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Parathyroid hormone (PTH) (Parathyrin)

 PTHY_CANLF              Reviewed;         115 AA.
P52212;
01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
01-OCT-1996, sequence version 1.
12-SEP-2018, entry version 110.
RecName: Full=Parathyroid hormone;
Short=PTH;
AltName: Full=Parathyrin;
Flags: Precursor;
Name=PTH;
Canis lupus familiaris (Dog) (Canis familiaris).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
Canis.
NCBI_TaxID=9615;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Parathyroid;
PubMed=7642102; DOI=10.1016/0378-1119(94)00912-C;
Rosol T.J., Steinmeyer C.L., McCauley L.K., Groene A., DeWille J.W.,
Capen C.C.;
"Sequences of the cDNAs encoding canine parathyroid hormone-related
protein and parathyroid hormone.";
Gene 160:241-243(1995).
-!- FUNCTION: PTH elevates calcium level by dissolving the salts in
bone and preventing their renal excretion. Stimulates [1-14C]-2-
deoxy-D-glucose (2DG) transport and glycogen synthesis in
osteoblastic cells (By similarity). {ECO:0000250}.
-!- SUBUNIT: Interacts with PTH1R (via N-terminal extracellular
domain). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted.
-!- SIMILARITY: Belongs to the parathyroid hormone family.
{ECO:0000305}.
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EMBL; U15662; AAA82584.1; -; mRNA.
PIR; JC4202; JC4202.
RefSeq; NP_001003302.1; NM_001003302.1.
RefSeq; XP_005633342.1; XM_005633285.2.
RefSeq; XP_013977895.1; XM_014122420.1.
UniGene; Cfa.3855; -.
ProteinModelPortal; P52212; -.
SMR; P52212; -.
STRING; 9615.ENSCAFP00000012029; -.
PaxDb; P52212; -.
Ensembl; ENSCAFT00000012999; ENSCAFP00000012029; ENSCAFG00000008177.
GeneID; 403986; -.
KEGG; cfa:403986; -.
CTD; 5741; -.
VGNC; VGNC:45153; PTH.
eggNOG; ENOG410J02X; Eukaryota.
eggNOG; ENOG410ZH2H; LUCA.
GeneTree; ENSGT00390000018603; -.
HOGENOM; HOG000033707; -.
HOVERGEN; HBG008319; -.
InParanoid; P52212; -.
KO; K05261; -.
OMA; EIQFMHN; -.
OrthoDB; EOG091G13ZF; -.
TreeFam; TF336197; -.
Reactome; R-CFA-373080; Class B/2 (Secretin family receptors).
Reactome; R-CFA-418555; G alpha (s) signalling events.
Proteomes; UP000002254; Chromosome 21.
Bgee; ENSCAFG00000008177; Expressed in 2 organ(s), highest expression level in prefrontal cortex.
GO; GO:0005615; C:extracellular space; IBA:GO_Central.
GO; GO:0005622; C:intracellular; IEA:GOC.
GO; GO:0005179; F:hormone activity; IBA:GO_Central.
GO; GO:0031856; F:parathyroid hormone receptor binding; IBA:GO_Central.
GO; GO:0051428; F:peptide hormone receptor binding; ISS:UniProtKB.
GO; GO:0047485; F:protein N-terminus binding; IEA:Ensembl.
GO; GO:0003705; F:transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; IEA:Ensembl.
GO; GO:0031857; F:type 1 parathyroid hormone receptor binding; IEA:Ensembl.
GO; GO:0007202; P:activation of phospholipase C activity; IEA:Ensembl.
GO; GO:0007189; P:adenylate cyclase-activating G-protein coupled receptor signaling pathway; IEA:Ensembl.
GO; GO:0030282; P:bone mineralization; IEA:Ensembl.
GO; GO:0045453; P:bone resorption; IBA:GO_Central.
GO; GO:0006816; P:calcium ion transport; IEA:Ensembl.
GO; GO:0007267; P:cell-cell signaling; IBA:GO_Central.
GO; GO:0006874; P:cellular calcium ion homeostasis; IEA:Ensembl.
GO; GO:0034645; P:cellular macromolecule biosynthetic process; IEA:Ensembl.
GO; GO:0048873; P:homeostasis of number of cells within a tissue; IEA:Ensembl.
GO; GO:0010960; P:magnesium ion homeostasis; IEA:Ensembl.
GO; GO:0071866; P:negative regulation of apoptotic process in bone marrow; IEA:Ensembl.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:0055062; P:phosphate ion homeostasis; IEA:Ensembl.
GO; GO:0030501; P:positive regulation of bone mineralization; IEA:Ensembl.
GO; GO:0071864; P:positive regulation of cell proliferation in bone marrow; IEA:Ensembl.
GO; GO:0046326; P:positive regulation of glucose import; ISS:UniProtKB.
GO; GO:0045725; P:positive regulation of glycogen biosynthetic process; ISS:UniProtKB.
GO; GO:0060732; P:positive regulation of inositol phosphate biosynthetic process; IEA:Ensembl.
GO; GO:0090290; P:positive regulation of osteoclast proliferation; IEA:Ensembl.
GO; GO:0009967; P:positive regulation of signal transduction; IEA:Ensembl.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:0001501; P:skeletal system development; IBA:GO_Central.
InterPro; IPR003625; PTH.
InterPro; IPR001415; PTH/PTH-rel.
PANTHER; PTHR10541:SF2; PTHR10541:SF2; 1.
Pfam; PF01279; Parathyroid; 1.
PIRSF; PIRSF001832; PTH; 1.
SMART; SM00087; PTH; 1.
PROSITE; PS00335; PARATHYROID; 1.
3: Inferred from homology;
Cleavage on pair of basic residues; Complete proteome; Hormone;
Reference proteome; Secreted; Signal.
SIGNAL 1 25 {ECO:0000250}.
PROPEP 26 31 {ECO:0000250}.
/FTId=PRO_0000023245.
CHAIN 32 115 Parathyroid hormone.
/FTId=PRO_0000023246.
REGION 51 69 Important for receptor binding.
{ECO:0000250}.
SEQUENCE 115 AA; 12957 MW; FC38F77F1C8CFE56 CRC64;
MMSAKDMVKV MIVMFAICFL AKSDGKPVKK RSVSEIQFMH NLGKHLSSME RVEWLRKKLQ
DVHNFVALGA PIAHRDGSSQ RPLKKEDNVL VESYQKSLGE ADKADVDVLT KAKSQ


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