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Peroxisomal targeting signal 1 receptor (PTS1 receptor) (PTS1R) (PTS1-BP) (Peroxin-5) (Peroxisomal C-terminal targeting signal import receptor) (Peroxisome receptor 1)

 PEX5_CRIGR              Reviewed;         640 AA.
Q920N5; Q7TNJ1; Q920N3;
01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
01-DEC-2001, sequence version 1.
05-DEC-2018, entry version 87.
RecName: Full=Peroxisomal targeting signal 1 receptor;
Short=PTS1 receptor;
Short=PTS1R;
AltName: Full=PTS1-BP;
AltName: Full=Peroxin-5;
AltName: Full=Peroxisomal C-terminal targeting signal import receptor;
AltName: Full=Peroxisome receptor 1;
Name=PEX5;
Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Cricetidae; Cricetinae; Cricetulus.
NCBI_TaxID=10029;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, AND
CHARACTERIZATION OF VARIANT ARG-343.
TISSUE=Ovary;
PubMed=11606046; DOI=10.1006/bbrc.2001.5773;
Ito R., Huang Y., Yao C., Shimozawa N., Suzuki Y., Kondo N.,
Imanaka T., Usuda N., Ito M.;
"Temperature-sensitive phenotype of Chinese hamster ovary cells
defective in PEX5 gene.";
Biochem. Biophys. Res. Commun. 288:321-327(2001).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), FUNCTION, AND SUBCELLULAR
LOCATION.
TISSUE=Ovary;
PubMed=16428307; DOI=10.1093/jb/mvi175;
Ito R., Morita M., Takahashi N., Shimozawa N., Usuda N., Imanaka T.,
Ito M.;
"Identification of Pex5pM, and retarded maturation of 3-ketoacyl-CoA
thiolase and acyl-CoA oxidase in CHO cells expressing mutant Pex5p
isoforms.";
J. Biochem. 138:781-790(2005).
[3]
FUNCTION, AND INTERACTION WITH PEX7; PEX13 AND PEX14.
PubMed=11865044; DOI=10.1128/MCB.22.6.1639-1655.2002;
Otera H., Setoguchi K., Hamasaki M., Kumashiro T., Shimizu N.,
Fujiki Y.;
"Peroxisomal targeting signal receptor Pex5p interacts with cargoes
and import machinery components in a spatiotemporally differentiated
manner: conserved Pex5p WXXXF/Y motifs are critical for matrix protein
import.";
Mol. Cell. Biol. 22:1639-1655(2002).
[4]
UBIQUITINATION AT CYS-11, AND MUTAGENESIS OF CYS-11.
PubMed=21554508; DOI=10.1111/j.1600-0854.2011.01217.x;
Okumoto K., Misono S., Miyata N., Matsumoto Y., Mukai S., Fujiki Y.;
"Cysteine ubiquitination of PTS1 receptor Pex5p regulates Pex5p
recycling.";
Traffic 12:1067-1083(2011).
[5]
INTERACTION WITH VWA8.
PubMed=30204880; DOI=10.1093/jb/mvy073;
Niwa H., Miyauchi-Nanri Y., Okumoto K., Mukai S., Noi K., Ogura T.,
Fujiki Y.;
"A newly isolated Pex7-binding, atypical PTS2 protein P7BP2 is a novel
dynein-type AAA+ protein.";
J. Biochem. 0:0-0(2018).
-!- FUNCTION: Binds to the C-terminal PTS1-type tripeptide peroxisomal
targeting signal (SKL-type) and plays an essential role in
peroxisomal protein import. {ECO:0000269|PubMed:11606046,
ECO:0000269|PubMed:11865044, ECO:0000269|PubMed:16428307}.
-!- SUBUNIT: Interacts with PEX12 (By similarity). Interacts with
PEX7, PEX13 and PEX14 (PubMed:11865044). Interacts (Cys-linked
ubiquitinated) with ZFAND6 (By similarity). Isoform 1 but not
isoform 3 interacts with isoform 2 of VWA8 in a PEX7-dependent
manner (PubMed:30204880). {ECO:0000250|UniProtKB:P50542,
ECO:0000269|PubMed:11865044, ECO:0000269|PubMed:30204880}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16428307}.
Peroxisome membrane {ECO:0000269|PubMed:16428307}; Peripheral
membrane protein {ECO:0000269|PubMed:16428307}. Note=Its
distribution appears to be dynamic. It is probably a cycling
receptor found mainly in the cytoplasm and as well associated to
the peroxisomal membrane through a docking factor (PEX13).
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=3;
Name=1; Synonyms=Pex5pL, PTS1RL;
IsoId=Q920N5-1; Sequence=Displayed;
Name=2; Synonyms=Pex5pM, PTS1RM;
IsoId=Q920N5-2; Sequence=VSP_024717;
Name=3; Synonyms=Pex5pS, PTS1RS;
IsoId=Q920N5-3; Sequence=VSP_024716;
-!- PTM: Monoubiquitination at Cys-11 is required for proper export
from peroxisomes and recycling. {ECO:0000269|PubMed:21554508}.
-!- SIMILARITY: Belongs to the peroxisomal targeting signal receptor
family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; AB065000; BAB69071.1; -; mRNA.
EMBL; AB063320; BAB69070.1; -; mRNA.
EMBL; AB098709; BAC81427.1; -; mRNA.
RefSeq; NP_001230930.1; NM_001244001.1. [Q920N5-1]
RefSeq; XP_007644336.1; XM_007646146.2. [Q920N5-2]
ProteinModelPortal; Q920N5; -.
SMR; Q920N5; -.
IntAct; Q920N5; 26.
PRIDE; Q920N5; -.
Ensembl; ENSCGRT00000022069; ENSCGRP00000021764; ENSCGRG00000015784.
Ensembl; ENSCGRT00001026058; ENSCGRP00001021814; ENSCGRG00001020537.
GeneID; 100689015; -.
KEGG; cge:100689015; -.
CTD; 5830; -.
HOVERGEN; HBG053575; -.
KO; K13342; -.
GO; GO:0005623; C:cell; IEA:GOC.
GO; GO:0005829; C:cytosol; ISS:UniProtKB.
GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
GO; GO:0005739; C:mitochondrion; IEA:GOC.
GO; GO:0005782; C:peroxisomal matrix; ISS:UniProtKB.
GO; GO:0005778; C:peroxisomal membrane; IEA:UniProtKB-SubCell.
GO; GO:0005777; C:peroxisome; ISS:UniProtKB.
GO; GO:0005052; F:peroxisome matrix targeting signal-1 binding; ISS:UniProtKB.
GO; GO:0008022; F:protein C-terminus binding; ISS:UniProtKB.
GO; GO:0048468; P:cell development; IEA:Ensembl.
GO; GO:0021795; P:cerebral cortex cell migration; IEA:Ensembl.
GO; GO:0021895; P:cerebral cortex neuron differentiation; IEA:Ensembl.
GO; GO:0007029; P:endoplasmic reticulum organization; IEA:Ensembl.
GO; GO:0006635; P:fatty acid beta-oxidation; IEA:Ensembl.
GO; GO:0007006; P:mitochondrial membrane organization; IEA:Ensembl.
GO; GO:0050905; P:neuromuscular process; IEA:Ensembl.
GO; GO:0001764; P:neuron migration; IEA:Ensembl.
GO; GO:0040018; P:positive regulation of multicellular organism growth; IEA:Ensembl.
GO; GO:0016558; P:protein import into peroxisome matrix; IEA:Ensembl.
GO; GO:0016561; P:protein import into peroxisome matrix, translocation; ISS:UniProtKB.
GO; GO:0006625; P:protein targeting to peroxisome; ISS:UniProtKB.
GO; GO:0051262; P:protein tetramerization; ISS:UniProtKB.
GO; GO:0000038; P:very long-chain fatty acid metabolic process; IEA:Ensembl.
Gene3D; 1.25.40.10; -; 1.
InterPro; IPR024113; PTS1R.
InterPro; IPR024111; PTS1R_family.
InterPro; IPR013026; TPR-contain_dom.
InterPro; IPR011990; TPR-like_helical_dom_sf.
InterPro; IPR019734; TPR_repeat.
PANTHER; PTHR10130; PTHR10130; 1.
PANTHER; PTHR10130:SF2; PTHR10130:SF2; 1.
Pfam; PF13181; TPR_8; 1.
SMART; SM00028; TPR; 4.
SUPFAM; SSF48452; SSF48452; 1.
PROSITE; PS50005; TPR; 5.
PROSITE; PS50293; TPR_REGION; 1.
1: Evidence at protein level;
Alternative splicing; Cytoplasm; Membrane; Peroxisome; Phosphoprotein;
Polymorphism; Protein transport; Repeat; Thioester bond; TPR repeat;
Transport; Ubl conjugation.
CHAIN 1 640 Peroxisomal targeting signal 1 receptor.
/FTId=PRO_0000285543.
REPEAT 336 369 TPR 1.
REPEAT 371 403 TPR 2.
REPEAT 404 437 TPR 3.
REPEAT 454 486 TPR 4.
REPEAT 489 522 TPR 5.
REPEAT 524 556 TPR 6.
REPEAT 558 590 TPR 7.
MOD_RES 115 115 Phosphoserine.
{ECO:0000250|UniProtKB:P50542}.
MOD_RES 153 153 Phosphoserine.
{ECO:0000250|UniProtKB:P50542}.
MOD_RES 155 155 Phosphoserine.
{ECO:0000250|UniProtKB:P50542}.
MOD_RES 167 167 Phosphoserine.
{ECO:0000250|UniProtKB:P50542}.
MOD_RES 280 280 Phosphoserine.
{ECO:0000250|UniProtKB:P50542}.
CROSSLNK 11 11 Glycyl cysteine thioester (Cys-Gly)
(interchain with G-Cter in ubiquitin).
{ECO:0000269|PubMed:21554508}.
VAR_SEQ 216 252 Missing (in isoform 2).
{ECO:0000303|PubMed:11606046}.
/FTId=VSP_024717.
VAR_SEQ 216 222 Missing (in isoform 3).
{ECO:0000303|PubMed:16428307}.
/FTId=VSP_024716.
VARIANT 343 343 G -> R (loss of peroxisomal import at 37C
for proteins with type-1 targeting
sequences).
{ECO:0000269|PubMed:11606046}.
MUTAGEN 11 11 C->A: Acumulates in peroxisomes and
abrogates peroxisomal import of PTS1- and
PTS2-containing proteins.
{ECO:0000269|PubMed:21554508}.
SEQUENCE 640 AA; 70834 MW; 473432F41BA4880F CRC64;
MAMRELVEGE CGGANPLMKL ATHFTQDKAL RQEGLRPGPW PPGASAAETV SKPLGVGSED
ELVAEFLQDQ NAPLVSRAPQ TFKMDDLLAE MQEIEQSNFR QAPQRAPGVA DLALSENWAQ
EFLAAGDAVD VAQDYNETDW SQEFIAEVTD PLSVSPARWA EEYLEQSEEK LWLGEPEGSS
TTDRWYDDYH PEEDLQHTAS DFVSKVDDPK LANSEFLKFV RQIGEGQVSL ESAAGSGRAQ
AEQWAAEFIQ QQGTSEAWVD QFTRSGNTSA LDVEFERAKS AIESDVDFWD KLQAELEEMA
KRDAEAHPWL SDYDDLTSAS YDKGYQFEEE NPLRDHPQAF EEGLRRLEEG DLPNAVLLFE
AAVQQDPKHM EAWQYLGTTQ AENEQELLAI SALRRCLELK PDNRTALMAL AVSFTNESLQ
RQACETLRDW LRYSPAYAHL VTPGEEGASG AGLGPSKRVL GSLLSDSLFL EVKELFLAAV
RLDPTSIDPD VQCGLGVLFN LSGEYDKAVD CFTAALSVRP NDYLLWNKLG ATLANGNQSE
EAVAAYRRAL ELQPGYIRSR YNLGISCINL GAHREAVEHF LEALNMQRKS RGPRGEGGAM
SENIWSTLRL ALSMLGQSDA YGAADARDLS ALLAMFGLPQ


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