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Phorbol-12-myristate-13-acetate-induced protein 1 (Protein Noxa)

 APR_RAT                 Reviewed;         105 AA.
Q5U777;
20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
07-DEC-2004, sequence version 1.
10-MAY-2017, entry version 78.
RecName: Full=Phorbol-12-myristate-13-acetate-induced protein 1;
AltName: Full=Protein Noxa;
Name=Pmaip1; Synonyms=Noxa;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Sprague-Dawley; TISSUE=Embryonic brain;
Yakovlev A.G.;
Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Promotes activation of caspases and apoptosis. Promotes
mitochondrial membrane changes and efflux of apoptogenic proteins
from the mitochondria. Contributes to p53/TP53-dependent apoptosis
after radiation exposure. Promotes proteasomal degradation of
MCL1. Competes with BAK1 and with BIM/BCL2L11 for binding to MCL1;
can displace BAK1 and BIM/BCL2L11 from their binding sites (By
similarity). {ECO:0000250}.
-!- SUBUNIT: Interacts with MCL1, BCL2A1 and BAX. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
-!- DOMAIN: The BH3 motif is essential for pro-apoptotic activity.
{ECO:0000250}.
-!- SIMILARITY: Belongs to the PMAIP1 family. {ECO:0000305}.
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EMBL; AY788892; AAV51955.1; -; mRNA.
RefSeq; NP_001008386.1; NM_001008385.1.
UniGene; Rn.163380; -.
ProteinModelPortal; Q5U777; -.
SMR; Q5U777; -.
STRING; 10116.ENSRNOP00000025361; -.
PhosphoSitePlus; Q5U777; -.
PaxDb; Q5U777; -.
Ensembl; ENSRNOT00000025362; ENSRNOP00000025361; ENSRNOG00000018770.
GeneID; 492821; -.
KEGG; rno:492821; -.
UCSC; RGD:1359266; rat.
CTD; 5366; -.
RGD; 1359266; Pmaip1.
eggNOG; ENOG410J6XT; Eukaryota.
eggNOG; ENOG4111AWA; LUCA.
GeneTree; ENSGT00530000065105; -.
HOGENOM; HOG000034021; -.
HOVERGEN; HBG095669; -.
InParanoid; Q5U777; -.
KO; K10131; -.
OMA; ADLKDEC; -.
OrthoDB; EOG091G1040; -.
TreeFam; TF339379; -.
Reactome; R-RNO-111448; Activation of NOXA and translocation to mitochondria.
Reactome; R-RNO-111453; BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members.
PRO; PR:Q5U777; -.
Proteomes; UP000002494; Chromosome 18.
Bgee; ENSRNOG00000018770; -.
Genevisible; Q5U777; RN.
GO; GO:0005739; C:mitochondrion; IDA:RGD.
GO; GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:Ensembl.
GO; GO:0006915; P:apoptotic process; IEP:RGD.
GO; GO:0042771; P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; IEA:Ensembl.
GO; GO:0070059; P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; IEA:Ensembl.
GO; GO:0048147; P:negative regulation of fibroblast proliferation; IEA:Ensembl.
GO; GO:0010917; P:negative regulation of mitochondrial membrane potential; IEA:Ensembl.
GO; GO:0043065; P:positive regulation of apoptotic process; IMP:RGD.
GO; GO:0043517; P:positive regulation of DNA damage response, signal transduction by p53 class mediator; IEA:Ensembl.
GO; GO:0043525; P:positive regulation of neuron apoptotic process; IEA:Ensembl.
GO; GO:1900740; P:positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; IEA:Ensembl.
GO; GO:0001836; P:release of cytochrome c from mitochondria; IEA:Ensembl.
GO; GO:0009411; P:response to UV; IEA:Ensembl.
GO; GO:0010165; P:response to X-ray; IEA:Ensembl.
GO; GO:0043029; P:T cell homeostasis; IEA:Ensembl.
InterPro; IPR024140; Noxa.
PANTHER; PTHR14299; PTHR14299; 1.
Pfam; PF15150; PMAIP1; 2.
3: Inferred from homology;
Apoptosis; Complete proteome; Mitochondrion; Reference proteome;
Repeat.
CHAIN 1 105 Phorbol-12-myristate-13-acetate-induced
protein 1.
/FTId=PRO_0000333231.
REGION 92 101 Required for mitochondrial location.
{ECO:0000250}.
MOTIF 27 35 BH3 1.
MOTIF 80 88 BH3 2.
SEQUENCE 105 AA; 11901 MW; 76EF4EE17827890E CRC64;
MPGRKARRNA PLNPTRAELP PEFAAQLRKI GDKVYCTWSA PDITAVLAQM PGKKSRKSTM
RRSPSPTRVP ADLKDECDQL RRIGDKVNLR QKLLNFISKL FNLIT


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