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Pancreas/duodenum homeobox protein 1 (Insulin promoter factor 1) (IPF-1) (Islet/duodenum homeobox 1) (IDX-1) (Somatostatin-transactivating factor 1) (STF-1)

 PDX1_RAT                Reviewed;         283 AA.
P52947;
01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
01-OCT-1996, sequence version 1.
12-SEP-2018, entry version 133.
RecName: Full=Pancreas/duodenum homeobox protein 1;
AltName: Full=Insulin promoter factor 1;
Short=IPF-1;
AltName: Full=Islet/duodenum homeobox 1;
Short=IDX-1;
AltName: Full=Somatostatin-transactivating factor 1;
Short=STF-1;
Name=Pdx1; Synonyms=Ipf1;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=7907546;
Miller C.P., McGehee R.E. Jr., Habener J.F.;
"IDX-1: a new homeodomain transcription factor expressed in rat
pancreatic islets and duodenum that transactivates the somatostatin
gene.";
EMBO J. 13:1145-1156(1994).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=7505393; DOI=10.1210/mend.7.10.7505393;
Leonard J., Peers B., Johnson T., Ferreri K., Lee S., Montminy M.R.;
"Characterization of somatostatin transactivating factor-1, a novel
homeobox factor that stimulates somatostatin expression in pancreatic
islet cells.";
Mol. Endocrinol. 7:1275-1283(1993).
[3]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-268, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=22673903; DOI=10.1038/ncomms1871;
Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A.,
Lundby C., Olsen J.V.;
"Quantitative maps of protein phosphorylation sites across 14
different rat organs and tissues.";
Nat. Commun. 3:876-876(2012).
-!- FUNCTION: Activates insulin and somatostatin gene transcription.
Key regulator of islet peptide hormone expression but also
responsible for the development of the pancreas, most probably by
determining maturation and differentiation of common pancreatic
precursor cells in the developing gut. As part of a
PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved
in the transcriptional activation of the ELA1 enhancer; the
complex binds to the enhancer B element and cooperates with the
transcription factor 1 complex (PTF1) bound to the enhancer A
element. Binds the DNA sequence 5'-CC[CT]TAATGGG-3'.
-!- SUBUNIT: Interacts with the basic helix-loop-helix domains of
TCF3(E47) and NEUROD1 and with HMG-I(Y). Interacts with SPOP and
the methyltransferase SETD7. Part of a PDX1:PBX1b:MEIS2b complex
(By similarity). {ECO:0000250}.
-!- INTERACTION:
Q9WTV5:Psmd9; NbExp=3; IntAct=EBI-7626093, EBI-7626072;
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-
ProRule:PRU00108}. Cytoplasm, cytosol {ECO:0000250}.
-!- TISSUE SPECIFICITY: Duodenum and pancreas (Langerhans islet beta
cells and small subsets of endocrine non-beta-cells, at low levels
in acinar cells).
-!- DOMAIN: The Antp-type hexapeptide mediates heterodimerization with
PBX on a regulatory element of the somatostatin promoter.
-!- DOMAIN: The homeodomain, which contains the nuclear localization
signal, not only mediates DNA-binding, but also acts as a protein-
protein interaction domain for TCF3(E47), NEUROD1 and HMG-I(Y).
{ECO:0000250}.
-!- PTM: Phosphorylated by the SAPK2 pathway at high intracellular
glucose concentration. Phosphorylated by HIPK2 on Ser-268 upon
glucose accumulation. This phosphorylation mediates subnuclear
localization shifting. Phosphorylation by PASK may lead to
translocation into the cytosol (By similarity). {ECO:0000250}.
-!- SIMILARITY: Belongs to the Antp homeobox family. IPF1/XlHbox-8
subfamily. {ECO:0000305}.
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EMBL; U04833; AAA18355.1; -; mRNA.
EMBL; S67435; AAB29317.1; -; mRNA.
PIR; S42634; S42634.
RefSeq; NP_074043.3; NM_022852.3.
UniGene; Rn.54603; -.
ProteinModelPortal; P52947; -.
SMR; P52947; -.
IntAct; P52947; 1.
MINT; P52947; -.
STRING; 10116.ENSRNOP00000066935; -.
iPTMnet; P52947; -.
PhosphoSitePlus; P52947; -.
PaxDb; P52947; -.
PRIDE; P52947; -.
Ensembl; ENSRNOT00000071942; ENSRNOP00000066935; ENSRNOG00000046458.
GeneID; 29535; -.
KEGG; rno:29535; -.
CTD; 3651; -.
RGD; 62387; Pdx1.
eggNOG; KOG0489; Eukaryota.
eggNOG; ENOG410ZTBY; LUCA.
GeneTree; ENSGT00910000144005; -.
HOVERGEN; HBG004525; -.
InParanoid; P52947; -.
KO; K07594; -.
OMA; PPPCLYM; -.
OrthoDB; EOG091G0GVH; -.
PhylomeDB; P52947; -.
PRO; PR:P52947; -.
Proteomes; UP000002494; Chromosome 12.
Genevisible; P52947; RN.
GO; GO:0005737; C:cytoplasm; IDA:RGD.
GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
GO; GO:0005634; C:nucleus; IDA:RGD.
GO; GO:0003700; F:DNA-binding transcription factor activity; IMP:RGD.
GO; GO:1990841; F:promoter-specific chromatin binding; IDA:RGD.
GO; GO:0046982; F:protein heterodimerization activity; IDA:RGD.
GO; GO:0044877; F:protein-containing complex binding; IDA:RGD.
GO; GO:0000978; F:RNA polymerase II proximal promoter sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0043565; F:sequence-specific DNA binding; IDA:RGD.
GO; GO:0008134; F:transcription factor binding; IPI:RGD.
GO; GO:0031100; P:animal organ regeneration; IEP:RGD.
GO; GO:0010260; P:animal organ senescence; IEP:RGD.
GO; GO:0030154; P:cell differentiation; IMP:RGD.
GO; GO:0007417; P:central nervous system development; IEP:RGD.
GO; GO:0051594; P:detection of glucose; IDA:BHF-UCL.
GO; GO:0048565; P:digestive tract development; IEA:Ensembl.
GO; GO:0031017; P:exocrine pancreas development; IEA:Ensembl.
GO; GO:0042593; P:glucose homeostasis; IMP:RGD.
GO; GO:0006006; P:glucose metabolic process; IEA:Ensembl.
GO; GO:0001889; P:liver development; IEA:Ensembl.
GO; GO:0016331; P:morphogenesis of embryonic epithelium; IEA:Ensembl.
GO; GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl.
GO; GO:1902236; P:negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; IEA:Ensembl.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IMP:RGD.
GO; GO:2000675; P:negative regulation of type B pancreatic cell apoptotic process; IEA:Ensembl.
GO; GO:0031016; P:pancreas development; IEP:RGD.
GO; GO:0010942; P:positive regulation of cell death; IMP:RGD.
GO; GO:0008284; P:positive regulation of cell proliferation; IMP:RGD.
GO; GO:0043388; P:positive regulation of DNA binding; IMP:RGD.
GO; GO:0032024; P:positive regulation of insulin secretion; IMP:RGD.
GO; GO:0035774; P:positive regulation of insulin secretion involved in cellular response to glucose stimulus; IEA:Ensembl.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:RGD.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IMP:RGD.
GO; GO:0010468; P:regulation of gene expression; IMP:CACAO.
GO; GO:0006355; P:regulation of transcription, DNA-templated; TAS:RGD.
GO; GO:0043279; P:response to alkaloid; IEP:RGD.
GO; GO:0010157; P:response to chlorate; IEP:RGD.
GO; GO:0034097; P:response to cytokine; IEP:RGD.
GO; GO:0042493; P:response to drug; IEP:RGD.
GO; GO:0070542; P:response to fatty acid; IEP:RGD.
GO; GO:0051384; P:response to glucocorticoid; IEP:RGD.
GO; GO:0009749; P:response to glucose; IMP:RGD.
GO; GO:0010040; P:response to iron(II) ion; IEP:RGD.
GO; GO:0043201; P:response to leucine; IEP:RGD.
GO; GO:0033993; P:response to lipid; IEP:RGD.
GO; GO:0035094; P:response to nicotine; IEP:RGD.
GO; GO:0031667; P:response to nutrient levels; IEP:RGD.
GO; GO:0014070; P:response to organic cyclic compound; IEP:RGD.
GO; GO:0033273; P:response to vitamin; IEP:RGD.
GO; GO:0009611; P:response to wounding; IEP:RGD.
GO; GO:0007224; P:smoothened signaling pathway; IMP:RGD.
GO; GO:0048863; P:stem cell differentiation; IMP:RGD.
GO; GO:0006366; P:transcription by RNA polymerase II; IMP:RGD.
GO; GO:0006351; P:transcription, DNA-templated; IMP:RGD.
GO; GO:0060290; P:transdifferentiation; IEP:RGD.
GO; GO:0003309; P:type B pancreatic cell differentiation; IMP:BHF-UCL.
CDD; cd00086; homeodomain; 1.
InterPro; IPR009057; Homeobox-like_sf.
InterPro; IPR017995; Homeobox_antennapedia.
InterPro; IPR017970; Homeobox_CS.
InterPro; IPR001356; Homeobox_dom.
InterPro; IPR020479; Homeobox_metazoa.
Pfam; PF00046; Homeobox; 1.
PRINTS; PR00025; ANTENNAPEDIA.
PRINTS; PR00024; HOMEOBOX.
SMART; SM00389; HOX; 1.
SUPFAM; SSF46689; SSF46689; 1.
PROSITE; PS00027; HOMEOBOX_1; 1.
PROSITE; PS50071; HOMEOBOX_2; 1.
1: Evidence at protein level;
Activator; Complete proteome; Cytoplasm; DNA-binding; Homeobox;
Nucleus; Phosphoprotein; Reference proteome; Transcription;
Transcription regulation.
CHAIN 1 283 Pancreas/duodenum homeobox protein 1.
/FTId=PRO_0000049150.
DNA_BIND 146 205 Homeobox. {ECO:0000255|PROSITE-
ProRule:PRU00108}.
REGION 13 73 Transactivation domain.
MOTIF 118 123 Antp-type hexapeptide.
MOTIF 197 203 Nuclear localization signal.
{ECO:0000250}.
COMPBIAS 42 48 Poly-Pro.
COMPBIAS 216 220 Poly-Gly.
COMPBIAS 239 244 Poly-Pro.
MOD_RES 151 151 Phosphothreonine; by PASK.
{ECO:0000250|UniProtKB:P52946}.
MOD_RES 268 268 Phosphoserine.
{ECO:0000244|PubMed:22673903}.
CONFLICT 47 47 P -> T (in Ref. 1; AAA18355).
{ECO:0000305}.
CONFLICT 240 240 P -> K (in Ref. 1; AAA18355).
{ECO:0000305}.
CONFLICT 247 247 A -> V (in Ref. 1; AAA18355).
{ECO:0000305}.
SEQUENCE 283 AA; 30831 MW; C8C25FF2C75ED4E6 CRC64;
MNSEEQYYAA TQLYKDPCAF QRGPVPEFSA NPPACLYMGR QPPPPPPPQF AGSLGTLEQG
SPPDISPYEV PPLADDPAGA HLHHHLPAQL GLAHPPPGPF PNGTETGGLE EPSRVHLPFP
WMKSTKAHAW KSQWAGGAYA AEPEENKRTR TAYTRAQLLE LEKEFLFNKY ISRPRRVELA
VMLNLTERHI KIWFQNRRMK WKKEEDKKRS SGTTSGGGGG EEPEQDCAVT SGEELLALPP
PPPPGGAVPS GVPAAAREGR LPSGLSASPQ PSSIAPLRPQ EPR


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