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Phosphatidylinositol glycan anchor biosynthesis class U protein (Cell division cycle protein 91-like 1) (Protein CDC91-like 1) (GPI transamidase component PIG-U)

 PIGU_HUMAN              Reviewed;         435 AA.
Q9H490; Q7Z489; Q8N2F2;
25-MAR-2003, integrated into UniProtKB/Swiss-Prot.
23-JAN-2007, sequence version 3.
20-JUN-2018, entry version 134.
RecName: Full=Phosphatidylinositol glycan anchor biosynthesis class U protein;
AltName: Full=Cell division cycle protein 91-like 1;
Short=Protein CDC91-like 1;
AltName: Full=GPI transamidase component PIG-U;
Name=PIGU; Synonyms=CDC91L1; ORFNames=PSEC0205, UNQ3055/PRO9875;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 2-8,
FUNCTION, AND SUBUNIT.
TISSUE=Embryo;
PubMed=12802054; DOI=10.1091/mbc.E02-12-0794;
Hong Y., Ohishi K., Kang J.Y., Tanaka S., Inoue N., Nishimura J.,
Maeda Y., Kinoshita T.;
"Human PIG-U and yeast Cdc91p are the fifth subunit of GPI
transamidase that attaches GPI-anchors to proteins.";
Mol. Biol. Cell 14:1780-1789(2003).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Guo Z., Wu G., Sidransky D., Trink B.;
"PIG-U is a novel oncogene in human bladder cancer.";
Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Lin L., Yu R., Ke R., Li H., Zhou G., Shen C., Zheng G., Zhong G.,
Li M., Xiao W., Yang S.;
Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
PubMed=12975309; DOI=10.1101/gr.1293003;
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
Wood W.I., Godowski P.J., Gray A.M.;
"The secreted protein discovery initiative (SPDI), a large-scale
effort to identify novel human secreted and transmembrane proteins: a
bioinformatics assessment.";
Genome Res. 13:2265-2270(2003).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Embryo;
PubMed=16303743; DOI=10.1093/dnares/12.2.117;
Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J.,
Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S.,
Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.,
Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S.,
Isogai T.;
"Signal sequence and keyword trap in silico for selection of full-
length human cDNAs encoding secretion or membrane proteins from oligo-
capped cDNA libraries.";
DNA Res. 12:117-126(2005).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=11780052; DOI=10.1038/414865a;
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M.,
Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J.,
Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P.,
Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M.,
Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R.,
Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M.,
Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H.,
Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S.,
Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E.,
Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A.,
Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M.,
Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A.,
Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S.,
Rogers J.;
"The DNA sequence and comparative analysis of human chromosome 20.";
Nature 414:865-871(2001).
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Brain;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
-!- FUNCTION: Component of the GPI transamidase complex. May be
involved in the recognition of either the GPI attachment signal or
the lipid portion of GPI. {ECO:0000269|PubMed:12802054}.
-!- PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-
anchor biosynthesis.
-!- SUBUNIT: Forms a complex with PIGK/GPI8, PIGS, PIGT and
GPAA1/GAA1. {ECO:0000269|PubMed:12802054}.
-!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
{ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=Q9H490-1; Sequence=Displayed;
Name=2;
IsoId=Q9H490-2; Sequence=VSP_009543;
Note=No experimental confirmation available.;
-!- SIMILARITY: Belongs to the PIGU family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; AB086842; BAC53626.1; -; mRNA.
EMBL; AY422169; AAR23798.1; -; mRNA.
EMBL; AY339061; AAQ18022.1; -; mRNA.
EMBL; AY358816; AAQ89175.1; -; mRNA.
EMBL; AK075507; BAC11660.1; -; mRNA.
EMBL; AL118520; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC030512; AAH30512.1; -; mRNA.
CCDS; CCDS13239.1; -. [Q9H490-1]
RefSeq; NP_536724.1; NM_080476.4. [Q9H490-1]
UniGene; Hs.253319; -.
ProteinModelPortal; Q9H490; -.
SMR; Q9H490; -.
BioGrid; 126171; 34.
CORUM; Q9H490; -.
IntAct; Q9H490; 9.
MINT; Q9H490; -.
STRING; 9606.ENSP00000217446; -.
iPTMnet; Q9H490; -.
PhosphoSitePlus; Q9H490; -.
BioMuta; PIGU; -.
DMDM; 29336947; -.
EPD; Q9H490; -.
MaxQB; Q9H490; -.
PaxDb; Q9H490; -.
PeptideAtlas; Q9H490; -.
PRIDE; Q9H490; -.
ProteomicsDB; 80796; -.
ProteomicsDB; 80797; -. [Q9H490-2]
DNASU; 128869; -.
Ensembl; ENST00000217446; ENSP00000217446; ENSG00000101464. [Q9H490-1]
Ensembl; ENST00000374820; ENSP00000363953; ENSG00000101464. [Q9H490-2]
GeneID; 128869; -.
KEGG; hsa:128869; -.
UCSC; uc002xas.4; human. [Q9H490-1]
CTD; 128869; -.
DisGeNET; 128869; -.
EuPathDB; HostDB:ENSG00000101464.10; -.
GeneCards; PIGU; -.
HGNC; HGNC:15791; PIGU.
HPA; HPA041706; -.
HPA; HPA046766; -.
MIM; 608528; gene.
neXtProt; NX_Q9H490; -.
OpenTargets; ENSG00000101464; -.
PharmGKB; PA162399506; -.
eggNOG; KOG2552; Eukaryota.
eggNOG; ENOG410XST9; LUCA.
GeneTree; ENSGT00390000014941; -.
HOGENOM; HOG000189223; -.
HOVERGEN; HBG082139; -.
InParanoid; Q9H490; -.
KO; K05293; -.
OMA; WIYAGSG; -.
OrthoDB; EOG091G0F0I; -.
PhylomeDB; Q9H490; -.
TreeFam; TF101063; -.
Reactome; R-HSA-162791; Attachment of GPI anchor to uPAR.
UniPathway; UPA00196; -.
ChiTaRS; PIGU; human.
GeneWiki; PIGU; -.
GenomeRNAi; 128869; -.
PRO; PR:Q9H490; -.
Proteomes; UP000005640; Chromosome 20.
Bgee; ENSG00000101464; -.
CleanEx; HS_PIGU; -.
ExpressionAtlas; Q9H490; baseline and differential.
Genevisible; Q9H490; HS.
GO; GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
GO; GO:0042765; C:GPI-anchor transamidase complex; IDA:UniProtKB.
GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; IC:UniProtKB.
GO; GO:0016020; C:membrane; HDA:UniProtKB.
GO; GO:0005886; C:plasma membrane; IDA:HGNC.
GO; GO:0016255; P:attachment of GPI anchor to protein; IMP:UniProtKB.
GO; GO:0006506; P:GPI anchor biosynthetic process; IDA:HGNC.
GO; GO:0046425; P:regulation of JAK-STAT cascade; IDA:HGNC.
InterPro; IPR009600; PIG-U.
PANTHER; PTHR13121; PTHR13121; 1.
Pfam; PF06728; PIG-U; 1.
1: Evidence at protein level;
Alternative splicing; Complete proteome; Direct protein sequencing;
Endoplasmic reticulum; GPI-anchor biosynthesis; Membrane;
Reference proteome; Transmembrane; Transmembrane helix.
INIT_MET 1 1 Removed. {ECO:0000269|PubMed:12802054}.
CHAIN 2 435 Phosphatidylinositol glycan anchor
biosynthesis class U protein.
/FTId=PRO_0000121394.
TRANSMEM 66 86 Helical. {ECO:0000255}.
TRANSMEM 166 186 Helical. {ECO:0000255}.
TRANSMEM 188 208 Helical. {ECO:0000255}.
TRANSMEM 237 257 Helical. {ECO:0000255}.
TRANSMEM 259 279 Helical. {ECO:0000255}.
TRANSMEM 286 306 Helical. {ECO:0000255}.
TRANSMEM 313 333 Helical. {ECO:0000255}.
TRANSMEM 355 375 Helical. {ECO:0000255}.
TRANSMEM 386 406 Helical. {ECO:0000255}.
REGION 269 289 May be involved in recognition of long-
chain fatty acids in GPI.
VAR_SEQ 66 85 Missing (in isoform 2).
{ECO:0000303|Ref.3}.
/FTId=VSP_009543.
CONFLICT 407 407 Y -> N (in Ref. 5; BAC11660).
{ECO:0000305}.
SEQUENCE 435 AA; 50052 MW; 65FDD796AB533027 CRC64;
MAAPLVLVLV VAVTVRAALF RSSLAEFISE RVEVVSPLSS WKRVVEGLSL LDLGVSPYSG
AVFHETPLII YLFHFLIDYA ELVFMITDAL TAIALYFAIQ DFNKVVFKKQ KLLLELDQYA
PDVAELIRTP MEMRYIPLKV ALFYLLNPYT ILSCVAKSTC AINNTLIAFF ILTTIKGSAF
LSAIFLALAT YQSLYPLTLF VPGLLYLLQR QYIPVKMKSK AFWIFSWEYA MMYVGSLVVI
ICLSFFLLSS WDFIPAVYGF ILSVPDLTPN IGLFWYFFAE MFEHFSLFFV CVFQINVFFY
TIPLAIKLKE HPIFFMFIQI AVIAIFKSYP TVGDVALYMA FFPVWNHLYR FLRNIFVLTC
IIIVCSLLFP VLWHLWIYAG SANSNFFYAI TLTFNVGQIL LISDYFYAFL RREYYLTHGL
YLTAKDGTEA MLVLK


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