GENTAUR Molecular Products.

 PTF1A_MOUSE             Reviewed;         324 AA.
 Q9QX98; Q9QYF5; Q9QYF6;
 02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
 01-MAY-2000, sequence version 1.
 13-FEB-2019, entry version 138.
 RecName: Full=Pancreas transcription factor 1 subunit alpha;
 AltName: Full=Pancreas-specific transcription factor 1a;
 AltName: Full=bHLH transcription factor p48;
 AltName: Full=p48 DNA-binding subunit of transcription factor PTF1;
          Short=PTF1-p48;
 Name=Ptf1a; Synonyms=Ptf1p48;
 Mus musculus (Mouse).
 Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
 Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
 Muroidea; Muridae; Murinae; Mus; Mus.
 NCBI_TaxID=10090;
 [1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], DEVELOPMENTAL STAGE, AND
 INTERACTION WITH TCF3 AND RBPSUH.
 STRAIN=ICR; TISSUE=Embryo;
 PubMed=11318877; DOI=10.1046/j.1365-2443.2001.00422.x;
 Obata J., Yano M., Mimura H., Goto T., Nakayama R., Mibu Y., Oka C.,
 Kawaichi M.;
 "p48 subunit of mouse PTF1 binds to RBP-Jkappa/CBF-1, the
 intracellular mediator of Notch signalling, and is expressed in the
 neural tube of early stage embryos.";
 Genes Cells 6:345-360(2001).
 [2]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND INTERACTION WITH
 TCF12.
 STRAIN=129;
 PubMed=11562365; DOI=10.1074/jbc.M106264200;
 Rose S.D., Swift G.H., Peyton M.J., Hammer R.E., MacDonald R.J.;
 "The role of PTF1-P48 in pancreatic acinar gene expression.";
 J. Biol. Chem. 276:44018-44026(2001).
 [3]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
 STRAIN=129/SvJ;
 Wellauer P.K.;
 Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases.
 [4]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
 STRAIN=C57BL/6J; TISSUE=Pancreas;
 PubMed=16141072; DOI=10.1126/science.1112014;
 Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
 Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
 Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
 Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
 Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
 Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
 Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
 Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
 di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
 Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
 Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
 Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
 Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
 Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
 Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
 Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
 Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
 Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
 Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
 Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
 Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
 Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
 Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
 Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
 Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
 Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
 Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
 Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
 Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
 Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
 Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
 Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
 Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
 Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
 Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
 Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
 Hayashizaki Y.;
 "The transcriptional landscape of the mammalian genome.";
 Science 309:1559-1563(2005).
 [5]
 FUNCTION IN PANCREAS DEVELOPMENT, TISSUE SPECIFICITY, AND DISRUPTION
 PHENOTYPE.
 STRAIN=129/SvJ;
 PubMed=9851981; DOI=10.1101/gad.12.23.3752;
 Krapp A., Knoefler M., Ledermann B., Buerki K., Berney C.,
 Zoerkler N., Hagenbuechle O., Wellauer P.K.;
 "The bHLH protein PTF1-p48 protein is essential for the formation of
 the exocrine and the correct spatial organization of the endocrine
 pancreas.";
 Genes Dev. 12:3752-3763(1998).
 [6]
 FUNCTION IN PANCREAS DEVELOPMENT, AND DEVELOPMENTAL STAGE.
 PubMed=12185368; DOI=10.1038/ng959;
 Kawaguchi Y., Cooper B., Gannon M., Ray M., MacDonald R.J.,
 Wright C.V.;
 "The role of the transcriptional regulator Ptf1a in converting
 intestinal to pancreatic progenitors.";
 Nat. Genet. 32:128-134(2002).
 [7]
 FUNCTION IN PANCREAS AND CEREBELLAR DEVELOPMENT, DISRUPTION PHENOTYPE,
 AND DEVELOPMENTAL STAGE.
 PubMed=15543146; DOI=10.1038/ng1475;
 Sellick G.S., Barker K.T., Stolte-Dijkstra I., Fleischmann C.,
 Coleman R.J., Garrett C., Gloyn A.L., Edghill E.L., Hattersley A.T.,
 Wellauer P.K., Goodwin G., Houlston R.S.;
 "Mutations in PTF1A cause pancreatic and cerebellar agenesis.";
 Nat. Genet. 36:1301-1305(2004).
 [8]
 FUNCTION IN RETINA DEVELOPMENT, DEVELOPMENTAL STAGE, AND DISRUPTION
 PHENOTYPE.
 PubMed=17075007; DOI=10.1242/dev.02598;
 Fujitani Y., Fujitani S., Luo H., Qiu F., Burlison J., Long Q.,
 Kawaguchi Y., Edlund H., MacDonald R.J., Furukawa T., Fujikado T.,
 Magnuson M.A., Xiang M., Wright C.V.;
 "Ptf1a determines horizontal and amacrine cell fates during mouse
 retinal development.";
 Development 133:4439-4450(2006).
 [9]
 IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
 TISSUE=Pancreas;
 PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
 Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
 Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
 "A tissue-specific atlas of mouse protein phosphorylation and
 expression.";
 Cell 143:1174-1189(2010).
 -!- FUNCTION: Transcription factor implicated in the cell fate
     determination in various organs. Binds to the E-box consensus
     sequence 5'-CANNTG-3'. Plays a role in early and late pancreas
     development and differentiation. Important for determining whether
     cells allocated to the pancreatic buds continue towards pancreatic
     organogenesis or revert back to duodenal fates. May be involved in
     the maintenance of exocrine pancreas-specific gene expression
     including ELA1 and amylase. Required for the formation of
     pancreatic acinar and ductal cells. Plays an important role in
     cerebellar development. Directly regulated by FOXN4 and RORC
     during retinal development, FOXN4-PTF1A pathway plays a central
     role in directing the differentiation of retinal progenitors
     towards horizontal and amacrine fates.
     {ECO:0000269|PubMed:11562365, ECO:0000269|PubMed:12185368,
     ECO:0000269|PubMed:15543146, ECO:0000269|PubMed:17075007,
     ECO:0000269|PubMed:9851981}.
 -!- SUBUNIT: Component of the pancreas transcription factor 1 complex
     (PTF1) which is composed of TCF3/p75, TCF12/p64 and PTF1A/p48.
     TCF3 is responsible for the nuclear import of the p48/p64 complex.
     Interacts with TCF3 and RBPSUH/RBP-Jkappa.
     {ECO:0000269|PubMed:11318877, ECO:0000269|PubMed:11562365}.
 -!- SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=In the cytoplasm
     loses its ability to form the PTF1 complex.
 -!- TISSUE SPECIFICITY: Expressed in precursors of pancreatic islets,
     acini and ducts. {ECO:0000269|PubMed:9851981}.
 -!- DEVELOPMENTAL STAGE: Expressed at an early stage of pancreas
     development, shortly after the onset of endodermal budding that
     forms the pancreatic anlage. In 9.5 dpc embryo, expression is in
     the myelencephalon and the neural tube at the cervical level. In
     the 10.5 dpc embryo expression expands as a thin stripe to the
     posterior end of the neural tube. The central nervous system
     anterior to the myelencephalon is devoid of expression at this
     stage. In 12-12.5 dpc embryo, expression expands anteriorly to the
     cerebellum region. During retinogenesis, restricted to postmitotic
     neuronal precursor population in the ventricular zone of the
     developing retina. Not expressed before 12.5 dpc when is detected
     in the central region of the retina. By 14.5, expands from the
     center to the entire retina. Between 16.5 dpc and P1, continues to
     be expressed strongly in a subset of cells within the outer
     neuroblastic layer. Expression begins to be down-regulated by P2
     and is undetectable in retinas from P6.
     {ECO:0000269|PubMed:11318877, ECO:0000269|PubMed:12185368,
     ECO:0000269|PubMed:15543146, ECO:0000269|PubMed:17075007}.
 -!- DISRUPTION PHENOTYPE: Early postnatal lethal phenotype
     characterized by a lack of the exocrine pancreas, however, islet-
     like endocrine cell clusters are formed. A redirection of
     pancreatic precursors to intestinal fates is seen. At 16.5 dpc
     embryos show reduced size of cerebellar primordium and cerebellar
     aplasia. {ECO:0000269|PubMed:15543146,
     ECO:0000269|PubMed:17075007, ECO:0000269|PubMed:9851981}.
 -----------------------------------------------------------------------
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 EMBL; AB035674; BAA88247.1; -; Genomic_DNA.
 EMBL; AB035675; BAA88249.1; -; mRNA.
 EMBL; AF298116; AAG31604.1; -; Genomic_DNA.
 EMBL; AJ252156; CAB65273.1; -; Genomic_DNA.
 EMBL; AK007922; BAE43208.1; -; mRNA.
 CCDS; CCDS15715.1; -.
 RefSeq; NP_061279.2; NM_018809.2.
 UniGene; Mm.69647; -.
 ProteinModelPortal; Q9QX98; -.
 SMR; Q9QX98; -.
 BioGrid; 202451; 1.
 CORUM; Q9QX98; -.
 STRING; 10090.ENSMUSP00000028068; -.
 PhosphoSitePlus; Q9QX98; -.
 PaxDb; Q9QX98; -.
 PRIDE; Q9QX98; -.
 Ensembl; ENSMUST00000028068; ENSMUSP00000028068; ENSMUSG00000026735.
 GeneID; 19213; -.
 KEGG; mmu:19213; -.
 UCSC; uc012brh.1; mouse.
 CTD; 256297; -.
 MGI; MGI:1328312; Ptf1a.
 eggNOG; KOG4029; Eukaryota.
 eggNOG; ENOG411227D; LUCA.
 GeneTree; ENSGT00940000161000; -.
 HOGENOM; HOG000231913; -.
 HOVERGEN; HBG082224; -.
 InParanoid; Q9QX98; -.
 KO; K09073; -.
 OMA; YCCEAGA; -.
 OrthoDB; 1269550at2759; -.
 PhylomeDB; Q9QX98; -.
 TreeFam; TF315153; -.
 ChiTaRS; Ptf1a; mouse.
 PRO; PR:Q9QX98; -.
 Proteomes; UP000000589; Chromosome 2.
 Bgee; ENSMUSG00000026735; Expressed in 50 organ(s), highest expression level in dorsal pancreas.
 ExpressionAtlas; Q9QX98; baseline and differential.
 Genevisible; Q9QX98; MM.
 GO; GO:0005737; C:cytoplasm; ISS:HGNC.
 GO; GO:0005829; C:cytosol; TAS:Reactome.
 GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO; GO:0005634; C:nucleus; ISS:HGNC.
 GO; GO:0005667; C:transcription factor complex; IDA:MGI.
 GO; GO:0003682; F:chromatin binding; IDA:MGI.
 GO; GO:0003677; F:DNA binding; IDA:UniProtKB.
 GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:MGI.
 GO; GO:0070888; F:E-box binding; IDA:MGI.
 GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
 GO; GO:0000980; F:RNA polymerase II distal enhancer sequence-specific DNA binding; ISO:MGI.
 GO; GO:0043565; F:sequence-specific DNA binding; IDA:MGI.
 GO; GO:0035881; P:amacrine cell differentiation; IMP:UniProtKB.
 GO; GO:0030154; P:cell differentiation; IMP:MGI.
 GO; GO:0045165; P:cell fate commitment; IMP:MGI.
 GO; GO:0021549; P:cerebellum development; IMP:UniProtKB.
 GO; GO:0031018; P:endocrine pancreas development; TAS:Reactome.
 GO; GO:0031017; P:exocrine pancreas development; ISS:HGNC.
 GO; GO:0048699; P:generation of neurons; IDA:UniProtKB.
 GO; GO:0030902; P:hindbrain development; IDA:UniProtKB.
 GO; GO:0048663; P:neuron fate commitment; IDA:MGI.
 GO; GO:0031016; P:pancreas development; IMP:MGI.
 GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:MGI.
 GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:UniProtKB.
 GO; GO:0061074; P:regulation of neural retina development; IMP:UniProtKB.
 GO; GO:0006355; P:regulation of transcription, DNA-templated; IDA:UniProtKB.
 GO; GO:0010842; P:retina layer formation; IMP:UniProtKB.
 GO; GO:0060042; P:retina morphogenesis in camera-type eye; IMP:MGI.
 GO; GO:0048384; P:retinoic acid receptor signaling pathway; IDA:UniProtKB.
 GO; GO:0009888; P:tissue development; ISS:UniProtKB.
 CDD; cd00083; HLH; 1.
 Gene3D; 4.10.280.10; -; 1.
 InterPro; IPR011598; bHLH_dom.
 InterPro; IPR036638; HLH_DNA-bd_sf.
 Pfam; PF00010; HLH; 1.
 SMART; SM00353; HLH; 1.
 SUPFAM; SSF47459; SSF47459; 1.
 PROSITE; PS50888; BHLH; 1.
 1: Evidence at protein level;
 Complete proteome; Cytoplasm; Developmental protein; Differentiation;
 DNA-binding; Neurogenesis; Nucleus; Reference proteome; Transcription;
 Transcription regulation.
 CHAIN         1    324       Pancreas transcription factor 1 subunit
                              alpha.
                              /FTId=PRO_0000233144.
 DOMAIN      160    212       bHLH. {ECO:0000255|PROSITE-
                              ProRule:PRU00981}.
 CONFLICT      7      7       E -> K (in Ref. 1; BAA88247).
                              {ECO:0000305}.
 CONFLICT     11     11       G -> R (in Ref. 1; BAA88247).
                              {ECO:0000305}.
 CONFLICT    223    223       R -> H (in Ref. 1; BAA88247).
                              {ECO:0000305}.
 SEQUENCE   324 AA;  35185 MW;  E74109A84B5CFD79 CRC64;
 MDAVLLEHFP GGLDTFPSPY FDEEDFFTDQ SSRDPLEDSD ELLGDEQAEV EFLSHQLHEY
 CYRDGACLLL QPAPSAAPHA LAPPPLGDPG EPEDNVSYCC DAGAPLAAFP YSPGSPPSCL
 AYPCAAVLSP GARLGGLNGA AAAAAARRRR RVRSEAELQQ LRQAANVRER RRMQSINDAF
 EGLRSHIPTL PYEKRLSKVD TLRLAIGYIN FLSELVQADL PLRGSGAGGC GGPGGSRHLG
 EDSPGNQAQK VIICHRGTRS PSPSDPDYGL PPLAGHSLSW TDEKQLKEQN IIRTAKVWTP
 EDPRKLNSKS FDNIENEPPF EFVS

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