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Phosphatidylinositol 3-kinase VPS34 (PI3-kinase VPS34) (PI3K VPS34) (PtdIns-3-kinase VPS34) (EC 2.7.1.137) (Carboxypeptidase Y-deficient protein 15) (Vacuolar protein sorting-associated protein 34) (Vacuolar protein-targeting protein 29)

 VPS34_YEAST             Reviewed;         875 AA.
P22543; D6VYN8;
01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
01-AUG-1991, sequence version 1.
22-NOV-2017, entry version 171.
RecName: Full=Phosphatidylinositol 3-kinase VPS34;
Short=PI3-kinase VPS34;
Short=PI3K VPS34;
Short=PtdIns-3-kinase VPS34;
EC=2.7.1.137;
AltName: Full=Carboxypeptidase Y-deficient protein 15;
AltName: Full=Vacuolar protein sorting-associated protein 34;
AltName: Full=Vacuolar protein-targeting protein 29;
Name=VPS34; Synonyms=END12, PEP15, VPL7, VPT29;
OrderedLocusNames=YLR240W; ORFNames=L9672.10;
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
NCBI_TaxID=559292;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
PubMed=2247081; DOI=10.1128/MCB.10.12.6742;
Herman P.K., Emr S.D.;
"Characterization of VPS34, a gene required for vacuolar protein
sorting and vacuole segregation in Saccharomyces cerevisiae.";
Mol. Cell. Biol. 10:6742-6754(1990).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 204508 / S288c;
PubMed=9169871;
Johnston M., Hillier L.W., Riles L., Albermann K., Andre B.,
Ansorge W., Benes V., Brueckner M., Delius H., Dubois E.,
Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U.,
Heumann K., Heuss-Neitzel D., Hilbert H., Hilger F., Kleine K.,
Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T.,
Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E.,
Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M.,
Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C.,
Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M.,
Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H.,
Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A.,
Hani J., Hoheisel J.D.;
"The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.";
Nature 387:87-90(1997).
[3]
GENOME REANNOTATION.
STRAIN=ATCC 204508 / S288c;
PubMed=24374639; DOI=10.1534/g3.113.008995;
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M.,
Cherry J.M.;
"The reference genome sequence of Saccharomyces cerevisiae: Then and
now.";
G3 (Bethesda) 4:389-398(2014).
[4]
FUNCTION.
PubMed=3062374; DOI=10.1128/MCB.8.11.4936;
Robinson J.S., Klionsky D.J., Banta L.M., Emr S.D.;
"Protein sorting in Saccharomyces cerevisiae: isolation of mutants
defective in the delivery and processing of multiple vacuolar
hydrolases.";
Mol. Cell. Biol. 8:4936-4948(1988).
[5]
FUNCTION.
PubMed=2555343;
Auger K.R., Carpenter C.L., Cantley L.C., Varticovski L.;
"Phosphatidylinositol 3-kinase and its novel product,
phosphatidylinositol 3-phosphate, are present in Saccharomyces
cerevisiae.";
J. Biol. Chem. 264:20181-20184(1989).
[6]
FUNCTION, AND INTERACTION WITH VPS15.
PubMed=8387919;
Stack J.H., Herman P.K., Schu P.V., Emr S.D.;
"A membrane-associated complex containing the Vps15 protein kinase and
the Vps34 PI 3-kinase is essential for protein sorting to the yeast
lysosome-like vacuole.";
EMBO J. 12:2195-2204(1993).
[7]
FUNCTION, AND MUTAGENESIS OF ASP-731; ASN-736 AND ASP-749.
PubMed=8385367; DOI=10.1126/science.8385367;
Schu P.V., Takegawa K., Fry M.J., Stack J.H., Waterfield M.D.,
Emr S.D.;
"Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential
for protein sorting.";
Science 260:88-91(1993).
[8]
FUNCTION, AND AUTOPHOSPHORYLATION.
PubMed=7989323;
Stack J.H., Emr S.D.;
"Vps34p required for yeast vacuolar protein sorting is a multiple
specificity kinase that exhibits both protein kinase and
phosphatidylinositol-specific PI 3-kinase activities.";
J. Biol. Chem. 269:31552-31562(1994).
[9]
FUNCTION.
PubMed=7929582; DOI=10.1083/jcb.127.2.373;
Munn A.L., Riezman H.;
"Endocytosis is required for the growth of vacuolar H(+)-ATPase-
defective yeast: identification of six new END genes.";
J. Cell Biol. 127:373-386(1994).
[10]
FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH VPS15; VPS30;
VPS38 AND ATG14.
PubMed=11157979; DOI=10.1083/jcb.152.3.519;
Kihara A., Noda T., Ishihara N., Ohsumi Y.;
"Two distinct Vps34 phosphatidylinositol 3-kinase complexes function
in autophagy and carboxypeptidase Y sorting in Saccharomyces
cerevisiae.";
J. Cell Biol. 152:519-530(2001).
[11]
FUNCTION.
PubMed=11523784; DOI=10.1007/s004380100510;
Takahashi T., Shimoi H., Ito K.;
"Identification of genes required for growth under ethanol stress
using transposon mutagenesis in Saccharomyces cerevisiae.";
Mol. Genet. Genomics 265:1112-1119(2001).
[12]
FUNCTION.
PubMed=12244127; DOI=10.1242/jcs.00090;
Burda P., Padilla S.M., Sarkar S., Emr S.D.;
"Retromer function in endosome-to-Golgi retrograde transport is
regulated by the yeast Vps34 PtdIns 3-kinase.";
J. Cell Sci. 115:3889-3900(2002).
[13]
SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
PubMed=14562095; DOI=10.1038/nature02026;
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
Weissman J.S., O'Shea E.K.;
"Global analysis of protein localization in budding yeast.";
Nature 425:686-691(2003).
[14]
LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
PubMed=14562106; DOI=10.1038/nature02046;
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A.,
Dephoure N., O'Shea E.K., Weissman J.S.;
"Global analysis of protein expression in yeast.";
Nature 425:737-741(2003).
[15]
IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE
AUTOPHAGY-SPECIFIC VPS34 PI3-KINASE COMPLEX I, AND INTERACTION WITH
ATG38.
PubMed=24165940; DOI=10.1083/jcb.201304123;
Araki Y., Ku W.C., Akioka M., May A.I., Hayashi Y., Arisaka F.,
Ishihama Y., Ohsumi Y.;
"Atg38 is required for autophagy-specific phosphatidylinositol 3-
kinase complex integrity.";
J. Cell Biol. 203:299-313(2013).
-!- FUNCTION: Phosphatidylinositol 3-kinase required for cytoplasm to
vacuole transport (Cvt) and autophagy as a part of the autophagy-
specific VPS34 PI3-kinase complex I. This complex is essential to
recruit the ATG8-phosphatidylinositol conjugate and the ATG12-ATG5
conjugate to the pre-autophagosomal structure. Also involved in
endosome-to-Golgi retrograde transport as part of the VPS34 PI3-
kinase complex II. This second complex is required for the
endosome-to-Golgi retrieval of PEP1 and KEX2, and the recruitment
of VPS5 and VPS7, two components of the retromer complex, to
endosomal membranes (probably through the synthesis of a specific
pool of phosphatidylinositol 3-phosphate recruiting the retromer
to the endosomes). Its activation by VPS15 may lead to the
phosphorylation of phosphatidylinositol in the sorting compartment
membrane. Finally, it might also be involved in ethanol tolerance
and cell wall integrity. {ECO:0000269|PubMed:11157979,
ECO:0000269|PubMed:11523784, ECO:0000269|PubMed:12244127,
ECO:0000269|PubMed:2247081, ECO:0000269|PubMed:2555343,
ECO:0000269|PubMed:3062374, ECO:0000269|PubMed:7929582,
ECO:0000269|PubMed:7989323, ECO:0000269|PubMed:8385367,
ECO:0000269|PubMed:8387919}.
-!- CATALYTIC ACTIVITY: ATP + 1-phosphatidyl-1D-myo-inositol = ADP +
1-phosphatidyl-1D-myo-inositol 3-phosphate.
-!- ENZYME REGULATION: Phosphatidylinositol 3-kinase activity is
directly dependent on VPS15 protein kinase activity.
-!- SUBUNIT: Component of the autophagy-specific VPS34 PI3-kinase
complex I composed of VPS15, VPS30, VPS34, ATG14, AND ATG38; and
of the VPS34 PI3-kinase complex II composed of VPS15, VPS30, VPS34
and VPS38. Interacts directly with ATG38.
{ECO:0000269|PubMed:11157979, ECO:0000269|PubMed:24165940,
ECO:0000269|PubMed:8387919}.
-!- INTERACTION:
Q05789:ATG38; NbExp=5; IntAct=EBI-20405, EBI-35873;
P08539:GPA1; NbExp=3; IntAct=EBI-20405, EBI-7376;
P22219:VPS15; NbExp=3; IntAct=EBI-20405, EBI-20347;
-!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network
membrane {ECO:0000269|PubMed:11157979}; Peripheral membrane
protein {ECO:0000269|PubMed:11157979}. Endosome membrane
{ECO:0000269|PubMed:11157979}; Peripheral membrane protein
{ECO:0000269|PubMed:11157979}.
-!- PTM: Autophosphorylated. Might also be phosphorylated by VPS15.
-!- MISCELLANEOUS: Present with 1080 molecules/cell in log phase SD
medium. {ECO:0000269|PubMed:14562106}.
-!- SIMILARITY: Belongs to the PI3/PI4-kinase family.
{ECO:0000255|PROSITE-ProRule:PRU00880}.
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EMBL; X53531; CAA37610.1; -; Genomic_DNA.
EMBL; U20865; AAB67396.1; -; Genomic_DNA.
EMBL; U19027; AAB67422.2; -; Genomic_DNA.
EMBL; BK006945; DAA09554.1; -; Genomic_DNA.
PIR; A36369; A36369.
RefSeq; NP_013341.1; NM_001182127.1.
PDB; 5DFZ; X-ray; 4.40 A; C=1-875.
PDB; 5KC2; EM; 28.00 A; C=1-875.
PDBsum; 5DFZ; -.
PDBsum; 5KC2; -.
ProteinModelPortal; P22543; -.
SMR; P22543; -.
BioGrid; 31507; 113.
DIP; DIP-97N; -.
IntAct; P22543; 6.
MINT; MINT-2780608; -.
STRING; 4932.YLR240W; -.
iPTMnet; P22543; -.
MaxQB; P22543; -.
PRIDE; P22543; -.
EnsemblFungi; YLR240W; YLR240W; YLR240W.
GeneID; 850941; -.
KEGG; sce:YLR240W; -.
EuPathDB; FungiDB:YLR240W; -.
SGD; S000004230; VPS34.
GeneTree; ENSGT00760000119110; -.
HOGENOM; HOG000174003; -.
InParanoid; P22543; -.
KO; K00914; -.
OMA; FKKHEMG; -.
OrthoDB; EOG092C13UM; -.
BioCyc; YEAST:YLR240W-MONOMER; -.
BRENDA; 2.7.1.137; 984.
Reactome; R-SCE-1266695; Interleukin-7 signaling.
Reactome; R-SCE-1632852; Macroautophagy.
Reactome; R-SCE-1660499; Synthesis of PIPs at the plasma membrane.
Reactome; R-SCE-1660514; Synthesis of PIPs at the Golgi membrane.
Reactome; R-SCE-1660516; Synthesis of PIPs at the early endosome membrane.
Reactome; R-SCE-1660517; Synthesis of PIPs at the late endosome membrane.
Reactome; R-SCE-5668599; RHO GTPases Activate NADPH Oxidases.
PRO; PR:P22543; -.
Proteomes; UP000002311; Chromosome XII.
GO; GO:0005768; C:endosome; IDA:SGD.
GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
GO; GO:0000329; C:fungal-type vacuole membrane; IDA:SGD.
GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
GO; GO:0071561; C:nucleus-vacuole junction; IDA:SGD.
GO; GO:0005777; C:peroxisome; IDA:SGD.
GO; GO:0034271; C:phosphatidylinositol 3-kinase complex, class III, type I; IDA:SGD.
GO; GO:0034272; C:phosphatidylinositol 3-kinase complex, class III, type II; IDA:SGD.
GO; GO:0000407; C:pre-autophagosomal structure; IDA:SGD.
GO; GO:0016303; F:1-phosphatidylinositol-3-kinase activity; IDA:SGD.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0004672; F:protein kinase activity; IDA:SGD.
GO; GO:0000045; P:autophagosome assembly; IBA:GO_Central.
GO; GO:0030242; P:autophagy of peroxisome; IMP:SGD.
GO; GO:0006897; P:endocytosis; IBA:GO_Central.
GO; GO:0016197; P:endosomal transport; IBA:GO_Central.
GO; GO:0046854; P:phosphatidylinositol phosphorylation; IDA:SGD.
GO; GO:0048015; P:phosphatidylinositol-mediated signaling; IBA:GO_Central.
GO; GO:0032968; P:positive regulation of transcription elongation from RNA polymerase II promoter; IMP:SGD.
GO; GO:0006468; P:protein phosphorylation; IDA:SGD.
GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
GO; GO:0072593; P:reactive oxygen species metabolic process; IEA:EnsemblPlants.
GO; GO:0009651; P:response to salt stress; IEA:EnsemblPlants.
Gene3D; 1.10.1070.11; -; 1.
Gene3D; 2.60.40.150; -; 1.
InterPro; IPR016024; ARM-type_fold.
InterPro; IPR035892; C2_domain_sf.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR000403; PI3/4_kinase_cat_dom.
InterPro; IPR036940; PI3/4_kinase_cat_sf.
InterPro; IPR018936; PI3/4_kinase_CS.
InterPro; IPR002420; PI3K_C2_dom.
InterPro; IPR008290; PI3K_Vps34.
InterPro; IPR015433; PI_Kinase.
InterPro; IPR001263; PInositide-3_kin_accessory_dom.
PANTHER; PTHR10048; PTHR10048; 1.
Pfam; PF00454; PI3_PI4_kinase; 1.
Pfam; PF00792; PI3K_C2; 1.
Pfam; PF00613; PI3Ka; 1.
PIRSF; PIRSF000587; PI3K_Vps34; 1.
SMART; SM00142; PI3K_C2; 1.
SMART; SM00145; PI3Ka; 1.
SMART; SM00146; PI3Kc; 1.
SUPFAM; SSF48371; SSF48371; 2.
SUPFAM; SSF49562; SSF49562; 1.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS00915; PI3_4_KINASE_1; 1.
PROSITE; PS00916; PI3_4_KINASE_2; 1.
PROSITE; PS50290; PI3_4_KINASE_3; 1.
PROSITE; PS51547; PI3K_C2; 1.
PROSITE; PS51545; PIK_HELICAL; 1.
1: Evidence at protein level;
3D-structure; ATP-binding; Autophagy; Complete proteome; Endosome;
Golgi apparatus; Kinase; Membrane; Nucleotide-binding; Phosphoprotein;
Protein transport; Reference proteome; Transferase; Transport.
CHAIN 1 875 Phosphatidylinositol 3-kinase VPS34.
/FTId=PRO_0000088818.
DOMAIN 14 188 C2 PI3K-type. {ECO:0000255|PROSITE-
ProRule:PRU00880}.
DOMAIN 293 526 PIK helical. {ECO:0000255|PROSITE-
ProRule:PRU00878}.
DOMAIN 619 873 PI3K/PI4K. {ECO:0000255|PROSITE-
ProRule:PRU00269}.
MUTAGEN 731 731 D->A: Loss of kinase activity and no
vacuolar carboxypeptidase Y (PCR1)
sorting to the vacuole.
{ECO:0000269|PubMed:8385367}.
MUTAGEN 736 736 N->K: Loss of kinase activity and no
vacuolar carboxypeptidase Y (PCR1)
sorting to the vacuole.
{ECO:0000269|PubMed:8385367}.
MUTAGEN 749 749 D->E: Loss of kinase activity and no
vacuolar carboxypeptidase Y (PCR1)
sorting to the vacuole.
{ECO:0000269|PubMed:8385367}.
SEQUENCE 875 AA; 100921 MW; 806E3404EF260287 CRC64;
MSLNNITFCV SQDLDVPLKV KIKSLEGHKP LLKPSQKILN PELMLIGSNV FPSSDLIVSL
QVFDKERNRN LTLPIYTPYI PFRNSRTWDY WLTLPIRIKQ LTFSSHLRII LWEYNGSKQI
PFFNLETSIF NLKDCTLKRG FESLKFRYDV IDHCEVVTDN KDQENLNKYF QGEFTRLPWL
DEITISKLRK QRENRTWPQG TFVLNLEFPM LELPVVFIER EIMNTQMNIP TLKNNPGLST
DLREPNRNDP QIKISLGDKY HSTLKFYDPD QPNNDPIEEK YRRLERASKN ANLDKQVKPD
IKKRDYLNKI INYPPGTKLT AHEKGSIWKY RYYLMNNKKA LTKLLQSTNL REESERVEVL
ELMDSWAEID IDDALELLGS TFKNLSVRSY AVNRLKKASD KELELYLLQL VEAVCFENLS
TFSDKSNSEF TIVDAVSSQK LSGDSMLLST SHANQKLLKS ISSESETSGT ESLPIVISPL
AEFLIRRALV NPRLGSFFYW YLKSESEDKP YLDQILSSFW SRLDKKSRNI LNDQVRLINV
LRECCETIKR LKDTTAKKME LLVHLLETKV RPLVKVRPIA LPLDPDVLIC DVCPETSKVF
KSSLSPLKIT FKTTLNQPYH LMFKVGDDLR QDQLVVQIIS LMNELLKNEN VDLKLTPYKI
LATGPQEGAI EFIPNDTLAS ILSKYHGILG YLKLHYPDEN ATLGVQGWVL DNFVKSCAGY
CVITYILGVG DRHLDNLLVT PDGHFFHADF GYILGQDPKP FPPLMKLPPQ IIEAFGGAES
SNYDKFRSYC FVAYSILRRN AGLILNLFEL MKTSNIPDIR IDPNGAILRV RERFNLNMSE
EDATVHFQNL INDSVNALLP IVIDHLHNLA QYWRT


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San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




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