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Pancreatic secretory granule membrane major glycoprotein GP2 (Pancreatic zymogen granule membrane protein GP-2) (ZAP75)

 GP2_HUMAN               Reviewed;         537 AA.
P55259; A6NFM9; A6NJA8; Q13338; Q9UIF1;
01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
25-NOV-2008, sequence version 3.
20-JUN-2018, entry version 145.
RecName: Full=Pancreatic secretory granule membrane major glycoprotein GP2;
AltName: Full=Pancreatic zymogen granule membrane protein GP-2;
AltName: Full=ZAP75;
Flags: Precursor;
Name=GP2;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA).
PubMed=8666297; DOI=10.1016/0378-1119(96)00065-0;
Wong S.M.E., Lowe A.W.;
"Sequence of the cDNA encoding human GP-2, the major membrane protein
in the secretory granule of the exocrine pancreas.";
Gene 171:311-312(1996).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=15616553; DOI=10.1038/nature03187;
Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X.,
Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A.,
Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.,
Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L.,
Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A.,
Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D.,
Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J.,
Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I.,
Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W.,
Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A.,
Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S.,
Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L.,
Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A.,
Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L.,
Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N.,
Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M.,
Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L.,
Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D.,
Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P.,
Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M.,
Rubin E.M., Pennacchio L.A.;
"The sequence and analysis of duplication-rich human chromosome 16.";
Nature 432:988-994(2004).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [MRNA] OF 8-537 (ISOFORMS ALPHA AND 2).
PubMed=10760606; DOI=10.1016/S0167-4781(00)00057-9;
Fukuoka S.;
"Molecular cloning and sequences of cDNAs encoding alpha (large) and
beta (small) isoforms of human pancreatic zymogen granule membrane-
associated protein GP2.";
Biochim. Biophys. Acta 1491:376-380(2000).
[5]
NUCLEOTIDE SEQUENCE [MRNA] OF 8-537 (ISOFORM BETA).
TISSUE=Pancreas;
Fukuoka S.;
"Molecular structure of human pancreatic GP2, a major glycoprotein
with GPI anchor in the zymogen granule membranes.";
Submitted (SEP-1994) to the EMBL/GenBank/DDBJ databases.
-!- SUBUNIT: Interacts with SYCN. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor,
GPI-anchor {ECO:0000250}. Secreted {ECO:0000250}. Note=Secreted
after cleavage in the pancreatic juice.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=4;
Name=1;
IsoId=P55259-1; Sequence=Displayed;
Name=Beta;
IsoId=P55259-2; Sequence=VSP_006948;
Name=Alpha;
IsoId=P55259-3; Sequence=VSP_035750;
Name=2;
IsoId=P55259-4; Sequence=VSP_035749;
-!- TISSUE SPECIFICITY: Pancreatic secretory (zymogen) granule.
-!- CAUTION: It is uncertain whether Met-1 or Met-8 is the initiator.
{ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAB19240.1; Type=Erroneous initiation; Evidence={ECO:0000305};
-----------------------------------------------------------------------
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EMBL; U36221; AAB19240.1; ALT_INIT; mRNA.
EMBL; AC106796; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CH471186; EAW50311.1; -; Genomic_DNA.
EMBL; AB035541; BAA88166.1; -; mRNA.
EMBL; AB035542; BAA88167.1; -; mRNA.
EMBL; D38225; BAA07400.1; -; mRNA.
CCDS; CCDS10582.2; -. [P55259-3]
CCDS; CCDS42128.1; -. [P55259-1]
CCDS; CCDS45432.1; -. [P55259-4]
CCDS; CCDS45433.1; -. [P55259-2]
PIR; G02091; G02091.
RefSeq; NP_001007241.2; NM_001007240.2. [P55259-1]
RefSeq; NP_001493.2; NM_001502.3. [P55259-3]
UniGene; Hs.53985; -.
ProteinModelPortal; P55259; -.
SMR; P55259; -.
BioGrid; 109075; 3.
IntAct; P55259; 2.
STRING; 9606.ENSP00000370767; -.
iPTMnet; P55259; -.
PhosphoSitePlus; P55259; -.
BioMuta; GP2; -.
DMDM; 215274153; -.
PaxDb; P55259; -.
PeptideAtlas; P55259; -.
PRIDE; P55259; -.
ProteomicsDB; 56819; -.
ProteomicsDB; 56820; -. [P55259-2]
ProteomicsDB; 56821; -. [P55259-3]
ProteomicsDB; 56822; -. [P55259-4]
Ensembl; ENST00000302555; ENSP00000304044; ENSG00000169347. [P55259-3]
Ensembl; ENST00000341642; ENSP00000343861; ENSG00000169347. [P55259-4]
Ensembl; ENST00000381360; ENSP00000370765; ENSG00000169347. [P55259-2]
Ensembl; ENST00000381362; ENSP00000370767; ENSG00000169347. [P55259-1]
GeneID; 2813; -.
KEGG; hsa:2813; -.
UCSC; uc002dgv.4; human. [P55259-1]
CTD; 2813; -.
DisGeNET; 2813; -.
EuPathDB; HostDB:ENSG00000169347.16; -.
GeneCards; GP2; -.
HGNC; HGNC:4441; GP2.
HPA; HPA015739; -.
HPA; HPA016668; -.
MIM; 602977; gene.
neXtProt; NX_P55259; -.
OpenTargets; ENSG00000169347; -.
PharmGKB; PA28822; -.
eggNOG; ENOG410IVSV; Eukaryota.
eggNOG; ENOG410YDU6; LUCA.
GeneTree; ENSGT00530000063244; -.
HOGENOM; HOG000293303; -.
HOVERGEN; HBG004349; -.
InParanoid; P55259; -.
KO; K19899; -.
OMA; FQDQNYT; -.
OrthoDB; EOG091G06RJ; -.
PhylomeDB; P55259; -.
TreeFam; TF330284; -.
Reactome; R-HSA-163125; Post-translational modification: synthesis of GPI-anchored proteins.
GeneWiki; GP2_(gene); -.
GenomeRNAi; 2813; -.
PRO; PR:P55259; -.
Proteomes; UP000005640; Chromosome 16.
Bgee; ENSG00000169347; -.
CleanEx; HS_GP2; -.
ExpressionAtlas; P55259; baseline and differential.
Genevisible; P55259; HS.
GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
GO; GO:0005576; C:extracellular region; TAS:Reactome.
GO; GO:0005886; C:plasma membrane; TAS:Reactome.
InterPro; IPR001507; ZP_dom.
InterPro; IPR017977; ZP_dom_CS.
Pfam; PF00100; Zona_pellucida; 1.
PRINTS; PR00023; ZPELLUCIDA.
SMART; SM00241; ZP; 1.
PROSITE; PS00682; ZP_1; 1.
PROSITE; PS51034; ZP_2; 1.
2: Evidence at transcript level;
Alternative splicing; Cell membrane; Complete proteome;
Disulfide bond; EGF-like domain; Glycoprotein; GPI-anchor;
Lipoprotein; Membrane; Reference proteome; Secreted; Signal.
SIGNAL 1 28 {ECO:0000255}.
CHAIN 29 512 Pancreatic secretory granule membrane
major glycoprotein GP2.
/FTId=PRO_0000041657.
PROPEP 513 537 Removed in mature form. {ECO:0000255}.
/FTId=PRO_0000041658.
DOMAIN 186 230 EGF-like.
DOMAIN 228 484 ZP. {ECO:0000255|PROSITE-
ProRule:PRU00375}.
LIPID 512 512 GPI-anchor amidated asparagine.
{ECO:0000255}.
CARBOHYD 65 65 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 122 122 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 362 362 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 190 200 {ECO:0000250|UniProtKB:P07911}.
DISULFID 194 209 {ECO:0000250|UniProtKB:P07911}.
DISULFID 211 241 {ECO:0000250|UniProtKB:P07911}.
DISULFID 229 320 {ECO:0000250|UniProtKB:P07911}.
DISULFID 261 284 {ECO:0000250|UniProtKB:P07911}.
DISULFID 401 461 {ECO:0000250|UniProtKB:P07911,
ECO:0000255|PROSITE-ProRule:PRU00076}.
DISULFID 422 477 {ECO:0000250|UniProtKB:P07911}.
DISULFID 466 473 {ECO:0000250|UniProtKB:P07911}.
VAR_SEQ 31 180 Missing (in isoform 2).
{ECO:0000303|PubMed:10760606}.
/FTId=VSP_035749.
VAR_SEQ 32 178 Missing (in isoform Beta).
{ECO:0000303|Ref.5}.
/FTId=VSP_006948.
VAR_SEQ 179 181 Missing (in isoform Alpha).
{ECO:0000303|PubMed:10760606,
ECO:0000303|PubMed:8666297}.
/FTId=VSP_035750.
CONFLICT 189 189 K -> KK (in Ref. 5; BAA07400).
{ECO:0000305}.
CONFLICT 243 243 L -> Q (in Ref. 5; BAA07400).
{ECO:0000305}.
CONFLICT 248 248 L -> F (in Ref. 5; BAA07400).
{ECO:0000305}.
CONFLICT 505 505 A -> G (in Ref. 5; BAA07400).
{ECO:0000305}.
CONFLICT 535 537 WLF -> LAV (in Ref. 5; BAA07400).
{ECO:0000305}.
SEQUENCE 537 AA; 59480 MW; 8A6B6A0FC64F50B8 CRC64;
MPHLMERMVG SGLLWLALVS CILTQASAVQ RGYGNPIEAS SYGLDLDCGA PGTPEAHVCF
DPCQNYTLLD EPFRSTENSA GSQGCDKNMS GWYRFVGEGG VRMSETCVQV HRCQTDAPMW
LNGTHPALGD GITNHTACAH WSGNCCFWKT EVLVKACPGG YHVYRLEGTP WCNLRYCTVP
RDPSTVEDKC EKACRPEEEC LALNSTWGCF CRQDLNSSDV HSLQPQLDCG PREIKVKVDK
CLLGGLGLGE EVIAYLRDPN CSSILQTEER NWVSVTSPVQ ASACRNILER NQTHAIYKNT
LSLVNDFIIR DTILNINFQC AYPLDMKVSL QAALQPIVSS LNVSVDGNGE FIVRMALFQD
QNYTNPYEGD AVELSVESVL YVGAILEQGD TSRFNLVLRN CYATPTEDKA DLVKYFIIRN
SCSNQRDSTI HVEENGQSSE SRFSVQMFMF AGHYDLVFLH CEIHLCDSLN EQCQPSCSRS
QVRSEVPAID LARVLDLGPI TRRGAQSPGV MNGTPSTAGF LVAWPMVLLT VLLAWLF


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