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Paired box protein Pax-7

 PAX7_MOUSE              Reviewed;         503 AA.
P47239; Q9ES16;
01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
27-SEP-2004, sequence version 2.
22-NOV-2017, entry version 145.
RecName: Full=Paired box protein Pax-7;
Name=Pax7; Synonyms=Pax-7;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=BALB/cJ; TISSUE=Skeletal muscle;
PubMed=11030621; DOI=10.1016/S0092-8674(00)00066-0;
Seale P., Sabourin L.A., Girgis-Gabardo A., Mansouri A., Gruss P.,
Rudnicki M.A.;
"Pax7 is required for the specification of myogenic satellite cells.";
Cell 102:777-786(2000).
[2]
NUCLEOTIDE SEQUENCE [MRNA] OF 36-324, AND DEVELOPMENTAL STAGE.
PubMed=1982921; DOI=10.1016/0925-4773(90)90132-6;
Jostes B., Walther C., Gruss P.;
"The murine paired box gene, Pax7, is expressed specifically during
the development of the nervous and muscular system.";
Mech. Dev. 33:27-37(1990).
[3]
FUNCTION, INTERACTION WITH PAXBP1, REGION, AND SUBCELLULAR LOCATION.
PubMed=22862948; DOI=10.1016/j.stem.2012.05.022;
Diao Y., Guo X., Li Y., Sun K., Lu L., Jiang L., Fu X., Zhu H.,
Sun H., Wang H., Wu Z.;
"Pax3/7BP is a Pax7- and Pax3-binding protein that regulates the
proliferation of muscle precursor cells by an epigenetic mechanism.";
Cell Stem Cell 11:231-241(2012).
-!- FUNCTION: Transcription factor playing a role in myogenesis
through regulation of muscle precursor cells proliferation.
{ECO:0000269|PubMed:22862948}.
-!- SUBUNIT: Can bind to DNA as a heterodimer with PAX3. Interacts
with DAXX (By similarity). Interacts with PAXBP1; the interaction
links PAX7 to a WDR5-containing histone methyltransferase complex
(PubMed:22862948). {ECO:0000250|UniProtKB:P23759,
ECO:0000269|PubMed:22862948}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22862948}.
-!- DEVELOPMENTAL STAGE: Expressed specifically during the development
of the nervous and muscular system. {ECO:0000269|PubMed:1982921}.
-!- SIMILARITY: Belongs to the paired homeobox family. {ECO:0000305}.
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EMBL; AF254422; AAG16663.3; -; mRNA.
EMBL; U20792; AAA64491.1; -; mRNA.
CCDS; CCDS18850.1; -.
PIR; I49265; I49265.
RefSeq; NP_035169.1; NM_011039.2.
UniGene; Mm.218760; -.
ProteinModelPortal; P47239; -.
SMR; P47239; -.
BioGrid; 202034; 1.
CORUM; P47239; -.
STRING; 10090.ENSMUSP00000030508; -.
iPTMnet; P47239; -.
PhosphoSitePlus; P47239; -.
MaxQB; P47239; -.
PaxDb; P47239; -.
PRIDE; P47239; -.
Ensembl; ENSMUST00000030508; ENSMUSP00000030508; ENSMUSG00000028736.
GeneID; 18509; -.
KEGG; mmu:18509; -.
UCSC; uc008vms.1; mouse.
CTD; 5081; -.
MGI; MGI:97491; Pax7.
eggNOG; KOG0849; Eukaryota.
eggNOG; ENOG410XS01; LUCA.
GeneTree; ENSGT00680000099553; -.
HOGENOM; HOG000230939; -.
HOVERGEN; HBG009115; -.
InParanoid; P47239; -.
KO; K09381; -.
PhylomeDB; P47239; -.
TreeFam; TF351610; -.
PRO; PR:P47239; -.
Proteomes; UP000000589; Chromosome 4.
Bgee; ENSMUSG00000028736; -.
CleanEx; MM_PAX7; -.
ExpressionAtlas; P47239; baseline and differential.
Genevisible; P47239; MM.
GO; GO:0005634; C:nucleus; IDA:MGI.
GO; GO:0005667; C:transcription factor complex; TAS:MGI.
GO; GO:0043565; F:sequence-specific DNA binding; IDA:MGI.
GO; GO:0000983; F:transcription factor activity, RNA polymerase II core promoter sequence-specific; IDA:MGI.
GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; TAS:MGI.
GO; GO:0009887; P:animal organ morphogenesis; TAS:MGI.
GO; GO:0051216; P:cartilage development; IMP:MGI.
GO; GO:0006338; P:chromatin remodeling; IMP:MGI.
GO; GO:0021904; P:dorsal/ventral neural tube patterning; IDA:MGI.
GO; GO:0048706; P:embryonic skeletal system development; IMP:MGI.
GO; GO:0060415; P:muscle tissue morphogenesis; IGI:MGI.
GO; GO:0048663; P:neuron fate commitment; IGI:MGI.
GO; GO:0031062; P:positive regulation of histone methylation; IDA:MGI.
GO; GO:2000288; P:positive regulation of myoblast proliferation; IMP:MGI.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:MGI.
GO; GO:0010453; P:regulation of cell fate commitment; IMP:MGI.
GO; GO:0010468; P:regulation of gene expression; IMP:MGI.
GO; GO:0043393; P:regulation of protein binding; IMP:MGI.
GO; GO:0006355; P:regulation of transcription, DNA-templated; TAS:MGI.
GO; GO:0014813; P:skeletal muscle satellite cell commitment; IMP:MGI.
GO; GO:0007519; P:skeletal muscle tissue development; IMP:MGI.
GO; GO:0043403; P:skeletal muscle tissue regeneration; IMP:MGI.
GO; GO:0021527; P:spinal cord association neuron differentiation; IGI:MGI.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
CDD; cd00086; homeodomain; 1.
CDD; cd00131; PAX; 1.
Gene3D; 1.10.10.10; -; 2.
InterPro; IPR009057; Homeobox-like_sf.
InterPro; IPR017970; Homeobox_CS.
InterPro; IPR001356; Homeobox_dom.
InterPro; IPR003654; OAR_dom.
InterPro; IPR001523; Paired_dom.
InterPro; IPR022106; Pax7_C.
InterPro; IPR036388; WH-like_DNA-bd_sf.
Pfam; PF00046; Homeobox; 1.
Pfam; PF00292; PAX; 1.
Pfam; PF12360; Pax7; 1.
PRINTS; PR00027; PAIREDBOX.
SMART; SM00389; HOX; 1.
SMART; SM00351; PAX; 1.
SUPFAM; SSF46689; SSF46689; 2.
PROSITE; PS00027; HOMEOBOX_1; 1.
PROSITE; PS50071; HOMEOBOX_2; 1.
PROSITE; PS50803; OAR; 1.
PROSITE; PS00034; PAIRED_1; 1.
PROSITE; PS51057; PAIRED_2; 1.
1: Evidence at protein level;
Complete proteome; Developmental protein; DNA-binding; Homeobox;
Myogenesis; Nucleus; Paired box; Reference proteome; Transcription;
Transcription regulation.
CHAIN 1 503 Paired box protein Pax-7.
/FTId=PRO_0000050195.
DOMAIN 34 161 Paired. {ECO:0000255|PROSITE-
ProRule:PRU00381}.
DNA_BIND 215 274 Homeobox. {ECO:0000255|PROSITE-
ProRule:PRU00108}.
REGION 27 208 Sufficient to mediate interaction with
PAXBP1. {ECO:0000269|PubMed:22862948}.
MOTIF 477 489 OAR. {ECO:0000255|PROSITE-
ProRule:PRU00138}.
CONFLICT 60 60 V -> VV (in Ref. 2; AAA64491).
{ECO:0000305}.
CONFLICT 137 137 L -> W (in Ref. 2; AAA64491).
{ECO:0000305}.
CONFLICT 202 202 D -> G (in Ref. 2; AAA64491).
{ECO:0000305}.
CONFLICT 259 259 V -> F (in Ref. 2; AAA64491).
{ECO:0000305}.
SEQUENCE 503 AA; 54939 MW; 8ECC952C5C2FCA27 CRC64;
MAALPGAVPR MMRPGPGQNY PRTGFPLEVS TPLGQGRVNQ LGGVFINGRP LPNHIRHKIV
EMAHHGIRPC VISRQLRVSH GCVSKILCRY QETGSIRPGA IGGSKPRQVA TPDVEKKIEE
YKRENPGMFS WEIRDRLLKD GHCDRSTVPS VSSISRVLRI KFGKKEDDEE GDKKEEDGEK
KAKHSIDGIL GDKGNRLDEG SDVESEPDLP LKRKQRRSRT TFTAEQLEEL EKAFERTHYP
DIYTREELAQ RTKLTEARVQ VWFSNRRARW RKQAGANQLA AFNHLLPGGF PPTGMPTLPP
YQLPDSTYPT TTISQDGGST VHRPQPLPPS TMHQGGLAAA AAAADTSSAY GARHSFSSYS
DSFMNPGAPS NHMNPVSNGL SPQVMSILSN PSAVPPQPQA DFSISPLHGG LDSASSISAS
CSQRADSIKP GDSLPTSQSY CPPTYSTTGY SVDPVAGYQY SQYGQTAVDY LAKNVSLSTQ
RRMKLGEHSA VLGLLPVETG QAY


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