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Parathyroid hormone (PTH)

 PTHY_CHICK              Reviewed;         119 AA.
P15743;
01-APR-1990, integrated into UniProtKB/Swiss-Prot.
01-APR-1990, sequence version 1.
28-MAR-2018, entry version 115.
RecName: Full=Parathyroid hormone;
Short=PTH;
Flags: Precursor;
Name=PTH;
Gallus gallus (Chicken).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
Phasianidae; Phasianinae; Gallus.
NCBI_TaxID=9031;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=2710135; DOI=10.1210/mend-3-2-325;
Russell J., Sherwood L.M.;
"Nucleotide sequence of the DNA complementary to avian (chicken)
preproparathyroid hormone mRNA and the deduced sequence of the hormone
precursor.";
Mol. Endocrinol. 3:325-331(1989).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=3251402; DOI=10.1002/jbmr.5650030615;
Khosla S., Demay M., Pines M., Hurwitz S., Potts J.T. Jr.,
Kronenberg H.M.;
"Nucleotide sequence of cloned cDNAs encoding chicken
preproparathyroid hormone.";
J. Bone Miner. Res. 3:689-698(1988).
-!- FUNCTION: PTH elevates calcium level by dissolving the salts in
bone and preventing their renal excretion.
-!- SUBCELLULAR LOCATION: Secreted.
-!- SIMILARITY: Belongs to the parathyroid hormone family.
{ECO:0000305}.
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EMBL; M31604; AAA49093.1; -; mRNA.
EMBL; M36522; AAB02866.1; -; mRNA.
PIR; A34937; A34937.
RefSeq; NP_990783.1; NM_205452.2.
UniGene; Gga.78; -.
ProteinModelPortal; P15743; -.
SMR; P15743; -.
STRING; 9031.ENSGALP00000008579; -.
PaxDb; P15743; -.
Ensembl; ENSGALT00000061928; ENSGALP00000044567; ENSGALG00000042878.
GeneID; 396436; -.
KEGG; gga:396436; -.
CTD; 5741; -.
eggNOG; ENOG410J02X; Eukaryota.
eggNOG; ENOG410ZH2H; LUCA.
GeneTree; ENSGT00390000018603; -.
HOGENOM; HOG000033707; -.
HOVERGEN; HBG008319; -.
InParanoid; P15743; -.
KO; K05261; -.
OMA; EIQFMHN; -.
OrthoDB; EOG091G13ZF; -.
PhylomeDB; P15743; -.
TreeFam; TF336197; -.
Reactome; R-GGA-373080; Class B/2 (Secretin family receptors).
Reactome; R-GGA-418555; G alpha (s) signalling events.
PRO; PR:P15743; -.
Proteomes; UP000000539; Chromosome 5.
ExpressionAtlas; P15743; differential.
GO; GO:0005615; C:extracellular space; IBA:GO_Central.
GO; GO:0005622; C:intracellular; IEA:GOC.
GO; GO:0005179; F:hormone activity; IBA:GO_Central.
GO; GO:0031856; F:parathyroid hormone receptor binding; IBA:GO_Central.
GO; GO:0051428; F:peptide hormone receptor binding; IEA:Ensembl.
GO; GO:0047485; F:protein N-terminus binding; IEA:Ensembl.
GO; GO:0003705; F:transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; IEA:Ensembl.
GO; GO:0031857; F:type 1 parathyroid hormone receptor binding; IEA:Ensembl.
GO; GO:0007202; P:activation of phospholipase C activity; IEA:Ensembl.
GO; GO:0007189; P:adenylate cyclase-activating G-protein coupled receptor signaling pathway; IEA:Ensembl.
GO; GO:0007267; P:cell-cell signaling; IBA:GO_Central.
GO; GO:0006874; P:cellular calcium ion homeostasis; IEA:Ensembl.
GO; GO:0034645; P:cellular macromolecule biosynthetic process; IEA:Ensembl.
GO; GO:0048873; P:homeostasis of number of cells within a tissue; IEA:Ensembl.
GO; GO:0071866; P:negative regulation of apoptotic process in bone marrow; IEA:Ensembl.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:0030501; P:positive regulation of bone mineralization; IEA:Ensembl.
GO; GO:0030819; P:positive regulation of cAMP biosynthetic process; IEA:Ensembl.
GO; GO:0071864; P:positive regulation of cell proliferation in bone marrow; IEA:Ensembl.
GO; GO:0046326; P:positive regulation of glucose import; IEA:Ensembl.
GO; GO:0045725; P:positive regulation of glycogen biosynthetic process; IEA:Ensembl.
GO; GO:0060732; P:positive regulation of inositol phosphate biosynthetic process; IEA:Ensembl.
GO; GO:0090290; P:positive regulation of osteoclast proliferation; IEA:Ensembl.
GO; GO:0009967; P:positive regulation of signal transduction; IEA:Ensembl.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
InterPro; IPR003625; PTH.
InterPro; IPR001415; PTH/PTH-rel.
PANTHER; PTHR10541:SF2; PTHR10541:SF2; 1.
Pfam; PF01279; Parathyroid; 1.
PIRSF; PIRSF001832; PTH; 1.
SMART; SM00087; PTH; 1.
PROSITE; PS00335; PARATHYROID; 1.
3: Inferred from homology;
Cleavage on pair of basic residues; Complete proteome; Hormone;
Reference proteome; Secreted; Signal.
SIGNAL 1 25
PROPEP 26 31
/FTId=PRO_0000023257.
CHAIN 32 119 Parathyroid hormone.
/FTId=PRO_0000023258.
SEQUENCE 119 AA; 13943 MW; B309D8E772997F6E CRC64;
MTSTKNLAKA IVILYAICFF TNSDGRPMMK RSVSEMQLMH NLGEHRHTVE RQDWLQMKLQ
DVHSALEDAR TQRPRNKEDI VLGEIRNRRL LPEHLRAAVQ KKSIDLDKAY MNVLFKTKP


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