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PTS system beta-glucoside-specific EIIBCA component (EIIBCA-Bgl) (EII-Bgl) [Includes: Beta-glucoside-specific phosphotransferase enzyme IIB component (EC 2.7.1.-) (PTS system beta-glucoside-specific EIIB component); Beta-glucoside permease IIC component (PTS system beta-glucoside-specific EIIC component); Beta-glucoside-specific phosphotransferase enzyme IIA component (PTS system beta-glucoside-specific EIIA component)]

 PTV3B_ECOLI             Reviewed;         625 AA.
P08722; Q2M840;
01-AUG-1988, integrated into UniProtKB/Swiss-Prot.
01-AUG-1988, sequence version 1.
10-OCT-2018, entry version 167.
RecName: Full=PTS system beta-glucoside-specific EIIBCA component;
AltName: Full=EIIBCA-Bgl;
Short=EII-Bgl;
Includes:
RecName: Full=Beta-glucoside-specific phosphotransferase enzyme IIB component;
EC=2.7.1.-;
AltName: Full=PTS system beta-glucoside-specific EIIB component;
Includes:
RecName: Full=Beta-glucoside permease IIC component;
AltName: Full=PTS system beta-glucoside-specific EIIC component;
Includes:
RecName: Full=Beta-glucoside-specific phosphotransferase enzyme IIA component;
AltName: Full=PTS system beta-glucoside-specific EIIA component;
Name=bglF; Synonyms=bglC, bglS; OrderedLocusNames=b3722, JW3700;
Escherichia coli (strain K12).
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
Enterobacteriaceae; Escherichia.
NCBI_TaxID=83333;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=K12;
PubMed=3309161; DOI=10.1099/00221287-133-3-563;
Bramley H.F., Kornberg H.L.;
"Nucleotide sequence of bglC, the gene specifying enzymeIIbgl of the
PEP:sugar phosphotransferase system in Escherichia coli K12, and
overexpression of the gene product.";
J. Gen. Microbiol. 133:563-573(1987).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=K12;
PubMed=3034860; DOI=10.1128/jb.169.6.2579-2590.1987;
Schnetz K., Toloczyki C., Rak B.;
"Beta-glucoside (bgl) operon of Escherichia coli K-12: nucleotide
sequence, genetic organization, and possible evolutionary relationship
to regulatory components of two Bacillus subtilis genes.";
J. Bacteriol. 169:2579-2590(1987).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=K12 / MG1655 / ATCC 47076;
PubMed=7686882; DOI=10.1006/geno.1993.1230;
Burland V.D., Plunkett G. III, Daniels D.L., Blattner F.R.;
"DNA sequence and analysis of 136 kilobases of the Escherichia coli
genome: organizational symmetry around the origin of replication.";
Genomics 16:551-561(1993).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=K12 / MG1655 / ATCC 47076;
PubMed=9278503; DOI=10.1126/science.277.5331.1453;
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J.,
Mau B., Shao Y.;
"The complete genome sequence of Escherichia coli K-12.";
Science 277:1453-1462(1997).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
PubMed=16738553; DOI=10.1038/msb4100049;
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
"Highly accurate genome sequences of Escherichia coli K-12 strains
MG1655 and W3110.";
Mol. Syst. Biol. 2:E1-E5(2006).
[6]
TOPOLOGY [LARGE SCALE ANALYSIS].
STRAIN=K12 / MG1655 / ATCC 47076;
PubMed=15919996; DOI=10.1126/science.1109730;
Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
"Global topology analysis of the Escherichia coli inner membrane
proteome.";
Science 308:1321-1323(2005).
-!- FUNCTION: The phosphoenolpyruvate-dependent sugar
phosphotransferase system (sugar PTS), a major carbohydrate active
-transport system, catalyzes the phosphorylation of incoming sugar
substrates concomitantly with their translocation across the cell
membrane. This system is involved in beta-glucoside transport.
-!- FUNCTION: Acts as both a kinase and a phosphatase on BglG.
-!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane
protein.
-!- DOMAIN: The EIIB domain is phosphorylated by phospho-EIIA on a
cysteinyl or histidyl residue, depending on the transported sugar.
Then, it transfers the phosphoryl group to the sugar substrate
concomitantly with the sugar uptake processed by the EIIC domain.
-!- DOMAIN: The EIIC domain forms the PTS system translocation channel
and contains the specific substrate-binding site.
-!- DOMAIN: The EIIA domain is phosphorylated by phospho-HPr on a
histidyl residue. Then, it transfers the phosphoryl group to the
EIIB domain.
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; M15746; AAA83837.1; -; Genomic_DNA.
EMBL; M16487; AAA23510.1; -; Genomic_DNA.
EMBL; L10328; AAA62073.1; -; Genomic_DNA.
EMBL; U00096; AAC76745.1; -; Genomic_DNA.
EMBL; AP009048; BAE77566.1; -; Genomic_DNA.
PIR; C25977; C25977.
RefSeq; NP_418178.1; NC_000913.3.
RefSeq; WP_000137296.1; NZ_LN832404.1.
ProteinModelPortal; P08722; -.
SMR; P08722; -.
BioGrid; 4262137; 5.
DIP; DIP-9215N; -.
IntAct; P08722; 1.
STRING; 316385.ECDH10B_3909; -.
TCDB; 4.A.1.2.2; the pts glucose-glucoside (glc) family.
PaxDb; P08722; -.
PRIDE; P08722; -.
EnsemblBacteria; AAC76745; AAC76745; b3722.
EnsemblBacteria; BAE77566; BAE77566; BAE77566.
GeneID; 948236; -.
KEGG; ecj:JW3700; -.
KEGG; eco:b3722; -.
PATRIC; fig|1411691.4.peg.2979; -.
EchoBASE; EB0113; -.
EcoGene; EG10115; bglF.
eggNOG; ENOG4105C5Y; Bacteria.
eggNOG; COG1263; LUCA.
eggNOG; COG1264; LUCA.
eggNOG; COG2190; LUCA.
HOGENOM; HOG000102023; -.
InParanoid; P08722; -.
KO; K02755; -.
KO; K02756; -.
KO; K02757; -.
OMA; LWQVCVI; -.
PhylomeDB; P08722; -.
BioCyc; EcoCyc:BGLF-MONOMER; -.
BioCyc; MetaCyc:BGLF-MONOMER; -.
PRO; PR:P08722; -.
Proteomes; UP000000318; Chromosome.
Proteomes; UP000000625; Chromosome.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
GO; GO:0008982; F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity; IEA:InterPro.
GO; GO:0090563; F:protein-phosphocysteine-sugar phosphotransferase activity; IBA:GO_Central.
GO; GO:0034219; P:carbohydrate transmembrane transport; IBA:GO_Central.
GO; GO:0009401; P:phosphoenolpyruvate-dependent sugar phosphotransferase system; IBA:GO_Central.
CDD; cd00212; PTS_IIB_glc; 1.
Gene3D; 2.70.70.10; -; 1.
Gene3D; 3.30.1360.60; -; 1.
InterPro; IPR011055; Dup_hybrid_motif.
InterPro; IPR036878; Glu_permease_IIB.
InterPro; IPR018113; PTrfase_EIIB_Cys.
InterPro; IPR001127; PTS_EIIA_1_perm.
InterPro; IPR003352; PTS_EIIC.
InterPro; IPR013013; PTS_EIIC_1.
InterPro; IPR011297; PTS_IIABC_b_glu.
InterPro; IPR001996; PTS_IIB_1.
InterPro; IPR004719; PTS_maltose/Glc_sub_IIC.
Pfam; PF00358; PTS_EIIA_1; 1.
Pfam; PF00367; PTS_EIIB; 1.
Pfam; PF02378; PTS_EIIC; 1.
SUPFAM; SSF51261; SSF51261; 1.
SUPFAM; SSF55604; SSF55604; 1.
TIGRFAMs; TIGR00826; EIIB_glc; 1.
TIGRFAMs; TIGR00830; PTBA; 1.
TIGRFAMs; TIGR00852; pts-Glc; 1.
TIGRFAMs; TIGR01995; PTS-II-ABC-beta; 1.
PROSITE; PS51093; PTS_EIIA_TYPE_1; 1.
PROSITE; PS00371; PTS_EIIA_TYPE_1_HIS; 1.
PROSITE; PS51098; PTS_EIIB_TYPE_1; 1.
PROSITE; PS01035; PTS_EIIB_TYPE_1_CYS; 1.
PROSITE; PS51103; PTS_EIIC_TYPE_1; 1.
1: Evidence at protein level;
Cell inner membrane; Cell membrane; Complete proteome; Kinase;
Membrane; Phosphotransferase system; Reference proteome;
Sugar transport; Transferase; Transmembrane; Transmembrane helix;
Transport.
CHAIN 1 625 PTS system beta-glucoside-specific EIIBCA
component.
/FTId=PRO_0000186481.
TOPO_DOM 1 99 Periplasmic. {ECO:0000255}.
TRANSMEM 100 120 Helical. {ECO:0000255|PROSITE-
ProRule:PRU00426}.
TOPO_DOM 121 140 Cytoplasmic. {ECO:0000255}.
TRANSMEM 141 161 Helical. {ECO:0000255|PROSITE-
ProRule:PRU00426}.
TOPO_DOM 162 166 Periplasmic. {ECO:0000255}.
TRANSMEM 167 187 Helical. {ECO:0000255|PROSITE-
ProRule:PRU00426}.
TOPO_DOM 188 202 Cytoplasmic. {ECO:0000255}.
TRANSMEM 203 223 Helical. {ECO:0000255|PROSITE-
ProRule:PRU00426}.
TOPO_DOM 224 244 Periplasmic. {ECO:0000255}.
TRANSMEM 245 265 Helical. {ECO:0000255|PROSITE-
ProRule:PRU00426}.
TOPO_DOM 266 284 Cytoplasmic. {ECO:0000255}.
TRANSMEM 285 305 Helical. {ECO:0000255|PROSITE-
ProRule:PRU00426}.
TOPO_DOM 306 324 Periplasmic. {ECO:0000255}.
TRANSMEM 325 345 Helical. {ECO:0000255|PROSITE-
ProRule:PRU00426}.
TOPO_DOM 346 353 Cytoplasmic. {ECO:0000255}.
TRANSMEM 354 374 Helical. {ECO:0000255|PROSITE-
ProRule:PRU00426}.
TOPO_DOM 375 380 Periplasmic. {ECO:0000255}.
TRANSMEM 381 401 Helical. {ECO:0000255|PROSITE-
ProRule:PRU00426}.
TOPO_DOM 402 403 Cytoplasmic. {ECO:0000255}.
TRANSMEM 404 424 Helical. {ECO:0000255|PROSITE-
ProRule:PRU00426}.
TOPO_DOM 425 431 Periplasmic. {ECO:0000255}.
TRANSMEM 432 452 Helical. {ECO:0000255|PROSITE-
ProRule:PRU00426}.
TOPO_DOM 453 625 Cytoplasmic. {ECO:0000255}.
DOMAIN 1 84 PTS EIIB type-1. {ECO:0000255|PROSITE-
ProRule:PRU00421}.
DOMAIN 102 465 PTS EIIC type-1. {ECO:0000255|PROSITE-
ProRule:PRU00426}.
DOMAIN 495 599 PTS EIIA type-1. {ECO:0000255|PROSITE-
ProRule:PRU00416}.
ACT_SITE 24 24 Phosphocysteine intermediate; for EIIB
activity. {ECO:0000255|PROSITE-
ProRule:PRU00421}.
ACT_SITE 547 547 Tele-phosphohistidine intermediate; for
EIIA activity. {ECO:0000255|PROSITE-
ProRule:PRU00416}.
SEQUENCE 625 AA; 66483 MW; 9E12A2207125C4E6 CRC64;
MTELARKIVA GVGGADNIVS LMHCATRLRF KLKDESKAQA EVLKKTPGII MVVESGGQFQ
VVIGNHVADV FLAVNSVAGL DEKAQQAPEN DDKGNLLNRF VYVISGIFTP LIGLMAATGI
LKGMLALALT FQWTTEQSGT YLILFSASDA LFWFFPIILG YTAGKRFGGN PFTAMVIGGA
LVHPLILTAF ENGQKADALG LDFLGIPVTL LNYSSSVIPI IFSAWLCSIL ERRLNAWLPS
AIKNFFTPLL CLMVITPVTF LLVGPLSTWI SELIAAGYLW LYQAVPAFAG AVMGGFWQIF
VMFGLHWGLV PLCINNFTVL GYDTMIPLLM PAIMAQVGAA LGVFLCERDA QKKVVAGSAA
LTSLFGITEP AVYGVNLPRK YPFVIACISG ALGATIIGYA QTKVYSFGLP SIFTFMQTIP
STGIDFTVWA SVIGGVIAIG CAFVGTVMLH FITAKRQPAQ GAPQEKTPEV ITPPEQGGIC
SPMTGEIVPL IHVADTTFAS GLLGKGIAIL PSVGEVRSPV AGRIASLFAT LHAIGIESDD
GVEILIHVGI DTVKLDGKFF SAHVNVGDKV NTGDRLISFD IPAIREAGFD LTTPVLISNS
DDFTDVLPHG TAQISAGEPL LSIIR


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