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Phosphodiesterase (EC 3.1.4.-)

 U3K8Z6_FICAL            Unreviewed;       758 AA.
U3K8Z6;
13-NOV-2013, integrated into UniProtKB/TrEMBL.
13-NOV-2013, sequence version 1.
25-OCT-2017, entry version 27.
RecName: Full=Phosphodiesterase {ECO:0000256|RuleBase:RU363067};
EC=3.1.4.- {ECO:0000256|RuleBase:RU363067};
Name=PDE4D {ECO:0000313|Ensembl:ENSFALP00000011500};
Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae;
Ficedula.
NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000011500, ECO:0000313|Proteomes:UP000016665};
[1] {ECO:0000313|Ensembl:ENSFALP00000011500}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=23103876; DOI=10.1038/nature11584;
Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N.,
Kawakami T., Kunstner A., Makinen H., Nadachowska-Brzyska K.,
Qvarnstrom A., Uebbing S., Wolf J.B.;
"The genomic landscape of species divergence in Ficedula
flycatchers.";
Nature 491:756-760(2012).
[2] {ECO:0000313|Ensembl:ENSFALP00000011500}
IDENTIFICATION.
Ensembl;
Submitted (SEP-2013) to UniProtKB.
-!- COFACTOR:
Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
Evidence={ECO:0000256|RuleBase:RU363067};
Note=Binds 2 divalent metal cations per subunit. Site 1 may
preferentially bind zinc ions, while site 2 has a preference for
magnesium and/or manganese ions. {ECO:0000256|RuleBase:RU363067};
-!- SIMILARITY: Belongs to the cyclic nucleotide phosphodiesterase
family. {ECO:0000256|RuleBase:RU363067,
ECO:0000256|SAAS:SAAS00865541}.
-!- CAUTION: The sequence shown here is derived from an Ensembl
automatic analysis pipeline and should be considered as
preliminary data. {ECO:0000313|Ensembl:ENSFALP00000011500}.
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EMBL; AGTO01001075; -; NOT_ANNOTATED_CDS; Genomic_DNA.
Ensembl; ENSFALT00000011546; ENSFALP00000011500; ENSFALG00000011007.
GeneTree; ENSGT00760000118889; -.
OMA; QHEVEMP; -.
OrthoDB; EOG091G06CD; -.
Proteomes; UP000016665; Unplaced.
GO; GO:0005813; C:centrosome; IEA:Ensembl.
GO; GO:0005829; C:cytosol; IEA:Ensembl.
GO; GO:0031965; C:nuclear membrane; IEA:Ensembl.
GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:Ensembl.
GO; GO:0004115; F:3',5'-cyclic-AMP phosphodiesterase activity; IEA:Ensembl.
GO; GO:0051117; F:ATPase binding; IEA:Ensembl.
GO; GO:0030552; F:cAMP binding; IEA:Ensembl.
GO; GO:0008144; F:drug binding; IEA:Ensembl.
GO; GO:0044325; F:ion channel binding; IEA:Ensembl.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0097110; F:scaffold protein binding; IEA:Ensembl.
GO; GO:0007568; P:aging; IEA:Ensembl.
GO; GO:0006198; P:cAMP catabolic process; IEA:Ensembl.
GO; GO:0071872; P:cellular response to epinephrine stimulus; IEA:Ensembl.
GO; GO:0071222; P:cellular response to lipopolysaccharide; IEA:Ensembl.
GO; GO:0035264; P:multicellular organism growth; IEA:Ensembl.
GO; GO:0045822; P:negative regulation of heart contraction; IEA:Ensembl.
GO; GO:0033137; P:negative regulation of peptidyl-serine phosphorylation; IEA:Ensembl.
GO; GO:1901898; P:negative regulation of relaxation of cardiac muscle; IEA:Ensembl.
GO; GO:0030593; P:neutrophil chemotaxis; IEA:Ensembl.
GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl.
GO; GO:0032743; P:positive regulation of interleukin-2 production; IEA:Ensembl.
GO; GO:0032754; P:positive regulation of interleukin-5 production; IEA:Ensembl.
GO; GO:0030814; P:regulation of cAMP metabolic process; IEA:Ensembl.
GO; GO:0086004; P:regulation of cardiac muscle cell contraction; IEA:Ensembl.
GO; GO:0002027; P:regulation of heart rate; IEA:Ensembl.
GO; GO:0010880; P:regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; IEA:Ensembl.
GO; GO:0060314; P:regulation of ryanodine-sensitive calcium-release channel activity; IEA:Ensembl.
GO; GO:0006939; P:smooth muscle contraction; IEA:Ensembl.
GO; GO:0050852; P:T cell receptor signaling pathway; IEA:Ensembl.
CDD; cd00077; HDc; 1.
Gene3D; 1.10.1300.10; -; 1.
InterPro; IPR003607; HD/PDEase_dom.
InterPro; IPR023088; PDEase.
InterPro; IPR002073; PDEase_catalytic_dom.
InterPro; IPR036971; PDEase_catalytic_dom_sf.
InterPro; IPR023174; PDEase_CS.
Pfam; PF00233; PDEase_I; 1.
PRINTS; PR00387; PDIESTERASE1.
SMART; SM00471; HDc; 1.
PROSITE; PS00126; PDEASE_I; 1.
3: Inferred from homology;
Complete proteome {ECO:0000313|Proteomes:UP000016665};
Hydrolase {ECO:0000256|RuleBase:RU363067,
ECO:0000256|SAAS:SAAS00865573};
Metal-binding {ECO:0000256|RuleBase:RU363067,
ECO:0000256|SAAS:SAAS00865543};
Reference proteome {ECO:0000313|Proteomes:UP000016665}.
DOMAIN 409 584 HDc. {ECO:0000259|SMART:SM00471}.
SEQUENCE 758 AA; 85738 MW; 9A0077073889785F CRC64;
PPPPPPPPPP PPPPPPPPPP PPPPPPPPPP PLFFYYEYSN SHLTNLIQQW HMGMAETNRL
VGCKNRENRE KKIGALHSPG LPRRLVADVS WSPSSFSLSR ENFDVDNGTS SGRSPLDPMT
SPGSGLILQA NFVHSQRRES FLYRSDSDYD LSPKSMSRNS SIASDIHGDD LIVTPFAQVL
ASLRTVRNNF AALTNLQDRA PSKRSPMCSQ PSINKATITE EAYQKLASET MEELDWCLDQ
LETLQTRHSV SEMASNKFKR MLNRELTHLS EMSRSGNQVS EYISNTFLDK QHEVEIPSPT
QKEKEKKKRP MSQISGVKKL MHSSSLTNSS IPRFGVKTDQ EDVLAKELED LNKWGLQVFR
VAELSGNRPL TVIMHTIFQE RDLLKTFKIP VDTLITYLMT LEDHYHADVA YHNNIHAADV
VQSTHVLLST PALEAVFTDL EILAAIFASA IHDVDHPGVS NQFLINTNSE LALMYNDSSV
LENHHLAVGF KLLQEENCDI FQNLTKKQRQ SLRKMVIDIV LATDMSKHMN LLADLKTMVE
TKKVTSSGVL LLDNYSDRIQ VLQNMVHCAD LSNPTKPLHL YRQWTDRIME EFFRQGDRER
ERGMEISPMC DKHNASVEKS QVGFIDYIVH PLWETWADLV HPDAQDILDT LEDNREWYQS
TIPRSPSPAP EEKEEGKQGQ TEKFQFELTL EEDGESDTEK DSGSQVEEDT SFSDSKTLCT
QDSESTEIPL DEQVGEEVEE EENQTAEPCM VEEHSPDT


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