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Paired box protein Pax-5 (B-cell-specific transcription factor) (BSAP)

 PAX5_MOUSE              Reviewed;         391 AA.
Q02650;
01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
01-JUL-1993, sequence version 1.
22-NOV-2017, entry version 144.
RecName: Full=Paired box protein Pax-5;
AltName: Full=B-cell-specific transcription factor;
Short=BSAP;
Name=Pax5; Synonyms=Pax-5;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
PubMed=1516825; DOI=10.1101/gad.6.9.1589;
Adams B., Doerfler P., Aguzzi A., Kozmik Z., Urbanek P.,
Maurer-Fogy I., Busslinger M.;
"Pax-5 encodes the transcription factor BSAP and is expressed in B
lymphocytes, the developing CNS, and adult testis.";
Genes Dev. 6:1589-1607(1992).
[2]
NUCLEOTIDE SEQUENCE [MRNA] OF 17-136.
PubMed=1685142;
Walther C., Guenet J.-L., Simon D., Deutsch U., Jostes B.,
Goulding M.D., Plachov D., Balling R., Gruss P.;
"Pax: a murine multigene family of paired box-containing genes.";
Genomics 11:424-434(1991).
[3]
INTERACTION WITH DAXX.
PubMed=11799127; DOI=10.1074/jbc.M111763200;
Emelyanov A.V., Kovac C.R., Sepulveda M.A., Birshtein B.K.;
"The interaction of Pax5 (BSAP) with Daxx can result in
transcriptional activation in B cells.";
J. Biol. Chem. 277:11156-11164(2002).
-!- FUNCTION: May play an important role in B-cell differentiation as
well as neural development and spermatogenesis. Involved in the
regulation of the CD19 gene, a B-lymphoid-specific target gene.
-!- SUBUNIT: Interacts with ETS1, altering its DNA-binding properties
(By similarity). Interacts with DAXX and TLE4. Binds DNA as a
monomer. {ECO:0000250, ECO:0000269|PubMed:11799127}.
-!- INTERACTION:
Q9UER7:DAXX (xeno); NbExp=4; IntAct=EBI-296260, EBI-77321;
Q6NZQ4:Paxip1; NbExp=3; IntAct=EBI-296260, EBI-1395317;
-!- SUBCELLULAR LOCATION: Nucleus.
-!- DEVELOPMENTAL STAGE: Expressed at early B-cell differentiation, in
the developing CNS and in adult testis.
-!- PTM: O-glycosylated. {ECO:0000305}.
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EMBL; M97013; AAA37325.1; -; mRNA.
CCDS; CCDS18125.1; -.
PIR; B41061; B41061.
RefSeq; NP_032808.1; NM_008782.2.
UniGene; Mm.439659; -.
ProteinModelPortal; Q02650; -.
SMR; Q02650; -.
BioGrid; 202032; 4.
IntAct; Q02650; 9.
MINT; MINT-246854; -.
STRING; 10090.ENSMUSP00000014174; -.
iPTMnet; Q02650; -.
PhosphoSitePlus; Q02650; -.
MaxQB; Q02650; -.
PaxDb; Q02650; -.
PRIDE; Q02650; -.
Ensembl; ENSMUST00000014174; ENSMUSP00000014174; ENSMUSG00000014030.
GeneID; 18507; -.
KEGG; mmu:18507; -.
UCSC; uc008srx.1; mouse.
CTD; 5079; -.
MGI; MGI:97489; Pax5.
eggNOG; KOG3862; Eukaryota.
eggNOG; ENOG410ZT0S; LUCA.
GeneTree; ENSGT00680000099553; -.
HOGENOM; HOG000230938; -.
HOVERGEN; HBG009115; -.
InParanoid; Q02650; -.
KO; K09383; -.
OMA; YSTYNDS; -.
OrthoDB; EOG091G0S4E; -.
PhylomeDB; Q02650; -.
TreeFam; TF315397; -.
Reactome; R-MMU-8939245; RUNX1 regulates transcription of genes involved in BCR signaling.
PRO; PR:Q02650; -.
Proteomes; UP000000589; Chromosome 4.
Bgee; ENSMUSG00000014030; -.
CleanEx; MM_PAX5; -.
ExpressionAtlas; Q02650; baseline and differential.
Genevisible; Q02650; MM.
GO; GO:0005829; C:cytosol; ISO:MGI.
GO; GO:0001650; C:fibrillar center; ISO:MGI.
GO; GO:0043231; C:intracellular membrane-bounded organelle; ISO:MGI.
GO; GO:0005654; C:nucleoplasm; ISO:MGI.
GO; GO:0005634; C:nucleus; IDA:MGI.
GO; GO:0005667; C:transcription factor complex; TAS:MGI.
GO; GO:0003677; F:DNA binding; IDA:MGI.
GO; GO:0000978; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding; IDA:NTNU_SB.
GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IDA:MGI.
GO; GO:0001077; F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding; IDA:NTNU_SB.
GO; GO:0030534; P:adult behavior; IMP:MGI.
GO; GO:0007568; P:aging; IMP:MGI.
GO; GO:0009887; P:animal organ morphogenesis; TAS:MGI.
GO; GO:0021987; P:cerebral cortex development; IMP:MGI.
GO; GO:0071542; P:dopaminergic neuron differentiation; TAS:ParkinsonsUK-UCL.
GO; GO:0048701; P:embryonic cranial skeleton morphogenesis; IMP:MGI.
GO; GO:0021670; P:lateral ventricle development; IMP:MGI.
GO; GO:0051573; P:negative regulation of histone H3-K9 methylation; IMP:MGI.
GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:MGI.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; TAS:UniProtKB.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:NTNU_SB.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; TAS:UniProtKB.
GO; GO:0006355; P:regulation of transcription, DNA-templated; IDA:MGI.
GO; GO:0035914; P:skeletal muscle cell differentiation; IMP:MGI.
GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
CDD; cd00131; PAX; 1.
Gene3D; 1.10.10.10; -; 2.
InterPro; IPR009057; Homeobox-like_sf.
InterPro; IPR001523; Paired_dom.
InterPro; IPR022130; Pax2_C.
InterPro; IPR036388; WH-like_DNA-bd_sf.
Pfam; PF00292; PAX; 1.
Pfam; PF12403; Pax2_C; 1.
PRINTS; PR00027; PAIREDBOX.
SMART; SM00351; PAX; 1.
SUPFAM; SSF46689; SSF46689; 1.
PROSITE; PS00034; PAIRED_1; 1.
PROSITE; PS51057; PAIRED_2; 1.
1: Evidence at protein level;
Complete proteome; Developmental protein; Differentiation;
Direct protein sequencing; DNA-binding; Glycoprotein; Neurogenesis;
Nucleus; Paired box; Reference proteome; Spermatogenesis;
Transcription; Transcription regulation.
CHAIN 1 391 Paired box protein Pax-5.
/FTId=PRO_0000050184.
DOMAIN 16 142 Paired. {ECO:0000255|PROSITE-
ProRule:PRU00381}.
SEQUENCE 391 AA; 42231 MW; D703E94808DE8EC8 CRC64;
MDLEKNYPTP RTIRTGHGGV NQLGGVFVNG RPLPDVVRQR IVELAHQGVR PCDISRQLRV
SHGCVSKILG RYYETGSIKP GVIGGSKPKV ATPKVVEKIA EYKRQNPTMF AWEIRDRLLA
ERVCDNDTVP SVSSINRIIR TKVQQPPNQP VPASSHSIVS TGSVTQVSSV STDSAGSSYS
ISGILGITSP SADTNKRKRD EGIQESPVPN GHSLPGRDFL RKQMRGDLFT QQQLEVLDRV
FERQHYSDIF TTTEPIKPEQ TTEYSAMASL AGGLDDMKAN LTSPTPADIG SSVPGPQSYP
IVTGRDLAST TLPGYPPHVP PAGQGSYSAP TLTGMVPGSE FSGSPYSHPQ YSSYNDSWRF
PNPGLLGSPY YYSPAARGAA PPAAATAYDR H


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