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Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH/PTHrP type I receptor) (PTH/PTHr receptor) (Parathyroid hormone 1 receptor) (PTH1 receptor)

 PTH1R_RAT               Reviewed;         591 AA.
P25961;
01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
01-MAY-1992, sequence version 1.
31-JAN-2018, entry version 137.
RecName: Full=Parathyroid hormone/parathyroid hormone-related peptide receptor;
AltName: Full=PTH/PTHrP type I receptor;
Short=PTH/PTHr receptor;
AltName: Full=Parathyroid hormone 1 receptor;
Short=PTH1 receptor;
Flags: Precursor;
Name=Pth1r; Synonyms=Pthr, Pthr1;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH PTH AND PTHLH,
AND SUBCELLULAR LOCATION.
TISSUE=Bone;
PubMed=1313566; DOI=10.1073/pnas.89.7.2732;
Abou-Samra A.-B., Jueppner H., Force T., Freeman M.W., Kong X.-F.,
Schipani E., Urena P., Richards J., Bonventre J.V., Potts J.T. Jr.,
Kronenberg H.M., Segre G.V.;
"Expression cloning of a common receptor for parathyroid hormone and
parathyroid hormone-related peptide from rat osteoblast-like cells: a
single receptor stimulates intracellular accumulation of both cAMP and
inositol trisphosphates and increases intracellular free calcium.";
Proc. Natl. Acad. Sci. U.S.A. 89:2732-2736(1992).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=8020952; DOI=10.1006/geno.1994.1122;
Pausova Z., Bourdon J., Clayton D., Mattei M.-G., Seldin M.F.,
Janicic N., Riviere M., Szpirer J., Levan G., Szpirer C.;
"Cloning of a parathyroid hormone/parathyroid hormone-related peptide
receptor (PTHR) cDNA from a rat osteosarcoma (UMR 106) cell line:
chromosomal assignment of the gene in the human, mouse, and rat
genomes.";
Genomics 20:20-26(1994).
-!- FUNCTION: Receptor for parathyroid hormone and for parathyroid
hormone-related peptide. The activity of this receptor is mediated
by G proteins which activate adenylyl cyclase and also a
phosphatidylinositol-calcium second messenger system.
{ECO:0000269|PubMed:1313566}.
-!- SUBUNIT: Interacts (via N-terminal extracellular domain) with
PTHLH and PTH (PubMed:1313566). Homodimer in the absence of bound
ligand. Peptide hormone binding leads to dissociation of the
homodimer (By similarity). {ECO:0000250|UniProtKB:Q03431,
ECO:0000269|PubMed:1313566}.
-!- INTERACTION:
P62873:GNB1 (xeno); NbExp=3; IntAct=EBI-15714549, EBI-357130;
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:1313566};
Multi-pass membrane protein {ECO:0000305}.
-!- PTM: N-glycosylated. {ECO:0000250|UniProtKB:Q03431}.
-!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
{ECO:0000305}.
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EMBL; M77184; AAA41811.1; -; mRNA.
EMBL; L19475; AAA68098.1; -; mRNA.
PIR; I54195; I54195.
RefSeq; NP_064458.1; NM_020073.2.
RefSeq; XP_006244060.1; XM_006243998.3.
RefSeq; XP_006244061.1; XM_006243999.2.
UniGene; Rn.48025; -.
ProteinModelPortal; P25961; -.
SMR; P25961; -.
BioGrid; 248587; 1.
CORUM; P25961; -.
DIP; DIP-46025N; -.
IntAct; P25961; 2.
STRING; 10116.ENSRNOP00000028435; -.
BindingDB; P25961; -.
ChEMBL; CHEMBL6038; -.
GuidetoPHARMACOLOGY; 331; -.
iPTMnet; P25961; -.
PhosphoSitePlus; P25961; -.
PaxDb; P25961; -.
PRIDE; P25961; -.
Ensembl; ENSRNOT00000028435; ENSRNOP00000028435; ENSRNOG00000020948.
GeneID; 56813; -.
KEGG; rno:56813; -.
UCSC; RGD:3442; rat.
CTD; 5745; -.
RGD; 3442; Pth1r.
eggNOG; KOG4564; Eukaryota.
eggNOG; ENOG410XRS2; LUCA.
GeneTree; ENSGT00760000118800; -.
HOGENOM; HOG000008248; -.
HOVERGEN; HBG008318; -.
InParanoid; P25961; -.
KO; K04585; -.
OMA; YAGCRVA; -.
OrthoDB; EOG091G0NF8; -.
PhylomeDB; P25961; -.
TreeFam; TF315710; -.
Reactome; R-RNO-373080; Class B/2 (Secretin family receptors).
Reactome; R-RNO-418555; G alpha (s) signalling events.
PRO; PR:P25961; -.
Proteomes; UP000002494; Chromosome 8.
Bgee; ENSRNOG00000020948; -.
Genevisible; P25961; RN.
GO; GO:0016324; C:apical plasma membrane; IDA:BHF-UCL.
GO; GO:0016323; C:basolateral plasma membrane; IDA:BHF-UCL.
GO; GO:0031526; C:brush border membrane; IDA:RGD.
GO; GO:0005737; C:cytoplasm; IDA:RGD.
GO; GO:0070062; C:extracellular exosome; ISO:RGD.
GO; GO:0005887; C:integral component of plasma membrane; ISO:RGD.
GO; GO:0005622; C:intracellular; ISO:RGD.
GO; GO:0005634; C:nucleus; IDA:RGD.
GO; GO:0005886; C:plasma membrane; IMP:RGD.
GO; GO:0043235; C:receptor complex; IDA:BHF-UCL.
GO; GO:0004991; F:parathyroid hormone receptor activity; IDA:BHF-UCL.
GO; GO:0017046; F:peptide hormone binding; IDA:BHF-UCL.
GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
GO; GO:0043621; F:protein self-association; ISO:RGD.
GO; GO:0007189; P:adenylate cyclase-activating G-protein coupled receptor signaling pathway; IDA:BHF-UCL.
GO; GO:0007188; P:adenylate cyclase-modulating G-protein coupled receptor signaling pathway; IDA:BHF-UCL.
GO; GO:0007568; P:aging; IEP:RGD.
GO; GO:0030282; P:bone mineralization; ISO:RGD.
GO; GO:0045453; P:bone resorption; ISO:RGD.
GO; GO:0048469; P:cell maturation; ISO:RGD.
GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
GO; GO:0006874; P:cellular calcium ion homeostasis; ISO:RGD.
GO; GO:0002062; P:chondrocyte differentiation; ISO:RGD.
GO; GO:0007187; P:G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; IMP:RGD.
GO; GO:0008285; P:negative regulation of cell proliferation; ISO:RGD.
GO; GO:0001503; P:ossification; ISO:RGD.
GO; GO:0002076; P:osteoblast development; ISO:RGD.
GO; GO:0007200; P:phospholipase C-activating G-protein coupled receptor signaling pathway; IDA:RGD.
GO; GO:0008284; P:positive regulation of cell proliferation; ISO:RGD.
GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IDA:RGD.
GO; GO:0060732; P:positive regulation of inositol phosphate biosynthetic process; IDA:BHF-UCL.
GO; GO:0001501; P:skeletal system development; ISO:RGD.
Gene3D; 4.10.1240.10; -; 1.
InterPro; IPR017981; GPCR_2-like.
InterPro; IPR036445; GPCR_2_extracell_dom_sf.
InterPro; IPR001879; GPCR_2_extracellular_dom.
InterPro; IPR002170; GPCR_2_parathyroid_rcpt.
InterPro; IPR000832; GPCR_2_secretin-like.
InterPro; IPR017983; GPCR_2_secretin-like_CS.
PANTHER; PTHR12011:SF24; PTHR12011:SF24; 1.
Pfam; PF00002; 7tm_2; 1.
Pfam; PF02793; HRM; 1.
PRINTS; PR00249; GPCRSECRETIN.
PRINTS; PR00393; PTRHORMONER.
SMART; SM00008; HormR; 1.
SUPFAM; SSF111418; SSF111418; 1.
PROSITE; PS00649; G_PROTEIN_RECEP_F2_1; 1.
PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
1: Evidence at protein level;
Cell membrane; Complete proteome; Disulfide bond;
G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
Reference proteome; Signal; Transducer; Transmembrane;
Transmembrane helix.
SIGNAL 1 26 {ECO:0000255}.
CHAIN 27 591 Parathyroid hormone/parathyroid hormone-
related peptide receptor.
/FTId=PRO_0000012848.
TOPO_DOM 27 188 Extracellular. {ECO:0000255}.
TRANSMEM 189 212 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 213 219 Cytoplasmic. {ECO:0000255}.
TRANSMEM 220 239 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 240 282 Extracellular. {ECO:0000255}.
TRANSMEM 283 306 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 307 320 Cytoplasmic. {ECO:0000255}.
TRANSMEM 321 342 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 343 361 Extracellular. {ECO:0000255}.
TRANSMEM 362 382 Helical; Name=5. {ECO:0000255}.
TOPO_DOM 383 409 Cytoplasmic. {ECO:0000255}.
TRANSMEM 410 428 Helical; Name=6. {ECO:0000255}.
TOPO_DOM 429 440 Extracellular. {ECO:0000255}.
TRANSMEM 441 463 Helical; Name=7. {ECO:0000255}.
TOPO_DOM 464 591 Cytoplasmic. {ECO:0000255}.
MOTIF 474 477 Important for interaction with G
proteins. {ECO:0000250}.
CARBOHYD 151 151 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 161 161 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 166 166 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 176 176 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 48 117 {ECO:0000250|UniProtKB:Q03431}.
DISULFID 108 148 {ECO:0000250|UniProtKB:Q03431}.
DISULFID 131 170 {ECO:0000250|UniProtKB:Q03431}.
SEQUENCE 591 AA; 66261 MW; 21944F3051B9E9C1 CRC64;
MGAARIAPSL ALLLCCPVLS SAYALVDADD VFTKEEQIFL LHRAQAQCDK LLKEVLHTAA
NIMESDKGWT PASTSGKPRK EKASGKFYPE SKENKDVPTG SRRRGRPCLP EWDNIVCWPL
GAPGEVVAVP CPDYIYDFNH KGHAYRRCDR NGSWEVVPGH NRTWANYSEC LKFMTNETRE
REVFDRLGMI YTVGYSMSLA SLTVAVLILA YFRRLHCTRN YIHMHMFLSF MLRAASIFVK
DAVLYSGFTL DEAERLTEEE LHIIAQVPPP PAAAAVGYAG CRVAVTFFLY FLATNYYWIL
VEGLYLHSLI FMAFFSEKKY LWGFTIFGWG LPAVFVAVWV GVRATLANTG CWDLSSGHKK
WIIQVPILAS VVLNFILFIN IIRVLATKLR ETNAGRCDTR QQYRKLLRST LVLVPLFGVH
YTVFMALPYT EVSGTLWQIQ MHYEMLFNSF QGFFVAIIYC FCNGEVQAEI RKSWSRWTLA
LDFKRKARSG SSSYSYGPMV SHTSVTNVGP RAGLSLPLSP RLPPATTNGH SQLPGHAKPG
APATETETLP VTMAVPKDDG FLNGSCSGLD EEASGSARPP PLLQEEWETV M


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