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Peroxisomal nicotinamide adenine dinucleotide carrier (Peroxisomal NAD carrier) (Peroxisomal membrane protein 38, (PMP36)) (AtPMP38) (Protein ABERRANT PEROXISOME MORPHOLOGY 3) (Solute carrier family 25 member 17)

 PXN_ARATH               Reviewed;         331 AA.
O04200; Q8L9P5;
09-JAN-2013, integrated into UniProtKB/Swiss-Prot.
01-JUL-1997, sequence version 1.
25-APR-2018, entry version 126.
RecName: Full=Peroxisomal nicotinamide adenine dinucleotide carrier;
AltName: Full=Peroxisomal NAD carrier;
AltName: Full=Peroxisomal membrane protein 38, (PMP36);
Short=AtPMP38;
AltName: Full=Protein ABERRANT PEROXISOME MORPHOLOGY 3;
AltName: Full=Solute carrier family 25 member 17;
Name=PXN; Synonyms=APEM3; OrderedLocusNames=At2g39970;
ORFNames=T28M21.13;
Arabidopsis thaliana (Mouse-ear cress).
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae;
Arabidopsis.
NCBI_TaxID=3702;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND SUBCELLULAR LOCATION.
PubMed=11522909; DOI=10.1093/pcp/pce108;
Fukao Y., Hayashi Y., Mano S., Hayashi M., Nishimura M.;
"Developmental analysis of a putative ATP/ADP carrier protein
localized on glyoxysomal membranes during the peroxisome transition in
pumpkin cotyledons.";
Plant Cell Physiol. 42:835-841(2001).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=cv. Columbia;
PubMed=10617197; DOI=10.1038/45471;
Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L.,
Moffat K.S., Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L.,
Tallon L.J., Gill J.E., Adams M.D., Carrera A.J., Creasy T.H.,
Goodman H.M., Somerville C.R., Copenhaver G.P., Preuss D.,
Nierman W.C., White O., Eisen J.A., Salzberg S.L., Fraser C.M.,
Venter J.C.;
"Sequence and analysis of chromosome 2 of the plant Arabidopsis
thaliana.";
Nature 402:761-768(1999).
[3]
GENOME REANNOTATION.
STRAIN=cv. Columbia;
PubMed=27862469; DOI=10.1111/tpj.13415;
Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
Town C.D.;
"Araport11: a complete reannotation of the Arabidopsis thaliana
reference genome.";
Plant J. 89:789-804(2017).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=cv. Columbia;
PubMed=14593172; DOI=10.1126/science.1088305;
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J.,
Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F.,
Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.,
Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J.,
Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y.,
Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P.,
Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F.,
Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M.,
Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J.,
Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T.,
Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y.,
Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.;
"Empirical analysis of transcriptional activity in the Arabidopsis
genome.";
Science 302:842-846(2003).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
Feldmann K.A.;
"Full-length cDNA from Arabidopsis thaliana.";
Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
[6]
IDENTIFICATION, AND SUBCELLULAR LOCATION.
PubMed=19073763; DOI=10.1105/tpc.108.062042;
Linka N., Theodoulou F.L., Haslam R.P., Linka M., Napier J.A.,
Neuhaus H.E., Weber A.P.;
"Peroxisomal ATP import is essential for seedling development in
Arabidopsis thaliana.";
Plant Cell 20:3241-3257(2008).
[7]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
STRAIN=cv. Columbia;
PubMed=19245862; DOI=10.1016/j.jprot.2009.02.004;
Jones A.M.E., MacLean D., Studholme D.J., Serna-Sanz A.,
Andreasson E., Rathjen J.P., Peck S.C.;
"Phosphoproteomic analysis of nuclei-enriched fractions from
Arabidopsis thaliana.";
J. Proteomics 72:439-451(2009).
[8]
FUNCTION, DISRUPTION PHENOTYPE, SUBUNIT, AND TISSUE SPECIFICITY.
PubMed=22034551; DOI=10.1093/pcp/pcr147;
Mano S., Nakamori C., Fukao Y., Araki M., Matsuda A., Kondo M.,
Nishimura M.;
"A defect of peroxisomal membrane protein 38 causes enlargement of
peroxisomes.";
Plant Cell Physiol. 52:2157-2172(2011).
[9]
FUNCTION, SUBSTRATE SPECIFICITY, ENZYME REGULATION, AND
BIOPHYSICOCHEMICAL PROPERTIES.
PubMed=22555559; DOI=10.1007/s10863-012-9445-0;
Agrimi G., Russo A., Pierri C.L., Palmieri F.;
"The peroxisomal NAD+ carrier of Arabidopsis thaliana transports
coenzyme A and its derivatives.";
J. Bioenerg. Biomembr. 44:333-340(2012).
[10]
FUNCTION, SUBCELLULAR LOCATION, BIOPHYSICOCHEMICAL PROPERTIES, TISSUE
SPECIFICITY, AND DISRUPTION PHENOTYPE.
PubMed=21895810; DOI=10.1111/j.1365-313X.2011.04775.x;
Bernhardt K., Wilkinson S., Weber A.P., Linka N.;
"A peroxisomal carrier delivers NAD? and contributes to optimal fatty
acid degradation during storage oil mobilization.";
Plant J. 69:1-13(2012).
-!- FUNCTION: Mediates the NAD(+) import into peroxisomes. Favors the
NAD(+)(in)/AMP(out) antiport exchange, but is also able to
catalyze a low unidirectional transport that might be essential
under special conditions. Transports CoA, dephospho-CoA, acetyl-
CoA, adenosine 3',5'-diphosphate (PAP), NAD(+), AMP, ADP and NADH,
but has no activity with ATP, GTP, GDP, NADPH, NADP(+) or FAD.
Required for peroxisomes proliferation.
{ECO:0000269|PubMed:21895810, ECO:0000269|PubMed:22034551,
ECO:0000269|PubMed:22555559}.
-!- ENZYME REGULATION: Inhibited by pyridoxal 5'-phosphate,
bathophenanthroline, tannic acid, mersalyl, mercuric chloride and
bromocresol purple. {ECO:0000269|PubMed:22555559}.
-!- BIOPHYSICOCHEMICAL PROPERTIES:
Kinetic parameters:
KM=102 uM for for the NAD(+)/NAD(+) exchange
{ECO:0000269|PubMed:21895810, ECO:0000269|PubMed:22555559};
KM=119 uM for for the AMP/AMP exchange
{ECO:0000269|PubMed:21895810, ECO:0000269|PubMed:22555559};
Vmax=166 umol/min/g enzyme for the NAD(+)/NAD(+) exchange
{ECO:0000269|PubMed:21895810, ECO:0000269|PubMed:22555559};
Vmax=416 umol/min/g enzyme for the AMP/AMP exchange
{ECO:0000269|PubMed:21895810, ECO:0000269|PubMed:22555559};
-!- SUBUNIT: Homodimer. {ECO:0000269|PubMed:22034551}.
-!- SUBCELLULAR LOCATION: Glyoxysome membrane
{ECO:0000269|PubMed:11522909, ECO:0000269|PubMed:19073763,
ECO:0000269|PubMed:21895810}; Multi-pass membrane protein
{ECO:0000269|PubMed:11522909, ECO:0000269|PubMed:19073763,
ECO:0000269|PubMed:21895810}.
-!- TISSUE SPECIFICITY: Expressed in cotyledons, hypocotyls, vascular
tissues, trichomes, hydathodes, seeds, pedicels, flowers and
stigma. {ECO:0000269|PubMed:21895810,
ECO:0000269|PubMed:22034551}.
-!- DISRUPTION PHENOTYPE: No germination or growth inhibition, but
delayed storage oil mobilization. Decreased sensitivity to 4-(2,4-
dichlorophenoxy)butanoic acid (2,4-DB), a precursor converted in
vivo by beta-oxidation into the herbicide 2,4-
dichlorophenoxyacetic acid (2,4-D). Enlarged peroxisomes.
{ECO:0000269|PubMed:21895810, ECO:0000269|PubMed:22034551}.
-!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29)
family. {ECO:0000305}.
-!- CAUTION: Was originally thought to be an adenine nucleotide
carrier. {ECO:0000305|PubMed:11522909}.
-----------------------------------------------------------------------
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EMBL; AB047148; BAB62814.1; -; mRNA.
EMBL; AF002109; AAB95282.1; -; Genomic_DNA.
EMBL; CP002685; AEC09757.1; -; Genomic_DNA.
EMBL; AY039858; AAK63962.1; -; mRNA.
EMBL; BT003020; AAO23585.1; -; mRNA.
EMBL; AY088311; AAM65850.1; -; mRNA.
PIR; F84823; F84823.
RefSeq; NP_181526.1; NM_129555.4.
UniGene; At.14666; -.
ProteinModelPortal; O04200; -.
BioGrid; 3922; 1.
STRING; 3702.AT2G39970.1; -.
TCDB; 2.A.29.6.2; the mitochondrial carrier (mc) family.
iPTMnet; O04200; -.
PaxDb; O04200; -.
ProMEX; O04200; -.
EnsemblPlants; AT2G39970.1; AT2G39970.1; AT2G39970.
GeneID; 818584; -.
Gramene; AT2G39970.1; AT2G39970.1; AT2G39970.
KEGG; ath:AT2G39970; -.
Araport; AT2G39970; -.
TAIR; locus:2061176; AT2G39970.
eggNOG; KOG0769; Eukaryota.
eggNOG; ENOG410ZNC0; LUCA.
HOGENOM; HOG000159426; -.
InParanoid; O04200; -.
KO; K13354; -.
OMA; YITVKSQ; -.
OrthoDB; EOG09360FE6; -.
PhylomeDB; O04200; -.
Reactome; R-ATH-389599; Alpha-oxidation of phytanate.
PRO; PR:O04200; -.
Proteomes; UP000006548; Chromosome 2.
ExpressionAtlas; O04200; baseline and differential.
Genevisible; O04200; AT.
GO; GO:0046861; C:glyoxysomal membrane; IEA:UniProtKB-SubCell.
GO; GO:0005779; C:integral component of peroxisomal membrane; IBA:GO_Central.
GO; GO:0005743; C:mitochondrial inner membrane; IBA:GO_Central.
GO; GO:0005777; C:peroxisome; IDA:TAIR.
GO; GO:0005774; C:vacuolar membrane; IDA:TAIR.
GO; GO:0015217; F:ADP transmembrane transporter activity; IBA:GO_Central.
GO; GO:0080122; F:AMP transmembrane transporter activity; IBA:GO_Central.
GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
GO; GO:0005347; F:ATP transmembrane transporter activity; IBA:GO_Central.
GO; GO:0015228; F:coenzyme A transmembrane transporter activity; IBA:GO_Central.
GO; GO:0015230; F:FAD transmembrane transporter activity; IBA:GO_Central.
GO; GO:0044610; F:FMN transmembrane transporter activity; IBA:GO_Central.
GO; GO:0051724; F:NAD transmembrane transporter activity; IBA:GO_Central.
GO; GO:0006839; P:mitochondrial transport; IBA:GO_Central.
GO; GO:0043132; P:NAD transport; IMP:TAIR.
GO; GO:0015858; P:nucleoside transport; IBA:GO_Central.
GO; GO:0044375; P:regulation of peroxisome size; IMP:TAIR.
Gene3D; 1.50.40.10; -; 1.
InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
InterPro; IPR023395; Mt_carrier_dom_sf.
Pfam; PF00153; Mito_carr; 3.
SUPFAM; SSF103506; SSF103506; 1.
PROSITE; PS50920; SOLCAR; 3.
1: Evidence at protein level;
Antiport; Complete proteome; Glyoxysome; Membrane; Peroxisome;
Reference proteome; Repeat; Transmembrane; Transmembrane helix;
Transport.
CHAIN 1 331 Peroxisomal nicotinamide adenine
dinucleotide carrier.
/FTId=PRO_0000420694.
TRANSMEM 5 25 Helical; Name=1. {ECO:0000255}.
TRANSMEM 63 85 Helical; Name=2. {ECO:0000255}.
TRANSMEM 116 136 Helical; Name=3. {ECO:0000255}.
TRANSMEM 180 200 Helical; Name=4. {ECO:0000255}.
TRANSMEM 235 255 Helical; Name=5. {ECO:0000255}.
TRANSMEM 293 313 Helical; Name=6. {ECO:0000255}.
REPEAT 2 91 Solcar 1.
REPEAT 109 216 Solcar 2.
REPEAT 229 320 Solcar 3.
CONFLICT 331 331 S -> I (in Ref. 5; AAM65850).
{ECO:0000305}.
SEQUENCE 331 AA; 36213 MW; 28F6A06215E98EF2 CRC64;
MSDALINGLA GAGGGIIAQL LTYPLQTVNT RQQTERDLKR EKRKLGTIEH MCQVVKQEGW
ERLYGGLAPS LAGTAASQGV YYYFYQVFRN RAEATALARK KKGLGDGSVG MFASLLVAAF
AGSVNVLMTN PIWVIVTRMQ THRKMTKDQT AAPESPSSNA EALVAVEPRP YGTFNTIREV
YDEAGITGFW KGVIPTLIMV SNPSMQFMLY ETMLTKLKKK RALKGSNNVT ALETFLLGAV
AKLGATVTTY PLLVVKSRLQ AKQVTTGDKR QQYKGTLDAI LKMIRYEGLY GFYKGMSTKI
VQSVLAAAVL FMIKEELVKG AKLLLSNATS S


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