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Peripheral myelin protein 22 (PMP-22) (Protein CD25) (SR13 myelin protein) (Schwann cell membrane glycoprotein) (SAG)

 PMP22_RAT               Reviewed;         160 AA.
P25094;
01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
01-MAY-1992, sequence version 1.
23-MAY-2018, entry version 126.
RecName: Full=Peripheral myelin protein 22;
Short=PMP-22;
AltName: Full=Protein CD25;
AltName: Full=SR13 myelin protein;
AltName: Full=Schwann cell membrane glycoprotein;
Short=SAG;
Name=Pmp22; Synonyms=Cd25, Pmp-22;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Wistar; TISSUE=Sciatic nerve;
PubMed=1935894;
Spreyer P., Kuhn G., Hanemann C.O., Gillen C., Schaal H., Kuhn R.,
Lemke G., Mueller H.W.;
"Axon-regulated expression of a Schwann cell transcript that is
homologous to a 'growth arrest-specific' gene.";
EMBO J. 10:3661-3668(1991).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Sciatic nerve;
PubMed=1714591; DOI=10.1073/pnas.88.16.7195;
Welcher A.A., Suter U., de Leon M., Snipes G.J., Shooter E.M.;
"A myelin protein is encoded by the homologue of a growth arrest-
specific gene.";
Proc. Natl. Acad. Sci. U.S.A. 88:7195-7199(1991).
[3]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=1287719;
Welcher A.A., de Leon M., Suter U., Snipes G.J., Meakin S.O.,
Shooter E.M.;
"Isolation of transcriptionally regulated sequences associated with
neuronal and non-neuronal cell interactions.";
Prog. Brain Res. 94:163-176(1992).
[4]
PROTEIN SEQUENCE OF 1-30, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
PubMed=1376775;
Dieperink M.E., O'Neill A., Magnoni G., Wollmann R.L.,
Heinrikson R.L., Zucher-Neely H.A., Stefansson K.;
"SAG: a Schwann cell membrane glycoprotein.";
J. Neurosci. 12:2177-2185(1992).
-!- FUNCTION: Might be involved in growth regulation, and in
myelinization in the peripheral nervous system.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass
membrane protein {ECO:0000250}.
-!- TISSUE SPECIFICITY: Found exclusively in the peripheral nervous
system. Present in both myelinating and nonmyelinating Schwann
cells. Found in the tumors of Schwann cell lineage where axons are
present (neurofibromas) but not where axons are absent
(schwannomas). {ECO:0000269|PubMed:1376775}.
-!- DEVELOPMENTAL STAGE: Levels increase between embryonic day 21
(E21) and postnatal day 0 (PND0) and then gradually increase up to
PND15. There is a slight increase between PND15 and adulthood.
{ECO:0000269|PubMed:1376775}.
-!- INDUCTION: Strongly down-regulated in the initial phase after
sciatic nerve injury.
-!- SIMILARITY: Belongs to the PMP-22/EMP/MP20 family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; X62431; CAA44297.1; -; mRNA.
EMBL; M69139; AAA73063.1; -; mRNA.
EMBL; S55427; AAB25374.1; -; mRNA.
PIR; A41144; A41144.
RefSeq; NP_058733.1; NM_017037.1.
RefSeq; XP_006246646.1; XM_006246584.3.
UniGene; Rn.1476; -.
ProteinModelPortal; P25094; -.
STRING; 10116.ENSRNOP00000051201; -.
ChEMBL; CHEMBL2007624; -.
PaxDb; P25094; -.
Ensembl; ENSRNOT00000041606; ENSRNOP00000051201; ENSRNOG00000003338.
Ensembl; ENSRNOT00000081415; ENSRNOP00000069909; ENSRNOG00000003338.
GeneID; 24660; -.
KEGG; rno:24660; -.
UCSC; RGD:3359; rat.
CTD; 5376; -.
RGD; 3359; Pmp22.
eggNOG; ENOG410IWVJ; Eukaryota.
eggNOG; ENOG4111SX3; LUCA.
GeneTree; ENSGT00510000046328; -.
HOGENOM; HOG000059542; -.
HOVERGEN; HBG001690; -.
InParanoid; P25094; -.
KO; K19289; -.
OMA; RFYITGV; -.
OrthoDB; EOG091G0RF4; -.
PhylomeDB; P25094; -.
TreeFam; TF330414; -.
PRO; PR:P25094; -.
Proteomes; UP000002494; Chromosome 10.
Bgee; ENSRNOG00000003338; -.
Genevisible; P25094; RN.
GO; GO:0005923; C:bicellular tight junction; IDA:RGD.
GO; GO:0043218; C:compact myelin; IDA:RGD.
GO; GO:0016021; C:integral component of membrane; IDA:RGD.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0032060; P:bleb assembly; IEA:Ensembl.
GO; GO:0007050; P:cell cycle arrest; IEA:UniProtKB-KW.
GO; GO:0008219; P:cell death; IEA:Ensembl.
GO; GO:0030154; P:cell differentiation; IDA:RGD.
GO; GO:0042552; P:myelination; IDA:RGD.
GO; GO:0008285; P:negative regulation of cell proliferation; IDA:BHF-UCL.
GO; GO:0010977; P:negative regulation of neuron projection development; IDA:BHF-UCL.
GO; GO:0007422; P:peripheral nervous system development; IC:BHF-UCL.
InterPro; IPR003936; PMP22.
InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
InterPro; IPR004032; PMP22_EMP_MP20.
PANTHER; PTHR10671:SF7; PTHR10671:SF7; 1.
Pfam; PF00822; PMP22_Claudin; 1.
PRINTS; PR01453; EPMEMFAMILY.
PRINTS; PR01458; PMYELIN22.
PROSITE; PS01221; PMP22_1; 1.
PROSITE; PS01222; PMP22_2; 1.
1: Evidence at protein level;
Cell cycle; Cell membrane; Complete proteome;
Direct protein sequencing; Glycoprotein; Growth arrest; Membrane;
Reference proteome; Transmembrane; Transmembrane helix.
CHAIN 1 160 Peripheral myelin protein 22.
/FTId=PRO_0000164652.
TOPO_DOM 1 1 Cytoplasmic. {ECO:0000255}.
TRANSMEM 2 31 Helical. {ECO:0000250}.
TOPO_DOM 32 64 Extracellular. {ECO:0000255}.
TRANSMEM 65 91 Helical. {ECO:0000250}.
TOPO_DOM 92 95 Cytoplasmic. {ECO:0000255}.
TRANSMEM 96 119 Helical. {ECO:0000250}.
TOPO_DOM 120 133 Extracellular. {ECO:0000255}.
TRANSMEM 134 156 Helical. {ECO:0000250}.
TOPO_DOM 157 160 Cytoplasmic. {ECO:0000255}.
CARBOHYD 41 41 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CONFLICT 22 22 S -> K (in Ref. 4; AA sequence).
{ECO:0000305}.
CONFLICT 30 30 V -> E (in Ref. 1; CAA44297).
{ECO:0000305}.
SEQUENCE 160 AA; 17946 MW; 8DB9B2F2CF6D4903 CRC64;
MLLLLLGILF LHIAVLVLLF VSTIVSQWLV GNGHRTDLWQ NCTTSALGAV QHCYSSSVSE
WLQSVQATMI LSVIFSVLSL FLFFCQLFTL TKGGRFYITG VFQILAGLCV MSAAAIYTVR
HSEWHVNNDY SYGFAYILAW VAFPLALLSG IIYVILRKRE


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