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Penicillin G acylase (EC 3.5.1.11) (Penicillin G amidase) (Penicillin G amidohydrolase) [Cleaved into: Penicillin G acylase subunit alpha; Penicillin G acylase subunit beta]

 PAC_BACME               Reviewed;         802 AA.
Q60136; Q9S463;
18-OCT-2001, integrated into UniProtKB/Swiss-Prot.
01-NOV-1996, sequence version 1.
28-FEB-2018, entry version 93.
RecName: Full=Penicillin G acylase;
EC=3.5.1.11;
AltName: Full=Penicillin G amidase;
AltName: Full=Penicillin G amidohydrolase;
Contains:
RecName: Full=Penicillin G acylase subunit alpha;
Contains:
RecName: Full=Penicillin G acylase subunit beta;
Flags: Precursor;
Name=pac; Synonyms=pga;
Bacillus megaterium.
Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
NCBI_TaxID=1404;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 14945 / NBRC 13498 / 3781;
Kang J.H., Kim S.J., Park Y.C., Hwang Y., Yoo O.J., Kim Y.C.;
"Nucleotide sequence of the penicillin G acylase gene from Bacillus
megaterium and characteristics of the enzyme.";
Misainmurhag Hoiji 32:215-221(1994).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 14945 / NBRC 13498 / 3781;
PubMed=7875576; DOI=10.1111/j.1574-6968.1995.tb07370.x;
Martin L.M., Prieto A.M., Cortes E., Garcia J.L.;
"Cloning and sequencing of the pac gene encoding the penicillin G
acylase of Bacillus megaterium ATCC 14945.";
FEMS Microbiol. Lett. 125:287-292(1995).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=CA4098;
PubMed=12114980;
Yang S., Huang Y.H., Huang X.D., Li S.Y., Yuan Z.Y.;
"High expression of penicillin G acylase gene from Bacillus megaterium
in Bacillus subtilis.";
Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 31:601-603(1999).
-!- CATALYTIC ACTIVITY: Penicillin + H(2)O = a carboxylate + 6-
aminopenicillanate.
-!- COFACTOR:
Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000305};
Note=Binds 1 Ca(2+) ion per subunit. {ECO:0000305};
-!- SUBUNIT: Heterodimer of an alpha subunit and a beta subunit
processed from the same precursor. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
-!- SIMILARITY: Belongs to the peptidase S45 family. {ECO:0000305}.
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EMBL; U07682; AAB41343.1; -; Unassigned_DNA.
EMBL; Z37542; CAA85774.1; -; Genomic_DNA.
EMBL; AF161313; AAD45609.1; -; Genomic_DNA.
PIR; S49252; S49252.
ProteinModelPortal; Q60136; -.
SMR; Q60136; -.
PRIDE; Q60136; -.
BRENDA; 3.5.1.11; 656.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0008953; F:penicillin amidase activity; IEA:UniProtKB-EC.
GO; GO:0017000; P:antibiotic biosynthetic process; IEA:InterPro.
GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
CDD; cd03748; Ntn_PGA; 1.
Gene3D; 1.10.439.10; -; 1.
Gene3D; 3.60.20.10; -; 3.
InterPro; IPR029055; Ntn_hydrolases_N.
InterPro; IPR014395; Pen/GL7ACA/AHL_acylase.
InterPro; IPR023343; Penicillin_amidase_dom1.
InterPro; IPR033813; PGA_C.
InterPro; IPR002692; S45.
PANTHER; PTHR34218; PTHR34218; 1.
Pfam; PF01804; Penicil_amidase; 1.
PIRSF; PIRSF001227; Pen_acylase; 1.
SUPFAM; SSF56235; SSF56235; 2.
3: Inferred from homology;
Antibiotic resistance; Calcium; Hydrolase; Metal-binding; Secreted;
Signal; Zymogen.
SIGNAL 1 24 {ECO:0000255}.
CHAIN 25 802 Penicillin G acylase.
/FTId=PRO_0000027341.
CHAIN 25 234 Penicillin G acylase subunit alpha.
/FTId=PRO_0000027342.
PROPEP 235 265 Spacer peptide.
/FTId=PRO_0000027343.
CHAIN 266 802 Penicillin G acylase subunit beta.
/FTId=PRO_0000027344.
ACT_SITE 266 266 Nucleophile. {ECO:0000250}.
METAL 177 177 Calcium. {ECO:0000255}.
METAL 341 341 Calcium. {ECO:0000255}.
VARIANT 3 3 T -> M (in strain: CA4098).
VARIANT 224 224 D -> E (in strain: CA4098).
VARIANT 232 232 I -> K (in strain: CA4098).
VARIANT 254 254 T -> S (in strain: CA4098).
VARIANT 349 349 A -> T (in strain: CA4098).
VARIANT 470 470 S -> N (in strain: CA4098).
VARIANT 524 524 F -> Y (in strain: CA4098).
VARIANT 569 569 Q -> P (in strain: CA4098).
VARIANT 586 586 I -> A (in strain: CA4098).
VARIANT 657 657 N -> S (in strain: CA4098).
VARIANT 740 740 T -> K (in strain: CA4098).
VARIANT 789 791 NKA -> YKS (in strain: CA4098).
SEQUENCE 802 AA; 91988 MW; 877CA0564E50DFBD CRC64;
MKTKWLISVI ILFVFIFPQN LVFAGEDKNE GVKVVRDNFG VPHLYAKNKK DLYEAYGYVM
AKDRLFQLEM FRRGNEGTVS EIFGEDYLSK DEQSRRDGYS NKEIKKMIDG LDRQPKELIA
KFAEGISRYV NEALKDPDDK LSKEFHEYQF LPQKWTSTDV VRVYMVSMTY FMDNHQELKN
AEILAKLEHE YGTEVSRKMF DDLVWKNDPS APTSIVSEGK PKRDSSSQSL QILSSAVIKA
SEKVGKEREN FVQTSEELGL PLKIGSNAAI VGSEKSATGN ALLFSGPQVG FVAPGFLYEV
GLHAPGFDME GSGFIGYPFI MFGANNHFAL SATAGYGNVT DIFEEKLNAK NSSQYLYKGK
WRDMEKRKES FTVKGDNGEK KTVEKIYYRT VHGPVISRDE TNKVAYSKSW SFRGTEAQSM
SAYMKANWAK NLKEFENAAS EYTMSLNWYY ADKKGDIAYY HVGRYPVRNS KIDERIPTPG
TGEYEWKGFI PFKENPHVIN PKNGYVVNWN NKPSKEWVNG EYSFYWGEDN RVQQYINGME
ARGKVTLEDI NEINYTASFA QLRANLFKQL LIDVLDKNKS TNGNYIYLIE KLEEWNNLKE
DENKDGYYDA GIAAFFDEWW NNLHDKLFMD ELGDFYGITK EITDHRYGAS LAYKILNKES
TNYKWVNVDQ EKIIMESTNE VLAKLQSEKG LKAEKWRMPI KTMTFGEKSL IGIPHGYGSM
TPIIEMNRGS ENHYIEMTPT GPSGFNITPP GQIGFVKKDG TISDHYDDQL VMFAEWKFKP
YLFNKKDINK AAKNVSALNM SK


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