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Parkinsonism associated deglycase

 F6WPB4_HORSE            Unreviewed;       189 AA.
F6WPB4;
27-JUL-2011, integrated into UniProtKB/TrEMBL.
27-JUL-2011, sequence version 1.
12-SEP-2018, entry version 52.
SubName: Full=Parkinsonism associated deglycase {ECO:0000313|Ensembl:ENSECAP00000014829};
Name=PARK7 {ECO:0000313|Ensembl:ENSECAP00000014829,
ECO:0000313|VGNC:VGNC:21165};
Equus caballus (Horse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000014829, ECO:0000313|Proteomes:UP000002281};
[1] {ECO:0000313|Ensembl:ENSECAP00000014829, ECO:0000313|Proteomes:UP000002281}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000014829,
ECO:0000313|Proteomes:UP000002281};
PubMed=19892987; DOI=10.1126/science.1178158;
Broad Institute Genome Sequencing Platform;
Broad Institute Whole Genome Assembly Team;
Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H.,
Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N.,
Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L.,
Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J.,
Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J.,
Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R.,
Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F.,
Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L.,
Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M.,
White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
"Genome sequence, comparative analysis, and population genetics of the
domestic horse.";
Science 326:865-867(2009).
[2] {ECO:0000313|Ensembl:ENSECAP00000014829}
IDENTIFICATION.
STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000014829};
Ensembl;
Submitted (JUL-2011) to UniProtKB.
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RefSeq; XP_001495448.1; XM_001495398.4.
ProteinModelPortal; F6WPB4; -.
STRING; 9796.ENSECAP00000014829; -.
MEROPS; C56.971; -.
PaxDb; F6WPB4; -.
PRIDE; F6WPB4; -.
Ensembl; ENSECAT00000018192; ENSECAP00000014829; ENSECAG00000017251.
GeneID; 100052123; -.
KEGG; ecb:100052123; -.
CTD; 11315; -.
VGNC; VGNC:21165; PARK7.
eggNOG; KOG2764; Eukaryota.
eggNOG; COG0693; LUCA.
GeneTree; ENSGT00390000001231; -.
InParanoid; F6WPB4; -.
KO; K05687; -.
OMA; MMNGSHY; -.
OrthoDB; EOG091G12NS; -.
TreeFam; TF300119; -.
Proteomes; UP000002281; Chromosome 2.
Bgee; ENSECAG00000017251; Expressed in 3 organ(s), highest expression level in adult mammalian kidney.
GO; GO:0044297; C:cell body; IEA:Ensembl.
GO; GO:0000785; C:chromatin; IEA:Ensembl.
GO; GO:0005829; C:cytosol; IEA:Ensembl.
GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
GO; GO:0005758; C:mitochondrial intermembrane space; IEA:Ensembl.
GO; GO:0005759; C:mitochondrial matrix; IEA:Ensembl.
GO; GO:0005747; C:mitochondrial respiratory chain complex I; IEA:Ensembl.
GO; GO:0043005; C:neuron projection; IEA:Ensembl.
GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
GO; GO:0016605; C:PML body; IEA:Ensembl.
GO; GO:0098793; C:presynapse; IEA:GOC.
GO; GO:0050681; F:androgen receptor binding; IEA:Ensembl.
GO; GO:1903135; F:cupric ion binding; IEA:Ensembl.
GO; GO:1903136; F:cuprous ion binding; IEA:Ensembl.
GO; GO:0019955; F:cytokine binding; IEA:Ensembl.
GO; GO:0019900; F:kinase binding; IEA:Ensembl.
GO; GO:0036478; F:L-dopa decarboxylase activator activity; IEA:Ensembl.
GO; GO:0045340; F:mercury ion binding; IEA:Ensembl.
GO; GO:0003729; F:mRNA binding; IEA:Ensembl.
GO; GO:0008233; F:peptidase activity; IEA:Ensembl.
GO; GO:0051920; F:peroxiredoxin activity; IEA:Ensembl.
GO; GO:0036524; F:protein deglycase activity; IEA:Ensembl.
GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
GO; GO:0070491; F:repressing transcription factor binding; IEA:Ensembl.
GO; GO:0097110; F:scaffold protein binding; IEA:Ensembl.
GO; GO:0044388; F:small protein activating enzyme binding; IEA:Ensembl.
GO; GO:0016532; F:superoxide dismutase copper chaperone activity; IEA:Ensembl.
GO; GO:0003713; F:transcription coactivator activity; IEA:Ensembl.
GO; GO:0036470; F:tyrosine 3-monooxygenase activator activity; IEA:Ensembl.
GO; GO:0044390; F:ubiquitin-like protein conjugating enzyme binding; IEA:Ensembl.
GO; GO:1990381; F:ubiquitin-specific protease binding; IEA:Ensembl.
GO; GO:0008344; P:adult locomotory behavior; IEA:Ensembl.
GO; GO:0036471; P:cellular response to glyoxal; IEA:Ensembl.
GO; GO:0070301; P:cellular response to hydrogen peroxide; IEA:Ensembl.
GO; GO:0010273; P:detoxification of copper ion; IEA:Ensembl.
GO; GO:0050787; P:detoxification of mercury ion; IEA:Ensembl.
GO; GO:0006281; P:DNA repair; IEA:Ensembl.
GO; GO:0051583; P:dopamine uptake involved in synaptic transmission; IEA:Ensembl.
GO; GO:0018323; P:enzyme active site formation via L-cysteine sulfinic acid; IEA:Ensembl.
GO; GO:0042593; P:glucose homeostasis; IEA:Ensembl.
GO; GO:0036531; P:glutathione deglycation; IEA:Ensembl.
GO; GO:0106046; P:guanine deglycation, glyoxal removal; IEA:Ensembl.
GO; GO:0106045; P:guanine deglycation, methylglyoxal removal; IEA:Ensembl.
GO; GO:0042743; P:hydrogen peroxide metabolic process; IEA:Ensembl.
GO; GO:0030073; P:insulin secretion; IEA:Ensembl.
GO; GO:0051899; P:membrane depolarization; IEA:Ensembl.
GO; GO:0060081; P:membrane hyperpolarization; IEA:Ensembl.
GO; GO:0007005; P:mitochondrion organization; IEA:Ensembl.
GO; GO:2001268; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; IEA:Ensembl.
GO; GO:1902236; P:negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; IEA:Ensembl.
GO; GO:0010629; P:negative regulation of gene expression; IEA:Ensembl.
GO; GO:1903384; P:negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway; IEA:Ensembl.
GO; GO:1905259; P:negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway; IEA:Ensembl.
GO; GO:0032435; P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:Ensembl.
GO; GO:1901984; P:negative regulation of protein acetylation; IEA:Ensembl.
GO; GO:0032091; P:negative regulation of protein binding; IEA:Ensembl.
GO; GO:0046826; P:negative regulation of protein export from nucleus; IEA:Ensembl.
GO; GO:1903094; P:negative regulation of protein K48-linked deubiquitination; IEA:Ensembl.
GO; GO:0006469; P:negative regulation of protein kinase activity; IEA:Ensembl.
GO; GO:0033234; P:negative regulation of protein sumoylation; IEA:Ensembl.
GO; GO:1903427; P:negative regulation of reactive oxygen species biosynthetic process; IEA:Ensembl.
GO; GO:1903122; P:negative regulation of TRAIL-activated apoptotic signaling pathway; IEA:Ensembl.
GO; GO:0051444; P:negative regulation of ubiquitin-protein transferase activity; IEA:Ensembl.
GO; GO:2000157; P:negative regulation of ubiquitin-specific protease activity; IEA:Ensembl.
GO; GO:0036527; P:peptidyl-arginine deglycation; IEA:Ensembl.
GO; GO:0036526; P:peptidyl-cysteine deglycation; IEA:Ensembl.
GO; GO:0036528; P:peptidyl-lysine deglycation; IEA:Ensembl.
GO; GO:0002866; P:positive regulation of acute inflammatory response to antigenic stimulus; IEA:Ensembl.
GO; GO:2000825; P:positive regulation of androgen receptor activity; IEA:Ensembl.
GO; GO:1903181; P:positive regulation of dopamine biosynthetic process; IEA:Ensembl.
GO; GO:0032757; P:positive regulation of interleukin-8 production; IEA:Ensembl.
GO; GO:1903197; P:positive regulation of L-dopa biosynthetic process; IEA:Ensembl.
GO; GO:1902958; P:positive regulation of mitochondrial electron transport, NADH to ubiquinone; IEA:Ensembl.
GO; GO:0033864; P:positive regulation of NAD(P)H oxidase activity; IEA:Ensembl.
GO; GO:2000277; P:positive regulation of oxidative phosphorylation uncoupler activity; IEA:Ensembl.
GO; GO:1902177; P:positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; IEA:Ensembl.
GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IEA:Ensembl.
GO; GO:0090073; P:positive regulation of protein homodimerization activity; IEA:Ensembl.
GO; GO:1900182; P:positive regulation of protein localization to nucleus; IEA:Ensembl.
GO; GO:1903168; P:positive regulation of pyrroline-5-carboxylate reductase activity; IEA:Ensembl.
GO; GO:1903428; P:positive regulation of reactive oxygen species biosynthetic process; IEA:Ensembl.
GO; GO:1901671; P:positive regulation of superoxide dismutase activity; IEA:Ensembl.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:2000679; P:positive regulation of transcription regulatory region DNA binding; IEA:Ensembl.
GO; GO:0036529; P:protein deglycation, glyoxal removal; IEA:Ensembl.
GO; GO:0036530; P:protein deglycation, methylglyoxal removal; IEA:Ensembl.
GO; GO:0006517; P:protein deglycosylation; IEA:Ensembl.
GO; GO:0050821; P:protein stabilization; IEA:Ensembl.
GO; GO:0051881; P:regulation of mitochondrial membrane potential; IEA:Ensembl.
Gene3D; 3.40.50.880; -; 1.
InterPro; IPR029062; Class_I_gatase-like.
InterPro; IPR006287; DJ-1.
InterPro; IPR002818; DJ-1/PfpI.
Pfam; PF01965; DJ-1_PfpI; 1.
SUPFAM; SSF52317; SSF52317; 1.
TIGRFAMs; TIGR01383; not_thiJ; 1.
4: Predicted;
Complete proteome {ECO:0000313|Proteomes:UP000002281};
Reference proteome {ECO:0000313|Proteomes:UP000002281}.
DOMAIN 4 170 DJ-1_PfpI. {ECO:0000259|Pfam:PF01965}.
SEQUENCE 189 AA; 19948 MW; 9CD4C4FA2F705055 CRC64;
MASKRALVIL AKGAEEMETV IPVDVMRRAG IKVTIAGLAG KDPVQCSRDV VICPDASLED
AKKQGPYDVV VLPGGNLGAQ NLSESAAVKE ILKEQEKRKG LIAAICAGPT ALLAHEIGFG
SKVTTHPQAK DKIMNGSHYS YSENRVEKDG LILTSRGPGT SFEFALAIVE ALSGKEVADQ
VKAPLVLKD


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