,
Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H.,
Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S.,
Collins F.S.;
"Genome sequence of the Brown Norway rat yields insights into
mammalian evolution.";
Nature 428:493-521(2004).
[2] {ECO:0000313|EMBL:EDL80874.1}
NUCLEOTIDE SEQUENCE.
STRAIN=BN {ECO:0000313|EMBL:EDL80874.1};
PubMed=15632090; DOI=10.1101/gr.2889405;
Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M.,
Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z.,
Istrail S., Li P., Sutton G.;
"Gene and alternative splicing annotation with AIR.";
Genome Res. 15:54-66(2005).
[3] {ECO:0000313|EMBL:EDL80874.1}
NUCLEOTIDE SEQUENCE.
STRAIN=BN {ECO:0000313|EMBL:EDL80874.1};
Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H.,
Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M.,
Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L.,
Lu F., Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C.,
Sutton G.G., Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[4] {ECO:0000313|Ensembl:ENSRNOP00000058880}
IDENTIFICATION.
STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000058880};
Ensembl;
Submitted (JUL-2011) to UniProtKB.
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EMBL; AABR07050212; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CH473968; EDL80874.1; -; Genomic_DNA.
RefSeq; NP_001100164.1; NM_001106694.1.
UniGene; Rn.219286; -.
UniGene; Rn.219317; -.
STRING; 10116.ENSRNOP00000058880; -.
Ensembl; ENSRNOT00000065497; ENSRNOP00000058880; ENSRNOG00000015385.
GeneID; 298575; -.
KEGG; rno:298575; -.
CTD; 65018; -.
RGD; 1305769; Pink1.
eggNOG; KOG4158; Eukaryota.
eggNOG; ENOG410YE6P; LUCA.
GeneTree; ENSGT00390000001206; -.
KO; K05688; -.
Reactome; R-RNO-5205685; Pink/Parkin Mediated Mitophagy.
Proteomes; UP000002494; Chromosome 5.
Bgee; ENSRNOG00000015385; Expressed in 10 organ(s), highest expression level in skeletal muscle tissue.
GO; GO:0030426; C:growth cone; IDA:RGD.
GO; GO:0005743; C:mitochondrial inner membrane; IDA:ParkinsonsUK-UCL.
GO; GO:0005758; C:mitochondrial intermembrane space; IDA:ParkinsonsUK-UCL.
GO; GO:0005741; C:mitochondrial outer membrane; IDA:RGD.
GO; GO:0004674; F:protein serine/threonine kinase activity; IMP:ParkinsonsUK-UCL.
GO; GO:0031625; F:ubiquitin protein ligase binding; IPI:RGD.
GO; GO:1904881; P:cellular response to hydrogen sulfide; IDA:RGD.
GO; GO:0043066; P:negative regulation of apoptotic process; IMP:RGD.
GO; GO:0010629; P:negative regulation of gene expression; IMP:ParkinsonsUK-UCL.
GO; GO:1903751; P:negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide; IMP:ParkinsonsUK-UCL.
GO; GO:1901215; P:negative regulation of neuron death; IMP:RGD.
GO; GO:0018105; P:peptidyl-serine phosphorylation; IMP:ParkinsonsUK-UCL.
GO; GO:1904925; P:positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization; IMP:RGD.
GO; GO:0090141; P:positive regulation of mitochondrial fission; IMP:RGD.
GO; GO:1904783; P:positive regulation of NMDA glutamate receptor activity; IMP:RGD.
GO; GO:0001934; P:positive regulation of protein phosphorylation; IMP:RGD.
GO; GO:0002931; P:response to ischemia; IEP:RGD.
4: Predicted;
Complete proteome {ECO:0000313|Proteomes:UP000002494};
Kinase {ECO:0000313|EMBL:EDL80874.1};
Reference proteome {ECO:0000313|Proteomes:UP000002494};
Transferase {ECO:0000313|EMBL:EDL80874.1}.
SEQUENCE 257 AA; 27522 MW; 81E05DF7FF06EB7C CRC64;
MAVRQALGRG LQLGRALLLR FAPKPGPVSG WGKPGPGAAW GRGERPGRVS SPGAQPRPLG
LPLPDRYRFF RQSVAGLAAR IQRQFVVRAR GGAGPCGRAV FLAFGLGLGL IEEKQAESRR
AASACQEIQA IFTQKNKQVS DPLDTRRWQG FRLEDYLIGQ AIGKGCNAAV YEATMPTLPQ
HLEKAKHLGL LGKGPDVVSK GADGEQAPGA PAFPFAIKMM WNISAGSSSE AILSKMSQEL
EALGSANRKG TLQQFRR


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