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Peptidoglycan-recognition protein SB2 (EC 3.5.1.28)

 PGSB2_DROME             Reviewed;         182 AA.
Q9VV96; Q70PX1; Q70PX3; Q70PX5;
10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
01-MAY-2000, sequence version 1.
30-AUG-2017, entry version 116.
RecName: Full=Peptidoglycan-recognition protein SB2;
EC=3.5.1.28;
Flags: Precursor;
Name=PGRP-SB2; ORFNames=CG9697;
Drosophila melanogaster (Fruit fly).
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
Ephydroidea; Drosophilidae; Drosophila; Sophophora.
NCBI_TaxID=7227;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=DI7, Draveil, KY024, KY038, Loua, Monty5, P.bourg, S30, Tahiti,
Texas, and ZW141;
PubMed=14738318; DOI=10.1007/s00239-003-2506-6;
Jiggins F.M., Hurst G.D.D.;
"The evolution of parasite recognition genes in the innate immune
system: purifying selection on Drosophila melanogaster peptidoglycan
recognition proteins.";
J. Mol. Evol. 57:598-605(2003).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley;
PubMed=10731132; DOI=10.1126/science.287.5461.2185;
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D.,
Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G.,
Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D.,
Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J.,
Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C.,
Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z.,
Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X.,
Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H.,
Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A.,
Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X.,
Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
"The genome sequence of Drosophila melanogaster.";
Science 287:2185-2195(2000).
[3]
GENOME REANNOTATION.
STRAIN=Berkeley;
PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
Lewis S.E.;
"Annotation of the Drosophila melanogaster euchromatic genome: a
systematic review.";
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
[4]
IDENTIFICATION, AND DEVELOPMENTAL STAGE.
PubMed=11106397; DOI=10.1073/pnas.97.25.13772;
Werner T., Liu G., Kang D., Ekengren S., Steiner H., Hultmark D.;
"A family of peptidoglycan recognition proteins in the fruit fly
Drosophila melanogaster.";
Proc. Natl. Acad. Sci. U.S.A. 97:13772-13777(2000).
-!- FUNCTION: N-acetylmuramyl-L-alanine amidase involved in innate
immunity by degrading bacterial peptidoglycans (PGN). Probably
plays a scavenger role by digesting biologically active PGN into
biologically inactive fragments. Has no direct bacteriolytic
activity (By similarity). {ECO:0000250}.
-!- CATALYTIC ACTIVITY: Hydrolyzes the link between N-acetylmuramoyl
residues and L-amino acid residues in certain cell-wall
glycopeptides.
-!- COFACTOR:
Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
Evidence={ECO:0000250|UniProtKB:Q8INK6};
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
-!- DEVELOPMENTAL STAGE: Not expressed in adults.
{ECO:0000269|PubMed:11106397}.
-!- SIMILARITY: Belongs to the N-acetylmuramoyl-L-alanine amidase 2
family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; AJ556575; CAD89140.1; -; Genomic_DNA.
EMBL; AJ556576; CAD89141.1; -; Genomic_DNA.
EMBL; AJ556577; CAD89142.1; -; Genomic_DNA.
EMBL; AJ556578; CAD89143.1; -; Genomic_DNA.
EMBL; AJ556579; CAD89144.1; -; Genomic_DNA.
EMBL; AJ556580; CAD89145.1; -; Genomic_DNA.
EMBL; AJ556581; CAD89146.1; -; Genomic_DNA.
EMBL; AJ556582; CAD89147.1; -; Genomic_DNA.
EMBL; AJ556583; CAD89148.1; -; Genomic_DNA.
EMBL; AJ556584; CAD89149.1; -; Genomic_DNA.
EMBL; AJ556585; CAD89150.1; -; Genomic_DNA.
EMBL; AE014296; AAF49421.1; -; Genomic_DNA.
RefSeq; NP_648916.1; NM_140659.3.
UniGene; Dm.24013; -.
ProteinModelPortal; Q9VV96; -.
SMR; Q9VV96; -.
STRING; 7227.FBpp0305802; -.
PaxDb; Q9VV96; -.
PRIDE; Q9VV96; -.
EnsemblMetazoa; FBtr0075320; FBpp0075079; FBgn0043577.
GeneID; 39869; -.
KEGG; dme:Dmel_CG9697; -.
UCSC; CG9697-RA; d. melanogaster.
CTD; 39869; -.
FlyBase; FBgn0043577; PGRP-SB2.
GeneTree; ENSGT00390000016833; -.
InParanoid; Q9VV96; -.
KO; K01446; -.
OrthoDB; EOG091G0O6Z; -.
PhylomeDB; Q9VV96; -.
GenomeRNAi; 39869; -.
PRO; PR:Q9VV96; -.
Proteomes; UP000000803; Chromosome 3L.
Bgee; FBgn0043577; -.
ExpressionAtlas; Q9VV96; differential.
Genevisible; Q9VV96; DM.
GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
GO; GO:0008745; F:N-acetylmuramoyl-L-alanine amidase activity; ISS:FlyBase.
GO; GO:0042834; F:peptidoglycan binding; ISS:FlyBase.
GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
GO; GO:0006955; P:immune response; ISS:FlyBase.
GO; GO:0045087; P:innate immune response; NAS:UniProtKB.
GO; GO:0009253; P:peptidoglycan catabolic process; ISS:FlyBase.
CDD; cd06583; PGRP; 1.
Gene3D; 3.40.80.10; -; 1.
InterPro; IPR002502; Amidase_domain.
InterPro; IPR017331; Peptidoglycan_recognition.
InterPro; IPR015510; PGRP.
InterPro; IPR006619; PGRP_domain_met/bac.
PANTHER; PTHR11022; PTHR11022; 1.
Pfam; PF01510; Amidase_2; 1.
PIRSF; PIRSF037945; PGRPs; 1.
SMART; SM00644; Ami_2; 1.
SMART; SM00701; PGRP; 1.
SUPFAM; SSF55846; SSF55846; 1.
2: Evidence at transcript level;
Complete proteome; Disulfide bond; Glycoprotein; Hydrolase; Immunity;
Innate immunity; Metal-binding; Reference proteome; Secreted; Signal;
Zinc.
SIGNAL 1 17 {ECO:0000255}.
CHAIN 18 182 Peptidoglycan-recognition protein SB2.
/FTId=PRO_0000023908.
METAL 47 47 Zinc; via pros nitrogen.
{ECO:0000250|UniProtKB:Q8INK6}.
METAL 155 155 Zinc; via pros nitrogen.
{ECO:0000250|UniProtKB:Q8INK6}.
METAL 163 163 Zinc. {ECO:0000250|UniProtKB:Q8INK6}.
SITE 81 81 Important for catalytic activity;
essential for amidase activity and zinc
hydrate coordination.
{ECO:0000250|UniProtKB:P00806}.
CARBOHYD 149 149 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 54 60 {ECO:0000250|UniProtKB:Q8INK6}.
VARIANT 15 15 A -> V (in strain: ZW141).
VARIANT 51 51 T -> A (in strain: Loua).
VARIANT 62 62 L -> S (in strain: ZW141).
VARIANT 152 152 V -> L (in strain: Draveil, Loua, Monty5,
P.bourg, Tahiti, Texas and ZW141).
SEQUENCE 182 AA; 20459 MW; 99AC18AD426BC308 CRC64;
MKLQLALVLC GLTLALGQIV PRSSWCPVPI SPRMPRLMVP VRLIIIHHTV TAPCFNPHQC
QLVLRQIRAD HMRRKFRDIG YNFLIGGDGR IYEGLGFGIR GEHAPRYNSQ SIGIAFIGNF
QTGLPPSQML QAARTLIQIA VQRRQVSPNY SVVGHCQTKA TACPGIHLLN ELKKWPNWRP
KP


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