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Phosphatidylinositol transfer protein 3 (CRAL-TRIO domain-containing protein pitC) (Random slug protein 5)

 PITC_DICDI              Reviewed;         364 AA.
Q55CU8; O15915;
14-APR-2009, integrated into UniProtKB/Swiss-Prot.
24-MAY-2005, sequence version 1.
23-MAY-2018, entry version 72.
RecName: Full=Phosphatidylinositol transfer protein 3;
AltName: Full=CRAL-TRIO domain-containing protein pitC;
AltName: Full=Random slug protein 5;
Name=pitC {ECO:0000303|PubMed:10769190}; Synonyms=rsc5;
ORFNames=DDB_G0269182;
Dictyostelium discoideum (Slime mold).
Eukaryota; Amoebozoa; Mycetozoa; Dictyostelids; Dictyosteliales;
Dictyosteliaceae; Dictyostelium.
NCBI_TaxID=44689;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=AX4;
Iranfar N., Loomis W.F.;
Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=AX4;
PubMed=15875012; DOI=10.1038/nature03481;
Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A.,
Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q.,
Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F.,
Bankier A.T., Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P.,
Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P.,
Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N.,
Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M.,
Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I.,
Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R.,
Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
Knights A., Loulseged H., Mungall K.L., Oliver K., Price C.,
Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D.,
Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S.,
Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T.,
Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A.,
Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M.,
Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G.,
Kuspa A.;
"The genome of the social amoeba Dictyostelium discoideum.";
Nature 435:43-57(2005).
[3]
IDENTIFICATION.
PubMed=10769190; DOI=10.1042/bj3470837;
Swigart P., Insall R., Wilkins A., Cockcroft S.;
"Purification and cloning of phosphatidylinositol transfer proteins
from Dictyostelium discoideum: homologues of both mammalian PITPs and
Saccharomyces cerevisiae sec14p are found in the same cell.";
Biochem. J. 347:837-843(2000).
-!- FUNCTION: Has phosphatidylinositol transfer activity (By
similarity). {ECO:0000250|UniProtKB:P53860}.
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EMBL; U82515; AAB69635.1; -; mRNA.
EMBL; AAFI02000005; EAL71941.1; -; Genomic_DNA.
RefSeq; XP_646383.1; XM_641291.1.
ProteinModelPortal; Q55CU8; -.
SMR; Q55CU8; -.
STRING; 44689.DDB0216218; -.
PaxDb; Q55CU8; -.
PRIDE; Q55CU8; -.
EnsemblProtists; EAL71941; EAL71941; DDB_G0269182.
GeneID; 8617338; -.
KEGG; ddi:DDB_G0269182; -.
dictyBase; DDB_G0269182; pitC.
eggNOG; KOG1470; Eukaryota.
eggNOG; ENOG410Y3Q0; LUCA.
InParanoid; Q55CU8; -.
OMA; VARNWDV; -.
PhylomeDB; Q55CU8; -.
PRO; PR:Q55CU8; -.
Proteomes; UP000002195; Chromosome 1.
Proteomes; UP000002195; Unassembled WGS sequence.
GO; GO:0008526; F:phosphatidylinositol transporter activity; IDA:dictyBase.
CDD; cd00170; SEC14; 1.
Gene3D; 3.40.525.10; -; 1.
InterPro; IPR001251; CRAL-TRIO_dom.
InterPro; IPR036865; CRAL-TRIO_dom_sf.
InterPro; IPR011074; CRAL/TRIO_N_dom.
InterPro; IPR036273; CRAL/TRIO_N_dom_sf.
Pfam; PF00650; CRAL_TRIO; 1.
Pfam; PF03765; CRAL_TRIO_N; 1.
SMART; SM01100; CRAL_TRIO_N; 1.
SMART; SM00516; SEC14; 1.
SUPFAM; SSF46938; SSF46938; 1.
SUPFAM; SSF52087; SSF52087; 1.
PROSITE; PS50191; CRAL_TRIO; 1.
2: Evidence at transcript level;
Complete proteome; Lipid transport; Reference proteome; Transport.
CHAIN 1 364 Phosphatidylinositol transfer protein 3.
/FTId=PRO_0000368228.
DOMAIN 113 281 CRAL-TRIO. {ECO:0000255|PROSITE-
ProRule:PRU00056}.
COMPBIAS 309 349 Lys-rich.
CONFLICT 304 324 TETDSKKQKKEKKKEEKEKKK -> SCRIFFQFILLIYFIN
LIDFI (in Ref. 1; AAB69635).
{ECO:0000305}.
CONFLICT 325 364 Missing (in Ref. 1; AAB69635).
{ECO:0000305}.
SEQUENCE 364 AA; 42386 MW; 68DEABD6FBF72599 CRC64;
MESTASTSDS ASAITTGLSE VDINQQSPPI ILKEGEIFDP LKNLNEKQLE AFKEIKSNFS
DLTDPTDIAF CTDMCFLRYL RARNYIVSKS EKMLRDTLEW RKKFRPQDIQ LGGDIREIGS
AGCVYVNKRD KKGRPIIFAV PRNDTLKNVP SELKFKNLVY WLEQGFSRMD EPKGIEQFCF
IVDYKDFGSG NMDMKTNLEA MHFLLDHCPE RMGQSLFLDP PALFWFAWKI ISPFLNEVTL
SKVRFINSKK VDGKRTFAEL LEYVDIENLE QNLGGNLDYN YNIDEYLKEN PDPIVDTPPI
TFSTETDSKK QKKEKKKEEK EKKKEEKEKK KEEKEEKKKE KEEKKKLKKE ASFTKQQENA
DEVD


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