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Phosphatidylinositol 3-kinase regulatory subunit alpha (Phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (P85 alpha))

 Q80UI5_MOUSE            Unreviewed;       454 AA.
Q80UI5;
01-JUN-2003, integrated into UniProtKB/TrEMBL.
01-JUN-2003, sequence version 1.
25-OCT-2017, entry version 112.
SubName: Full=Phosphatidylinositol 3-kinase regulatory subunit alpha {ECO:0000313|Ensembl:ENSMUSP00000047004};
SubName: Full=Phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (P85 alpha) {ECO:0000313|EMBL:AAH51106.1};
Name=Pik3r1 {ECO:0000313|EMBL:AAH51106.1,
ECO:0000313|Ensembl:ENSMUSP00000047004, ECO:0000313|MGI:MGI:97583};
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090 {ECO:0000313|EMBL:AAH51106.1};
[1] {ECO:0000313|EMBL:AAH51106.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Mix FVB/N {ECO:0000313|EMBL:AAH51106.1};
TISSUE=Mammary tumor. WAP-TGF alpha model. 7 months old
{ECO:0000313|EMBL:AAH51106.1};
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M.,
Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S.,
Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F.,
Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J.,
Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N.,
Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B.,
Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B.,
Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S.,
Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R.,
Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L.,
Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E.,
Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D.,
Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G.,
Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J.,
Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L.,
Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D.,
Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A.,
Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S.,
Makowski K.A., Bosak S., Malek J.;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[2] {ECO:0000213|PubMed:15592455}
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=15592455; DOI=10.1038/nbt1046;
Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,
Zha X.M., Polakiewicz R.D., Comb M.J.;
"Immunoaffinity profiling of tyrosine phosphorylation in cancer
cells.";
Nat. Biotechnol. 23:94-101(2005).
[3] {ECO:0000213|PubMed:17947660}
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=17947660;
Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y.,
Kawakami T., Salomon A.R.;
"Quantitative time-resolved phosphoproteomic analysis of mast cell
signaling.";
J. Immunol. 179:5864-5876(2007).
[4] {ECO:0000213|PubMed:18034455}
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=18034455; DOI=10.1021/pr0701254;
Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.;
"Large-scale identification and evolution indexing of tyrosine
phosphorylation sites from murine brain.";
J. Proteome Res. 7:311-318(2008).
[5] {ECO:0000313|Ensembl:ENSMUSP00000047004, ECO:0000313|Proteomes:UP000000589}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000047004,
ECO:0000313|Proteomes:UP000000589};
PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
Lindblad-Toh K., Eichler E.E., Ponting C.P.;
"Lineage-specific biology revealed by a finished genome assembly of
the mouse.";
PLoS Biol. 7:E1000112-E1000112(2009).
[6] {ECO:0000213|PubMed:21183079}
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
[7] {ECO:0000313|Ensembl:ENSMUSP00000047004}
IDENTIFICATION.
STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000047004};
Ensembl;
Submitted (FEB-2012) to UniProtKB.
-----------------------------------------------------------------------
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EMBL; AC107663; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AC153139; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC051106; AAH51106.1; -; mRNA.
RefSeq; NP_001020126.1; NM_001024955.2.
UniGene; Mm.259333; -.
IntAct; Q80UI5; 1.
MINT; MINT-137238; -.
Ensembl; ENSMUST00000035532; ENSMUSP00000047004; ENSMUSG00000041417.
GeneID; 18708; -.
UCSC; uc007rrs.3; mouse.
CTD; 5295; -.
MGI; MGI:97583; Pik3r1.
eggNOG; KOG4637; Eukaryota.
eggNOG; ENOG410XP6R; LUCA.
GeneTree; ENSGT00390000010431; -.
HOGENOM; HOG000008438; -.
HOVERGEN; HBG082100; -.
ChiTaRS; Pik3r1; mouse.
Proteomes; UP000000589; Chromosome 13.
Bgee; ENSMUSG00000041417; -.
GO; GO:0005911; C:cell-cell junction; IEA:Ensembl.
GO; GO:0005801; C:cis-Golgi network; IEA:Ensembl.
GO; GO:0005829; C:cytosol; IEA:Ensembl.
GO; GO:0005634; C:nucleus; IEA:Ensembl.
GO; GO:1990578; C:perinuclear endoplasmic reticulum membrane; IEA:Ensembl.
GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:InterPro.
GO; GO:0043234; C:protein complex; IEA:Ensembl.
GO; GO:0043560; F:insulin receptor substrate binding; IEA:Ensembl.
GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
GO; GO:0035014; F:phosphatidylinositol 3-kinase regulator activity; IEA:InterPro.
GO; GO:0036312; F:phosphatidylinositol 3-kinase regulatory subunit binding; IEA:Ensembl.
GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
GO; GO:0008134; F:transcription factor binding; IEA:Ensembl.
GO; GO:0030183; P:B cell differentiation; IEA:Ensembl.
GO; GO:0001678; P:cellular glucose homeostasis; IEA:Ensembl.
GO; GO:0032869; P:cellular response to insulin stimulus; IEA:Ensembl.
GO; GO:0034644; P:cellular response to UV; IEA:Ensembl.
GO; GO:0008625; P:extrinsic apoptotic signaling pathway via death domain receptors; IEA:Ensembl.
GO; GO:0008630; P:intrinsic apoptotic signaling pathway in response to DNA damage; IEA:Ensembl.
GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
GO; GO:0001953; P:negative regulation of cell-matrix adhesion; IEA:Ensembl.
GO; GO:0045671; P:negative regulation of osteoclast differentiation; IEA:Ensembl.
GO; GO:0051531; P:NFAT protein import into nucleus; IEA:Ensembl.
GO; GO:0030335; P:positive regulation of cell migration; IEA:Ensembl.
GO; GO:0042993; P:positive regulation of transcription factor import into nucleus; IEA:Ensembl.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO; GO:0032760; P:positive regulation of tumor necrosis factor production; IEA:Ensembl.
GO; GO:0006468; P:protein phosphorylation; IEA:Ensembl.
GO; GO:0046626; P:regulation of insulin receptor signaling pathway; IEA:Ensembl.
GO; GO:1903076; P:regulation of protein localization to plasma membrane; IEA:Ensembl.
GO; GO:0051492; P:regulation of stress fiber assembly; IEA:Ensembl.
GO; GO:0034976; P:response to endoplasmic reticulum stress; IEA:Ensembl.
CDD; cd09930; SH2_cSH2_p85_like; 1.
CDD; cd09942; SH2_nSH2_p85_like; 1.
Gene3D; 3.30.505.10; -; 2.
InterPro; IPR032498; PI3K_P85_iSH2.
InterPro; IPR035020; PI3kinase_P85_cSH2.
InterPro; IPR035022; PI3kinase_P85_nSH2.
InterPro; IPR001720; PI3kinase_P85_p55.
InterPro; IPR000980; SH2.
InterPro; IPR036860; SH2_dom_sf.
PANTHER; PTHR10155; PTHR10155; 1.
Pfam; PF16454; PI3K_P85_iSH2; 1.
Pfam; PF00017; SH2; 2.
PRINTS; PR00401; SH2DOMAIN.
SMART; SM00252; SH2; 2.
SUPFAM; SSF55550; SSF55550; 2.
PROSITE; PS50001; SH2; 2.
1: Evidence at protein level;
Coiled coil {ECO:0000256|SAM:Coils};
Complete proteome {ECO:0000313|Proteomes:UP000000589};
Kinase {ECO:0000313|EMBL:AAH51106.1};
Proteomics identification {ECO:0000213|EPD:Q80UI5,
ECO:0000213|MaxQB:Q80UI5, ECO:0000213|PeptideAtlas:Q80UI5};
Reference proteome {ECO:0000313|Proteomes:UP000000589};
SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
Transferase {ECO:0000313|EMBL:AAH51106.1}.
DOMAIN 63 158 SH2. {ECO:0000259|PROSITE:PS50001}.
DOMAIN 354 448 SH2. {ECO:0000259|PROSITE:PS50001}.
COILED 258 292 {ECO:0000256|SAM:Coils}.
SEQUENCE 454 AA; 53399 MW; 543B736F6439FFFF CRC64;
MYTTVWTMED LDLECAKTDI NCGTDLVFYI EMDPPALPPK PPKPTTVANN SMNNNMSLQD
AEWYWGDISR EEVNEKLRDT ADGTFLVRDA STKMHGDYTL TLRKGGNNKL IKIFHRDGKY
GFSDPLTFNS VVELINHYRN ESLAQYNPKL DVKLLYPVSK YQQDQVVKED NIEAVGKKLH
EYNTQFQEKS REYDRLYEEY TRTSQEIQMK RTAIEAFNET IKIFEEQCQT QERYSKEYIE
KFKREGNEKE IQRIMHNHDK LKSRISEIID SRRRLEEDLK KQAAEYREID KRMNSIKPDL
IQLRKTRDQY LMWLTQKGVR QKKLNEWLGN ENTEDQYSLV EDDEDLPHHD EKTWNVGSSN
RNKAENLLRG KRDGTFLVRE SSKQGCYACS VVVDGEVKHC VINKTATGYG FAEPYNLYSS
LKELVLHYQH TSLVQHNDSL NVTLAYPVYA QQRR


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