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Paired mesoderm homeobox protein 2B (Neuroblastoma Phox) (NBPhox) (PHOX2B homeodomain protein) (Paired-like homeobox 2B)

 PHX2B_MOUSE             Reviewed;         314 AA.
O35690;
15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
01-JAN-1998, sequence version 1.
22-NOV-2017, entry version 132.
RecName: Full=Paired mesoderm homeobox protein 2B;
AltName: Full=Neuroblastoma Phox;
Short=NBPhox;
AltName: Full=PHOX2B homeodomain protein;
AltName: Full=Paired-like homeobox 2B;
Name=Phox2b; Synonyms=Pmx2b;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=9374403;
Pattyn A., Morin X., Cremer H., Goridis C., Brunet J.-F.;
"Expression and interactions of the two closely related homeobox genes
Phox2a and Phox2b during neurogenesis.";
Development 124:4065-4075(1997).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=10395798; DOI=10.1006/geno.1999.5845;
Yokoyama M., Watanabe H., Nakamura M.;
"Genomic structure and functional characterization of NBPhox (PMX2B),
a homeodomain protein specific to catecholaminergic cells that is
involved in second messenger-mediated transcriptional activation.";
Genomics 59:40-50(1999).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J; TISSUE=Brain;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
INTERACTION WITH TRIM11.
PubMed=18275850; DOI=10.1016/j.bbrc.2008.01.165;
Hong S.J., Chae H., Lardaro T., Hong S., Kim K.S.;
"Trim11 increases expression of dopamine beta-hydroxylase gene by
interacting with Phox2b.";
Biochem. Biophys. Res. Commun. 368:650-655(2008).
-!- SUBUNIT: Interacts with TRIM11. {ECO:0000269|PubMed:18275850}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-
ProRule:PRU00108}.
-!- SIMILARITY: Belongs to the paired homeobox family. {ECO:0000305}.
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EMBL; Y14493; CAA74833.1; -; mRNA.
EMBL; AB015672; BAA82671.1; -; Genomic_DNA.
EMBL; BC079610; AAH79610.1; -; mRNA.
CCDS; CCDS19316.1; -.
RefSeq; NP_032914.1; NM_008888.3.
UniGene; Mm.62505; -.
ProteinModelPortal; O35690; -.
SMR; O35690; -.
BioGrid; 202270; 1.
STRING; 10090.ENSMUSP00000012664; -.
PhosphoSitePlus; O35690; -.
MaxQB; O35690; -.
PaxDb; O35690; -.
PeptideAtlas; O35690; -.
PRIDE; O35690; -.
Ensembl; ENSMUST00000012664; ENSMUSP00000012664; ENSMUSG00000012520.
GeneID; 18935; -.
KEGG; mmu:18935; -.
UCSC; uc008xpm.1; mouse.
CTD; 8929; -.
MGI; MGI:1100882; Phox2b.
eggNOG; KOG0484; Eukaryota.
eggNOG; ENOG4111YNP; LUCA.
GeneTree; ENSGT00900000140809; -.
HOGENOM; HOG000013060; -.
HOVERGEN; HBG094678; -.
InParanoid; O35690; -.
KO; K09330; -.
OMA; QGWASAP; -.
OrthoDB; EOG091G0YX9; -.
PhylomeDB; O35690; -.
TreeFam; TF351612; -.
PRO; PR:O35690; -.
Proteomes; UP000000589; Chromosome 5.
Bgee; ENSMUSG00000012520; -.
CleanEx; MM_PHOX2B; -.
ExpressionAtlas; O35690; baseline and differential.
Genevisible; O35690; MM.
GO; GO:0000790; C:nuclear chromatin; ISO:MGI.
GO; GO:0005634; C:nucleus; IDA:MGI.
GO; GO:0000978; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding; ISO:MGI.
GO; GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; ISO:MGI.
GO; GO:0001077; F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding; ISO:MGI.
GO; GO:0048483; P:autonomic nervous system development; ISO:MGI.
GO; GO:0003360; P:brainstem development; IEA:Ensembl.
GO; GO:0048468; P:cell development; IMP:MGI.
GO; GO:0021533; P:cell differentiation in hindbrain; IMP:MGI.
GO; GO:0071773; P:cellular response to BMP stimulus; IDA:MGI.
GO; GO:0071542; P:dopaminergic neuron differentiation; IMP:BHF-UCL.
GO; GO:0048894; P:efferent axon development in a lateral line nerve; IMP:MGI.
GO; GO:0048484; P:enteric nervous system development; IMP:BHF-UCL.
GO; GO:0010001; P:glial cell differentiation; IMP:MGI.
GO; GO:0021934; P:hindbrain tangential cell migration; IMP:MGI.
GO; GO:0048839; P:inner ear development; IMP:MGI.
GO; GO:0021723; P:medullary reticular formation development; IEP:BHF-UCL.
GO; GO:0008285; P:negative regulation of cell proliferation; IMP:MGI.
GO; GO:0045665; P:negative regulation of neuron differentiation; IGI:MGI.
GO; GO:1901166; P:neural crest cell migration involved in autonomic nervous system development; IMP:BHF-UCL.
GO; GO:0030182; P:neuron differentiation; IMP:MGI.
GO; GO:0001764; P:neuron migration; IMP:MGI.
GO; GO:0003358; P:noradrenergic neuron development; IMP:UniProtKB.
GO; GO:0003357; P:noradrenergic neuron differentiation; IMP:BHF-UCL.
GO; GO:0048486; P:parasympathetic nervous system development; IMP:BHF-UCL.
GO; GO:0045666; P:positive regulation of neuron differentiation; IGI:MGI.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.
GO; GO:0010468; P:regulation of gene expression; IMP:UniProtKB.
GO; GO:0002087; P:regulation of respiratory gaseous exchange by neurological system process; IMP:BHF-UCL.
GO; GO:0060541; P:respiratory system development; IMP:BHF-UCL.
GO; GO:0061452; P:retrotrapezoid nucleus neuron differentiation; IMP:BHF-UCL.
GO; GO:0035914; P:skeletal muscle cell differentiation; IMP:MGI.
GO; GO:0061549; P:sympathetic ganglion development; IMP:UniProtKB.
GO; GO:0048485; P:sympathetic nervous system development; IMP:BHF-UCL.
CDD; cd00086; homeodomain; 1.
InterPro; IPR009057; Homeobox-like_sf.
InterPro; IPR017970; Homeobox_CS.
InterPro; IPR001356; Homeobox_dom.
Pfam; PF00046; Homeobox; 1.
SMART; SM00389; HOX; 1.
SUPFAM; SSF46689; SSF46689; 1.
PROSITE; PS00027; HOMEOBOX_1; 1.
PROSITE; PS50071; HOMEOBOX_2; 1.
1: Evidence at protein level;
Complete proteome; Developmental protein; DNA-binding; Homeobox;
Nucleus; Reference proteome.
CHAIN 1 314 Paired mesoderm homeobox protein 2B.
/FTId=PRO_0000049263.
DNA_BIND 98 157 Homeobox. {ECO:0000255|PROSITE-
ProRule:PRU00108}.
COMPBIAS 159 167 Poly-Ala.
COMPBIAS 212 217 Poly-Gly.
COMPBIAS 241 260 Poly-Ala.
SEQUENCE 314 AA; 31621 MW; 40737F71948B595A CRC64;
MYKMEYSYLN SSAYESCMAG MDTSSLASAY ADFSSCSQAS GFQYNPIRTT FGATSGCPSL
TPGSCSLGTL RDHQSSPYAA VPYKLFTDHG GLNEKRKQRR IRTTFTSAQL KELERVFAET
HYPDIYTREE LALKIDLTEA RVQVWFQNRR AKFRKQERAA AAAAAAAKNG SSGKKSDSSR
DDESKEAKST DPDSTGGPGP NPNPTPSCGA NGGGGGGPSP AGAPGAAGPG GPGGEPGKGG
AAAAAAAAAA AAAAAAAAAA GGLAAAGGPG QGWAPGPGPI TSIPDSLGGP FASVLSSLQR
PNGAKAALVK SSMF


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