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Pancreas transcription factor 1 subunit alpha (Pancreas-specific transcription factor 1a) (bHLH transcription factor p48)

 PTF1A_DANRE             Reviewed;         265 AA.
Q7ZSX3;
02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
01-JUN-2003, sequence version 1.
25-OCT-2017, entry version 98.
RecName: Full=Pancreas transcription factor 1 subunit alpha;
AltName: Full=Pancreas-specific transcription factor 1a;
AltName: Full=bHLH transcription factor p48;
Name=ptf1a; ORFNames=si:zc142h2.2, zgc:112216;
Danio rerio (Zebrafish) (Brachydanio rerio).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
Cyprinidae; Danio.
NCBI_TaxID=7955;
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND DEVELOPMENTAL STAGE.
PubMed=15183727; DOI=10.1016/j.ydbio.2004.02.023;
Lin J.W., Biankin A.V., Horb M.E., Ghosh B., Prasad N.B., Yee N.S.,
Pack M.A., Leach S.D.;
"Differential requirement for ptf1a in endocrine and exocrine lineages
of developing zebrafish pancreas.";
Dev. Biol. 270:474-486(2004).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Tuebingen;
PubMed=23594743; DOI=10.1038/nature12111;
Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G.,
Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B.,
Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S.,
Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C.,
Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H.,
Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C.,
Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
Humphries M., Sycamore N., Barker D., Saunders D., Wallis J.,
Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S.,
Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R.,
Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R.,
Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R.,
Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A.,
Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S.,
Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J.,
Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
Stemple D.L.;
"The zebrafish reference genome sequence and its relationship to the
human genome.";
Nature 496:498-503(2013).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Larva;
NIH - Zebrafish Gene Collection (ZGC) project;
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Transcription factor implicated in the cell fate
determination in various organs. Binds to the E-box consensus
sequence 5'-CANNTG-3'. Required for exocrine pancreatic
development. Plays a central role in directing the differentiation
of retinal progenitors towards horizontal and amacrine fates.
{ECO:0000269|PubMed:15183727}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-
ProRule:PRU00981}.
-!- DEVELOPMENTAL STAGE: Expression detected 24 hpf (hours post
fertilization), in developing hindbrain, most abundant in
rhombomeres 2 and 3. Neural expression peaks at 48 hpf, at which
point transcripts are found in the hindbrain, rhombic lip, and
optic precursors. The exocrine pancreas represents a population of
cells encircling the embryonic islet. At 72 hpf, expressed
throughout the endodermal region corresponding to the exocrine
pancreas. Expression is restricted to the exocrine pancreas
following an early period of transient neural expression. Positive
exocrine precursors and insulin-positive endocrine elements are
both temporally and spatially segregated during embryogenesis.
{ECO:0000269|PubMed:15183727}.
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EMBL; AY245546; AAO92259.1; -; mRNA.
EMBL; AL845362; CAD60845.1; -; Genomic_DNA.
EMBL; BC093269; AAH93269.1; -; mRNA.
RefSeq; NP_997524.1; NM_207641.2.
UniGene; Dr.86563; -.
ProteinModelPortal; Q7ZSX3; -.
SMR; Q7ZSX3; -.
STRING; 7955.ENSDARP00000011265; -.
PaxDb; Q7ZSX3; -.
Ensembl; ENSDART00000021987; ENSDARP00000011265; ENSDARG00000014479.
GeneID; 368662; -.
KEGG; dre:368662; -.
CTD; 256297; -.
ZFIN; ZDB-GENE-030616-579; ptf1a.
eggNOG; KOG4029; Eukaryota.
eggNOG; ENOG411227D; LUCA.
GeneTree; ENSGT00730000110958; -.
HOGENOM; HOG000231913; -.
HOVERGEN; HBG082224; -.
InParanoid; Q7ZSX3; -.
KO; K09073; -.
OMA; HQLHEYC; -.
OrthoDB; EOG091G0RR2; -.
PhylomeDB; Q7ZSX3; -.
TreeFam; TF315153; -.
PRO; PR:Q7ZSX3; -.
Proteomes; UP000000437; Chromosome 2.
Bgee; ENSDARG00000014479; -.
GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO; GO:0005634; C:nucleus; ISS:UniProtKB.
GO; GO:0005667; C:transcription factor complex; ISS:UniProtKB.
GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
GO; GO:0043565; F:sequence-specific DNA binding; IPI:ZFIN.
GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IGI:ZFIN.
GO; GO:0035881; P:amacrine cell differentiation; IMP:ZFIN.
GO; GO:0009887; P:animal organ morphogenesis; IMP:ZFIN.
GO; GO:0030154; P:cell differentiation; IMP:ZFIN.
GO; GO:0009790; P:embryo development; ISS:UniProtKB.
GO; GO:0031017; P:exocrine pancreas development; IMP:ZFIN.
GO; GO:0048699; P:generation of neurons; ISS:UniProtKB.
GO; GO:0030902; P:hindbrain development; ISS:UniProtKB.
GO; GO:0031016; P:pancreas development; IMP:ZFIN.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IGI:ZFIN.
GO; GO:0006355; P:regulation of transcription, DNA-templated; ISS:UniProtKB.
GO; GO:0048384; P:retinoic acid receptor signaling pathway; ISS:UniProtKB.
GO; GO:0009888; P:tissue development; ISS:UniProtKB.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
CDD; cd00083; HLH; 1.
Gene3D; 4.10.280.10; -; 1.
InterPro; IPR011598; bHLH_dom.
InterPro; IPR036638; HLH_DNA-bd_sf.
Pfam; PF00010; HLH; 1.
SMART; SM00353; HLH; 1.
SUPFAM; SSF47459; SSF47459; 1.
PROSITE; PS50888; BHLH; 1.
2: Evidence at transcript level;
Complete proteome; DNA-binding; Nucleus; Reference proteome;
Transcription; Transcription regulation.
CHAIN 1 265 Pancreas transcription factor 1 subunit
alpha.
/FTId=PRO_0000233146.
DOMAIN 115 167 bHLH. {ECO:0000255|PROSITE-
ProRule:PRU00981}.
COMPBIAS 20 68 Asp-rich.
SEQUENCE 265 AA; 30447 MW; FBC91669CFBBC5D9 CRC64;
MDTVLDPFTG LDSFSSSYFD DDDFFTDHSS RDHLDTDDFL DEDVDFLTNQ IQEYYKDSRI
SQDGDYCDVG NFSFSSSSST FSYGCADSTS ELSPHRDGGL LKRRRRMRSE VEMQQLRQAA
NVRERRRMQS INDAFEGLRS HIPTLPYEKR LSKVDTLRLA IGYINFLAEL VQSDMPIRNP
HSDALNQPKK VIICHRGTRS PSPNDPDYGL PPLAGHSLSW TDEKQLKDQN IIRTAKVWTP
EDPRKLHLKS SINNIENEPP FNFIS


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