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Phosphodiesterase (EC 3.1.4.-) (Fragment)

 Q91VY2_MOUSE            Unreviewed;       542 AA.
Q91VY2;
01-DEC-2001, integrated into UniProtKB/TrEMBL.
01-DEC-2001, sequence version 1.
25-OCT-2017, entry version 91.
RecName: Full=Phosphodiesterase {ECO:0000256|RuleBase:RU363067};
EC=3.1.4.- {ECO:0000256|RuleBase:RU363067};
Flags: Fragment;
Name=Pde4b {ECO:0000313|EMBL:AAH07155.1, ECO:0000313|MGI:MGI:99557};
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090 {ECO:0000313|EMBL:AAH07155.1};
[1] {ECO:0000313|EMBL:AAH07155.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Mix FVB/N {ECO:0000313|EMBL:AAH07155.1};
TISSUE=Mammary tumor. WAP-TGF alpha model. 7 months old
{ECO:0000313|EMBL:AAH07155.1};
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M.,
Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S.,
Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F.,
Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J.,
Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N.,
Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B.,
Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B.,
Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S.,
Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R.,
Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L.,
Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E.,
Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D.,
Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G.,
Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J.,
Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L.,
Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D.,
Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A.,
Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S.,
Makowski K.A., Bosak S., Malek J.;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
-!- COFACTOR:
Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
Evidence={ECO:0000256|RuleBase:RU363067};
Note=Binds 2 divalent metal cations per subunit. Site 1 may
preferentially bind zinc ions, while site 2 has a preference for
magnesium and/or manganese ions. {ECO:0000256|RuleBase:RU363067};
-!- SIMILARITY: Belongs to the cyclic nucleotide phosphodiesterase
family. {ECO:0000256|RuleBase:RU363067,
ECO:0000256|SAAS:SAAS00865541}.
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EMBL; BC007155; AAH07155.1; -; mRNA.
UniGene; Mm.20181; -.
ProteinModelPortal; Q91VY2; -.
PaxDb; Q91VY2; -.
MGI; MGI:99557; Pde4b.
eggNOG; KOG3689; Eukaryota.
eggNOG; ENOG410XRI7; LUCA.
HOVERGEN; HBG108239; -.
ChiTaRS; Pde4b; mouse.
GO; GO:0071944; C:cell periphery; IDA:MGI.
GO; GO:0005813; C:centrosome; IDA:MGI.
GO; GO:0005829; C:cytosol; IDA:MGI.
GO; GO:0043197; C:dendritic spine; IDA:MGI.
GO; GO:0060076; C:excitatory synapse; IDA:MGI.
GO; GO:0000930; C:gamma-tubulin complex; IDA:MGI.
GO; GO:0016020; C:membrane; IDA:MGI.
GO; GO:0014069; C:postsynaptic density; IDA:MGI.
GO; GO:0008021; C:synaptic vesicle; IDA:MGI.
GO; GO:0004115; F:3',5'-cyclic-AMP phosphodiesterase activity; ISS:MGI.
GO; GO:0030552; F:cAMP binding; ISO:MGI.
GO; GO:0043015; F:gamma-tubulin binding; IDA:MGI.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0006198; P:cAMP catabolic process; ISO:MGI.
GO; GO:0035690; P:cellular response to drug; IDA:MGI.
GO; GO:0071222; P:cellular response to lipopolysaccharide; IMP:MGI.
GO; GO:0050900; P:leukocyte migration; IMP:MGI.
GO; GO:0030593; P:neutrophil chemotaxis; IMP:MGI.
GO; GO:0001780; P:neutrophil homeostasis; IMP:MGI.
GO; GO:0032729; P:positive regulation of interferon-gamma production; ISO:MGI.
GO; GO:0032743; P:positive regulation of interleukin-2 production; ISO:MGI.
GO; GO:0050852; P:T cell receptor signaling pathway; ISO:MGI.
CDD; cd00077; HDc; 1.
Gene3D; 1.10.1300.10; -; 1.
InterPro; IPR003607; HD/PDEase_dom.
InterPro; IPR023088; PDEase.
InterPro; IPR002073; PDEase_catalytic_dom.
InterPro; IPR036971; PDEase_catalytic_dom_sf.
InterPro; IPR023174; PDEase_CS.
Pfam; PF00233; PDEase_I; 1.
PRINTS; PR00387; PDIESTERASE1.
SMART; SM00471; HDc; 1.
PROSITE; PS00126; PDEASE_I; 1.
2: Evidence at transcript level;
Hydrolase {ECO:0000256|RuleBase:RU363067,
ECO:0000256|SAAS:SAAS00865573};
Metal-binding {ECO:0000256|RuleBase:RU363067,
ECO:0000256|SAAS:SAAS00865543}.
DOMAIN 209 384 HDc. {ECO:0000259|SMART:SM00471}.
NON_TER 1 1 {ECO:0000313|EMBL:AAH07155.1}.
SEQUENCE 542 AA; 62279 MW; 8B6296D416275B34 CRC64;
ASLQPLQPNY LSVCLFPEES YQKLAMETLE ELDWCLDQLE TIQTYRSVSE MASNKFKRML
NRELTHLSEM SRSGNQVSEY ISNTFLDKQN DVEIPSPTQK DREKKKKQQL MTQISGVKKL
MHSSSLNNTS ISRFGVNTEN EDHLAKELED LNKWGLNIFN VAGYSHNRPL TCIMYAIFQE
RDLLKTFKIS SDTFVTYMMT LEDHYHSDVA YHNSLHAADV AQSTHVLLST PALDAVFTDL
EILAAIFAAA IHDVDHPGVS NQFLINTNSE LALMYNDESV LENHHLAVGF KLLQEEHCDI
FQNLTKKQRQ TLRKMVIDMV LATDMSKHMS LLADLKTMVE TKKVTSSGVL LLDNYTDRIQ
VLRNMVHCAD LSNPTKSLEL YRQWTDRIME EFFQQGDKER ERGMEISPMC DKHTASVEKS
QVGFIDYIVH PLWETWADLV QPDAQDILDT LEDNRNWYQS MIPQSPSPPL DERSRDCQGL
MEKFQFELTL EEEDSEGPEK EGEGHSYFSS TKTLCVIDPE NRDSLEETDI DIATEDKSPI
DT


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