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Phosphoenolpyruvate carboxykinase [GTP] (PEP carboxykinase) (PEPCK) (EC 4.1.1.32) (GTP-dependent phosphoenolpyruvate carboxykinase) (GTP-PEPCK)

 A0A1L8N2K1_9SPIO        Unreviewed;       632 AA.
A0A1L8N2K1;
15-MAR-2017, integrated into UniProtKB/TrEMBL.
15-MAR-2017, sequence version 1.
25-APR-2018, entry version 8.
RecName: Full=Phosphoenolpyruvate carboxykinase [GTP] {ECO:0000256|HAMAP-Rule:MF_00452};
Short=PEP carboxykinase {ECO:0000256|HAMAP-Rule:MF_00452};
Short=PEPCK {ECO:0000256|HAMAP-Rule:MF_00452};
EC=4.1.1.32 {ECO:0000256|HAMAP-Rule:MF_00452};
AltName: Full=GTP-dependent phosphoenolpyruvate carboxykinase {ECO:0000256|HAMAP-Rule:MF_00452};
Short=GTP-PEPCK {ECO:0000256|HAMAP-Rule:MF_00452};
Name=pckG {ECO:0000256|HAMAP-Rule:MF_00452};
ORFNames=BKP49_03200 {ECO:0000313|EMBL:OJF77155.1};
Treponema sp. CETP13.
Bacteria; Spirochaetes; Spirochaetales; Spirochaetaceae; Treponema.
NCBI_TaxID=1908540 {ECO:0000313|EMBL:OJF77155.1};
[1] {ECO:0000313|EMBL:OJF77155.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Nathani N.M., Tikariha H., Hinsu A.T., Purohit H.J., Joshi C.G.;
"Candidatus Treponema sp. CETP13 genome retrieved from CETP activated
sludge metagenomes.";
Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Catalyzes the conversion of oxaloacetate (OAA) to
phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic
pathway that produces glucose from lactate and other precursors
derived from the citric acid cycle. {ECO:0000256|HAMAP-
Rule:MF_00452}.
-!- CATALYTIC ACTIVITY: GTP + oxaloacetate = GDP + phosphoenolpyruvate
+ CO(2). {ECO:0000256|HAMAP-Rule:MF_00452}.
-!- COFACTOR:
Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
Evidence={ECO:0000256|HAMAP-Rule:MF_00452};
Note=Binds 1 Mn(2+) ion per subunit. {ECO:0000256|HAMAP-
Rule:MF_00452};
-!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
{ECO:0000256|HAMAP-Rule:MF_00452}.
-!- SUBUNIT: Monomer. {ECO:0000256|HAMAP-Rule:MF_00452}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00452}.
-!- SIMILARITY: Belongs to the phosphoenolpyruvate carboxykinase [GTP]
family. {ECO:0000256|HAMAP-Rule:MF_00452}.
-!- CAUTION: Lacks conserved residue(s) required for the propagation
of feature annotation. {ECO:0000256|HAMAP-Rule:MF_00452}.
-!- CAUTION: The sequence shown here is derived from an
EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
preliminary data. {ECO:0000313|EMBL:OJF77155.1}.
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EMBL; MLPZ01000003; OJF77155.1; -; Genomic_DNA.
UniPathway; UPA00138; -.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
GO; GO:0030145; F:manganese ion binding; IEA:UniProtKB-UniRule.
GO; GO:0004613; F:phosphoenolpyruvate carboxykinase (GTP) activity; IEA:UniProtKB-UniRule.
GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-UniRule.
Gene3D; 3.40.449.10; -; 2.
Gene3D; 3.90.228.20; -; 2.
HAMAP; MF_00452; PEPCK_GTP; 1.
InterPro; IPR018091; PEP_carboxykin_GTP_CS.
InterPro; IPR013035; PEP_carboxykinase_C.
InterPro; IPR008209; PEP_carboxykinase_GTP.
InterPro; IPR035077; PEP_carboxykinase_GTP_C.
InterPro; IPR035078; PEP_carboxykinase_GTP_N.
InterPro; IPR008210; PEP_carboxykinase_N.
PANTHER; PTHR11561; PTHR11561; 1.
Pfam; PF00821; PEPCK_C; 1.
Pfam; PF17297; PEPCK_N; 1.
PIRSF; PIRSF001348; PEP_carboxykinase_GTP; 1.
SUPFAM; SSF68923; SSF68923; 1.
PROSITE; PS00505; PEPCK_GTP; 1.
3: Inferred from homology;
Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00452};
Decarboxylase {ECO:0000256|HAMAP-Rule:MF_00452,
ECO:0000256|SAAS:SAAS00647546};
Gluconeogenesis {ECO:0000256|HAMAP-Rule:MF_00452};
GTP-binding {ECO:0000256|HAMAP-Rule:MF_00452};
Kinase {ECO:0000313|EMBL:OJF77155.1};
Lyase {ECO:0000256|HAMAP-Rule:MF_00452,
ECO:0000256|SAAS:SAAS00647546};
Manganese {ECO:0000256|HAMAP-Rule:MF_00452};
Metal-binding {ECO:0000256|HAMAP-Rule:MF_00452};
Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00452};
Pyruvate {ECO:0000313|EMBL:OJF77155.1};
Transferase {ECO:0000313|EMBL:OJF77155.1}.
DOMAIN 30 241 PEPCK_N. {ECO:0000259|Pfam:PF17297}.
DOMAIN 246 611 PEPCK_C. {ECO:0000259|Pfam:PF00821}.
NP_BIND 276 281 GTP. {ECO:0000256|HAMAP-Rule:MF_00452}.
REGION 222 224 Substrate binding. {ECO:0000256|HAMAP-
Rule:MF_00452}.
REGION 390 392 Substrate binding. {ECO:0000256|HAMAP-
Rule:MF_00452}.
ACT_SITE 277 277 {ECO:0000256|HAMAP-Rule:MF_00452}.
METAL 231 231 Manganese. {ECO:0000256|HAMAP-
Rule:MF_00452}.
METAL 250 250 Manganese; via tele nitrogen.
{ECO:0000256|HAMAP-Rule:MF_00452}.
METAL 294 294 Manganese. {ECO:0000256|HAMAP-
Rule:MF_00452}.
BINDING 87 87 Substrate. {ECO:0000256|HAMAP-
Rule:MF_00452}.
BINDING 275 275 Substrate. {ECO:0000256|HAMAP-
Rule:MF_00452}.
BINDING 392 392 GTP. {ECO:0000256|HAMAP-Rule:MF_00452}.
BINDING 424 424 GTP. {ECO:0000256|HAMAP-Rule:MF_00452}.
SEQUENCE 632 AA; 71414 MW; FE051A7C43EF83DF CRC64;
MSKYDNLLKG KMTDESWTRL TALKNEKVME FVGEFAEHCN PKTIYVCDDS TESEEYVKAA
AIKNGEESKL ANSEQTIHYD GYGDQARDKV NTRYIVYPEN LESMKAMNSL PYDEGYKEVM
SYAKNGMAGK EAYVKCFTEG PTDSIFTVPC IQMTDSAYVC HSETILYRPG YEYIKKNNSQ
DFFRFVHTAG ELDELGCSKN VDKRRIYMDC QNNIVYSTNN QYAGNSLGMK KHSMRLSINK
AGKEGWLCEH MFLMACMGTG KNEGRKTYFA GAYPSGCGKT STAMIPGEKI VGDDITYFRN
IDGEFRGVNF EQGIFGIIKD VNAEDDPVIF ANLMKNQEII FSNVLTGPDN KPYWLGMGMD
TPKSGKNHHG AWKEGDKDAN GNEVKLAHAN SRYTMRLSYL DNYDKEGFES KTGVKVQGIL
YGGRDSSISV PCEESATWRD GILLKACTLE SETTAQTLGA EGVLKPSPMA CMDFVSYPLG
QYTMNNIKFG EGVKDCPKIF STNYFLKGPK GEFLTSKLAK KVWLHWAEGR VYGEYEAIDT
PTGKIPLYED IAKLFKEYLP KEEFSKETYT YMFTFRTQAI IDKIVRTKKF FAEKDPNVPA
EINNYWDAKV KELEAVKAKY GNEIKPGEYK GL


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