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Penicillin G acylase (EC 3.5.1.11) (Penicillin G amidase) (Penicillin G amidohydrolase) [Cleaved into: Penicillin G acylase subunit alpha; Penicillin G acylase subunit beta]

 PAC_ARTVI               Reviewed;         802 AA.
P31956;
01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
01-JUL-1993, sequence version 1.
28-FEB-2018, entry version 92.
RecName: Full=Penicillin G acylase;
EC=3.5.1.11;
AltName: Full=Penicillin G amidase;
AltName: Full=Penicillin G amidohydrolase;
Contains:
RecName: Full=Penicillin G acylase subunit alpha;
Contains:
RecName: Full=Penicillin G acylase subunit beta;
Flags: Precursor;
Name=pac; Synonyms=pa;
Arthrobacter viscosus.
Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
Rhizobiaceae; Rhizobium/Agrobacterium group; Rhizobium.
NCBI_TaxID=1673;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 15294 / DSM 20159 / IFO 13497 / LMG 16186 / NCIMB 10268;
PubMed=8200542; DOI=10.1016/0378-1119(94)90608-4;
Konstantinovic M., Marjanovic N., Ljubijankic G., Glisin V.;
"The penicillin amidase of Arthrobacter viscosus (ATCC 15294).";
Gene 143:79-83(1994).
[2]
PROTEIN SEQUENCE OF 27-67 AND 266-303.
STRAIN=ATCC 15294 / DSM 20159 / IFO 13497 / LMG 16186 / NCIMB 10268;
PubMed=3214149;
Ohashi H., Katsuta Y., Hashizume T., Abe S.N., Kajiura H., Hattori H.,
Kamei T., Yano M.;
"Molecular cloning of the penicillin G acylase gene from Arthrobacter
viscosus.";
Appl. Environ. Microbiol. 54:2603-2607(1988).
-!- CATALYTIC ACTIVITY: Penicillin + H(2)O = a carboxylate + 6-
aminopenicillanate.
-!- COFACTOR:
Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000305};
Note=Binds 1 Ca(2+) ion per subunit. {ECO:0000305};
-!- SUBUNIT: Heterodimer of an alpha subunit and a beta subunit
processed from the same precursor. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
-!- SIMILARITY: Belongs to the peptidase S45 family. {ECO:0000305}.
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EMBL; L04471; AAA22077.1; -; Genomic_DNA.
PIR; I39665; I39665.
ProteinModelPortal; P31956; -.
SMR; P31956; -.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0008953; F:penicillin amidase activity; IEA:UniProtKB-EC.
GO; GO:0017000; P:antibiotic biosynthetic process; IEA:InterPro.
GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
CDD; cd03748; Ntn_PGA; 1.
Gene3D; 1.10.439.10; -; 1.
Gene3D; 3.60.20.10; -; 3.
InterPro; IPR029055; Ntn_hydrolases_N.
InterPro; IPR014395; Pen/GL7ACA/AHL_acylase.
InterPro; IPR023343; Penicillin_amidase_dom1.
InterPro; IPR033813; PGA_C.
InterPro; IPR002692; S45.
PANTHER; PTHR34218; PTHR34218; 1.
Pfam; PF01804; Penicil_amidase; 1.
PIRSF; PIRSF001227; Pen_acylase; 1.
SUPFAM; SSF56235; SSF56235; 2.
1: Evidence at protein level;
Antibiotic resistance; Calcium; Direct protein sequencing; Hydrolase;
Metal-binding; Secreted; Signal; Zymogen.
SIGNAL 1 26 {ECO:0000269|PubMed:3214149}.
CHAIN 27 802 Penicillin G acylase.
/FTId=PRO_0000027337.
CHAIN 27 234 Penicillin G acylase subunit alpha.
/FTId=PRO_0000027338.
PROPEP 235 265 Spacer peptide.
{ECO:0000269|PubMed:3214149}.
/FTId=PRO_0000027339.
CHAIN 266 802 Penicillin G acylase subunit beta.
/FTId=PRO_0000027340.
ACT_SITE 266 266 Nucleophile. {ECO:0000250}.
METAL 177 177 Calcium. {ECO:0000255}.
METAL 341 341 Calcium. {ECO:0000255}.
SEQUENCE 802 AA; 92113 MW; 9863E58C526C85D7 CRC64;
MKMKWLISVI ILFVFIFPQN LVFAGEDKNE GVKVVRDNFG VPHLYAKNKK DLYEAYGYVM
AKDRLFQLEM FRRGNEGTVS EIFGEDYLSK DEQSRRDGYS NKEIKKMIDG LDRQPRELIA
KFAEGISRYV NEALKDPDDK LSKEFHEYQF LPQKWTSTDV VRVYMVSMTY LWIITRELKN
AEILAKLEHE YGTEVSRKMF DDLVWKNDPS APTSIVSEGK PKRESSSQSL QKLSSAVIKA
SEKVGKEREN FVQSSEELGL PLKIGSNAAI VGSEKSATGN ALLFSGPQVG FVAPGFLYEV
GLHAPGFDME GSGFIGYPFI MFGANNHFAL SATAGYGNVT DIFEEKLNTK NSSQYLYKGK
WRDMEKRKES FTVKGDNGEK KTVEKIYYRT VHGPVISRDE TNKVAYSKYV SFRGTEAQSM
SAYMKANWAK NLKEFENAAS EYTMSLNWYY ADKKGDIAYY HVGRYPVRNN KIDERIPTPG
TGEYEWKGFI PFKENPHVIN PKNGYVVNWN NKPSKEWVNG EYSYYWGEDN RVQQYINGME
ARGKVTLEDI NEINYTASFA QLRANLFKPL LIDVLDKNKS TNGNYTYLIE KLEEWNNLKE
DENKDGYYDA GIAAFFDEWW NNLHDKLFMD ELGDFYGITK EITDHRYGAS LAYKNISKES
TNYKWVNVDQ EKIIMESTNE VLAKLQSEKG LKAEKWRMPI KTMTFGEKSL IGIPHGYGSM
TPIIEMNRGS ENHYIEMTPK GPSGFNITPP GQIGFVKKDG TISDHYDDQL VMFAEWKFKP
YLFNKKDIYK AATNVSALNM SK


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