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Penicillin-binding protein 2B

 PBP2_STRPN              Reviewed;         680 AA.
P0A3M5; P10524;
15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
15-MAR-2005, sequence version 1.
25-OCT-2017, entry version 83.
RecName: Full=Penicillin-binding protein 2B;
Name=penA; Synonyms=pbp2b; OrderedLocusNames=SP_1673;
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4).
Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
Streptococcus.
NCBI_TaxID=170187;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC BAA-334 / TIGR4;
PubMed=11463916; DOI=10.1126/science.1061217;
Tettelin H., Nelson K.E., Paulsen I.T., Eisen J.A., Read T.D.,
Peterson S.N., Heidelberg J.F., DeBoy R.T., Haft D.H., Dodson R.J.,
Durkin A.S., Gwinn M.L., Kolonay J.F., Nelson W.C., Peterson J.D.,
Umayam L.A., White O., Salzberg S.L., Lewis M.R., Radune D.,
Holtzapple E.K., Khouri H.M., Wolf A.M., Utterback T.R., Hansen C.L.,
McDonald L.A., Feldblyum T.V., Angiuoli S.V., Dickinson T.,
Hickey E.K., Holt I.E., Loftus B.J., Yang F., Smith H.O., Venter J.C.,
Dougherty B.A., Morrison D.A., Hollingshead S.K., Fraser C.M.;
"Complete genome sequence of a virulent isolate of Streptococcus
pneumoniae.";
Science 293:498-506(2001).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 195-680.
STRAIN=64147;
PubMed=2654541; DOI=10.1111/j.1365-2958.1989.tb00108.x;
Dowson C.G., Hutchison A., Spratt B.G.;
"Extensive re-modelling of the transpeptidase domain of penicillin-
binding protein 2B of a penicillin-resistant South African isolate of
Streptococcus pneumoniae.";
Mol. Microbiol. 3:95-102(1989).
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass
membrane protein {ECO:0000250}.
-!- SIMILARITY: Belongs to the transpeptidase family. {ECO:0000305}.
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EMBL; AE005672; AAK75752.1; -; Genomic_DNA.
EMBL; X13136; CAA31526.1; -; Genomic_DNA.
PIR; B35965; B35965.
PIR; G95194; G95194.
ProteinModelPortal; P0A3M5; -.
SMR; P0A3M5; -.
ChEMBL; CHEMBL1255133; -.
DrugBank; DB01150; Cefprozil.
DrugBank; DB01147; Cloxacillin.
DrugBank; DB05659; faropenem medoxomil.
EnsemblBacteria; AAK75752; AAK75752; SP_1673.
KEGG; spn:SP_1673; -.
eggNOG; ENOG4107RF6; Bacteria.
eggNOG; COG0768; LUCA.
HOGENOM; HOG000013470; -.
KO; K00687; -.
OMA; SCDTYYY; -.
BRENDA; 2.4.1.129; 1960.
PRO; PR:P0A3M5; -.
Proteomes; UP000000585; Chromosome.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0008658; F:penicillin binding; IEA:InterPro.
GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:UniProtKB-KW.
GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
InterPro; IPR012338; Beta-lactam/transpept-like.
InterPro; IPR005311; PBP_dimer.
InterPro; IPR036138; PBP_dimer_sf.
InterPro; IPR001460; PCN-bd_Tpept.
Pfam; PF03717; PBP_dimer; 1.
Pfam; PF00905; Transpeptidase; 1.
SUPFAM; SSF56519; SSF56519; 2.
SUPFAM; SSF56601; SSF56601; 1.
3: Inferred from homology;
Antibiotic resistance; Cell membrane; Cell shape;
Cell wall biogenesis/degradation; Complete proteome; Membrane;
Peptidoglycan synthesis; Transmembrane; Transmembrane helix.
CHAIN 1 680 Penicillin-binding protein 2B.
/FTId=PRO_0000195455.
TRANSMEM 9 29 Helical. {ECO:0000255}.
ACT_SITE 386 386 Acyl-ester intermediate.
{ECO:0000250|UniProtKB:P0AD65}.
VARIANT 333 333 E -> G (in strain: 64147).
VARIANT 426 432 TQAYGSF -> PAFSRPM (in strain: 64147).
VARIANT 446 446 T -> A (in strain: 64147).
VARIANT 476 476 E -> G (in strain: 64147).
VARIANT 489 489 T -> S (in strain: 64147).
VARIANT 512 512 Y -> F (in strain: 64147).
VARIANT 538 538 N -> D (in strain: 64147).
VARIANT 597 597 G -> E (in strain: 64147).
VARIANT 674 676 QKY -> NQH (in strain: 64147).
SEQUENCE 680 AA; 73873 MW; 56BF2C1AA9B54C3B CRC64;
MRKFNSHSIP IRLNLLFSIV ILLFMTIIGR LLYMQVLNKD FYEKKLASAS QTKITSSSAR
GEIYDASGKP LVENTLKQVV SFTRSNKMTA TDLKETAKKL LTYVSISSPN LTERQLADYY
LADPEIYKKI VEALPSEKRL DSDGNRLSES ELYNNAVDSV QTSQLNYTED EKKEIYLFSQ
LNAVGNFATG TIATDPLNDS QVAVIASISK EMPGISISTS WDRKVLETSL SSIVGSVSSE
KAGLPAEEAE AYLKKGYSLN DRVGTSYLEK QYEETLQGKR SVKEIHLDKY GNMESVDTIE
EGSKGNNIKL TIDLAFQDSV DALLKSYFNS ELENGGAKYS EGVYAVALNP KTGAVLSMSG
IKHDLKTGEL TPDSLGTVTN VFVPGSVVKA ATISSGWENG VLSGNQTLTD QSIVFQGSAP
INSWYTQAYG SFPITAVQAL EYSSNTYMVQ TALGLMGQTY QPNMFVGTSN LESAMEKLRS
TFGEYGLGTA TGIDLPDEST GFVPKEYSFA NYITNAFGQF DNYTPMQLAQ YVATIANNGV
RVAPRIVEGI YGNNDKGGLG DLIQQLQPTE MNKVNISDSD MSILHQGFYQ VAHGTSGLTT
GRAFSNGALV SISGKTGTAE SYVADGQQAT NTNAVAYAPS DNPQIAVAVV FPHNTNLTNG
VGPSIARDII NLYQKYHPMN


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