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Peroxisome proliferator-activated receptor delta (PPAR-delta) (Nuclear hormone receptor 1) (NUC1) (Nuclear receptor subfamily 1 group C member 2) (Peroxisome proliferator-activated receptor beta) (PPAR-beta)

 PPARD_MOUSE             Reviewed;         440 AA.
P35396; P37239;
01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
01-JUN-1994, sequence version 1.
22-NOV-2017, entry version 172.
RecName: Full=Peroxisome proliferator-activated receptor delta;
Short=PPAR-delta;
AltName: Full=Nuclear hormone receptor 1;
Short=NUC1;
AltName: Full=Nuclear receptor subfamily 1 group C member 2;
AltName: Full=Peroxisome proliferator-activated receptor beta;
Short=PPAR-beta;
Name=Ppard; Synonyms=Nr1c2, Pparb;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=C57BL/6J; TISSUE=Adipocyte;
PubMed=7836471; DOI=10.1074/jbc.270.5.2367;
Amri E.-Z., Bonino F., Ailhaud G., Abumrad N.A., Grimaldi P.A.;
"Cloning of a protein that mediates transcriptional effects of fatty
acids in preadipocytes. Homology to peroxisome proliferator-activated
receptors.";
J. Biol. Chem. 270:2367-2371(1995).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Liver;
PubMed=8041794; DOI=10.1073/pnas.91.15.7355;
Kliewer S.A., Forman B.M., Blumberg B., Ong E.S., Borgmeyer U.,
Mangelsdorf D.J., Umesono K., Evans R.M.;
"Differential expression and activation of a family of murine
peroxisome proliferator-activated receptors.";
Proc. Natl. Acad. Sci. U.S.A. 91:7355-7359(1994).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J; TISSUE=Brain;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
NUCLEOTIDE SEQUENCE [MRNA] OF 1-145.
STRAIN=BALB/cJ; TISSUE=Brain;
PubMed=8240342; DOI=10.1006/bbrc.1993.2302;
Chen F., Law S.W., O'Malley B.W.;
"Identification of two mPPAR related receptors and evidence for the
existence of five subfamily members.";
Biochem. Biophys. Res. Commun. 196:671-677(1993).
-!- FUNCTION: Ligand-activated transcription factor. Receptor that
binds peroxisome proliferators such as hypolipidemic drugs and
fatty acids. Has a preference for poly-unsaturated fatty acids,
such as gamma-linoleic acid and eicosapentanoic acid. Once
activated by a ligand, the receptor binds to promoter elements of
target genes. Regulates the peroxisomal beta-oxidation pathway of
fatty acids. Functions as transcription activator for the acyl-CoA
oxidase gene. Decreases expression of NPC1L1 once activated by a
ligand (By similarity). {ECO:0000250}.
-!- SUBUNIT: Heterodimer with the retinoid X receptor.
-!- SUBCELLULAR LOCATION: Nucleus.
-!- TISSUE SPECIFICITY: Heart, adrenal and intestine.
-!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR1
subfamily. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAA03332.1; Type=Erroneous initiation; Evidence={ECO:0000305};
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution-NoDerivs License
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EMBL; L28116; AAA63394.1; -; mRNA.
EMBL; U10375; AAA19972.1; -; mRNA.
EMBL; BC070398; AAH70398.1; -; mRNA.
EMBL; U01665; AAA03332.1; ALT_INIT; mRNA.
CCDS; CCDS28575.1; -.
PIR; I55442; I55442.
RefSeq; NP_035275.1; NM_011145.3.
UniGene; Mm.328914; -.
ProteinModelPortal; P35396; -.
SMR; P35396; -.
BioGrid; 202319; 12.
DIP; DIP-29851N; -.
IntAct; P35396; 4.
STRING; 10090.ENSMUSP00000002320; -.
BindingDB; P35396; -.
ChEMBL; CHEMBL2458; -.
SwissLipids; SLP:000000397; -.
PhosphoSitePlus; P35396; -.
EPD; P35396; -.
PaxDb; P35396; -.
PRIDE; P35396; -.
Ensembl; ENSMUST00000002320; ENSMUSP00000002320; ENSMUSG00000002250.
GeneID; 19015; -.
KEGG; mmu:19015; -.
UCSC; uc008bqk.1; mouse.
CTD; 5467; -.
MGI; MGI:101884; Ppard.
eggNOG; KOG3575; Eukaryota.
eggNOG; ENOG410XRZC; LUCA.
GeneTree; ENSGT00870000136388; -.
HOGENOM; HOG000261626; -.
HOVERGEN; HBG106004; -.
InParanoid; P35396; -.
KO; K04504; -.
OMA; SLGMSHN; -.
OrthoDB; EOG091G05U8; -.
PhylomeDB; P35396; -.
TreeFam; TF316304; -.
Reactome; R-MMU-200425; Import of palmitoyl-CoA into the mitochondrial matrix.
Reactome; R-MMU-204174; Regulation of pyruvate dehydrogenase (PDH) complex.
Reactome; R-MMU-383280; Nuclear Receptor transcription pathway.
Reactome; R-MMU-5362517; Signaling by Retinoic Acid.
PRO; PR:P35396; -.
Proteomes; UP000000589; Chromosome 17.
Bgee; ENSMUSG00000002250; -.
CleanEx; MM_PPARD; -.
ExpressionAtlas; P35396; baseline and differential.
Genevisible; P35396; MM.
GO; GO:0000790; C:nuclear chromatin; IDA:BHF-UCL.
GO; GO:0005634; C:nucleus; IDA:MGI.
GO; GO:0003677; F:DNA binding; IDA:MGI.
GO; GO:0008144; F:drug binding; ISS:UniProtKB.
GO; GO:0008047; F:enzyme activator activity; TAS:UniProtKB.
GO; GO:0070539; F:linoleic acid binding; ISS:UniProtKB.
GO; GO:0008289; F:lipid binding; ISS:UniProtKB.
GO; GO:0051059; F:NF-kappaB binding; IEA:Ensembl.
GO; GO:0004879; F:nuclear receptor activity; ISS:UniProtKB.
GO; GO:0016501; F:prostacyclin receptor activity; TAS:UniProtKB.
GO; GO:0046982; F:protein heterodimerization activity; IPI:MGI.
GO; GO:0046965; F:retinoid X receptor binding; TAS:UniProtKB.
GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
GO; GO:0003707; F:steroid hormone receptor activity; IEA:InterPro.
GO; GO:0003713; F:transcription coactivator activity; IEA:Ensembl.
GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; ISO:MGI.
GO; GO:0008134; F:transcription factor binding; ISO:MGI.
GO; GO:0001227; F:transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding; IDA:BHF-UCL.
GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
GO; GO:0060612; P:adipose tissue development; IMP:MGI.
GO; GO:0006915; P:apoptotic process; ISO:MGI.
GO; GO:0097190; P:apoptotic signaling pathway; ISO:MGI.
GO; GO:0008366; P:axon ensheathment; IMP:MGI.
GO; GO:0030154; P:cell differentiation; IDA:MGI.
GO; GO:0008283; P:cell proliferation; IMP:MGI.
GO; GO:0031589; P:cell-substrate adhesion; IMP:MGI.
GO; GO:0009987; P:cellular process; TAS:MGI.
GO; GO:0071456; P:cellular response to hypoxia; IGI:MGI.
GO; GO:0071222; P:cellular response to lipopolysaccharide; IEA:Ensembl.
GO; GO:0046697; P:decidualization; IEA:Ensembl.
GO; GO:0007566; P:embryo implantation; IDA:MGI.
GO; GO:0008544; P:epidermis development; TAS:MGI.
GO; GO:0006635; P:fatty acid beta-oxidation; IEP:UniProtKB.
GO; GO:0015908; P:fatty acid transport; IEP:UniProtKB.
GO; GO:0007507; P:heart development; IEA:Ensembl.
GO; GO:0051546; P:keratinocyte migration; IMP:MGI.
GO; GO:0043616; P:keratinocyte proliferation; IMP:MGI.
GO; GO:0006629; P:lipid metabolic process; IMP:MGI.
GO; GO:0009299; P:mRNA transcription; IEA:Ensembl.
GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
GO; GO:0030308; P:negative regulation of cell growth; IEA:Ensembl.
GO; GO:0032966; P:negative regulation of collagen biosynthetic process; IEA:Ensembl.
GO; GO:0050680; P:negative regulation of epithelial cell proliferation; IGI:MGI.
GO; GO:0050728; P:negative regulation of inflammatory response; IEA:Ensembl.
GO; GO:0045662; P:negative regulation of myoblast differentiation; IMP:CACAO.
GO; GO:1902894; P:negative regulation of pri-miRNA transcription from RNA polymerase II promoter; IDA:BHF-UCL.
GO; GO:0014912; P:negative regulation of smooth muscle cell migration; IEA:Ensembl.
GO; GO:0048662; P:negative regulation of smooth muscle cell proliferation; IEA:Ensembl.
GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:MGI.
GO; GO:0008654; P:phospholipid biosynthetic process; IEA:Ensembl.
GO; GO:0001890; P:placenta development; IMP:MGI.
GO; GO:0097755; P:positive regulation of blood vessel diameter; IEA:Ensembl.
GO; GO:0008284; P:positive regulation of cell proliferation; IMP:MGI.
GO; GO:0045684; P:positive regulation of epidermis development; IEA:Ensembl.
GO; GO:0010628; P:positive regulation of gene expression; IMP:CACAO.
GO; GO:0032024; P:positive regulation of insulin secretion; IEA:Ensembl.
GO; GO:2000288; P:positive regulation of myoblast proliferation; IMP:CACAO.
GO; GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase signaling; IDA:MGI.
GO; GO:0043415; P:positive regulation of skeletal muscle tissue regeneration; IMP:CACAO.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
GO; GO:0006029; P:proteoglycan metabolic process; IEA:Ensembl.
GO; GO:0042127; P:regulation of cell proliferation; IGI:MGI.
GO; GO:0045598; P:regulation of fat cell differentiation; IMP:MGI.
GO; GO:0050796; P:regulation of insulin secretion; NAS:UniProtKB.
GO; GO:0014842; P:regulation of skeletal muscle satellite cell proliferation; IMP:CACAO.
GO; GO:0014823; P:response to activity; IEA:Ensembl.
GO; GO:0009749; P:response to glucose; IEA:Ensembl.
GO; GO:0033189; P:response to vitamin A; IEA:Ensembl.
GO; GO:0006776; P:vitamin A metabolic process; IEA:Ensembl.
GO; GO:0042060; P:wound healing; IMP:MGI.
Gene3D; 1.10.565.10; -; 2.
Gene3D; 3.30.50.10; -; 1.
InterPro; IPR003074; 1Cnucl_rcpt.
InterPro; IPR003075; 1Cnucl_rcpt_B.
InterPro; IPR035500; NHR_like_dom_sf.
InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
InterPro; IPR001723; Nuclear_hrmn_rcpt.
InterPro; IPR001628; Znf_hrmn_rcpt.
InterPro; IPR013088; Znf_NHR/GATA.
Pfam; PF00104; Hormone_recep; 1.
Pfam; PF00105; zf-C4; 1.
PRINTS; PR01288; PROXISOMEPAR.
PRINTS; PR01290; PROXISOMPABR.
PRINTS; PR00398; STRDHORMONER.
PRINTS; PR00047; STROIDFINGER.
SMART; SM00430; HOLI; 1.
SMART; SM00399; ZnF_C4; 1.
SUPFAM; SSF48508; SSF48508; 1.
PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
2: Evidence at transcript level;
Activator; Complete proteome; DNA-binding; Metal-binding; Nucleus;
Receptor; Reference proteome; Transcription; Transcription regulation;
Zinc; Zinc-finger.
CHAIN 1 440 Peroxisome proliferator-activated
receptor delta.
/FTId=PRO_0000053487.
DNA_BIND 70 144 Nuclear receptor. {ECO:0000255|PROSITE-
ProRule:PRU00407}.
ZN_FING 73 93 NR C4-type. {ECO:0000255|PROSITE-
ProRule:PRU00407}.
ZN_FING 110 132 NR C4-type. {ECO:0000255|PROSITE-
ProRule:PRU00407}.
REGION 253 440 Ligand-binding. {ECO:0000255}.
CONFLICT 149 150 EA -> DG (in Ref. 2; AAA19972).
{ECO:0000305}.
SEQUENCE 440 AA; 49715 MW; 58E0F595DD193FDA CRC64;
MEQPQEETPE AREEEKEEVA MGDGAPELNG GPEHTLPSSS CADLSQNSSP SSLLDQLQMG
CDGASGGSLN MECRVCGDKA SGFHYGVHAC EGCKGFFRRT IRMKLEYEKC DRICKIQKKN
RNKCQYCRFQ KCLALGMSHN AIRFGRMPEA EKRKLVAGLT ASEGCQHNPQ LADLKAFSKH
IYNAYLKNFN MTKKKARSIL TGKSSHNAPF VIHDIETLWQ AEKGLVWKQL VNGLPPYNEI
SVHVFYRCQS TTVETVRELT EFAKNIPNFS SLFLNDQVTL LKYGVHEAIF AMLASIVNKD
GLLVANGSGF VTHEFLRSLR KPFSDIIEPK FEFAVKFNAL ELDDSDLALF IAAIILCGDR
PGLMNVPQVE AIQDTILRAL EFHLQVNHPD SQYLFPKLLQ KMADLRQLVT EHAQMMQWLK
KTESETLLHP LLQEIYKDMY


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