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Peroxisomal fatty acid beta-oxidation multifunctional protein (MFP) [Includes: Enoyl-CoA hydratase/3-2-trans-enoyl-CoA isomerase/3-hydroxybutyryl-CoA epimerase (EC 4.2.1.17) (EC 5.1.2.3) (EC 5.3.3.8); 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35)]

 MFP_ORYSJ               Reviewed;         726 AA.
Q8W1L6; Q0E238; Q336K1; Q6K7T9;
15-DEC-2003, integrated into UniProtKB/Swiss-Prot.
30-MAY-2006, sequence version 2.
05-DEC-2018, entry version 111.
RecName: Full=Peroxisomal fatty acid beta-oxidation multifunctional protein;
Short=MFP;
Includes:
RecName: Full=Enoyl-CoA hydratase/3-2-trans-enoyl-CoA isomerase/3-hydroxybutyryl-CoA epimerase;
EC=4.2.1.17;
EC=5.1.2.3;
EC=5.3.3.8;
Includes:
RecName: Full=3-hydroxyacyl-CoA dehydrogenase;
EC=1.1.1.35;
Name=MFP; OrderedLocusNames=Os02g0274100, LOC_Os02g17390;
ORFNames=P0413A11.18;
Oryza sativa subsp. japonica (Rice).
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
Spermatophyta; Magnoliophyta; Liliopsida; Poales; Poaceae; BOP clade;
Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
NCBI_TaxID=39947;
[1] {ECO:0000305}
NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, RNA-BINDING,
MICROTUBULE-BINDING, AND CATALYTIC ACTIVITY.
TISSUE=Seed {ECO:0000269|PubMed:11706039};
PubMed=11706039; DOI=10.1074/jbc.M109510200;
Chuong S.D.X., Mullen R.T., Muench D.G.;
"Identification of a rice RNA- and microtubule-binding protein as the
multifunctional protein, a peroxisomal enzyme involved in the beta-
oxidation of fatty acids.";
J. Biol. Chem. 277:2419-2429(2002).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=cv. Nipponbare;
PubMed=16100779; DOI=10.1038/nature03895;
International rice genome sequencing project (IRGSP);
"The map-based sequence of the rice genome.";
Nature 436:793-800(2005).
[3]
GENOME REANNOTATION.
STRAIN=cv. Nipponbare;
PubMed=18089549; DOI=10.1093/nar/gkm978;
The rice annotation project (RAP);
"The rice annotation project database (RAP-DB): 2008 update.";
Nucleic Acids Res. 36:D1028-D1033(2008).
[4]
GENOME REANNOTATION.
STRAIN=cv. Nipponbare;
PubMed=24280374; DOI=10.1186/1939-8433-6-4;
Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H.,
McCombie W.R., Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S.,
Childs K.L., Davidson R.M., Lin H., Quesada-Ocampo L.,
Vaillancourt B., Sakai H., Lee S.S., Kim J., Numa H., Itoh T.,
Buell C.R., Matsumoto T.;
"Improvement of the Oryza sativa Nipponbare reference genome using
next generation sequence and optical map data.";
Rice 6:4-4(2013).
[5]
NUCLEOTIDE SEQUENCE [MRNA] OF 7-726.
Gaur R., Tyagi A.K.;
"Isolation and characterization of a multi-functional protein (OsMFP)
gene from rice.";
Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Multifunctional enzyme involved in fatty acid beta-
oxidation. Also binds to RNA and microtubules. Possible role in
subcellular mRNA localization and RNA-cytoskeleton interactions.
{ECO:0000269|PubMed:11706039, ECO:0000303|PubMed:11706039}.
-!- CATALYTIC ACTIVITY:
Reaction=a (3S)-hydroxyacyl-CoA = a (2E)-enoyl CoA + H2O;
Xref=Rhea:RHEA:16105, ChEBI:CHEBI:15377, ChEBI:CHEBI:57318,
ChEBI:CHEBI:58856; EC=4.2.1.17;
Evidence={ECO:0000269|PubMed:11706039};
-!- CATALYTIC ACTIVITY:
Reaction=a 4-saturated-(3S)-hydroxyacyl-CoA = a (3E)-enoyl-CoA +
H2O; Xref=Rhea:RHEA:20724, ChEBI:CHEBI:15377, ChEBI:CHEBI:58521,
ChEBI:CHEBI:137480; EC=4.2.1.17;
Evidence={ECO:0000269|PubMed:11706039};
-!- CATALYTIC ACTIVITY:
Reaction=a (3Z)-enoyl-CoA = a (2E)-enoyl-CoA;
Xref=Rhea:RHEA:45900, ChEBI:CHEBI:85097, ChEBI:CHEBI:85489;
EC=5.3.3.8; Evidence={ECO:0000269|PubMed:11706039};
-!- CATALYTIC ACTIVITY:
Reaction=a (3E)-enoyl-CoA = a (2E)-enoyl-CoA;
Xref=Rhea:RHEA:45228, ChEBI:CHEBI:58521, ChEBI:CHEBI:85097;
EC=5.3.3.8; Evidence={ECO:0000269|PubMed:11706039};
-!- CATALYTIC ACTIVITY:
Reaction=(3S)-hydroxybutanoyl-CoA = (3R)-hydroxybutanoyl-CoA;
Xref=Rhea:RHEA:21760, ChEBI:CHEBI:57315, ChEBI:CHEBI:57316;
EC=5.1.2.3; Evidence={ECO:0000250|UniProtKB:Q39659,
ECO:0000269|PubMed:11706039};
-!- CATALYTIC ACTIVITY:
Reaction=a (3S)-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+)
+ NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378,
ChEBI:CHEBI:57318, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945,
ChEBI:CHEBI:90726; EC=1.1.1.35;
Evidence={ECO:0000269|PubMed:11706039};
-!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
-!- SUBUNIT: Monomer. {ECO:0000303|PubMed:11706039, ECO:0000305}.
-!- SUBCELLULAR LOCATION: Peroxisome {ECO:0000305}. Cytoplasm,
cytoskeleton {ECO:0000305}.
-!- DOMAIN: The epimerase and isomerase activities are contained in
the N-terminal region while the dehydrogenase activity is in the
C-terminal region. {ECO:0000250|UniProtKB:Q39659}.
-!- SIMILARITY: In the N-terminal section; belongs to the enoyl-CoA
hydratase/isomerase family. {ECO:0000305}.
-!- SIMILARITY: In the central section; belongs to the 3-hydroxyacyl-
CoA dehydrogenase family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAL35606.1; Type=Frameshift; Positions=544, 549; Evidence={ECO:0000305};
Sequence=AAQ13901.1; Type=Erroneous initiation; Evidence={ECO:0000305};
-----------------------------------------------------------------------
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EMBL; AF442962; AAL35606.1; ALT_FRAME; mRNA.
EMBL; AP004771; BAD21833.1; -; Genomic_DNA.
EMBL; AP008208; BAF08450.1; -; Genomic_DNA.
EMBL; AP014958; BAS78079.1; -; Genomic_DNA.
EMBL; AF220609; AAQ13901.1; ALT_INIT; mRNA.
RefSeq; XP_015625624.1; XM_015770138.1.
UniGene; Os.9729; -.
ProteinModelPortal; Q8W1L6; -.
SMR; Q8W1L6; -.
STRING; 39947.LOC_Os02g17390.1; -.
PaxDb; Q8W1L6; -.
PRIDE; Q8W1L6; -.
EnsemblPlants; Os02t0274100-01; Os02t0274100-01; Os02g0274100.
GeneID; 4328997; -.
Gramene; Os02t0274100-01; Os02t0274100-01; Os02g0274100.
KEGG; osa:4328997; -.
eggNOG; KOG1683; Eukaryota.
eggNOG; COG1024; LUCA.
eggNOG; COG1250; LUCA.
HOGENOM; HOG000261347; -.
InParanoid; Q8W1L6; -.
KO; K10527; -.
OMA; IDLCMIL; -.
OrthoDB; EOG09360359; -.
Reactome; R-OSA-390247; Beta-oxidation of very long chain fatty acids.
UniPathway; UPA00659; -.
Proteomes; UP000059680; Chromosome 2.
ExpressionAtlas; Q8W1L6; differential.
Genevisible; Q8W1L6; OS.
GO; GO:0005618; C:cell wall; IEA:EnsemblPlants.
GO; GO:0009507; C:chloroplast; IEA:EnsemblPlants.
GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
GO; GO:0005777; C:peroxisome; IBA:GO_Central.
GO; GO:0009506; C:plasmodesma; IEA:EnsemblPlants.
GO; GO:0018812; F:3-hydroxyacyl-CoA dehydratase activity; IDA:UniProtKB.
GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IBA:GO_Central.
GO; GO:0008692; F:3-hydroxybutyryl-CoA epimerase activity; ISS:UniProtKB.
GO; GO:0004165; F:dodecenoyl-CoA delta-isomerase activity; ISS:UniProtKB.
GO; GO:0004300; F:enoyl-CoA hydratase activity; IDA:UniProtKB.
GO; GO:0008017; F:microtubule binding; IDA:UniProtKB.
GO; GO:0003729; F:mRNA binding; IDA:UniProtKB.
GO; GO:0006635; P:fatty acid beta-oxidation; IDA:UniProtKB.
GO; GO:0009908; P:flower development; IEA:EnsemblPlants.
GO; GO:0009695; P:jasmonic acid biosynthetic process; IEA:EnsemblPlants.
InterPro; IPR006180; 3-OHacyl-CoA_DH_CS.
InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
InterPro; IPR006108; 3HC_DH_C.
InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
InterPro; IPR033346; AIM1.
InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
InterPro; IPR018376; Enoyl-CoA_hyd/isom_CS.
InterPro; IPR001753; Enoyl-CoA_hydra/iso.
InterPro; IPR036291; NAD(P)-bd_dom_sf.
PANTHER; PTHR23309:SF10; PTHR23309:SF10; 1.
Pfam; PF00725; 3HCDH; 1.
Pfam; PF02737; 3HCDH_N; 1.
Pfam; PF00378; ECH_1; 1.
SUPFAM; SSF48179; SSF48179; 2.
SUPFAM; SSF51735; SSF51735; 1.
SUPFAM; SSF52096; SSF52096; 1.
PROSITE; PS00067; 3HCDH; 1.
PROSITE; PS00166; ENOYL_COA_HYDRATASE; 1.
1: Evidence at protein level;
Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing;
Fatty acid metabolism; Isomerase; Lipid metabolism; Lyase;
Microtubule; Multifunctional enzyme; NAD; Oxidoreductase; Peroxisome;
Reference proteome; RNA-binding.
CHAIN 1 726 Peroxisomal fatty acid beta-oxidation
multifunctional protein.
/FTId=PRO_0000109252.
CONFLICT 178 178 G -> R (in Ref. 5; AAQ13901).
{ECO:0000305}.
CONFLICT 345 345 L -> R (in Ref. 1; AAL35606).
{ECO:0000305}.
CONFLICT 384 384 S -> C (in Ref. 1; AAL35606).
{ECO:0000305}.
SEQUENCE 726 AA; 78461 MW; AFB6E3D2AD02E03E CRC64;
MAGAIRVTME VGADGVAVVT ICNPPVNALH PIIIQGLKEK YAEAMDRDDV KAIVLTGAGG
KFCGGFDINV FTEVHKTGNV SLMPDVSVEL VSNLMEAGKK PSVAAIQGLA LGGGLELTMG
CHARISTPEA QLGLPELTLG IIPGFGGTQR LPRLVGLPKA IEMMLQSKFI TAKEGKEGGL
VDALCSPDEL IKMSRLWALE IANYRKPWIR SLARTDRLGS LSEARSVLNS ARQQAKKVAA
NLPQHQACLD VMEEGVLCGG HAGVLKEAKV FKELVLSPTS KALVHAFFAQ RLTTKVPGVT
DVQLKPRKIR KVAVIGGGLM GSGIATALLV SNTSVVLKEV NPQFLQRGQK MIAANLEGLV
KRGSLTKDKM NKAMSLLKGA LDYSDFKDVD MVIEAVIEKI PLKQSIFSDL EKVCPPHCIL
ATNTSTIDLN VVGEKTNSQD RIIGAHFFSP AHIMPLLEIV RTEKTSPQAI LDLITVGKMI
KKVPVVVGNC TGFAVNRTFF PYTQGSHLLV SIGIDVFRID RVISSFGMPM GPFQLQDLAG
YGVALAVKDI YAAAFGTRNL DSNLVDLMVQ NGRQGKSNGK GYYLYEKGGK PKPDPSVQVV
IDEYRRCAKT MPGGKPVTLS DQDILEMIFF PVVNEACRVM DENVVIRASD LDIASILGMG
FPKFRGGLVF WADTIGAPYI HSKLSKWTEI YGDFFKPSSY LEDRAKRSLP LSAPNATQQA
SSRSRM


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