Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Peroxisome proliferator-activated receptor alpha (PPAR-alpha) (Nuclear receptor subfamily 1 group C member 1)

 PPARA_CANLF             Reviewed;         468 AA.
Q95N78;
25-OCT-2002, integrated into UniProtKB/Swiss-Prot.
01-DEC-2001, sequence version 1.
23-MAY-2018, entry version 135.
RecName: Full=Peroxisome proliferator-activated receptor alpha;
Short=PPAR-alpha;
AltName: Full=Nuclear receptor subfamily 1 group C member 1;
Name=PPARA; Synonyms=NR1C1;
Canis lupus familiaris (Dog) (Canis familiaris).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
Canis.
NCBI_TaxID=9615;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
Nagasawa M., Ide T., Murakami K.;
"Dog PPAR alpha cDNA sequence.";
Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Ligand-activated transcription factor. Key regulator of
lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-
2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated
by oleylethanolamide, a naturally occurring lipid that regulates
satiety. Receptor for peroxisome proliferators such as
hypolipidemic drugs and fatty acids. Regulates the peroxisomal
beta-oxidation pathway of fatty acids. Functions as transcription
activator for the ACOX1 and P450 genes. Transactivation activity
requires heterodimerization with RXRA and is antagonized by NR2C2.
May be required for the propagation of clock information to
metabolic pathways regulated by PER2 (By similarity).
{ECO:0000250}.
-!- SUBUNIT: Heterodimer; with RXRA. This heterodimerization is
required for DNA binding and transactivation activity. Interacts
with NCOA3 coactivator. Interacts with CITED2; the interaction
stimulates its transcriptional activity. Also interacts with
PPARBP in vitro. Interacts with AKAP13, LPIN1, PRDM16 and
coactivator NCOA6. Interacts with ASXL1 and ASXL2. Interacts with
PER2. Interacts with SIRT1; the interaction seems to be modulated
by NAD(+) levels (By similarity). {ECO:0000250|UniProtKB:P23204,
ECO:0000250|UniProtKB:P37230, ECO:0000250|UniProtKB:Q07869}.
-!- SUBCELLULAR LOCATION: Nucleus.
-!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR1
subfamily. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; AF350327; AAK38655.1; -; mRNA.
RefSeq; NP_001003093.1; NM_001003093.1.
RefSeq; XP_005625734.1; XM_005625677.1.
RefSeq; XP_013972720.1; XM_014117245.1.
UniGene; Cfa.3519; -.
ProteinModelPortal; Q95N78; -.
SMR; Q95N78; -.
STRING; 9615.ENSCAFP00000001118; -.
BindingDB; Q95N78; -.
ChEMBL; CHEMBL2847; -.
PaxDb; Q95N78; -.
Ensembl; ENSCAFT00000001222; ENSCAFP00000001118; ENSCAFG00000000788.
GeneID; 403654; -.
KEGG; cfa:403654; -.
CTD; 5465; -.
VGNC; VGNC:44834; PPARA.
eggNOG; KOG3575; Eukaryota.
eggNOG; ENOG410XRZC; LUCA.
GeneTree; ENSGT00870000136388; -.
HOGENOM; HOG000261626; -.
HOVERGEN; HBG106004; -.
InParanoid; Q95N78; -.
KO; K07294; -.
OMA; FSFTEYQ; -.
OrthoDB; EOG091G05U8; -.
TreeFam; TF316304; -.
Reactome; R-CFA-383280; Nuclear Receptor transcription pathway.
Reactome; R-CFA-400206; Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha).
PRO; PR:Q95N78; -.
Proteomes; UP000002254; Chromosome 10.
Bgee; ENSCAFG00000000788; -.
GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
GO; GO:0003677; F:DNA binding; ISS:AgBase.
GO; GO:0003700; F:DNA binding transcription factor activity; ISS:AgBase.
GO; GO:0008144; F:drug binding; ISS:UniProtKB.
GO; GO:0008289; F:lipid binding; ISS:UniProtKB.
GO; GO:0004879; F:nuclear receptor activity; IEA:Ensembl.
GO; GO:0000978; F:RNA polymerase II proximal promoter sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0001103; F:RNA polymerase II repressing transcription factor binding; IEA:Ensembl.
GO; GO:0043565; F:sequence-specific DNA binding; ISS:AgBase.
GO; GO:0038023; F:signaling receptor activity; ISS:AgBase.
GO; GO:0003707; F:steroid hormone receptor activity; IEA:Ensembl.
GO; GO:0001077; F:transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0001190; F:transcriptional activator activity, RNA polymerase II transcription factor binding; IEA:Ensembl.
GO; GO:0001078; F:transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0031624; F:ubiquitin conjugating enzyme binding; IEA:Ensembl.
GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
GO; GO:0032922; P:circadian regulation of gene expression; ISS:UniProtKB.
GO; GO:0070166; P:enamel mineralization; IEA:Ensembl.
GO; GO:0008544; P:epidermis development; ISS:AgBase.
GO; GO:0006631; P:fatty acid metabolic process; ISS:AgBase.
GO; GO:0032099; P:negative regulation of appetite; ISS:UniProtKB.
GO; GO:0010887; P:negative regulation of cholesterol storage; IEA:Ensembl.
GO; GO:0050728; P:negative regulation of inflammatory response; IEA:Ensembl.
GO; GO:1903038; P:negative regulation of leukocyte cell-cell adhesion; IEA:Ensembl.
GO; GO:0010745; P:negative regulation of macrophage derived foam cell differentiation; IEA:Ensembl.
GO; GO:1902894; P:negative regulation of pri-miRNA transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:0010871; P:negative regulation of receptor biosynthetic process; IEA:Ensembl.
GO; GO:0010891; P:negative regulation of sequestering of triglyceride; IEA:Ensembl.
GO; GO:0046321; P:positive regulation of fatty acid oxidation; IEA:Ensembl.
GO; GO:0045722; P:positive regulation of gluconeogenesis; IEA:Ensembl.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:AgBase.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
GO; GO:0072366; P:regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO; GO:0042752; P:regulation of circadian rhythm; ISS:UniProtKB.
GO; GO:0019217; P:regulation of fatty acid metabolic process; ISS:AgBase.
GO; GO:0072363; P:regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO; GO:0072369; P:regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO; GO:0042060; P:wound healing; IEA:Ensembl.
Gene3D; 3.30.50.10; -; 1.
InterPro; IPR003074; 1Cnucl_rcpt.
InterPro; IPR035500; NHR_like_dom_sf.
InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
InterPro; IPR001723; Nuclear_hrmn_rcpt.
InterPro; IPR003076; PPAR-alpha.
InterPro; IPR001628; Znf_hrmn_rcpt.
InterPro; IPR013088; Znf_NHR/GATA.
Pfam; PF00104; Hormone_recep; 1.
Pfam; PF00105; zf-C4; 1.
PRINTS; PR01288; PROXISOMEPAR.
PRINTS; PR01289; PROXISOMPAAR.
PRINTS; PR00398; STRDHORMONER.
PRINTS; PR00047; STROIDFINGER.
SMART; SM00430; HOLI; 1.
SMART; SM00399; ZnF_C4; 1.
SUPFAM; SSF48508; SSF48508; 1.
PROSITE; PS51843; NR_LBD; 1.
PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
2: Evidence at transcript level;
Activator; Biological rhythms; Complete proteome; DNA-binding;
Lipid-binding; Metal-binding; Nucleus; Receptor; Reference proteome;
Transcription; Transcription regulation; Zinc; Zinc-finger.
CHAIN 1 468 Peroxisome proliferator-activated
receptor alpha.
/FTId=PRO_0000053479.
DOMAIN 239 466 NR LBD. {ECO:0000255|PROSITE-
ProRule:PRU01189}.
DNA_BIND 99 173 Nuclear receptor. {ECO:0000255|PROSITE-
ProRule:PRU00407}.
ZN_FING 102 122 NR C4-type. {ECO:0000255|PROSITE-
ProRule:PRU00407}.
ZN_FING 139 161 NR C4-type. {ECO:0000255|PROSITE-
ProRule:PRU00407}.
REGION 304 433 Required for heterodimerization with
RXRA. {ECO:0000250}.
SITE 433 433 Essential for heterodimerization with
RXRA. {ECO:0000250}.
SEQUENCE 468 AA; 52123 MW; 11F2C2F9AAB176D5 CRC64;
MVDTESPICP LSPLEADDLE SPLSEEFLQE MGNIQEISQS IGEDSSGSFS FTEYQYLGSG
PGSDGSVITD TLSPAPSPSS VTHPAAPGGA EEPSSVALNI ECRICGDRAS GYHYGVHACE
GCKGFFRRTI RLKLAYDKCD RSCKIQKKNR NKCQYCRFHK CLSVGMSHNA IRFGRMPRSE
KAKLKAEILT CEQDPEDAET ADLKSLAKRI YEAYLKNFNM NKVKARVILA GKASNNPPFV
IHDMETLCMA EKTLVAKLVA NGIQNKEAEV RIFHCCQCTS VETVTELTEF AKSIPGFANL
DLNDQVTLLK YGVYEAIFAM LSSVMNKDGM LVAYGNGFIT REFLKSLRKP FCDIMEPKFD
FAMKFNALEL DDSDISLFVA AIICCGDRPG LLNVGHIEKM QEGIVHVLKL HLQTNHPDNI
FLFPKLLQKM ADLRQLVTEH AQLVQVIKKT ESDAALHPLL QEIYRDMY


Related products :

Catalog number Product name Quantity
E0934m ELISA kit Mouse,Mus musculus,Nr1c1,Nuclear receptor subfamily 1 group C member 1,Peroxisome proliferator-activated receptor alpha,Ppar,Ppara,PPAR-alpha 96T
E0934r ELISA Nr1c1,Nuclear receptor subfamily 1 group C member 1,Peroxisome proliferator-activated receptor alpha,Ppar,Ppara,PPAR-alpha,Rat,Rattus norvegicus 96T
E0934r ELISA kit Nr1c1,Nuclear receptor subfamily 1 group C member 1,Peroxisome proliferator-activated receptor alpha,Ppar,Ppara,PPAR-alpha,Rat,Rattus norvegicus 96T
U0934r CLIA Nr1c1,Nuclear receptor subfamily 1 group C member 1,Peroxisome proliferator-activated receptor alpha,Ppar,Ppara,PPAR-alpha,Rat,Rattus norvegicus 96T
E0934m ELISA Mouse,Mus musculus,Nr1c1,Nuclear receptor subfamily 1 group C member 1,Peroxisome proliferator-activated receptor alpha,Ppar,Ppara,PPAR-alpha 96T
U0934m CLIA Mouse,Mus musculus,Nr1c1,Nuclear receptor subfamily 1 group C member 1,Peroxisome proliferator-activated receptor alpha,Ppar,Ppara,PPAR-alpha 96T
E0934h ELISA kit Homo sapiens,Human,NR1C1,Nuclear receptor subfamily 1 group C member 1,Peroxisome proliferator-activated receptor alpha,PPAR,PPARA,PPAR-alpha 96T
E0934h ELISA Homo sapiens,Human,NR1C1,Nuclear receptor subfamily 1 group C member 1,Peroxisome proliferator-activated receptor alpha,PPAR,PPARA,PPAR-alpha 96T
U0934h CLIA Homo sapiens,Human,NR1C1,Nuclear receptor subfamily 1 group C member 1,Peroxisome proliferator-activated receptor alpha,PPAR,PPARA,PPAR-alpha 96T
32-204 PPAR gamma(PPARG), which encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. Three subtypes of PPARs are known PPAR-alpha, PPAR-delta, and PPAR-g 0.1 mL
E0934c ELISA kit Canis familiaris,Canis lupus familiaris,Dog,NR1C1,Nuclear receptor subfamily 1 group C member 1,Peroxisome proliferator-activated receptor alpha,PPARA,PPAR-alpha 96T
U0934c CLIA Canis familiaris,Canis lupus familiaris,Dog,NR1C1,Nuclear receptor subfamily 1 group C member 1,Peroxisome proliferator-activated receptor alpha,PPARA,PPAR-alpha 96T
E0934c ELISA Canis familiaris,Canis lupus familiaris,Dog,NR1C1,Nuclear receptor subfamily 1 group C member 1,Peroxisome proliferator-activated receptor alpha,PPARA,PPAR-alpha 96T
E2041m ELISA Mouse,Mus musculus,Nr1c2,NUC1,Nuclear hormone receptor 1,Nuclear receptor subfamily 1 group C member 2,Peroxisome proliferator-activated receptor beta,Peroxisome proliferator-activated receptor 96T
U2041m CLIA Mouse,Mus musculus,Nr1c2,NUC1,Nuclear hormone receptor 1,Nuclear receptor subfamily 1 group C member 2,Peroxisome proliferator-activated receptor beta,Peroxisome proliferator-activated receptor d 96T
U2041h CLIA kit Homo sapiens,Human,NR1C2,NUC1,NUCI,Nuclear hormone receptor 1,Nuclear receptor subfamily 1 group C member 2,Peroxisome proliferator-activated receptor beta,Peroxisome proliferator-activated 96T
E2041h ELISA kit Homo sapiens,Human,NR1C2,NUC1,NUCI,Nuclear hormone receptor 1,Nuclear receptor subfamily 1 group C member 2,Peroxisome proliferator-activated receptor beta,Peroxisome proliferator-activated 96T
E2041h ELISA Homo sapiens,Human,NR1C2,NUC1,NUCI,Nuclear hormone receptor 1,Nuclear receptor subfamily 1 group C member 2,Peroxisome proliferator-activated receptor beta,Peroxisome proliferator-activated rece 96T
U2041h CLIA Homo sapiens,Human,NR1C2,NUC1,NUCI,Nuclear hormone receptor 1,Nuclear receptor subfamily 1 group C member 2,Peroxisome proliferator-activated receptor beta,Peroxisome proliferator-activated recep 96T
E2041m ELISA kit Mouse,Mus musculus,Nr1c2,NUC1,Nuclear hormone receptor 1,Nuclear receptor subfamily 1 group C member 2,Peroxisome proliferator-activated receptor beta,Peroxisome proliferator-activated rece 96T
U2041m CLIA kit Mouse,Mus musculus,Nr1c2,NUC1,Nuclear hormone receptor 1,Nuclear receptor subfamily 1 group C member 2,Peroxisome proliferator-activated receptor beta,Peroxisome proliferator-activated recep 96T
E0886p ELISA kit NR1C3,Nuclear receptor subfamily 1 group C member 3,Peroxisome proliferator-activated receptor gamma,Pig,PPARG,PPAR-gamma,Sus scrofa 96T
U0886p CLIA NR1C3,Nuclear receptor subfamily 1 group C member 3,Peroxisome proliferator-activated receptor gamma,Pig,PPARG,PPAR-gamma,Sus scrofa 96T
E0886p ELISA NR1C3,Nuclear receptor subfamily 1 group C member 3,Peroxisome proliferator-activated receptor gamma,Pig,PPARG,PPAR-gamma,Sus scrofa 96T
E0886b ELISA Bos taurus,Bovine,NR1C3,Nuclear receptor subfamily 1 group C member 3,Peroxisome proliferator-activated receptor gamma,PPARG,PPAR-gamma 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur