GENTAUR Molecular Products.

 PXG_SESIN               Reviewed;         245 AA.
 Q9SQ57;
 22-FEB-2012, integrated into UniProtKB/Swiss-Prot.
 01-MAY-2000, sequence version 1.
 25-OCT-2017, entry version 41.
 RecName: Full=Peroxygenase;
          EC=1.11.2.3;
 AltName: Full=Caleosin;
          Short=SiCLO;
 Name=SOP1;
 Sesamum indicum (Oriental sesame) (Sesamum orientale).
 Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
 Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
 Pentapetalae; asterids; lamiids; Lamiales; Pedaliaceae; Sesamum.
 NCBI_TaxID=4182;
 [1]
 NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, CALCIUM-BINDING, PROTEIN
 SEQUENCE OF 44-58 AND 169-182, SUBCELLULAR LOCATION, AND DEVELOPMENTAL
 STAGE.
 PubMed=10589521; DOI=10.1093/oxfordjournals.pcp.a029490;
 Chen J.C., Tsai C.C., Tzen J.T.;
 "Cloning and secondary structure analysis of caleosin, a unique
 calcium-binding protein in oil bodies of plant seeds.";
 Plant Cell Physiol. 40:1079-1086(1999).
 [2]
 PROTEIN SEQUENCE OF N-TERMINUS, AND ACETYLATION AT ALA-2.
 PubMed=16198588; DOI=10.1016/j.plaphy.2005.07.008;
 Lin L.J., Liao P.C., Yang H.H., Tzen J.T.;
 "Determination and analyses of the N-termini of oil-body proteins,
 steroleosin, caleosin and oleosin.";
 Plant Physiol. Biochem. 43:770-776(2005).
 [3]
 UBIQUITINATION AT LYS-165 AND LYS-235, AND DEVELOPMENTAL STAGE.
 PubMed=21041098; DOI=10.1016/j.plaphy.2010.10.001;
 Hsiao E.S., Tzen J.T.;
 "Ubiquitination of oleosin-H and caleosin in sesame oil bodies after
 seed germination.";
 Plant Physiol. Biochem. 49:77-81(2011).
 -!- FUNCTION: Calcium-binding peroxygenase involved in the degradation
     of storage lipid in oil bodies. May be involved in the interaction
     between oil bodies and vacuoles during seed germination (By
     similarity). {ECO:0000250, ECO:0000269|PubMed:10589521}.
 -!- CATALYTIC ACTIVITY: RH + ROOH = ROH + ROH.
 -!- COFACTOR:
     Name=heme b; Xref=ChEBI:CHEBI:60344; Evidence={ECO:0000250};
     Note=Binds 1 heme b (iron(II)-protoporphyrin IX) group.
     {ECO:0000250};
 -!- COFACTOR:
     Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
 -!- SUBUNIT: Homodimer. {ECO:0000250}.
 -!- SUBCELLULAR LOCATION: Lipid droplet {ECO:0000269|PubMed:10589521}.
     Microsome membrane {ECO:0000269|PubMed:10589521}.
 -!- DEVELOPMENTAL STAGE: Expressed in maturing seeds 2 weeks after
     flowering. Decreases gradually after germination.
     {ECO:0000269|PubMed:10589521, ECO:0000269|PubMed:21041098}.
 -!- DOMAIN: Transmembrane regions are predicted by sequence analysis
     tools, but these regions probably constitute hydrophobic domains
     associated to phospholipids.
 -!- DOMAIN: The proline-knot motif (121-130) may be involved in
     targeting to lipid bodies.
 -!- SIMILARITY: Belongs to the caleosin family. {ECO:0000305}.
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 EMBL; AF109921; AAF13743.1; -; mRNA.
 RefSeq; NP_001291323.1; NM_001304394.1.
 SMR; Q9SQ57; -.
 iPTMnet; Q9SQ57; -.
 GeneID; 105171741; -.
 KEGG; sind:105171741; -.
 KO; K17991; -.
 GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
 GO; GO:0005811; C:lipid droplet; IEA:UniProtKB-SubCell.
 GO; GO:0031090; C:organelle membrane; IEA:UniProtKB-SubCell.
 GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO; GO:1990137; F:plant seed peroxidase activity; IEA:UniProtKB-EC.
 InterPro; IPR007736; Caleosin-related.
 PANTHER; PTHR31495; PTHR31495; 1.
 Pfam; PF05042; Caleosin; 1.
 1: Evidence at protein level;
 Acetylation; Calcium; Direct protein sequencing;
 Endoplasmic reticulum; Heme; Iron; Isopeptide bond; Lipid droplet;
 Membrane; Metal-binding; Microsome; Oxidoreductase; Ubl conjugation.
 INIT_MET      1      1       Removed. {ECO:0000269|PubMed:16198588}.
 CHAIN         2    245       Peroxygenase.
                              /FTId=PRO_0000415560.
 DOMAIN       65    100       EF-hand.
 CA_BIND      78     89       {ECO:0000255}.
 MOTIF       121    130       Proline-knot.
 COMPBIAS      7     10       Poly-Ala.
 METAL        73     73       Iron (heme axial ligand). {ECO:0000250}.
 MOD_RES       2      2       N-acetylalanine.
                              {ECO:0000269|PubMed:16198588}.
 CROSSLNK    165    165       Glycyl lysine isopeptide (Lys-Gly)
                              (interchain with G-Cter in ubiquitin).
                              {ECO:0000269|PubMed:21041098}.
 CROSSLNK    235    235       Glycyl lysine isopeptide (Lys-Gly)
                              (interchain with G-Cter in ubiquitin).
                              {ECO:0000269|PubMed:21041098}.
 SEQUENCE   245 AA;  27636 MW;  1AAD636019C0CA41 CRC64;
 MATHVLAAAA ERNAALAPDA PLAPVTMERP VRTDLETSIP KPYMARGLVA PDMDHPNGTP
 GHVHDNLSVL QQHCAFFDQD DNGIIYPWET YSGLRQIGFN VIASLIMAIV INVALSYPTL
 PGWIPSPFFP IYLYNIHKAK HGSDSGTYDT EGRYLPMNFE NLFSKHARTM PDRLTLGELW
 SMTEANREAF DIFGWIASKM EWTLLYILAR DQDGFLSKEA IRRCYDGSLF EYCAKMQRGA
 EDKMK

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