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Peroxisome proliferator-activated receptor alpha (PPAR-alpha) (Nuclear receptor subfamily 1 group C member 1)
PPARA_CANLF Reviewed; 468 AA.
Q95N78;
25-OCT-2002, integrated into UniProtKB/Swiss-Prot.
01-DEC-2001, sequence version 1.
28-MAR-2018, entry version 134.
RecName: Full=Peroxisome proliferator-activated receptor alpha;
Short=PPAR-alpha;
AltName: Full=Nuclear receptor subfamily 1 group C member 1;
Name=PPARA; Synonyms=NR1C1;
Canis lupus familiaris (Dog) (Canis familiaris).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
Canis.
NCBI_TaxID=9615;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
Nagasawa M., Ide T., Murakami K.;
"Dog PPAR alpha cDNA sequence.";
Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Ligand-activated transcription factor. Key regulator of
lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-
2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated
by oleylethanolamide, a naturally occurring lipid that regulates
satiety. Receptor for peroxisome proliferators such as
hypolipidemic drugs and fatty acids. Regulates the peroxisomal
beta-oxidation pathway of fatty acids. Functions as transcription
activator for the ACOX1 and P450 genes. Transactivation activity
requires heterodimerization with RXRA and is antagonized by NR2C2.
May be required for the propagation of clock information to
metabolic pathways regulated by PER2 (By similarity).
{ECO:0000250}.
-!- SUBUNIT: Heterodimer; with RXRA. This heterodimerization is
required for DNA binding and transactivation activity. Interacts
with NCOA3 coactivator. Interacts with CITED2; the interaction
stimulates its transcriptional activity. Also interacts with
PPARBP in vitro. Interacts with AKAP13, LPIN1, PRDM16 and
coactivator NCOA6. Interacts with ASXL1 and ASXL2. Interacts with
PER2. Interacts with SIRT1; the interaction seems to be modulated
by NAD(+) levels (By similarity). {ECO:0000250|UniProtKB:P23204,
ECO:0000250|UniProtKB:P37230, ECO:0000250|UniProtKB:Q07869}.
-!- SUBCELLULAR LOCATION: Nucleus.
-!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR1
subfamily. {ECO:0000305}.
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EMBL; AF350327; AAK38655.1; -; mRNA.
RefSeq; NP_001003093.1; NM_001003093.1.
RefSeq; XP_005625734.1; XM_005625677.1.
RefSeq; XP_013972720.1; XM_014117245.1.
UniGene; Cfa.3519; -.
ProteinModelPortal; Q95N78; -.
SMR; Q95N78; -.
STRING; 9615.ENSCAFP00000001118; -.
BindingDB; Q95N78; -.
ChEMBL; CHEMBL2847; -.
PaxDb; Q95N78; -.
Ensembl; ENSCAFT00000001222; ENSCAFP00000001118; ENSCAFG00000000788.
GeneID; 403654; -.
KEGG; cfa:403654; -.
CTD; 5465; -.
VGNC; VGNC:44834; PPARA.
eggNOG; KOG3575; Eukaryota.
eggNOG; ENOG410XRZC; LUCA.
GeneTree; ENSGT00870000136388; -.
HOGENOM; HOG000261626; -.
HOVERGEN; HBG106004; -.
InParanoid; Q95N78; -.
KO; K07294; -.
OMA; FSFTEYQ; -.
OrthoDB; EOG091G05U8; -.
TreeFam; TF316304; -.
Reactome; R-CFA-383280; Nuclear Receptor transcription pathway.
Reactome; R-CFA-400206; Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha).
PRO; PR:Q95N78; -.
Proteomes; UP000002254; Chromosome 10.
Bgee; ENSCAFG00000000788; -.
GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
GO; GO:0003677; F:DNA binding; ISS:AgBase.
GO; GO:0003700; F:DNA binding transcription factor activity; ISS:AgBase.
GO; GO:0008144; F:drug binding; ISS:UniProtKB.
GO; GO:0008289; F:lipid binding; ISS:UniProtKB.
GO; GO:0004879; F:nuclear receptor activity; IEA:Ensembl.
GO; GO:0004872; F:receptor activity; ISS:AgBase.
GO; GO:0000978; F:RNA polymerase II proximal promoter sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0001103; F:RNA polymerase II repressing transcription factor binding; IEA:Ensembl.
GO; GO:0043565; F:sequence-specific DNA binding; ISS:AgBase.
GO; GO:0003707; F:steroid hormone receptor activity; IEA:Ensembl.
GO; GO:0001077; F:transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0001190; F:transcriptional activator activity, RNA polymerase II transcription factor binding; IEA:Ensembl.
GO; GO:0001078; F:transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0031624; F:ubiquitin conjugating enzyme binding; IEA:Ensembl.
GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
GO; GO:0032922; P:circadian regulation of gene expression; ISS:UniProtKB.
GO; GO:0070166; P:enamel mineralization; IEA:Ensembl.
GO; GO:0008544; P:epidermis development; ISS:AgBase.
GO; GO:0006631; P:fatty acid metabolic process; ISS:AgBase.
GO; GO:0032099; P:negative regulation of appetite; ISS:UniProtKB.
GO; GO:0010887; P:negative regulation of cholesterol storage; IEA:Ensembl.
GO; GO:0050728; P:negative regulation of inflammatory response; IEA:Ensembl.
GO; GO:1903038; P:negative regulation of leukocyte cell-cell adhesion; IEA:Ensembl.
GO; GO:0010745; P:negative regulation of macrophage derived foam cell differentiation; IEA:Ensembl.
GO; GO:1902894; P:negative regulation of pri-miRNA transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:0010871; P:negative regulation of receptor biosynthetic process; IEA:Ensembl.
GO; GO:0010891; P:negative regulation of sequestering of triglyceride; IEA:Ensembl.
GO; GO:0046321; P:positive regulation of fatty acid oxidation; IEA:Ensembl.
GO; GO:0045722; P:positive regulation of gluconeogenesis; IEA:Ensembl.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:AgBase.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
GO; GO:0072366; P:regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO; GO:0042752; P:regulation of circadian rhythm; ISS:UniProtKB.
GO; GO:0019217; P:regulation of fatty acid metabolic process; ISS:AgBase.
GO; GO:0072363; P:regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO; GO:0072369; P:regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO; GO:0042060; P:wound healing; IEA:Ensembl.
Gene3D; 3.30.50.10; -; 1.
InterPro; IPR003074; 1Cnucl_rcpt.
InterPro; IPR035500; NHR_like_dom_sf.
InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
InterPro; IPR001723; Nuclear_hrmn_rcpt.
InterPro; IPR003076; PPAR-alpha.
InterPro; IPR001628; Znf_hrmn_rcpt.
InterPro; IPR013088; Znf_NHR/GATA.
Pfam; PF00104; Hormone_recep; 1.
Pfam; PF00105; zf-C4; 1.
PRINTS; PR01288; PROXISOMEPAR.
PRINTS; PR01289; PROXISOMPAAR.
PRINTS; PR00398; STRDHORMONER.
PRINTS; PR00047; STROIDFINGER.
SMART; SM00430; HOLI; 1.
SMART; SM00399; ZnF_C4; 1.
SUPFAM; SSF48508; SSF48508; 1.
PROSITE; PS51843; NR_LBD; 1.
PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
2: Evidence at transcript level;
Activator; Biological rhythms; Complete proteome; DNA-binding;
Lipid-binding; Metal-binding; Nucleus; Receptor; Reference proteome;
Transcription; Transcription regulation; Zinc; Zinc-finger.
CHAIN 1 468 Peroxisome proliferator-activated
receptor alpha.
/FTId=PRO_0000053479.
DOMAIN 239 466 NR LBD. {ECO:0000255|PROSITE-
ProRule:PRU01189}.
DNA_BIND 99 173 Nuclear receptor. {ECO:0000255|PROSITE-
ProRule:PRU00407}.
ZN_FING 102 122 NR C4-type. {ECO:0000255|PROSITE-
ProRule:PRU00407}.
ZN_FING 139 161 NR C4-type. {ECO:0000255|PROSITE-
ProRule:PRU00407}.
REGION 304 433 Required for heterodimerization with
RXRA. {ECO:0000250}.
SITE 433 433 Essential for heterodimerization with
RXRA. {ECO:0000250}.
SEQUENCE 468 AA; 52123 MW; 11F2C2F9AAB176D5 CRC64;
MVDTESPICP LSPLEADDLE SPLSEEFLQE MGNIQEISQS IGEDSSGSFS FTEYQYLGSG
PGSDGSVITD TLSPAPSPSS VTHPAAPGGA EEPSSVALNI ECRICGDRAS GYHYGVHACE
GCKGFFRRTI RLKLAYDKCD RSCKIQKKNR NKCQYCRFHK CLSVGMSHNA IRFGRMPRSE
KAKLKAEILT CEQDPEDAET ADLKSLAKRI YEAYLKNFNM NKVKARVILA GKASNNPPFV
IHDMETLCMA EKTLVAKLVA NGIQNKEAEV RIFHCCQCTS VETVTELTEF AKSIPGFANL
DLNDQVTLLK YGVYEAIFAM LSSVMNKDGM LVAYGNGFIT REFLKSLRKP FCDIMEPKFD
FAMKFNALEL DDSDISLFVA AIICCGDRPG LLNVGHIEKM QEGIVHVLKL HLQTNHPDNI
FLFPKLLQKM ADLRQLVTEH AQLVQVIKKT ESDAALHPLL QEIYRDMY
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WP566: canonical wnt - zebrafish
WP1003: Ovarian Infertility Genes
WP1004: Kit Receptor Signaling Pathway
WP1011: T Cell Receptor Signaling Pathway
WP1014: Androgen receptor signaling pathway
WP1025: B Cell Receptor Signaling Pathway
WP1045: TGF-beta Receptor Signaling Pathway
WP1046: Signaling of Hepatocyte Growth Factor Receptor
WP1047: TNF-alpha NF-kB Signaling Pathway
WP1067: Toll-like receptor signaling pathway
WP1112: EPO Receptor Signaling
WP1120: Ovarian Infertility Genes
WP1121: Kit Receptor Signaling Pathway
WP1130: T Cell Receptor Signaling Pathway
WP1133: Androgen receptor signaling pathway
WP1144: B Cell Receptor Signaling Pathway
WP1161: TGF-beta Receptor Signaling Pathway
WP1162: Signaling of Hepatocyte Growth Factor Receptor
WP1163: TNF-alpha NF-kB Signaling Pathway
WP1183: Toll-like receptor signaling pathway
WP1206: Signaling of Hepatocyte Growth Factor Receptor
WP1209: EBV LMP1 signaling
WP1224: EBV LMP1 signaling
WP1225: estrogen signalling
Related Genes :
[PEX1] Peroxisome biogenesis factor 1 (Peroxin-1) (Peroxisome biogenesis disorder protein 1)
[PEX10 RNF69] Peroxisome biogenesis factor 10 (Peroxin-10) (Peroxisomal biogenesis factor 10) (Peroxisome assembly protein 10) (RING finger protein 69)
[PEX2 PAF1 PMP3 PMP35 PXMP3 RNF72] Peroxisome biogenesis factor 2 (35 kDa peroxisomal membrane protein) (Peroxin-2) (Peroxisomal membrane protein 3) (Peroxisome assembly factor 1) (PAF-1) (RING finger protein 72)
[PEX12 PAF3] Peroxisome assembly protein 12 (Peroxin-12) (Peroxisome assembly factor 3) (PAF-3)
[PEX12 APM4 At3g04460 T27C4.11] Peroxisome biogenesis protein 12 (Peroxin-12) (AtPEX12) (Pex12p) (Protein ABERRANT PEROXISOME MORPHOLOGY 4)
[PEX10 At2g26350 T9J22.2] Peroxisome biogenesis factor 10 (PER10) (Peroxin-10) (Peroxisomal biogenesis factor 10) (AtPEX10) (AthPEX10) (Peroxisome assembly protein 10) (Pex10p)
[PEX14 PED2 At5g62810 MQB2.13] Peroxisomal membrane protein PEX14 (Peroxin-14) (AtPEX14) (Peroxisome biogenesis protein 14) (Pex14p) (Protein PEROXISOME DEFECTIVE 2)
[PPARD NR1C2 PPARB] Peroxisome proliferator-activated receptor delta (PPAR-delta) (NUCI) (Nuclear hormone receptor 1) (NUC1) (Nuclear receptor subfamily 1 group C member 2) (Peroxisome proliferator-activated receptor beta) (PPAR-beta)
[Pex2 Paf1 Pmp35 Pxmp3] Peroxisome biogenesis factor 2 (Peroxin-2) (Peroxisomal membrane protein 3) (Peroxisome assembly factor 1) (PAF-1)
[PEX13 AMC APM2 At3g07560 F21O3.27] Peroxisomal membrane protein 13 (ABSTINENCE BY MUTUAL CONSENT) (Peroxin-13) (AtPEX13) (Peroxisome biogenesis protein 13) (Pex13p) (Protein ABERRANT PEROXISOME MORPHOLOGY 2) (Protein AMC)
[Ppard Nr1c2 Pparb] Peroxisome proliferator-activated receptor delta (PPAR-delta) (Nuclear hormone receptor 1) (NUC1) (Nuclear receptor subfamily 1 group C member 2) (Peroxisome proliferator-activated receptor beta) (PPAR-beta)
[Pex2 Paf1 Pmp35 Pxmp3] Peroxisome biogenesis factor 2 (Peroxin-2) (Peroxisomal membrane protein 3) (Peroxisome assembly factor 1) (PAF-1)
[PPARD NR1C2 PPARB] Peroxisome proliferator-activated receptor delta (PPAR-delta) (Nuclear receptor subfamily 1 group C member 2) (Peroxisome proliferator-activated receptor beta) (PPAR-beta)
[PEX6 PXAAA1] Peroxisome assembly factor 2 (PAF-2) (Peroxin-6) (Peroxisomal biogenesis factor 6) (Peroxisomal-type ATPase 1)
[PPARG NR1C3] Peroxisome proliferator-activated receptor gamma (PPAR-gamma) (Nuclear receptor subfamily 1 group C member 3)
[PEX5 PXR1] Peroxisomal targeting signal 1 receptor (PTS1 receptor) (PTS1R) (PTS1-BP) (Peroxin-5) (Peroxisomal C-terminal targeting signal import receptor) (Peroxisome receptor 1)
[PEX26] Peroxisome assembly protein 26 (Peroxin-26)
[PPARA NR1C1 PPAR] Peroxisome proliferator-activated receptor alpha (PPAR-alpha) (Nuclear receptor subfamily 1 group C member 1)
[PEX5 At5g56290 MXK23.3] Peroxisome biogenesis protein 5 (Peroxin-5) (AtPEX5) (Peroxisomal targeting signal type 1 receptor) (Pex5p)
[PEX16 SSE1 At2g45690 F17K2.22] Peroxisome biogenesis protein 16 (Peroxin-16) (AtPEX16) (AtPex16p) (Protein SHRUNKEN SEED 1)
[PEX2 TED3 At1g79810 F19K16.23 F20B17.23] Peroxisome biogenesis protein 2 (E3 ubiquitin-protein ligase PEX2) (Peroxin-2) (AtPEX2) (AthPEX2) (Pex2p)
[Pex5 Pxr1] Peroxisomal targeting signal 1 receptor (PTS1 receptor) (PTS1R) (PTS1-BP) (PXR1P) (Peroxin-5) (Peroxisomal C-terminal targeting signal import receptor) (Peroxisome receptor 1)
[Pex5 Pex5_predicted] Peroxisomal targeting signal 1 receptor (PTS1 receptor) (PTS1R) (PTS1-BP) (Peroxin-5) (Peroxisomal C-terminal targeting signal import receptor) (Peroxisome receptor 1)
[Pparg Nr1c3] Peroxisome proliferator-activated receptor gamma (PPAR-gamma) (Nuclear receptor subfamily 1 group C member 3)
[Ppara Nr1c1 Ppar] Peroxisome proliferator-activated receptor alpha (PPAR-alpha) (Nuclear receptor subfamily 1 group C member 1)
[PEX6 PAS8 YNL329C N0310] Peroxisomal ATPase PEX6 (Peroxin-6) (Peroxisomal assembly protein 8) (Peroxisome biosynthesis protein PAS8)
[PEX1 PAS1 YKL197C] Peroxisomal ATPase PEX1 (Peroxin-1) (Peroxisomal assembly protein 1) (Peroxisome biogenesis protein PAS1)
[PEX5] Peroxisomal targeting signal 1 receptor (PTS1 receptor) (PTS1R) (PTS1-BP) (Peroxin-5) (Peroxisomal C-terminal targeting signal import receptor) (Peroxisome receptor 1)
[Pparg Nr1c3] Peroxisome proliferator-activated receptor gamma (PPAR-gamma) (Nuclear receptor subfamily 1 group C member 3)
[PPARG NR1C3] Peroxisome proliferator-activated receptor gamma (PPAR-gamma) (Nuclear receptor subfamily 1 group C member 3)
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