Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Penicillin-binding protein 1A (PBP-1a) (PBP1a) [Includes: Penicillin-insensitive transglycosylase (EC 2.4.1.129) (Peptidoglycan TGase); Penicillin-sensitive transpeptidase (EC 3.4.16.4) (DD-transpeptidase)]

 PBPA_VIBCH              Reviewed;         825 AA.
Q9KNU5;
20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
20-JUN-2001, sequence version 2.
22-NOV-2017, entry version 126.
RecName: Full=Penicillin-binding protein 1A;
Short=PBP-1a;
Short=PBP1a;
Includes:
RecName: Full=Penicillin-insensitive transglycosylase;
EC=2.4.1.129 {ECO:0000250|UniProtKB:P02918};
AltName: Full=Peptidoglycan TGase;
Includes:
RecName: Full=Penicillin-sensitive transpeptidase;
EC=3.4.16.4 {ECO:0000250|UniProtKB:P02918};
AltName: Full=DD-transpeptidase;
Name=mrcA; Synonyms=ponA; OrderedLocusNames=VC_2635;
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961).
Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales;
Vibrionaceae; Vibrio.
NCBI_TaxID=243277;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 39315 / El Tor Inaba N16961;
PubMed=10952301; DOI=10.1038/35020000;
Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L.,
Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A.,
Gill S.R., Nelson K.E., Read T.D., Tettelin H., Richardson D.L.,
Ermolaeva M.D., Vamathevan J.J., Bass S., Qin H., Dragoi I.,
Sellers P., McDonald L.A., Utterback T.R., Fleischmann R.D.,
Nierman W.C., White O., Salzberg S.L., Smith H.O., Colwell R.R.,
Mekalanos J.J., Venter J.C., Fraser C.M.;
"DNA sequence of both chromosomes of the cholera pathogen Vibrio
cholerae.";
Nature 406:477-483(2000).
-!- FUNCTION: Cell wall formation. Synthesis of cross-linked
peptidoglycan from the lipid intermediates. The enzyme has a
penicillin-insensitive transglycosylase N-terminal domain
(formation of linear glycan strands) and a penicillin-sensitive
transpeptidase C-terminal domain (cross-linking of the peptide
subunits). {ECO:0000250}.
-!- CATALYTIC ACTIVITY: (GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-
Lys-D-Ala-D-Ala))(n)-diphosphoundecaprenol + GlcNAc-(1->4)-
Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-
diphosphoundecaprenol = (GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-
Glu-L-Lys-D-Ala-D-Ala))(n+1)-diphosphoundecaprenol + undecaprenyl
diphosphate. {ECO:0000250|UniProtKB:P02918}.
-!- CATALYTIC ACTIVITY: Preferential cleavage: (Ac)(2)-L-Lys-D-Ala-|-
D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are
N-acyl substituents of D-alanine. {ECO:0000250|UniProtKB:P02918}.
-!- PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis.
-!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Single-
pass type II membrane protein {ECO:0000250}.
-!- SIMILARITY: In the N-terminal section; belongs to the
glycosyltransferase 51 family. {ECO:0000305}.
-!- SIMILARITY: In the C-terminal section; belongs to the
transpeptidase family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAF95776.1; Type=Erroneous initiation; Evidence={ECO:0000305};
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; AE003852; AAF95776.1; ALT_INIT; Genomic_DNA.
PIR; B82051; B82051.
RefSeq; NP_232263.1; NC_002505.1.
ProteinModelPortal; Q9KNU5; -.
SMR; Q9KNU5; -.
STRING; 243277.VC2635; -.
CAZy; GT51; Glycosyltransferase Family 51.
DNASU; 2615652; -.
EnsemblBacteria; AAF95776; AAF95776; VC_2635.
GeneID; 2615652; -.
KEGG; vch:VC2635; -.
PATRIC; fig|243277.26.peg.2513; -.
eggNOG; ENOG4108JQC; Bacteria.
eggNOG; COG5009; LUCA.
KO; K05366; -.
OMA; LAQMAMI; -.
UniPathway; UPA00219; -.
Proteomes; UP000000584; Chromosome 1.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0003824; F:catalytic activity; ISS:TIGR.
GO; GO:0008658; F:penicillin binding; IEA:InterPro.
GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:UniProtKB-EC.
GO; GO:0009002; F:serine-type D-Ala-D-Ala carboxypeptidase activity; IEA:UniProtKB-EC.
GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
GO; GO:0009252; P:peptidoglycan biosynthetic process; ISS:TIGR.
GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
Gene3D; 1.10.3810.10; -; 1.
InterPro; IPR012338; Beta-lactam/transpept-like.
InterPro; IPR001264; Glyco_trans_51.
InterPro; IPR023346; Lysozyme-like_dom_sf.
InterPro; IPR036950; PBP_transglycosylase.
InterPro; IPR031376; PCB_OB.
InterPro; IPR001460; PCN-bd_Tpept.
Pfam; PF17092; PCB_OB; 1.
Pfam; PF00912; Transgly; 1.
Pfam; PF00905; Transpeptidase; 1.
SUPFAM; SSF53955; SSF53955; 1.
SUPFAM; SSF56601; SSF56601; 3.
3: Inferred from homology;
Antibiotic resistance; Carboxypeptidase; Cell inner membrane;
Cell membrane; Cell shape; Cell wall biogenesis/degradation;
Complete proteome; Glycosyltransferase; Hydrolase; Membrane;
Multifunctional enzyme; Peptidoglycan synthesis; Protease;
Reference proteome; Signal-anchor; Transferase; Transmembrane;
Transmembrane helix.
CHAIN 1 825 Penicillin-binding protein 1A.
/FTId=PRO_0000083175.
TOPO_DOM 1 6 Cytoplasmic. {ECO:0000255}.
TRANSMEM 7 27 Helical; Signal-anchor for type II
membrane protein. {ECO:0000255}.
TOPO_DOM 28 825 Periplasmic. {ECO:0000255}.
REGION 48 216 Transglycosylase.
REGION 413 752 Transpeptidase.
ACT_SITE 86 86 Proton donor; for transglycosylase
activity. {ECO:0000250|UniProtKB:P02919}.
ACT_SITE 471 471 Acyl-ester intermediate; for
transpeptidase activity.
{ECO:0000250|UniProtKB:P02919}.
SEQUENCE 825 AA; 91987 MW; 8A9553DA2650B9D2 CRC64;
MKFIKRLLVF SLICIILGVT TIFGFYFYVK SDLPDVATLR DVQLQTPMQV FSQDGKLIAQ
FGEKRRIPLK LEEMPKELIE AVIATEDSRY YEHYGFDPIG ITRAAFAVLA SGSASQGAST
ITQQLARNFF LSNEKKVMRK VKEIFIAIHI EQLLSKQEIL ELYLNKIYLG YRSYGVGAAA
QAYFGKEVKD LTLGEIALIA GLPKAPSTMN PIYSVERATN RRNVVLQRML DEKYITKAEY
DAARAEPVLP KYHGAEIELN APYVAEIARA WMVERYGEEA AYTSGMNVYT TVDSKLQRAA
NQAAINNLLA YDERHGYRGA EKELWQVNQP AWSSTQLSEY LSNEPTYGDM FPAAVLSVEE
KSAQVWVKSY GVQTIAWEDM NWARRFINDD RQGPLPKSAN EFLAAGQQIW VRPRTQDGAI
TAWKLTQVPN ANTAFVAMNP ENGAVTALVG GFNFVHNKFN RATQSVRQVG SSIKPFIYSA
ALNKGLTLAT LINDAPINQW DESQGTAWRP KNSPPTYTGP TRLRIGLAQS KNVMAVRVLR
EVGLDETREY LTRFGFKLDQ LPRSETIALG AGSLTPVQMA QGFSVFANNG YFVEPFYISR
VENPFGNIEF SAEPKVVCHR ECSSELDEFA EQDAASPYAP KVISEQNAFL TREMLYSNIW
GGGEWSSDTG WNGTGWRAQA LKRRDIGGKT GTTNDSKDAW YNGYAPGIVG VAWVGFDDHS
RNLGKTAPNR NIEDDVSGAE SGGKTALPAW VEFMSLALQD VPVQQKAVPN NIARVRIDRD
TGLLTNKLDS SSMFEYFEAG TEPTEYVSEH VNESIYSTSS GEELF


Related products :

Catalog number Product name Quantity
AS11 1717 Antibody: Penicillin G, Total IgG (0.5mg), Immunogen: penicillin G , Host: rabbit , polyclonal, Confirmed reactivity: penicillin G (100 percent ), penicillin acid (90 percent ), cloxacillin (110 0.5 mg
AS11 1657 Antibody: Penicillin G, Total IgG (2.5mg), Immunogen: penicillin G , Host: rabbit , polyclonal, Confirmed reactivity: penicillin G (100 percent ), penicillin acid (90 percent ), cloxacillin (110 2.5 mg
AS11 1731 Antibody: Penicillin G, Serum (1ml), Immunogen: penicillin G , Host: rabbit , polyclonal, Confirmed reactivity: penicillin G (100 percent ), penicillin acid (90 percent ), cloxacillin (110 percen 1 ml
AS11 1642 Antibody: Penicillin G, Serum (0.1ml), Immunogen: penicillin G, Host: rabbit, polyclonal, Confirmed reactivity: penicillin G (100 percent ), penicillin acid (90 percent ), cloxacillin (110 percent ), 0.1 ml
AS11 1646 Antibody: Penicillin V, Total IgG (1 mg), Immunogen: penicillin V , Host: rabbit , polyclonal, Confirmed reactivity: penicillin V (100 percent ), cloxacillin (90 percent ), dicloxacillin (80 percen 1 mg
AS11 1751 Antibody: Penicillin V (0.2 mg total IgG), Immunogen: penicillin V , Host: rabbit , polyclonal, Confirmed reactivity: penicillin V (100 percent ), cloxacillin (90 percent ), dicloxacillin (80 perce 2.5 mg
AS11 1657 Antibody: Penicillin G, Total IgG (2.5mg) , Host: rabbit , polyclonal, Comfirmed reactivity: penicillin G (100 percent ), penicillin acid (90 percent ), cloxacillin (110 percent ), dicloxacillin (70 2.5 mg
AS11 1661 Antibody: Penicillin V, Serum (0.1 ml), Immunogen: penicillin V , Host: rabbit , polyclonal, Confirmed reactivity: penicillin V (100 percent ), cloxacillin (90 percent ), dicloxacillin (80 percent 0.1 ml
AS11 1661 Antibody: Penicillin V, Serum (0.1 ml) , Host: rabbit , polyclonal, Comfirmed reactivity: penicillin V (100 percent ), cloxacillin (90 percent ), dicloxacillin (80 percent ), penicillin G (20 percen 0.1 ml
AS11 1694 Antibody: Penicillin V, Serum (1 ml), Immunogen: penicillin V , Host: rabbit , polyclonal, Confirmed reactivity: penicillin V (100 percent ), cloxacillin (90 percent ), dicloxacillin (80 percent ), 1 ml
AS11 1751 Antibody: Penicillin V (0.2 mg total IgG) , Host: rabbit , polyclonal, Comfirmed reactivity: penicillin V (100 percent ), cloxacillin (90 percent ), dicloxacillin (80 percent ), penicillin G (20 per 2.5 mg
AS11 1642 Antibody: Penicillin G, Serum (0.1ml) , Host: rabbit, polyclonal, Comfirmed reactivity: penicillin G (100 percent ), penicillin acid (90 percent ), cloxacillin (110 percent ), dicloxacillin (70 percen 0.1 ml
AS11 1731 Antibody: Penicillin G, Serum (1ml) , Host: rabbit , polyclonal, Comfirmed reactivity: penicillin G (100 percent ), penicillin acid (90 percent ), cloxacillin (110 percent ), dicloxacillin (70 perce 1 ml
AE81025PE Penicillin G (benzyl penicillin) ELISA Kit 96T
69-57-8 Penicillin Series (Penicillin G Procaine_P - 1g
7219-9959 MOUSE ANTI PENICILLIN, Product Type Monoclonal Antibody, Specificity PENICILLIN, Target Species Fungal, Host Mouse, Format Purified, Isotypes IgG1, Applications E, Clone Pen_9 0.2 mg
SCH-7219-9959 MOUSE ANTI PENICILLIN, Product Type Monoclonal Antibody, Specificity PENICILLIN, Target Species Fungal, Host Mouse, Format Purified, Isotypes IgG1, Applications E, Clone Pen_9 0.2 mg
SCH-7220-0004 SHEEP ANTI PENICILLIN, Product Type Polyclonal Antibody, Specificity PENICILLIN, Target Species Fungal, Host Sheep, Format Serum, Isotypes Polyclonal IgG, Applications E, R, Clone 0.2 ml
7220-0004 SHEEP ANTI PENICILLIN, Product Type Polyclonal Antibody, Specificity PENICILLIN, Target Species Fungal, Host Sheep, Format Serum, Isotypes Polyclonal IgG, Applications E, R, Clone 0.2 ml
Mab-00819 Penicillin, Penicillin
Mab-00818 Penicillin, Penicillin
1406-05-9 Penicillin Penicillin 1g
orb62246 procaine penicillin procaine penicillin For research use only. 500 g
30034-13-0 Penicillin G sulfoxide p-methoxybenzyl e Penicillin G sulfoxide p- 1g
B280 PM Indicator Agar (Penicillin In Milk Indicator Agar) USE : For rapid detection of trace amounts of Penicillin in milk as per AOAC. 5x500gm


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur