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Pertactin autotransporter (P.95) [Cleaved into: Outer membrane protein P.70; Pertactin translocator]

 PERT_BORPA              Reviewed;         922 AA.
P24328;
01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
01-MAR-1992, sequence version 1.
28-FEB-2018, entry version 132.
RecName: Full=Pertactin autotransporter;
AltName: Full=P.95;
Contains:
RecName: Full=Outer membrane protein P.70;
Contains:
RecName: Full=Pertactin translocator;
Flags: Precursor;
Name=prn; OrderedLocusNames=BPP1150;
Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253).
Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
Alcaligenaceae; Bordetella.
NCBI_TaxID=257311;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=CN2591;
PubMed=2041476; DOI=10.1111/j.1365-2958.1991.tb02123.x;
Li L.J., Dougan G., Novotny P., Charles I.G.;
"P.70 pertactin, an outer-membrane protein from Bordetella
parapertussis: cloning, nucleotide sequence and surface expression in
Escherichia coli.";
Mol. Microbiol. 5:409-417(1991).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=12822 / ATCC BAA-587 / NCTC 13253;
PubMed=12910271; DOI=10.1038/ng1227;
Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R.,
Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L.,
Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A.,
Achtman M., Atkin R., Baker S., Basham D., Bason N., Cherevach I.,
Chillingworth T., Collins M., Cronin A., Davis P., Doggett J.,
Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K.,
Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C.,
Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K.,
Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K.,
Unwin L., Whitehead S., Barrell B.G., Maskell D.J.;
"Comparative analysis of the genome sequences of Bordetella pertussis,
Bordetella parapertussis and Bordetella bronchiseptica.";
Nat. Genet. 35:32-40(2003).
-!- FUNCTION: Agglutinogen that binds to eukaryotic cells; a process
mediated by the R-G-D sequence. Pertactin may have a role in
bacterial adhesion, and thus play a role in virulence. May
contribute to the disease state of whooping cough.
-!- SUBUNIT: Monomer.
-!- SUBCELLULAR LOCATION: Pertactin autotransporter: Periplasm
{ECO:0000250}.
-!- SUBCELLULAR LOCATION: Outer membrane protein P.70: Secreted. Cell
surface.
-!- SUBCELLULAR LOCATION: Pertactin translocator: Cell outer membrane
{ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=The
cleaved C-terminal fragment (autotransporter domain) is localized
in the outer membrane.
-!- DOMAIN: The signal peptide, cleaved at the inner membrane, guides
the autotransporter protein to the periplasmic space. Then,
insertion of the C-terminal translocator domain in the outer
membrane forms a hydrophilic pore for the translocation of the
passenger domain to the bacterial cell surface, with subsequent
cleavage (By similarity). {ECO:0000250}.
-!- MISCELLANEOUS: Synthesized only in the presence of low Mg(2+)
concentrations.
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EMBL; X54547; CAA38419.1; -; Genomic_DNA.
EMBL; BX640426; CAE36451.1; -; Genomic_DNA.
PIR; S15204; S15204.
RefSeq; WP_010927881.1; NC_002928.3.
ProteinModelPortal; P24328; -.
SMR; P24328; -.
EnsemblBacteria; CAE36451; CAE36451; BPP1150.
KEGG; bpa:BPP1150; -.
HOGENOM; HOG000115499; -.
KO; K12681; -.
OMA; YATYIAN; -.
BioCyc; BPAR257311:G1GSY-1182-MONOMER; -.
Proteomes; UP000001421; Chromosome.
GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
GO; GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
GO; GO:0009405; P:pathogenesis; IEA:UniProtKB-KW.
Gene3D; 2.160.20.20; -; 1.
InterPro; IPR005546; Autotransporte_beta.
InterPro; IPR036709; Autotransporte_beta_dom_sf.
InterPro; IPR006315; OM_autotransptr_brl.
InterPro; IPR012332; P22_tailspike-like_C_sf.
InterPro; IPR011050; Pectin_lyase_fold/virulence.
InterPro; IPR003992; Pertactin.
InterPro; IPR004899; Pertactin_central.
InterPro; IPR003991; Pertactin_virulence_factor.
Pfam; PF03797; Autotransporter; 1.
Pfam; PF03212; Pertactin; 1.
PRINTS; PR01482; PERTACTIN.
PRINTS; PR01484; PRTACTNFAMLY.
SMART; SM00869; Autotransporter; 1.
SUPFAM; SSF103515; SSF103515; 1.
SUPFAM; SSF51126; SSF51126; 1.
TIGRFAMs; TIGR01414; autotrans_barl; 1.
PROSITE; PS51208; AUTOTRANSPORTER; 1.
3: Inferred from homology;
Cell adhesion; Cell outer membrane; Complete proteome; Membrane;
Periplasm; Repeat; Secreted; Signal; Transmembrane;
Transmembrane beta strand; Virulence.
SIGNAL 1 34 {ECO:0000255}.
CHAIN 35 922 Pertactin autotransporter.
/FTId=PRO_0000002708.
CHAIN 35 643 Outer membrane protein P.70.
/FTId=PRO_0000002709.
CHAIN 644 922 Pertactin translocator.
/FTId=PRO_0000002710.
REPEAT 266 270 1.
REPEAT 271 275 2.
REPEAT 276 280 3.
REPEAT 281 285 4; approximate.
DOMAIN 654 922 Autotransporter. {ECO:0000255|PROSITE-
ProRule:PRU00556}.
REGION 266 290 4 X 5 AA tandem repeats of G-G-A-V-P.
REGION 575 603 9 X 3 AA approximate repeats of P-Q-P.
MOTIF 260 262 Cell attachment site; involved in
adhesion to various eukaryotic cell
lines.
SITE 643 644 Cleavage. {ECO:0000250}.
SEQUENCE 922 AA; 95178 MW; 3DF7BC58D4712478 CRC64;
MNMSLSRIVK AAPLRRTTLA MALGALGAAP AAYADWNNQS IIKAGERQHG IHIKQSDGAG
VRTATGTTIK VSGRQAQGVL LENPAAELRF QNGSVTSSGQ LFDEGVRRFL GTVTVKAGKL
VADHATLANV SDTRDDDGIA LYVAGEQAQA SIADSTLQGA GGVRVERGAN VTVQRSTIVD
GGLHIGTLQP LQPEDLPPSR VVLGDTSVTA VPASGAPAAV FVFGANELTV DGGHITGGRA
AGVAAMDGAI VHLQRATIRR GDAPAGGAVP GGAVPGGAVP GGFGPLLDGW YGVDVSDSTV
DLAQSIVEAP QLGAAIRAGR GARVTVSGGS LSAPHGNVIE TGGGARRFPP PASPLSITLQ
AGARAQGRAL LYRVLPEPVK LTLAGGAQGQ GDIVATELPP IPGASSGPLD VALASQARWT
GATRAVDSLS IDNATWVMTD NSNVGALRLA SDGSVDFQQP AEAGRFKVLM VDTLAGSGLF
RMNVFADLGL SDKLVVMRDA SGQHRLWVRN SGSEPASGNT MLLVQTPRGS AATFTLANKD
GKVDIGTYRY RLAANGNGQW SLVGAKAPPA PKPAPQPGPQ PGPQPPQPPQ PPQPPQPPQP
PQRQPEAPAP QPPAGRELSA AANAAVNTGG VGLASTLWYA ESNALSKRLG ELRLNPDAGG
AWGRGFAQRQ QLDNRAGRRF DQKVAGFELG ADHAVAVAGG RWHLGGLAGY TRGDRGFTGD
GGGHTDSVHV GGYATYIANS GFYLDATLRA SRLENDFKVA GSDGYAVKGK YRTHGVGVSL
EAGRRFAHAD GWFLEPQAEL AVFRVGGGAY RAANGLRVRD EGGSSVLGRL GLEVGKRIEL
AGGRQVQPYI KASVLQEFDG AGTVRTNGIA HRTELRGTRA ELGLGMAAAL GRGHSLYASY
EYSKGPKLAM PWTFHAGYRY SW


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