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Phosphoenolpyruvate carboxykinase, cytosolic [GTP] (PEPCK-C) (EC 4.1.1.32)

 PCKGC_CHICK             Reviewed;         622 AA.
P05153;
13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
13-AUG-1987, sequence version 1.
27-SEP-2017, entry version 124.
RecName: Full=Phosphoenolpyruvate carboxykinase, cytosolic [GTP];
Short=PEPCK-C;
EC=4.1.1.32;
Name=PCK1;
Gallus gallus (Chicken).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
Phasianidae; Phasianinae; Gallus.
NCBI_TaxID=9031;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=3094011; DOI=10.1073/pnas.83.20.7583;
Cook J.S., Weldon S.L., Garcia-Ruiz J.P., Hod Y., Hanson R.W.;
"Nucleotide sequence of the mRNA encoding the cytosolic form of
phosphoenolpyruvate carboxykinase (GTP) from the chicken.";
Proc. Natl. Acad. Sci. U.S.A. 83:7583-7587(1986).
-!- FUNCTION: Catalyzes the conversion of oxaloacetate (OAA) to
phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic
pathway that produces glucose from lactate and other precursors
derived from the citric acid cycle. {ECO:0000250}.
-!- CATALYTIC ACTIVITY: GTP + oxaloacetate = GDP + phosphoenolpyruvate
+ CO(2).
-!- COFACTOR:
Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
Note=Binds 1 Mn(2+) ion per subunit. {ECO:0000250};
-!- ENZYME REGULATION: Activity is affected by a number of hormones
regulating this metabolic process (such as glucagon, insulin, or
glucocorticoids).
-!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
-!- SUBUNIT: Monomer.
-!- SUBCELLULAR LOCATION: Cytoplasm.
-!- MISCELLANEOUS: In eukaryotes there are two isozymes: a cytoplasmic
one and a mitochondrial one.
-!- SIMILARITY: Belongs to the phosphoenolpyruvate carboxykinase [GTP]
family. {ECO:0000305}.
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EMBL; M14229; AAA49005.1; -; mRNA.
PIR; A26494; QYCHGC.
RefSeq; NP_990802.1; NM_205471.1.
UniGene; Gga.4447; -.
ProteinModelPortal; P05153; -.
SMR; P05153; -.
STRING; 9031.ENSGALP00000012342; -.
PaxDb; P05153; -.
GeneID; 396458; -.
KEGG; gga:396458; -.
CTD; 5105; -.
eggNOG; KOG3749; Eukaryota.
eggNOG; COG1274; LUCA.
HOGENOM; HOG000191700; -.
HOVERGEN; HBG053651; -.
InParanoid; P05153; -.
KO; K01596; -.
PhylomeDB; P05153; -.
Reactome; R-GGA-352875; Gluconeogenesis.
SABIO-RK; P05153; -.
UniPathway; UPA00138; -.
PRO; PR:P05153; -.
Proteomes; UP000000539; Unplaced.
GO; GO:0005829; C:cytosol; TAS:Reactome.
GO; GO:0050692; F:DBD domain binding; IDA:AgBase.
GO; GO:0051379; F:epinephrine binding; IDA:AgBase.
GO; GO:0005525; F:GTP binding; ISA:AgBase.
GO; GO:0008906; F:inosine kinase activity; TAS:AgBase.
GO; GO:0019157; F:malate oxidase activity; TAS:AgBase.
GO; GO:0030145; F:manganese ion binding; IDA:AgBase.
GO; GO:0003729; F:mRNA binding; IDA:AgBase.
GO; GO:0004550; F:nucleoside diphosphate kinase activity; ISS:AgBase.
GO; GO:0004613; F:phosphoenolpyruvate carboxykinase (GTP) activity; ISA:AgBase.
GO; GO:0047134; F:protein-disulfide reductase activity; TAS:AgBase.
GO; GO:0043565; F:sequence-specific DNA binding; IDA:AgBase.
GO; GO:0008343; P:adult feeding behavior; IMP:AgBase.
GO; GO:0007568; P:aging; ISA:AgBase.
GO; GO:0006522; P:alanine metabolic process; IDA:AgBase.
GO; GO:0006531; P:aspartate metabolic process; IDA:AgBase.
GO; GO:0071320; P:cellular response to cAMP; IDA:AgBase.
GO; GO:0071549; P:cellular response to dexamethasone stimulus; IDA:AgBase.
GO; GO:0071361; P:cellular response to ethanol; IDA:AgBase.
GO; GO:0071332; P:cellular response to fructose stimulus; ISA:AgBase.
GO; GO:0071377; P:cellular response to glucagon stimulus; ISA:AgBase.
GO; GO:0042149; P:cellular response to glucose starvation; IDA:AgBase.
GO; GO:0071333; P:cellular response to glucose stimulus; IDA:AgBase.
GO; GO:0071456; P:cellular response to hypoxia; ISA:AgBase.
GO; GO:0032869; P:cellular response to insulin stimulus; IDA:AgBase.
GO; GO:0071347; P:cellular response to interleukin-1; ISA:AgBase.
GO; GO:0071374; P:cellular response to parathyroid hormone stimulus; IDA:AgBase.
GO; GO:0071300; P:cellular response to retinoic acid; ISA:AgBase.
GO; GO:0071356; P:cellular response to tumor necrosis factor; ISA:AgBase.
GO; GO:0048589; P:developmental growth; IDA:AgBase.
GO; GO:0007586; P:digestion; TAS:AgBase.
GO; GO:0030703; P:eggshell formation; IMP:AgBase.
GO; GO:0009792; P:embryo development ending in birth or egg hatching; IMP:AgBase.
GO; GO:0048562; P:embryonic organ morphogenesis; IEP:AgBase.
GO; GO:0006094; P:gluconeogenesis; TAS:AgBase.
GO; GO:0006536; P:glutamate metabolic process; IDA:AgBase.
GO; GO:0006541; P:glutamine metabolic process; IDA:AgBase.
GO; GO:0019563; P:glycerol catabolic process; IDA:AgBase.
GO; GO:0006544; P:glycine metabolic process; IDA:AgBase.
GO; GO:0070365; P:hepatocyte differentiation; IEP:AgBase.
GO; GO:0050892; P:intestinal absorption; TAS:AgBase.
GO; GO:0072071; P:kidney interstitial fibroblast differentiation; TAS:AgBase.
GO; GO:0006089; P:lactate metabolic process; IDA:AgBase.
GO; GO:0016042; P:lipid catabolic process; TAS:AgBase.
GO; GO:0015743; P:malate transport; TAS:AgBase.
GO; GO:0006735; P:NADH regeneration; TAS:AgBase.
GO; GO:0045912; P:negative regulation of carbohydrate metabolic process; IDA:AgBase.
GO; GO:0018991; P:oviposition; IMP:AgBase.
GO; GO:0043950; P:positive regulation of cAMP-mediated signaling; IDA:AgBase.
GO; GO:0045913; P:positive regulation of carbohydrate metabolic process; IDA:AgBase.
GO; GO:0045722; P:positive regulation of gluconeogenesis; TAS:AgBase.
GO; GO:0006560; P:proline metabolic process; IDA:AgBase.
GO; GO:0019543; P:propionate catabolic process; IDA:AgBase.
GO; GO:0006090; P:pyruvate metabolic process; IDA:AgBase.
GO; GO:0060259; P:regulation of feeding behavior; IMP:AgBase.
GO; GO:0006111; P:regulation of gluconeogenesis; TAS:AgBase.
GO; GO:0046015; P:regulation of transcription by glucose; TAS:AgBase.
GO; GO:0051591; P:response to cAMP; IDA:AgBase.
GO; GO:0046898; P:response to cycloheximide; TAS:AgBase.
GO; GO:0051384; P:response to glucocorticoid; TAS:AgBase.
GO; GO:0070741; P:response to interleukin-6; ISA:AgBase.
GO; GO:0033993; P:response to lipid; ISA:AgBase.
GO; GO:0032496; P:response to lipopolysaccharide; ISA:AgBase.
GO; GO:1904640; P:response to methionine; ISA:AgBase.
GO; GO:0042594; P:response to starvation; IDA:AgBase.
GO; GO:0009069; P:serine family amino acid metabolic process; IDA:AgBase.
GO; GO:0019953; P:sexual reproduction; IMP:AgBase.
GO; GO:0007296; P:vitellogenesis; IMP:AgBase.
CDD; cd00819; PEPCK_GTP; 1.
Gene3D; 3.40.449.10; -; 1.
Gene3D; 3.90.228.20; -; 2.
HAMAP; MF_00452; PEPCK_GTP; 1.
InterPro; IPR018091; PEP_carboxykin_GTP_CS.
InterPro; IPR013035; PEP_carboxykinase_C.
InterPro; IPR008209; PEP_carboxykinase_GTP.
InterPro; IPR035077; PEP_carboxykinase_GTP_C.
InterPro; IPR035078; PEP_carboxykinase_GTP_N.
InterPro; IPR008210; PEP_carboxykinase_N.
PANTHER; PTHR11561; PTHR11561; 1.
Pfam; PF00821; PEPCK_C; 1.
Pfam; PF17297; PEPCK_N; 1.
PIRSF; PIRSF001348; PEP_carboxykinase_GTP; 1.
SUPFAM; SSF68923; SSF68923; 1.
PROSITE; PS00505; PEPCK_GTP; 1.
2: Evidence at transcript level;
Complete proteome; Cytoplasm; Decarboxylase; Gluconeogenesis;
GTP-binding; Lyase; Manganese; Metal-binding; Nucleotide-binding;
Reference proteome.
CHAIN 1 622 Phosphoenolpyruvate carboxykinase,
cytosolic [GTP].
/FTId=PRO_0000103631.
NP_BIND 287 292 GTP. {ECO:0000250|UniProtKB:P07379}.
NP_BIND 530 533 GTP. {ECO:0000250|UniProtKB:P07379}.
REGION 235 237 Substrate binding.
{ECO:0000250|UniProtKB:P07379}.
REGION 403 405 Substrate binding.
{ECO:0000250|UniProtKB:P07379}.
ACT_SITE 288 288 {ECO:0000250|UniProtKB:P07379}.
METAL 244 244 Manganese.
{ECO:0000250|UniProtKB:P07379}.
METAL 264 264 Manganese; via tele nitrogen.
{ECO:0000250|UniProtKB:P07379}.
METAL 311 311 Manganese.
{ECO:0000250|UniProtKB:P07379}.
BINDING 87 87 Substrate.
{ECO:0000250|UniProtKB:P07379}.
BINDING 286 286 Substrate.
{ECO:0000250|UniProtKB:P07379}.
BINDING 405 405 GTP. {ECO:0000250|UniProtKB:P07379}.
BINDING 436 436 GTP. {ECO:0000250|UniProtKB:P07379}.
SEQUENCE 622 AA; 69528 MW; 1BB1E708A3D5E722 CRC64;
MAPELKTEVN IISKVIQGDL ESLPPQVREF IESNAKLCQP ESIHICDGSE EENKKILDIM
VEQGMIKKLS KYENCWLALT NPRDVARIES KTVIITQEQR DTIPIPKTGS SQLGRWMSEE
DFEKAFNTRF PGCMQGRTMY VIPFSMGPIG SPLAKIGIEL TDSPYVVASM RMMTRMGTAA
LKALGNGEFV KCLHSVGCPL PLKEPLINNW PCNPELTLIA HLPDRREIIS FGSGYGGNSL
LGKKCFALRI ASRIAKEEGW LAEHMLILGI TNPEGEKKYF AAAFPSACGK TNLAMMNPSR
PGWKIECVGD DIAWMKFDEL GNLRAINPEN GFFGVAPGTS IKTNPNAIKT IFKNTIFTNV
AETSDGGVYW EGIDEPLPPG VTLTSWKNKD WTPDNGEPCA HPNSRFCTPA SQCPIMDPAW
ESPEGVPIEG IIFGGRRPAG VPLVYEAFNW QHGVFIGAAM RSEATAAAEH KGKIIMHDPF
AMRPFFGYNF GKYLAHWLSM AHRPAAKLPR IFHVNWFRKD SQGKFLWPGY GENSRVLEWM
FNRIQGKASA KSTAIGYIPA DTALNLKGLE DINLTELFNI SKEFWEKEVE EIKQYFEGQV
NADLPYEIER ELLALEMRIK QL


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