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Paired box protein Pax-8

 PAX8_MOUSE              Reviewed;         457 AA.
Q00288; P97342; Q6GU20;
01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
27-JUL-2011, sequence version 3.
22-NOV-2017, entry version 138.
RecName: Full=Paired box protein Pax-8;
Name=Pax8; Synonyms=Pax-8;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=1723950;
Plachov D., Chowdhury K., Walther C., Simon D., Guenet J.-L.,
Gruss P.;
"Pax8, a murine paired box gene expressed in the developing excretory
system and thyroid gland.";
Development 110:643-651(1990).
[2]
SEQUENCE REVISION TO 158; 263 AND 340.
PubMed=1516825; DOI=10.1101/gad.6.9.1589;
Adams B., Doerfler P., Aguzzi A., Kozmik Z., Urbanek P.,
Maurer-Fogy I., Busslinger M.;
"Pax-5 encodes the transcription factor BSAP and is expressed in B
lymphocytes, the developing CNS, and adult testis.";
Genes Dev. 6:1589-1607(1992).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=C57BL/6J; TISSUE=Kidney;
PubMed=9205117; DOI=10.1006/geno.1997.4735;
Okladnova O., Poleev A., Fantes J., Lee M., Plachov D., Horst J.;
"The genomic organization of the murine Pax 8 gene and
characterization of its basal promoter.";
Genomics 42:452-461(1997).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=C57BL/6J;
PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
Lindblad-Toh K., Eichler E.E., Ponting C.P.;
"Lineage-specific biology revealed by a finished genome assembly of
the mouse.";
PLoS Biol. 7:E1000112-E1000112(2009).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=FVB/N; TISSUE=Kidney;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[7]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-304, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Kidney;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
-!- FUNCTION: Thought to encode a transcription factor. It may have a
role in kidney cell differentiation. May play a regulatory role in
mammalian development.
-!- SUBUNIT: Interacts with WWTR1. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Nucleus.
-!- TISSUE SPECIFICITY: Expressed in the developing excretory system
and the thyroid gland.
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EMBL; X57487; CAA40725.1; -; mRNA.
EMBL; X99592; CAA67904.1; -; Genomic_DNA.
EMBL; X99593; CAA67904.1; JOINED; Genomic_DNA.
EMBL; X99594; CAA67904.1; JOINED; Genomic_DNA.
EMBL; X99595; CAA67904.1; JOINED; Genomic_DNA.
EMBL; X99596; CAA67904.1; JOINED; Genomic_DNA.
EMBL; X99597; CAA67904.1; JOINED; Genomic_DNA.
EMBL; X99598; CAA67904.1; JOINED; Genomic_DNA.
EMBL; AL732528; CAM17808.1; -; Genomic_DNA.
EMBL; CH466542; EDL08172.1; -; Genomic_DNA.
EMBL; BC020526; AAH20526.1; -; mRNA.
CCDS; CCDS15738.1; -.
PIR; A56925; A56925.
RefSeq; NP_035170.1; NM_011040.4.
UniGene; Mm.2533; -.
ProteinModelPortal; Q00288; -.
SMR; Q00288; -.
BioGrid; 202035; 2.
IntAct; Q00288; 1.
STRING; 10090.ENSMUSP00000028355; -.
iPTMnet; Q00288; -.
PhosphoSitePlus; Q00288; -.
MaxQB; Q00288; -.
PaxDb; Q00288; -.
PRIDE; Q00288; -.
Ensembl; ENSMUST00000028355; ENSMUSP00000028355; ENSMUSG00000026976.
GeneID; 18510; -.
KEGG; mmu:18510; -.
UCSC; uc008ipb.2; mouse.
CTD; 7849; -.
MGI; MGI:97492; Pax8.
eggNOG; KOG3862; Eukaryota.
eggNOG; ENOG410ZT0S; LUCA.
GeneTree; ENSGT00680000099553; -.
HOGENOM; HOG000230938; -.
HOVERGEN; HBG009115; -.
InParanoid; Q00288; -.
KO; K09293; -.
OMA; DTFSQHH; -.
OrthoDB; EOG091G0S4E; -.
TreeFam; TF315397; -.
PRO; PR:Q00288; -.
Proteomes; UP000000589; Chromosome 2.
Bgee; ENSMUSG00000026976; -.
CleanEx; MM_PAX8; -.
ExpressionAtlas; Q00288; baseline and differential.
Genevisible; Q00288; MM.
GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
GO; GO:0005634; C:nucleus; IDA:MGI.
GO; GO:0005667; C:transcription factor complex; TAS:MGI.
GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
GO; GO:0000978; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0000979; F:RNA polymerase II core promoter sequence-specific DNA binding; ISS:UniProtKB.
GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; ISS:UniProtKB.
GO; GO:0044212; F:transcription regulatory region DNA binding; IDA:UniProtKB.
GO; GO:0001077; F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding; IEA:Ensembl.
GO; GO:0009887; P:animal organ morphogenesis; TAS:MGI.
GO; GO:0001658; P:branching involved in ureteric bud morphogenesis; IEA:Ensembl.
GO; GO:0030154; P:cell differentiation; IMP:MGI.
GO; GO:0071371; P:cellular response to gonadotropin stimulus; ISO:MGI.
GO; GO:0007417; P:central nervous system development; IEP:UniProtKB.
GO; GO:0042472; P:inner ear morphogenesis; IGI:UniProtKB.
GO; GO:0072073; P:kidney epithelium development; IEP:UniProtKB.
GO; GO:0003337; P:mesenchymal to epithelial transition involved in metanephros morphogenesis; IEA:Ensembl.
GO; GO:0072164; P:mesonephric tubule development; IEP:UniProtKB.
GO; GO:0001823; P:mesonephros development; IMP:UniProtKB.
GO; GO:0072278; P:metanephric comma-shaped body morphogenesis; IEA:Ensembl.
GO; GO:0072221; P:metanephric distal convoluted tubule development; IMP:UniProtKB.
GO; GO:0072289; P:metanephric nephron tubule formation; IMP:UniProtKB.
GO; GO:0072284; P:metanephric S-shaped body morphogenesis; IEA:Ensembl.
GO; GO:0001656; P:metanephros development; IGI:MGI.
GO; GO:1900215; P:negative regulation of apoptotic process involved in metanephric collecting duct development; IMP:UniProtKB.
GO; GO:1900218; P:negative regulation of apoptotic process involved in metanephric nephron tubule development; IMP:UniProtKB.
GO; GO:0010667; P:negative regulation of cardiac muscle cell apoptotic process; IMP:BHF-UCL.
GO; GO:0072305; P:negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis; IMP:UniProtKB.
GO; GO:1900212; P:negative regulation of mesenchymal cell apoptotic process involved in metanephros development; IMP:UniProtKB.
GO; GO:0071599; P:otic vesicle development; IEA:Ensembl.
GO; GO:0090190; P:positive regulation of branching involved in ureteric bud morphogenesis; IMP:UniProtKB.
GO; GO:0072108; P:positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis; IMP:UniProtKB.
GO; GO:2000594; P:positive regulation of metanephric DCT cell differentiation; IMP:UniProtKB.
GO; GO:2000611; P:positive regulation of thyroid hormone generation; IMP:UniProtKB.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISO:MGI.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:UniProtKB.
GO; GO:0039003; P:pronephric field specification; IEP:UniProtKB.
GO; GO:0048793; P:pronephros development; IMP:UniProtKB.
GO; GO:0042981; P:regulation of apoptotic process; IMP:UniProtKB.
GO; GO:0072307; P:regulation of metanephric nephron tubule epithelial cell differentiation; IMP:UniProtKB.
GO; GO:2000612; P:regulation of thyroid-stimulating hormone secretion; ISS:UniProtKB.
GO; GO:0006355; P:regulation of transcription, DNA-templated; TAS:MGI.
GO; GO:0072050; P:S-shaped body morphogenesis; IEP:UniProtKB.
GO; GO:0006790; P:sulfur compound metabolic process; IEA:Ensembl.
GO; GO:0030878; P:thyroid gland development; IMP:MGI.
GO; GO:0006351; P:transcription, DNA-templated; IDA:UniProtKB.
GO; GO:0001655; P:urogenital system development; IGI:UniProtKB.
GO; GO:0003281; P:ventricular septum development; IMP:BHF-UCL.
CDD; cd00131; PAX; 1.
Gene3D; 1.10.10.10; -; 2.
InterPro; IPR009057; Homeobox-like_sf.
InterPro; IPR001523; Paired_dom.
InterPro; IPR022130; Pax2_C.
InterPro; IPR036388; WH-like_DNA-bd_sf.
Pfam; PF00292; PAX; 1.
Pfam; PF12403; Pax2_C; 1.
PRINTS; PR00027; PAIREDBOX.
SMART; SM00351; PAX; 1.
SUPFAM; SSF46689; SSF46689; 1.
PROSITE; PS00034; PAIRED_1; 1.
PROSITE; PS51057; PAIRED_2; 1.
1: Evidence at protein level;
Complete proteome; Developmental protein; Differentiation;
DNA-binding; Nucleus; Paired box; Phosphoprotein; Reference proteome;
Transcription; Transcription regulation.
CHAIN 1 457 Paired box protein Pax-8.
/FTId=PRO_0000050198.
DOMAIN 9 135 Paired. {ECO:0000255|PROSITE-
ProRule:PRU00381}.
COMPBIAS 316 328 Ser-rich.
MOD_RES 304 304 Phosphoserine.
{ECO:0000244|PubMed:21183079}.
CONFLICT 340 340 G -> D (in Ref. 2; no nucleotide entry).
{ECO:0000305}.
SEQUENCE 457 AA; 48793 MW; AAACD3EE54AA4488 CRC64;
MPHNSIRSGH GGLNQLGGAF VNGRPLPEVV RQRIVDLAHQ GVRPCDISRQ LRVSHGCVSK
ILGRYYETGS IRPGVIGGSK PKVATPKVVE KIGDYKRQNP TMFAWEIRDR LLAEGVCDND
TVPSVSSINR IIRTKVQQPF NLPMDSCVAT KSLSPGHTLI PSSAVTPPES PQSDSLGSTY
SINGLLGIAQ PGNDNKRKMD DSDQDSCRLS IDSQSSSSGP RKHLRTDTFS QHHLEALECP
FERQHYPEAY ASPSHTKGEQ GLYPLPLLNS ALDDGKATLT SSNTPLGRNL STHQTYPVVA
DPHSPFAIKQ ETPELSSSSS TPSSLSSSAF LDLQQVGSGG PAGASVPPFN AFPHAASVYG
QFTGQALLSG REMVGPTLPG YPPHIPTSGQ GSYASSAIAG MVAGSEYSGN AYSHTPYSSY
SEAWRFPNSS LLSSPYYYSS TSRPSAPPTS ATAFDHL


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